Xolox Side Effects

  • Generic Name or Active Ingridient: Oxycodone Hydrochloride And Acetaminophen

Xolox is an opioid pain reliever distributed by Rebel Distribution Corp. Xolox contains 10 mg of oxycodone hydrochloride and 500 mg of acetaminophen. Xolox is for oral administration only.

Doctors prescribe Xolox to relieve moderate to moderately severe pain. Recreational users target because of the euphoria oxycodone provides.

Oxycodone is a semi-synthetic opioid pain reliever, sometimes called a narcotic. Pharmacologists create oxycodone from thebaine, an alkaloid extracted from the opium poppy plant, Papaver somniferum.

Oxycodone, like other opioids, binds to nerve receptors to send messages of pleasure and relaxation to the brain. Oxycodone causes euphoria and changes the way the brain perceives pain by suppressing and exciting the central nervous system, or CNS. Because of this direct action on the CNS, many side effects associated with Xolox affect the central nervous system. Using Xolox with other CNS depressants, including alcohol or other pain relievers, increases these effects.

Opioids including oxycodone act directly on the breathing centers in the brain to soothe a nagging cough. Opioids may cause respiratory side effects including respiratory depression and other serious breathing problems.

Oxycodone and other opioids work on smooth muscle groups like those in the digestive system to curb diarrhea. As a result, Xolox may cause side effects involving the gastrointestinal tract.

Acetaminophen is a less-potent pain reliever that works differently than oxycodone to relieve pain. Acetaminophen blocks the production of prostaglandin, a natural chemical responsible for sending pain messages to the brain, signaling cells to leak fluid and cause inflammation and swelling, and triggers a high fever. Most people tolerate acetaminophen well when used at therapeutic doses.

Side Effect Information

All drugs, including Xolox, can cause side effects. Many people experience no, or minor, adverse reactions while using Xolox. Most side effects associated are not serious and go away after a few days of use at therapeutic doses. A few side effects are serious, requiring immediate medical attention.

Side effects associated with Xolox are typical of any opioid. Excessive doses and chronic Xolox use increases the risk for adverse reactions.

Abuse and Physical Dependence

The U.S. Drug Enforcement Agency, or DEA, classifies substances according to their relative potential for abuse. For example, the DEA classifies heroin as a schedule I drug, meaning it poses the greatest risk for abuse and offers no medical value. The DEA classifies all drugs containing oxycodone, including Xolox, as schedule II narcotics, meaning Xolox poses the same relative risk for abuse as raw opium.

Using Xolox continuously for more than a few weeks may cause the consumer to become opioid-dependent. An opioid-dependent person suffers flu-like withdrawal symptoms when he stops taking Xolox. Some medications, including naloxone, will reduce opioid levels and cause withdrawal symptoms in an opioid-dependent person.

Patients using Xolox for more than a few weeks should taper Xolox use over a two-week period to reduce the occurrence and severity of withdrawal symptoms. Withdrawal symptoms can cause flu-like symptoms such as abdominal cramps, nausea, vomiting and diarrhea, chills and hot flashes, sneezing, muscle aches and pronounced weakness. Other flu-like symptoms associated with Xolox withdrawal include watery eyes, runny or stuffy nose, sweating and goose bumps.

Other physical symptoms of Xolox withdrawal may include yawning, increased heart rate and blood pressure, restlessness or nervousness, insomnia and tremor. The patient may experience excessive salivation, loss of appetite and dilated pupils.

Psychological symptoms of withdrawal can include anxiety, irritability and depression.

To avoid withdrawal symptoms, a person who has taken Xolox continuously for more than a few weeks should wean himself from this medication by taking successively smaller doses further apart. A qualified detoxification facility can help a person whose withdrawal symptoms prevent him from quitting this drug.

Addiction

It is possible to become addicted to Xolox. Doctors diagnose a person as being addicted to Xolox if the patient experiences cravings and engages in drug seeking behavior when Xolox supplies run low. Without prompt and adequate treatment, Xolox addiction can cause disability or premature death.

