Xolox Detox

  • Generic Name or Active Ingridient: Oxycodone Hydrochloride And Acetaminophen

Doctors prescribe Xolox to relieve moderate to severe pain. Xolox contains oxycodone and acetaminophen. Oxycodone and acetaminophen work in different but complimentary ways to relieve pain better than either drug could alone. These different actions are important factors in the development of drug dependence; oxycodone and acetaminophen also affect the body in different ways during the Xolox detoxification process.

Most people use Xolox as prescribed and dispose of unused doses when they no longer need Xolox to control pain. Some people, however, use Xolox for non-medical reasons either to get high or to treat a different condition than the one the doctor had in mind when she wrote the prescription. About 5 million Americans use painkillers for non-medical use every year. This non-medical use increases the risk for developing dependence requiring Xolox detoxification.


Anyone who uses Xolox can become physically dependent on oxycodone. Oxycodone is a commonly prescribed semi-synthetic drug; U.S. pharmacists filled 58.2 million prescriptions for Xolox and other drugs containing oxycodone in 2010. Pharmaceutical companies make oxycodone from thebaine, an extract from the opium poppy plant. Scientists classify oxycodone as an opioid drug with an action similar to morphine and codeine.

The oxycodone in Xolox acts like other opioids to relieve pain, by acting directly on the nervous system to change the way the brain interprets pain signals. Oxycodone causes other neurological reactions, with the most immediately evident being sedation, relaxation, and euphoria. These neurological effects make oxycodone and other opioids attractive to recreational users.

Long-term oxycodone use causes other neurological reactions that alter how someone thinks, feels, and behaves. In time, these alterations negatively affect his ability to work, take care of personal responsibilities, and interact with others. Left untreated, Xolox abuse may lead to job loss and financial crisis, homelessness, divorce and loss of child custody, criminal activity and incarceration, illness, overdose, and death. These consequences have a profoundly negative effect on the individual’s physical, mental, and social well-being.


The acetaminophen in Xolox is not an opioid and not associated with abuse or dependence requiring detoxification, but long-term acetaminophen use can cause serious health problems, especially acute liver failure. These health hazards can cause complications during Xolox detoxification.

Dependence and Withdrawal

Anyone who uses Xolox continuously for more than a few weeks can become dependent on oxycodone and require detoxification, whether he uses Xolox for therapeutic purposes or for non-medical reasons. The human body adapts to the presence of some toxic substances, including the oxycodone in Xolox. In time, the body begins to depend on a certain level of oxycodone to feel normal - the body becomes opioid-dependent.

When oxycodone levels drop suddenly, the opioid-dependent body struggles to regain stability and recover from the toxic effects of Xolox use. Doctors refer to this as Xolox detoxification.

Xolox withdrawal symptoms

An opioid-dependent person experiences detoxification through unpleasant and demoralizing, flu-like withdrawal symptoms. These symptoms tend to appear in two waves, with the first set of symptoms beginning a few hours after the last dose of Xolox.

Early symptoms include:

  • Chills
  • Dilated pupils
  • muscle pain and body aches
  • Perspiration
  • Restlessness
  • Runny nose
  • Watery eyes
  • Yawning

Later, the individual may experience:

  • Anxiety
  • Appetite loss
  • Backache
  • Diarrhea
  • Increased blood pressure, respiratory rate, or heart rate
  • Insomnia
  • Irritability
  • Joint pain
  • Nausea and vomiting
  • Stomach cramps
  • Weakness

Withdrawal symptoms will persist for five days or longer, with symptoms continually worsening and reaching their most severe on or about the fourth day. Left uninterrupted, withdrawal symptoms fade by themselves as the body completes detoxification; withdrawal symptoms do not return unless the individual relapses to an opioid-dependent state.

Benefits of Detoxification

According to the Institute of Addiction Medicine, almost 2 million Americans are dependent on opioids like the oxycodone and will need to participate in some type of detoxification to reach an opioid-free state. In addition to cleansing the body from the toxic effects of Xolox, detoxification provides other benefits.

