Xodol Side Effects

Xodol combines the powerful opioid pain reliever hydrocodone with the less potent analgesic, acetaminophen. Physicians prescribe Xolox to reduce your moderate to severe pain.

Hydrocodone is the most widely prescribed drug on the American market. In 2010, U.S pharmacists filled more 139 million prescriptions for products containing hydrocodone, including Xodol. As the result of this wide availability, more people are now addicted to prescription painkillers than to illegal drugs. The National Institute on Drug Abuse, or NIDA, says that there were 1.9 million Americans addicted to prescription drugs like Xodol in 2010, That same year, there were only 329,000 heroin addicts.

Side Effect Information

Xodol could cause side effects for some people, although the majority of consumers do not experience side effects or have minor adverse reactions after using Xodol. Most commonly reported adverse reactions fade after continued use at prescribed doses. Sometimes these side effects can be serious, requiring immediate medical intervention.

Abuse, dependence and addiction are recognized side effects possible after Xodol consumption. The U.S. Drug Enforcement Agency, or DEA, classifies substances such as Xodol according to their potential for abuse relative to one another. The DEA classifies the hydrocodone component of Xodol as a schedule II controlled substance, which means it carries a relatively high risk for abuse.

You need a prescription from your doctor to get hydrocodone. Hydrocodone is available only in combination with other products. Xodol satisfies this requirement by combining hydrocodone with acetaminophen in one polydrug. Since Xodol contains less than 15 mg of hydrocodone, it is associated with less potential for abuse.

Anyone who uses Xodol for a long time may become physically dependent on this medication and suffer opioid withdrawal symptoms when they stop taking Xodol. The symptoms of opioid withdrawal usually appear in two phases. The first wave of symptoms typically starts about 12 hours after the last dose of opioids. This first set of symptoms include includes agitation, anxiety, muscle aches, watery eyes and insomnia. You might also have a runny nose, excessive sweating and yawning. Later on, your symptoms could include abdominal cramping, diarrhea, dilated pupils, goose bumps, nausea and vomiting.

The most serious adverse reaction to Xodol is a breathing problem that could interfere with respiration, leading to stopped breathing, circulatory depression, dangerously low blood pressure and shock. Doctors should anticipate side effects in all patients and prescribe dosages accordingly.

Respiratory depression is a common serious breathing problem associated with opioid use. Respiratory depression is sometimes fatal. When you have respiratory depression, your lungs do not adequately exchange oxygen for carbon dioxide and other toxins. Respiratory depression symptoms include slow or shallow breathing, unusual breathing patterns, gasping or wheezing, and a bluish tint around the eyes, mouth and fingertips.

Most Frequently Observed Xodol Side Effects

The most commonly reported adverse reactions associated with Xodol include feeling dizzy or lightheaded, sedated, nausea or vomiting. These are more common among ambulatory patients, or those able to walk around unattended. Lying down may help alleviate these symptoms in these consumers.

Allergic Reaction

Anyone can suffer an allergic reaction to Xodol. Get medical help right away at the first sign of an allergic reaction. An allergic reaction is a serious, potentially fatal medical emergency that requires professional intervention. Be sure to bring your container of Xodol along with all your medications to help emergency department physicians determine the cause of your allergic reaction.

Symptoms of an allergic reaction to medications may include:

  • Respiratory distress
  • Hives
  • Itchiness
  • Rash
  • Swelling of your face, mouth, tongue or lips
  • A tight feeling in your chest


Anaphylaxis is a serious, potentially fatal form of allergic reaction. While symptoms of anaphylaxis usually appear within moments of exposure to Xodol, it may be a half hour or longer before symptoms appear. Once symptoms appear, do not delay medical treatment.

Anaphylaxis symptoms include:

  • Hives
  • Itching
  • Flushed skin
  • Pale skin
  • Warm sensation
  • Feeling like your throat is closing
  • Feeling like your tongue is swelling
  • Feeling like you have a lump in your throat
  • Wheezing
  • Trouble breathing
  • Weak pulse
  • Rapid pulse
  • Nausea or vomiting
  • Dizziness
  • Fainting
  • Feeling of impending doom


You may be hypersensitive to Xodol. Hypersensitivity symptoms include dermatitis, skin rash, hives, itching and swelling of the face.

Non-Serious Side Effects

The most commonly reported side effects associated with this drug are not serious and disappear eventually. Continue taking this drug but notify the prescribing physician if the following side effects become unbearable or if they do not go away on their own:

Serious Side Effects

Some adverse reactions are serious and require immediate medical attention. Contact a doctor if you experience serious side effects, including:

By body system

Central Nervous System

The hydrocodone component of Xodol relieves pain and causes euphoria by acting directly on your central nervous system, or CNS. As the result, some of the most commonly-reported side effects associated with Xodol involve stimulation or depression of these areas in your brain and nervous system.

Xodol consumption could make you drowsy, lethargic or interfere with your physical performance. Xodol, as with other opioids, could cloud your thinking or impair your mental performance. This medication may also cause anxiety, fear, mood changes, psychic dependence or the emotion opposite of euphoria, dysphoria.

Gastrointestinal System

Using Xodol for a long time may cause trouble with your digestive system, including constipation. Drink 6 to 8 glasses of water each day you take Xodol to make it easier to move your bowels.

Genitourinary System

Xodol may cause side effects associated with your genitals or urinary tract, including spasms or urinary retention. Contact your doctor if you are not urinating as much as you think you should while taking Xodol.

Respiratory Depression

The hydrocodone in Xodol acts directly on the breathing center of your brain. Large doses of hydrocodone may cause your brain to "forget" how to breathe. The administration of naloxone or other medications reverse the effects of respiratory depression during Xodol overdose.

Special Senses

Chronic overdose of Xodol may cause hearing loss in some patients.


Xodol consumption may cause changes in your skin, including itching and rash.