Doctors prescribe Xodol to relieve moderate to severe pain. Xodol contains two pain relievers, hydrocodone and acetaminophen; this combination provides greater pain relief than either drug could give alone. Learn More About Xodol Uses

Other, off label uses for this medicine

Hydrocodone effectively soothes cough. Acetaminophen reduces fever. Xodol may be prescribed for off-label use for insomnia and coughing. More Off-Label Uses for Xodol


All dosages of Xodol tablets contain 300 mg of acetaminophen and varying amount of hydrocodone, ranging in strength from 5 mg to 10 mg. For example Xodol 5/300 contains 5 mg of hydrocodone and 300 mg of acetaminophen. Xodol is usually prescribed as one or two tablets every four to six hours as needed for pain; do not take more than 8 tablets in a 24 hour period. The usual prescription for Xodol 7.5/300 and Xodol 10/300 is one tablet every four to six hours as needed, with a daily maximum of six tablets.

Xodol has not been approved for use by children but your pediatrician may still prescribe it for your child.

Xodol is typically prescribed to be taken when needed for pain, so there is no need to worry if you miss a dose. Simply take more Xodol when you have pain provided enough time has passed since your last dose. If you are supposed to take Xodol on a regular schedule and you missed a dose, take another dose as soon as you can. If it is nearly time to take a scheduled dose, skip the missed dose and resume your normal schedule. Read More About Xodol Administration and Dosage


Xodol contains two drugs that act in different ways to reduce pain. When cells are injured through illness or trauma, they release a chemical messenger known as prostaglandin. Prostaglandin attaches to pain receptors in nerve endings; the nerves transmit specific information about the injury to the brain, including severity and exact location of the pain. Hydrocodone binds to pain receptors to change the way your brain perceives pain. Acetaminophen slows the production of prostaglandin, so less of this "pain messenger' reaches nerve endings.

More About How Xodol Works


Tell your doctor if you are allergic to Xodol or any other medication. An allergic reaction is a serious, potentially life-threatening medical emergency. Seek immediate help if you experience an allergic reaction shortly after taking Xodol. Symptoms of an allergic reaction include hives, difficulty breathing or swelling of your face, lips, tongue or throat.

You may not be able to take Xodol if you have a history of certain medical conditions. Tell your doctor about any serious or chronic illnesses including asthma, COPD, sleep apnea, or other breathing disorders. Make sure your doctor knows about your history of liver or kidney disease, a history of head injury or brain tumor, low blood pressure, a stomach or intestinal disorder or underactive thyroid. Talk with your physician about your history of Addison's disease or other adrenal gland disorder, curvature of the spine, mental illness or a history of drug or alcohol addiction.

Xodol can make you drowsy. Do not operate heavy machinery or drive a car until you know how Xodol affects you. Avoid engaging in risky behavior that requires you to be alert and awake. Alcohol and some medications can enhance this effect.

Do not consume alcohol while taking Xodol. Drinking alcohol increase the risk for liver damage associated with the acetaminophen in Xodol. Tell your doctor if you have ever had cirrhosis of the liver or normally consume three or more alcoholic beverages in one day.

The hydrocodone in Xodol can be habit-forming, especially if you take it for long periods of time. Tell your doctor if you have ever been dependent on drugs or alcohol before taking Xodol. Your physician may prescribe a different pain reliever.

Read More About Xodol Precautions


It is not known how taking Xodol can affect your unborn baby but it could cause breathing problems or withdrawal symptoms in newborns. Tell your doctor if you are pregnant or plan to become pregnant while taking Xodol. If you become pregnant while taking Xodol, call your doctor immediately. Hydrocodone and acetaminophen can pass into breast milk. Do not take Xodol while breastfeeding.

Don't quit taking Xodol abruptly. Stopping this medication suddenly may cause unpleasant withdrawal symptoms. Take Xodol less frequently to wean yourself from this narcotic. If you cannot quit Xodol because the withdrawal symptoms are too strong, talk with your doctor or qualified rehabilitation specialist about in-patient or out-patient detoxification and treatment. More Warnings About Using Xodol

Drug Interactions

Xodol may interact in an unfavorable or even dangerous way with other prescriptions, over-the-counter medications and herbal remedies. Give your doctor a complete and updated list of medicines. Be sure to tell your doctor if you take any of the following drugs:

  • Antidepressants such as amitriptyline, clomipramine, imipramine and others. Brand names for these medicines include Elavil, Etrafon, Anafranil, Janimine and Tofranil.
  • MAO inhibitors such as Marplan, Nardil, Azilect, Eldepryl, Emsam or Parnate.
  • Atropine (Donnatal, and others), Benztropine (Cogentin), Dimenhydrinate (Dramamine), Glycopyrrolate (Robinul), Mepenzolate (Cantil), Methscopolamine (Pamine) or Scopolamine (Transderm-Scop).
  • Bladder or Urinary Medications. Tell your doctor if you are taking medications like Enablex, Urispas, Ditropan, Oxytrol, Detrol or Vesicare.
  • Bronchodilators such as ipratropium or tiotropium. Brand names for these drugs include Atrovent and Spiriva.
  • Irritable Bowel Medications such as Bentyl, Anaspaz, Cystospaz, Levsin or Pro-Banthine.

More Drug Interactions

Side effects

You may experience side effects while taking Xodol. Some side effects can be severe or life-threatening. Seek medical assistance immediately if you experience severe side effects such as:

  • Shallow Breathing.
  • Slow Heartbeat.
  • Feeling Lightheaded or Fainting.
  • Confusion, Fear, Unusual Thoughts or Behavior.
  • Seizures.
  • Problems with Urination.
  • Nausea, Stomach Pain, Loss of Appetite.
  • Itching.
  • Dark Urine, Clay-Colored Stools.
  • Jaundice or Yellowing of the Skin or Eyes.

Consult with your doctor if your less serious side effects become severe.

Less Serious Side Effects:

  • Feeling Anxious, Dizzy, or Drowsy.
  • Mild Nausea, Vomiting, Upset Stomach, Constipation.
  • Headache.
  • Mood Changes.
  • Blurred Vision.
  • Ringing in Your Ears.
  • Dry mouth.

Learn More About Xodol Side Effects


Xodol overdose is a serious, life-threatening medical emergency. If you suspect that you or someone you know has taken an overdose of Xodol, seek emergency assistance immediately by going to the emergency room or calling an ambulance. If you are a very long distance from professional help, contact your local poison control center at 1-800-222-1222. Symptoms of overdose include:

  • Cold, Clammy Skin.
  • Circulatory Collapse.
  • Stupor.
  • Coma.
  • Depression.
  • Respiratory Depression.
  • Cardiac Arrest.
  • Death.

Learn More About Xodol Overdose


One active ingredient in Xodol, hydrocodone, is a Schedule III drug, which means may lead to moderate or low physical dependence or high psychological dependence. Recreational users and dependent abusers get Xodol by forging prescriptions, making bogus calls to pharmacies, going to multiple doctors and stealing from pharmacies, friends or family. Read More About Xodol Abuse


Anyone taking Xodol by prescription or as a recreational drug may suffer withdrawal symptoms when they stop taking the drug. Withdrawal is not necessarily a sign of willful or illegal substance abuse. Withdrawal is a normal, predictable, physical sign of dependency to a medication. Withdrawal symptoms may appear after you stop taking Xodol, especially if you have been taking high doses or using the opioid for a long period of time. Withdrawal symptoms and duration vary and may be so intense that they prohibit you from quitting Xodol without medical assistance. Speak with your physician if withdrawal symptoms stop you from quitting Xodol. Withdrawal symptoms include:

  • Intense Cravings for the Drug.
  • Irritability.
  • Nausea or Vomiting.
  • Muscle Aches.
  • Runny Nose or Eyes.
  • Dilated Pupils.
  • Sweating.
  • Diarrhea.
  • Yawning.
  • Fever and Chills.
  • Inability to Sleep.
  • Depression.

More About Xodol Withdrawal


Strong withdrawal symptoms may make dependency and addiction to Xodol difficult to overcome on your own. You may need the help of qualified professionals to help you quit taking Xodol. Quitting Xodol may be more difficult if you have been it for a long time or have taken large doses to control pain. other opiates.

Learn More About Xodol Detoxification Programs


Keep Xodol in a safe location where children, pets and adults who might consume this product willfully or accidentally cannot access this medication. Store Xodol at room temperatures between 68 to 77 degrees Fahrenheit, away from excessive heat and moisture. Never share Xodol or other opioids with others, especially with people with a history of alcohol or drug abuse. Keep track of your medication, taking note of any missing doses.

Read More About Storing Xodol