Xolox detoxification ends oxycodone withdrawal symptoms; this helps the patient feel better and think more clearly. Detoxification by itself, however, does little to change the behaviors that could cause a relapse. Most opioid-dependent people benefit from some amount of rehabilitation to learn how to identify situations that could potentially lead to drug abuse and how to refuse drugs when offered.

Xolox detoxification facilitates the patient’s entry into rehabilitation and helps him remain there long enough to reverse some of the neurological changes that affect his thoughts, emotions, and behaviors. Detoxification promotes abstinence, reducing the frequency and severity of relapses when they do occur.

Types of Xolox Detoxification

Only about 10 percent of people who detoxify get help from More than 21 million people in the United States needed treatment in 2011. Only about of those who needed it got it in a specialty facility, such as an inpatient hospital, inpatient or outpatient rehabilitation facility or mental health centers. Other individuals engaged in self-help, worked with a private physician, sought treatment in an emergency room or while incarcerated in a prison or local jail. These are all viable choices. Treatment choice depends heavily on individual needs. The National Institute on Drug Abuse, or NIDA, states there were 1.8 million admissions to treatment centers in the United States for help with drug and alcohol abuse during 2008. While alcohol abuse made up for most admissions, opiates accounted for about 20 percent of drug-related admissions.

Natural remedies

Many individuals seek out natural detoxification remedies, including acupuncture, meditation, yoga and massage. Others use a nutritional approach, consuming only certain herbs, vegetables, fruits, soups and juices to help the body naturally detoxify itself. Ginger and peppermint relieve nausea, for example, while chamomile and cayenne curb diarrhea.

Self-medication methods such as The Thomas Recipe. Includes a benzodiazepine such as Valium, Librium, Ativan or Xanax for anxiety and insomnia. Imodium for diarrhea, L-Tyrosine for malaise, Vitamin B6 and supplements along with hot baths for muscle aches and restless leg syndrome.

Medical Detox

Outpatient: Outpatient detoxification is appropriate for those patients that have been dependent on opioids for more than a year and who require little supervision. Usually done with replacement Drugs: Such as Methadone, Suboxone, Subutex and or Buprenorhine. Sometimes outpatient clinics will administer methadone or buprenorphine as a “step down” drug to ease withdrawal symptoms in patients attempting detoxification at home. Doctors refer to this as medication-assisted treatment or medically supervised withdrawal. Patients start out on a high dose of the replacement drug during the induction phase and reduce the daily dosage over the course of several days or weeks during the tapering phase.


German laboratories first synthesized methadone in 1939 as a pain reliever. In 1964, doctors developed methadone as a response to an epidemic of heroin use sweeping across New York City. The FDA approved methadone for use in the treatment of opioid dependence in 1972. About 100,000 Americans use a methadone maintenance program. Methadone patients come to the methadone clinic for a drink containing methadone. The effects of methadone last 24 to 36 hours. Some methadone clinics offer services including vocational and educational aid, referrals to other services, support for family members and treatment for co-existing substance abuse problems. Doctors normally start patients on 10 to 15 mg of methadone, increasing dosages by 10 mg each day until the patient no longer experiences withdrawal symptoms. Once the physician determines a safe and effective induction dose, he decreases subsequent doses by 10 mg each day until the patient is no longer dependent on opioids.


Taken three times a week under the tongue.

Some patients use buprenorphine as part of medically supervised withdrawal. While there is no set tapering schedule, some patients can complete detoxification in as little as one week, spending the first one to three days in the induction phase and tapering during days four through seven.

Buprenorphine is available under the brand name, Subutex.


Suboxone is a brand name preparations of buprenorphine that also contain naloxone, sometimes referred to as Narcan, which has little effect when dissolved under the tongue but neutralizes the effects of buprenorphine when injected. In September of 2012, Reckitt Benckiser voluntarily replaced buprenorphine tablets with film to discourage abuse and accidental exposure to children.