Tolerance

The human body can grow tolerant to the effects of Xolox. A person with high tolerance must take larger doses more frequently to achieve the same analgesic or euphoric effect. High tolerance may cause an individual to take larger doses of Xolox and, as the result, can increase the chances the consumer will experience side effects.

Someone with low tolerance is more sensitive to the effects of Xolox and, consequently, faces an increased risk for experiencing side effects.

Most Frequently Observed Side Effects

The most frequently reported adverse reactions include lightheadedness, dizziness, drowsiness or sedation, nausea and vomiting. These side effects are more common in ambulatory patients than in consumers confined to bed rest or a wheelchair. Lying down may ease these side effects.

Other Xolox side effects include euphoria and its emotional opposite dysphoria, along with constipation and itch.

Allergic Reaction

Anyone can suffer an allergic reaction to Xolox or any other medication. People allergic to oxycodone, acetaminophen or any ingredient in Xolox should not take this drug. Those who are allergic to other opioid drugs, including morphine or codeine, should not take Xolox.
Anyone can suffer an allergic reaction. An allergic reaction is a serious emergency that requires immediate professional care. Transport all suspected cases of an allergic reaction to Xolox to the nearest urgent care facility or emergency room. Take the Xolox bottle and any other medications to help emergency department doctors determine the cause of the reaction.

Symptoms of an allergic reaction may appear within seconds or minutes of exposure. Rarely, reactions develop 24 hours after exposure to an allergen. Common symptoms of a mild allergic reaction include:

  • Hives, especially over the neck and face
  • Itching
  • Nasal congestion
  • Rashes
  • Watery, red eyes

Symptoms of a moderate to severe reaction include:

  • Abdominal pain
  • Abnormal or high-pitched breathing sound
  • Anxiety
  • Chest discomfort or tightness
  • Cough
  • Diarrhea
  • Difficulty breathing
  • Difficulty swallowing
  • Dizziness or light-headedness
  • Flushing or redness of the face
  • Nausea or vomiting
  • Palpitations
  • Swelling of the face, eyes or tongue
  • Unconsciousness
  • Wheezing

Anaphylaxis is a serious, potentially fatal type of allergic reaction. Anaphylaxis usually starts within seconds or minutes of exposure, but anaphylaxis may start as late as a half an hour or longer after contact. Transport the victim to the hospital immediately and bring the bottle of Xolox along with all other medications.

Symptoms of anaphylaxis include:

  • Abdominal pain
  • Abnormal, high-pitched breathing sounds
  • Anxiety
  • Chest discomfort or tightness
  • Cough
  • Diarrhea
  • Difficulty breathing
  • Difficulty swallowing
  • Dizziness or light-headedness
  • Hives, itchiness
  • Nasal congestion
  • Nausea or vomiting
  • Palpitations
  • Skin redness
  • Slurred speech
  • Swelling of the face, eyes, or tongue
  • Unconsciousness
  • Wheezing

Signs include:

  • Abnormal heart rhythm
  • Blue skin from lack of oxygen
  • Fluid in the lungs
  • Hives
  • Low blood pressure
  • Mental confusion
  • Pale skin from shock
  • Rapid pulse
  • Swelling in the throat
  • Swelling of the eyes or face
  • Weakness
  • Wheezing

Hypersensitivity

Some consumers may be hypersensitive to the effects of Xolox. This individuals may experience skin eruptions, hives and redness of the skin. Reactions in the blood may include low platelet counts that can prevent clotting and prolong bleeding time and conditions affect red and white blood cell counts including neutropenia, pancytopenia and hemolytic anemia.

Serious Side Effects

The most serious side effects associated with drug use include respiratory depression, apnea, respiratory arrest, circulatory depression, hypotension, and shock. Respiratory depression is a condition where the lungs do not perform well, causing a lack of oxygen and build-up of toxic gases. Symptoms of respiratory depression include slow, shallow or irregular breathing and a bluish tint around the eyes, mouth and fingertips as the body struggles to get enough oxygen.

