- Generic Name or Active Ingridient: Oxycodone Hydrochloride And Acetaminophen
- Addison's Disease or Other Adrenal Gland Disorder
- Curvature of the Spine
- Enlarged Prostate
- History of Drug or Alcohol Addiction
- History of Head Injury or Brain Tumor
- Intestinal Disorder
- Kidney Disease
- Liver Disease
- Low Blood Pressure
- Mental Illness
- Pancreas Disorder
- Seizure Disorder
- Serious Breathing Disorders
- Sleep Apnea
- Stomach Disorder
- Underactive Thyroid
- Urination Problems
- Glycopyrrolate (Robinul)
- Mepenzolate (Cantil)
- Atropine (Donnatal and Others)
- Benztropine (Cogentin)
- Dimenhydrinate (Dramamine)
- Methscopolamine (Pamine)
- Scopolamine (Transderm-Scop)
- Darifenacin (Enablex)
- Flavoxate (Urispas)
- Oxybutynin (Ditropan and Oxytrol)
- Tolterodine (Detrol)
- Solifenacin (Vesicare)
- Ipratropium (Atrovent)
- Tiotropium (Spiriva)
- Dicyclomine (Bentyl)
- Hyoscyamine (Anaspaz, Cystospaz, Levsin and Others)
- Propantheline (Pro-Banthine)
- Blurred Vision
- Dry Mouth
- Mild Nausea
- Upset Stomach
- Bluish Lips or Skin
- Change In Consciousness
- Cold, Clammy Skin
- Extreme Sleepiness
- General Feeling of Discomfort or Illness
- Loss of Consciousness
- No Blood Pressure or Pulse
- Not Breathing
- Abdominal Cramps
- Runny Nose
- Trouble Sleeping
Doctors prescribe Xolox to reduce moderate to severe pain. Xolox is only available with a written prescription from a doctor. The U.S. Drug Enforcement Agency, or DEA, prohibits refills on Xolox; healthcare providers must write a new prescription when they determine a patient needs an opioid painkiller. Learn More about Xolox Uses
Other, off label uses for this medicine
Xolox may be used to treat pain accompanied by a cough and fever. The oxycodone component of Xolox reduces the urge to cough, while the acetaminophen in Xolox reduces fever.
More Off-Label Uses for Xolox
Xolox contains oxycodone and acetaminophen. Xolox is available in a capsule, tablet or solution. Xolox is for oral use.
The usual adult dose is one tablet, capsule or 5ml every six hours as needed to control pain. Do not exceed 12 tablets or 60 ml of solution in a 24-hour period.
Administer Xolox to a child only under a pediatrician's care.
Take Xolox with a full glass of water to prevent choking. Take Xolox with or without food; take Xolox with food if this medication upsets your stomach.
Doctors normally suggest patients take Xolox only as needed, rather than on a regular schedule. If you are supposed to take Xolox on a set schedule and miss a dose, take the missed dose as soon as you can. If it is almost time for another dose and you can put up with the pain, skip the missed dose and resume your normal schedule. Never take two doses in an effort to catch up.
Read More about Xolox Administration and Dosage
Xolox works with the chemistry and nervous system to change the way your brain perceives pain.
Injured or ill body cells produce prostaglandin, a chemical messenger that binds to pain receptors in nerve endings and sends messages about the pain to your brain. Your brain responds to that information by perceiving pain and taking appropriate action. For example if you stubbed your toe, your brain would respond by telling your body to say, "Ouch" while you hop around, holding your foot.
Xolox binds to pain receptors, blocking prostaglandins from attaching there. The opioid component of Xolox then sends messages of happiness and sedation. Instead of realizing you are in pain, opioids fool your brain into believing your body is healthy and happy.
The acetaminophen in Xolox eases pain and reduces fever by blocking the production of prostaglandins. While acetaminophen is a less potent pain reliever than oxycodone, the two analgesics work better together than either one could alone.
The oxycodone in Xolox affects your respiratory system by depressing the part of the brain responsible for breathing. Xolox can make your brain simply forget to breathe. The oxycodone in Xolox also acts directly on the cough center in your brain, making you unaware of the need to cough out excess phlegm or foreign objects from your lungs.
The opioid oxycodone found in Xolox acts on smooth muscle organs, such as your intestines, in a way that result in constipation. Soften stools to make it easier to move your bowels: drink six to eight full glasses of water every day you use Xolox. Increase your dietary fiber intake, thought to facilitate digestion. Do not use a laxative or stool softener while using Xolox without first discussing it with your healthcare provider. More about How Xolox Works
Do not take Xolox if you are allergic to oxycodone or acetaminophen or to any other opioid medications, such as codeine. Seek medical help immediately if you think you are suffering an allergic reaction. Symptoms of an allergic reaction include rash, hives, itching, difficulty breathing and swelling of the face, lips, mouth or tongue.