Inpatient Treat the individual symptoms of the withdrawal with a non opiate medication. One medication is given for anxiety, another for nausea, another for diarrhea, and another to decrease a derivative of adrenaline that becomes elevated during withdrawal. The benefit of this approach is that the withdrawal is less uncomfortable than quitting cold turkey and is not prolonged through the use of substitute opiate medications. The patient may receive an anti-emetic like Hydroxyzine or Promethazine to calm nausea, Loperamide for diarrhea, and Clonidine for a variety of symptoms including watery eyes, sweating and restlessness. The physician may administer naltrexone to lower opioid levels and initiate the detoxification process. Inpatient treatment is appropriate for those who: have suffered an overdose and cannot receive treatment safely in an outpatient setting. Are at risk for severe withdrawal symptoms or complications Have co-existing conditions that make outpatient detoxification unsafe Have a documented history of not engaging in or benefiting from less restrictive programs Have psychiatric problems that impair his ability to participate in treatment, including depression with suicidal thoughts or acute psychosis. Exhibit behaviors that may cause danger to himself or others Have not responded to less restrictive forms of treatment and suffers opioid dependence severe enough to pose a threat to the patient or others

Rapid Opiate Detox

Rapid opiate detox is a safe and effective procedure that rids the body of opiates while the patient rests in a comfortable “twilight sleep.”

Our detox center: Who we are and what we do

Fully accredited hospital, board-certified anesthesiologists, other medical professionals deliver compassionate and effective care for more than a decade. Pre-screening in an accredited facility for pre-existing conditions that undermine success. Create a treatment plan according to the patient’s personal needs. Complete detoxification. Follow up in an aftercare facility.

Detox Comparisons

Self-detoxification is the least expensive and most private. Associated with most risk for complications due to uncontrolled withdrawal symptoms.

Outpatient maintenance is better than self-detoxification in that it offers replacement drugs and counseling. Outpatient care reduces the risk for complications. Patients remain in treatment for months or years.

Inpatient care is better because it offers complete detoxification before the individual engages in rehabilitation. Inpatient care offers more monitoring.

The average length of stay for detoxification is 4 days, compared with 197 days for medication-assisted therapy.

Rapid detox is the most humane and efficient approach, offering fast and complete detoxification. Rapid detox brings the patient to a drug-free state in hours rather than days or months. Rapid detox frees the patient from the uncomfortable and demoralizing withdrawal symptoms that interfere with recovery.

Detox Possible Complications

The detoxification process is not usually a life-threatening procedure but complications can be dangerous. Pre-existing medical conditions and co-existing substance abuse problems increase the risk for complications, as do pregnancy and long-term or severe substance abuse.

Self Detox Possible Complications

Vomiting and diarrhea resulting in dehydration and electrolyte imbalance Withdrawal symptoms such as increased blood pressure, increased pulse, and sweating can worsen underlying cardiovascular conditions. Withdrawal may cause fever that fades with detoxification. Withdrawal can cause the patient to feel anxious, which can worsen pre-existing anxiety disorders. Detoxification can cause pain in patients who are still suffering from chronic pain conditions. Overdose from opioid pain relievers like this drug claim the lives of 14,800 Americans in 2008, killing more people than overdose from cocaine and heroin combined. Acetaminophen overdose is one of the most common poisonings worldwide and is the leading cause of acute liver failure in the United States. In 2005, Americans purchased more than 28 billion doses of products containing acetaminophen.

For some people, taking any more than the recommended total daily dose of 4,000 mg of acetaminophen can lead to serious liver injury. Doses exceeding 7,000 mg may result in death.

Outpatient Care Possible Complications

Methadone accounts for a third of opioid pain reliever deaths, up six fold in ten years, even though methadone sales account for only 2 percent of the prescription painkiller market. in 2009, there were 5.5 times as many deaths associated with methadone as there were in 1999. There is some risk for buprenorphine abuse, as the abuser dissolves and injects the buprenorphine tablet. Death is possible, especially when combining buprenorphine with benzodiazepines.

Inpatient Detox Possible Complications

Withdrawal from multiple substances, especially alcohol, benzodiazepines, sedatives and anti-anxiety drugs.

Rapid Detox Possible Complications

Allergic reaction. High doses of sedatives can cause problems with breathing, high blood pressure and heart rate. A patient may suffer infection, bruising or swelling at the injection site.