By body system

Body as a Whole

Xolox may cause adverse reactions to the body as a whole. Along with allergic reaction and anaphylaxis, general side effects include malaise, weakness and fatigue. Xolox use may cause chest pain, fever, hypothermia, thirst, headache and increased sweating. Xolox, as with other opioids, is associated with some cases of accidental overdose and non-accidental overdose.

Cardiovascular

Xolox side effects may involve the heart and circulatory system. Xolox use may cause high or low blood pressure or blood pressure changes when the consumer stands up. Other cardiovascular side effects include fast, slow or irregular heartbeats.

Central and Peripheral Nervous System

The oxycodone in Xolox works directly on the central and peripheral nervous system to relieve pain, calm anxiety, cause sedation and euphoria. As the result of this direct interaction between the nervous system and oxycodone, Xolox may cause adverse reactions in the nervous system. These adverse reactions may include stupor, tremor, numbness or tingling, lethargy, seizures, anxiety, mental impairment, agitation, cerebral edema, confusion and dizziness.

Fluid and Electrolyte

Xolox use may result in fluid and electrolyte imbalances, including dehydration, high potassium levels in the blood and imbalances in the acid/base levels of the blood.

Gastrointestinal

The direct action of oxycodone on the smooth muscles in the digestive tract may result in gastrointestinal side effects. Xolox consumers have reported stomach upset, taste disturbances, abdominal pain and bloating. Others have experienced increased sweating, diarrhea, dry mouth, gas, nausea and vomiting. Serious gastrointestinal Xolox side effects include pancreatitis, intestinal obstruction and blockage in the bowel.

Hepatic

Xolox may affect the liver and hepatic system, causing temporarily high levels of liver enzymes and bilirubin. Other Xolox hepatic side effects include hepatitis, liver failure, yellowing of the skin or eyes, liver damage and liver disease.

Hearing and Vestibular

Xolox use may cause hearing loss. Some Xolox consumers report tinnitus, or ringing in the ears.

Hematologic

Xolox use may affect the hematologic system and cause the bleeding disorder, thrombocytopenia.

Hypersensitivity

Some consumers are hypersensitive to the effects of Xolox and may experience acute anaphylaxis, swelling under the skin, asthma and other breathing problems, swelling of the throat and hives.

Metabolic and Nutritional

Xolox use may affect the body's chemical balance, resulting in high or low blood sugar levels or imbalances in the body's acid/base levels.

Musculoskeletal

Xolox consumers have reported musculoskeletal side effects including muscle aches and pain. Xolox use may cause the serious muscle problem, rhabdomyolysis.

Ocular

Using Xolox may affect the eyes, causing pinpoint pupils, visual disturbances and red eyes.

Psychiatric

Xolox consumption may cause psychiatric side effects including drug dependence and drug abuse. This drug may also cause insomnia, confusion, anxiety or agitation. Some Xolox consumers report a depressed level of consciousness, nervousness, hallucination and sleepiness. Serious psychiatric side effects include depression and suicide.

Respiratory System

The oxycodone in Xolox acts directly on the breathing centers in the brain, consequently Xolox may cause adverse reactions affecting the respiratory system. Xolox may cause Bronchospasm, shortness of breath, abnormally deep, shallow or rapid breathing, fluid in the lungs and swelling of the throat. Xolox may cause aspiration, where the victim vomits then inhales the stomach contents. Aspiration may result in fluid in the lungs or lung infection.

Skin and Appendages

Xolox use may cause adverse reactions affecting the skin, including redness, hives and rash. The consumer may experience flushing, or a warm sensation spreading across the skin.

Urogenital

Xolox use may cause adverse reactions affecting the kidneys and urinary tract. Xolox may cause the serious kidney diseases, interstitial nephritis and papillary necrosis, or cause renal insufficiency and failure. Using Xolox may result in high levels of protein in the urine or urinary retention.

Facts

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Risks