Anaphylaxis is a serious, potentially fatal form of allergic reaction. Signs of anaphylaxis include rash, itching, hoarseness, trouble breathing or trouble swallowing. Seek medical help immediately if you experience swelling of your hands, face, or mouth while you are using Xolox.
Xolox may cause dizziness or drowsiness and impair your ability to make decision. Do not operate a motor vehicle or other machinery until you know how this medication affects you. Avoid potentially unsafe activities that require fast reflexes while taking Xolox.
The DEA classifies Xolox as a schedule II controlled substance. The oxycodone in Xolox is associated with a high risk for abuse. Consuming large doses or using this drug more often than prescribed increases your risk for dependence, addiction and other side effects.
Tell your healthcare provider if your current Xolox prescription stops working to relieve your pain, as this is a sign that your body is growing tolerant to Xolox. The physician might increase your dose or recommend a different treatment for your symptoms.
Drinking alcoholic beverages or using products containing alcohol while taking Xolox can cause dangerous side effects, liver damage or death. Read the labels of foods, beverages and medications, especially over-the-counter preparations, to determine if they contain alcohol.
Discuss alcohol use with your doctor, especially if you normally drink more than three alcoholic beverages each day. It may be dangerous for you to take Xolox or other medications containing acetaminophen if you have ever had cirrhosis, commonly called alcoholic liver disease. Chronic alcoholics should not take more than 2000 mg of acetaminophen per day.
The oxycodone and acetaminophen in Xolox may affect the outcome of certain laboratory tests, including lowered blood sugar test results. Tell the technician about your Xolox use when submitting a blood or urine sample.
You may not be able to take Xolox if you have a history of certain medical conditions. Xolox may worsen your illness or interfere with treatment. Conversely, your ailment may change the way Xolox works in your body or affect the way your body processes Xolox.
Tell your physician about any significant illnesses or conditions, including:
Xolox may be habit-forming. To reduce your risk for developing a drug habit, do not take more Xolox than your doctor prescribes and stop using this medication when your doctor tells you to. Never share your medication with others, even if they express symptoms similar to your own.
Read More about Xolox Precautions
Do not take Xolox with other CNS depressants, which are medications that can make you sleepy or drowsy. Examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine. More examples include other prescription pain medicine or opioids, seizure medications, barbiturates, muscle relaxants or anesthetics, including some dental anesthetics.
Dizziness, lightheadedness or fainting may occur upon standing or sitting up from a lying position quickly. To avoid this, sit at the edge of bed or chair or a moment before rising slowly. Lie down for a while to reduce dizziness or lightheadedness.
Check with your doctor if you experience pain or tenderness in your upper stomach, or if you have pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. This could be a sign of liver damage.
Xolox is a FDA pregnancy category C, which means medical research has not yet established if Xolox harms an unborn baby. Tell the prescribing physician if you are pregnant or plan to become pregnant while taking Xolox; he will discuss the benefits and risks for taking this medication during pregnancy.
Do not take Xolox while breastfeeding. The oxycodone and acetaminophen in Xolox passes into breast milk and onto a nursing child.
Do not stop taking Xolox suddenly, or alter your dose drastically, unless a doctor tells you to. Discontinuing Xolox abruptly or using a lesser dose than usual may result in unpleasant withdrawal symptoms. Wean yourself from Xolox use by taking smaller doses increasingly further apart. If you find it difficult to discontinue Xolox use, you might have grown physically dependent to this product and require the help of detoxification specialists.
Xolox use is not appropriate for individuals with significant respiratory depression in unmonitored settings or without resuscitative equipment nearby. People with acute or severe bronchial asthma or other serious breathing problems should not use Xolox. Individuals with suspected or known paralytic ileus, a serious digestive problem, should not consume Xolox. More Warnings about Using Xolox
Xolox may interact with other drugs in unsafe or unfavorable ways. Give the prescribing physician and pharmacist filling the order a complete list of all the medications you take, including prescriptions, over-the-counter preparations, vitamins, supplements and herbal remedies. Do not start, stop or change the way you take any drug, including non-prescription medications and supplements, while you take Xolox without first discussing it with the prescribing physician.