Detox Myths

Self Detox Myths

Myth: Self-detoxification is safe. Fact: Self-detoxification produces uncontrolled withdrawal symptoms that may result in dangerous or life threatening complications.

Myth: Home remedies like The Thomas Recipe are safe and effective. Fact: Only a doctor has the medical knowledge and the legal power to prescribe safe and effective drugs.

Outpatient Detox Myths

Myth: It is cheaper to imprison drug abusers than to provide methadone. Fact: One year of methadone costs an average of $4,700 per patient. One year of imprisonment costs about $24,000 per person.

Myth: Methadone rots your teeth and bones. Fact: Like other drugs, methadone can cause a dry mouth, which promotes plaque, leading to tooth decay and gum disease. Drink water, brush and floss daily. Inadequate methadone doses may cause bone ache, a symptom of methadone withdrawal.

Myth: Methadone causes weight gain. Fact: Methadone may slow metabolism and cause urinary retention. Additionally, methadone restores a healthy appetite that leads to an increase in eating patterns and muscle mass.

Inpatient Detox Myths

Fact: Relapse rates for drug addiction are similar to those of other chronic diseases, such as high blood pressure, diabetes or asthma. Even with treatment, relapse rates for drug addiction are 40 to 60 percent.

Fact: Experts estimate every dollar spent on drug treatment programs returns a yield between $4 and $7 in reduced drug-related crime rates, criminal justice costs and theft. When these experts add in healthcare costs associated with dependence, savings rise to $12 gained for every dollar spent.

Rapid Detox Myths

Myth: Detox always involves suffering. Fact: Rapid detox is a humane approach to medical detoxification. Rapid detox patients enjoy a pleasant twilight sleep instead of enduring endless days of detoxification.

Myth: Medical detoxification takes eight or more hours. Fact: It takes a reputable expert one to two hours to perform rapid detox.

Detox and Pregnancy Women who are opioid-dependent face a higher risk for certain medical disorders, including anemia, blood infections, heart disease, depression and other mental disorders, hepatitis, pneumonia and gestational diabetes, or widely fluctuating blood sugar levels during pregnancy. Opioid-dependent women are at higher risk for contracting and spreading infectious diseases, including sexually transmitted diseases, HIV/AIDS and tuberculosis.

Opioid dependence increases risk for complications during pregnancy, labor and delivery. Hemorrhage, inflammation of the membrane surrounding the baby, separation of the tissue between the mother and baby, slowed fetal growth, premature labor and delivery, spontaneous abortion, fetal death. Methadone reduces these complications.

Using opioids regularly during pregnancy may result in neonatal abstinence syndrome, or NAS. A baby born with NAS suffers withdrawal symptoms during the first weeks or months of life. NAS babies also suffer from low birth weight, seizures, breathing problems, feeding difficulties and death.

Methadone is currently only approved treatment plan for pregnant women, although a recent study published in the New England Journal of Medicine calls buprenorphine “an acceptable treatment for opioid dependence in pregnant women.”

Self-Detoxification and Pregnancy

Inpatient Induction to Methadone Maintenance during Pregnancy

10 mg to 20 mg 5 - 10 mg Maximum 60 mg of methadone daily Fetal monitoring This inpatient stay typically lasts three days.

Outpatient Induction

Treatment specialists should observe the pregnant patient twice daily until her condition is stable, usually within 48 to 72 hours. Women using methadone to maintain opioid dependence may suffer withdrawal symptoms late in pregnancy and require larger doses of methadone.

Babies born to women taking methadone during pregnancy will remain under close observation in the hospital for 72 hours after delivery.

What is the Best Approach to Xolox Detoxification? It depends on the individuals specific needs and he or she should contact us for more information Least restrictive setting that is still likely to be safe and effective. Patients should base choice of treatment centers on the patient’s ability to cooperate and benefit from type of treatment offered, his ability to refrain from substance abuse, avoid high risk behaviors and his need for structure and support.

According to statistics cited by the U.S. DEA, the total number of emergency department visits associated with oxymorphone skyrocketed in just one year, rising from 855 ER visits in 2008 to 2,248 in 2009.