Certain drugs are known to interact with Xolox, including:
More Drug Interactions
Most people do not experience side effects while using this drug. Xolox, like all medications, may cause unwanted adverse reactions. Most of the more commonly reported side effects are not serious and go away with continued use. Continue taking Xolox but contact the prescribing physician if these non-serious side effects become intolerable or do not go away on their own:
Some adverse reactions are serious and require the attention of a doctor. Stop using Xolox and contact a doctor if you experience serious side effects such as: Shallow Breathing Slow Heartbeat Feeling Light-Headed or Fainting Confusion Unusual Thoughts or Behavior Seizure Urinary Problems
Some side effects may indicate liver damage. Contact your healthcare provider if you experience severe nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools or yellowing of the skin or eyes.
Learn More about Xolox Side Effects
Overdose is potentially fatal. If you think you or someone you know has taken a Xolox overdose, contact your local poison control center at 1-800-222-1222 or go to the nearest emergency room. Doctors and nurses there will administer drugs such as naloxone to lower Xolox to non-toxic levels. They will also perform life-saving treatments as necessary, such as establishing an airway, pumping the stomach or doing CPR.
Symptoms of overdose:
Learn More about Xolox Overdose
Individuals abuse opioid painkillers such as Xolox because of the way oxycodone gets them high. Abusers purchase opioids on the street, present fake prescriptions to pharmacies, visit multiple doctors or by steal drugs from friends, family members or even pharmacies and hospitals. The U.S. Drug Enforcement Agency, or DEA, calls this process "diversion" because of the way medicines are diverted from their prescribed use as a therapeutic medicine.
Long-term Xolox abuse increases the risk for physical dependence and opioid addiction in some people, especially those who use large doses to get high. When he cannot get Xolox, the physically dependent individual will suffer uncomfortable withdrawal symptoms; an addicted person will experience powerful cravings and exhibit drug-seeking behaviors.
Read More about Xolox Abuse
Medical professionals know that withdrawal symptoms are a predictable and normal outcome of a sudden drop in the level of Xolox in a person physically dependent on opioids. Withdrawal symptoms are a result of the detoxification process, which causes a variety of flu-like symptoms that can last five or more days as the levels of Xolox toxins gradually subside. Psychological symptoms associated with withdrawal may last much longer and be more devastating, preventing many from achieving a full recovery from dependence.
The human body adjusts to the presence of foreign substances, including the oxycodone in Xylox, by adjusting its own chemical balance. With continuous use, the body grows dependent on the drug; this means the person has to maintain a certain level of Xolox in order for his body to feel "normal." If the level of Xolox plummets quickly, his body battles to regain chemical balance, resulting in uncomfortable, flu-like withdrawal symptoms.
Rehabilitation specialists recognize withdrawal symptoms as physiological process; withdrawal is not as an indicator of a person's moral character or personal strength. A person might grow physically dependent on Xolox whether he takes it to relieve legitimate pain or if he abuses oxycodone to get high.
Withdrawal symptoms vary in severity and duration between individuals. The intensity and length of symptoms are frequently dependent on the length of time the person used Xolox and the dosages he consumed. Withdrawal symptoms may be overpowering, preventing even the most determined and disciplined individuals from quitting Xolox without medical intervention.
Withdrawal symptoms include:
More about Xolox Withdrawal
Xolox detoxification is the process of decreasing opioids to non-toxic levels. Detoxification happens either because the individual took less Xolox than usual, or because he has taken a drug to reduce opioid levels quickly. Detoxification causes uncomfortable withdrawal symptoms in a person who is dependent on opioids. Withdrawal symptoms are especially intolerable without the help of trained professionals.
Standard detoxification treatments typically include drugs such as naloxone that decrease opioid levels. The patient also receives a variety of medications intended to ease the resulting withdrawal symptoms, including drugs to calm anxiety, slow diarrhea, soothe tremors and help the patient sleep.
While the standard detoxification treatments usually shortens withdrawal time and eases uncomfortable physical symptoms, it does not treat the lengthy and demoralizing psychological symptoms associated with the detoxification process. Sometimes the fear of withdrawal prevents individuals from attempting recovery.
Most experts agree that rapid detox is the most efficient and humane method of detoxifying the opioid-dependent body. During the rapid detox procedure, board certified anesthesiologists give the patient sedatives and anesthesia alongside the standard detoxification drugs. The individual dozes in a pleasant "twilight sleep" during the detoxification process. When he awakens, he has no memory of the uncomfortable and demoralizing withdrawal symptoms associated with detoxification. Learn More about Xolox Detoxification Programs
Keep Xolox at room temperature, away from heat, light and moisture. Put out of the reach of children and pets. Store Xolox where adults cannot consume it by accident or on purpose.
Discard Xolox when you no longer need it to control pain or when a doctor tells you to stop using it. Flush unused Xolox down the toilet to avoid accidental use, abuse or overdose.
Read More about Storing Xolox