- Generic Name or Active Ingridient: Oxycodone Hydrochloride And Acetaminophen
Ortho-McNeil-Janssen Pharmaceuticals, Inc. makes Tylox in capsule form for oral use. Each Tylox capsule contains 5 mg of oxycodone and 500 mg of acetaminophen. Tylox is available by prescription only. Doctors prescribe Tylox to relieve moderate to moderately severe pain.
Oxycodone is an opioid - drug manufacturers create oxycodone from derivatives of the opium poppy plant. It is possible to become physically dependent on opium and its opioid derivatives, including the oxycodone in Tylox.
Acetaminophen is not an opioid and does not cause physical dependence requiring detoxification. Chronic acetaminophen use, however, can lead to serious health hazards including liver failure and acetaminophen overdose. Acetaminophen overdose is one of the most common poisonings worldwide and is the leading cause of acute liver failure in the United States. Someone that is physically dependent on Tylox will likely consume large amounts of acetaminophen and face an increased risk for these complications.
Oxycodone and acetaminophen work in different ways to relieve pain; these pharmacological actions can increase the risk for dependence and the need for detoxification. Acetaminophen reduces prostaglandin, a chemical responsible for transmitting pain messages, and causing inflammation and fever. Oxycodone, like other opioids, acts directly on the nervous system to change the way the brain interprets pain messages. Oxycodone causes other neurological actions, with most immediately noticeable effects being sedation, relaxation, slowed breathing, and pleasant euphoric feeling.
Oxycodone also causes non-therapeutic physical effects that can cause complications with chronic use and during Tylox detoxification. Opioids stiffen smooth muscle groups, like those lining the intestines and blood vessels, to make these muscles less functional. Because of the action on the digestive and cardiovascular systems, the consumer might experience constipation or blood pressure problems. Smooth muscles in the skin cause goose bumps when the individual shivers; smooth muscles in the eye cause pupils to dilate and contract. Tylox detoxification will also affect these body systems, causing increased blood pressure, pulse, goose bumps, and diarrhea.
With continual use, some of the neurological and physiological changes associated with Tylox become more permanent and alter how the consumer thinks, feels, and behaves. Left untreated, these alterations can interfere with work, fulfilling personal responsibilities, and healthy relationships with others. This can lead to job loss and financial hardship, divorce or loss of child custody, homelessness, incarceration, illness, overdose, and death. Tylox detoxification begins to reverse of these effects to start the individual on a path to recovery.
Oxycodone is widely prescribed in the United States: in 2010, U.S. pharmacists dispensed 58.2 million prescriptions for drugs containing oxycodone. Most patients use oxycodone as directed and throw away any unused doses when they no longer need it to control pain. Some people, however, use oxycodone for non-medical purposes, either to get high or to treat a different condition than the one the doctor had intended to treat when she wrote the prescription.
About 5 million Americans use painkillers for non-medical use every year. Anyone who uses Tylox regularly for longer than a few weeks can become physically dependent on oxycodone, whether he uses this medication for therapeutic or non-medical reasons.
A human body becomes accustomed to some toxic substances, including the oxycodone in Tylox. In time, the body begins to depend on a certain level of oxycodone to feel normal - the individual becomes opioid-dependent. According to statistics presented by the Institute of Addiction Medicine, almost 2 million Americans are dependent on the oxycodone in Tylox or on other opioids. Each of these individuals will need to participate in some form of detoxification to become free from opioid dependence.
When oxycodone levels fall drastically, the opioid-dependent body struggles to regain chemical stability and detoxify itself from the effects of Tylox. Doctors refer to this as detoxification. The opioid-dependent person experiences detoxification through unpleasant withdrawal symptoms. These symptoms affect the body systems impacted by opioid abuse, including the nervous system, digestive tract and cardiovascular system.
Opioid withdrawal symptoms typically appear in two waves, with the first set of symptoms beginning a few hours after the last dose of Tylox. Initially the patient will feel anxious or agitated and have trouble sleeping. His muscles will ache, and he may experience watery eyes and a runny nose. He will likely sweat and yawn excessively. Later, the individual will develop stomach cramps, diarrhea, nausea, and vomiting. His pupils will dilate and he will develop goose bumps.
Left uninterrupted, these symptoms will typically persist for five or more days then fade as the body completes Tylox detoxification and achieves an opioid-free state. Withdrawal symptoms do not come back unless the individual returns to an opioid-dependent state.
Someone can ease the severity of withdrawal symptoms by taking non-opioid withdrawal drugs, such as Imodium to curb diarrhea, without interfering with Tylox detoxification. He could stop withdrawal symptoms at any time by taking more oxycodone but this relapse would halt the detoxification process and return him to an opioid-dependent state.
Benefits of Detoxification
Tylox detoxification brings an opioid-dependent person to an opioid-free state but it is only one part of the recovery process. Detoxification alone does little to change the behaviors associated with drug abuse - most opioid-dependent people benefit from some degree of rehabilitation to learn how to live without drugs - but detoxification does facilitate a patient’s entry into a rehabilitation program.
Detoxification clarifies the patient’s thought processes in a way that helps him remain in rehabilitation long enough to fully reverse the neurological effects of drug dependence. Tylox detoxification removes the toxic substances that make a person feel ill and unhappy, helping him to feel healthy and happy; this improved physical and mental well-being promotes abstinence, reducing the frequency and severity of drug use episodes when they do occur.
Types of Detoxification
The word “detoxification” can also refer to the medical process of lowering opioid levels and relieving withdrawal symptoms. Tylox detoxification can occur at home, through an outpatient clinic, or at an inpatient hospital or special detoxification facility. Only about 10 percent of the people who need to detoxify do it through a specialty facility - the rest tried self-detoxification, going to a private physician, seeking help from an emergency room, checking into a general mental health facility, or quitting Tylox while in jail or prison.
These are all viable approaches to detoxification, as long as they bring the patient to an opioid-free state in a safe and effective manner. Each method of Tylox detoxification is appropriate for some patients.
When it comes time for a long-term Tylox user to discontinue this drug, his physician will usually suggest the patient wean himself from opioids rather than stopping abruptly. The patient should take a smaller dose each day until he reaches an opioid-free state. This tapering method works well for people who have been dependent for only a short time, have no underlying medical conditions that could cause complications, and who is likely to experience only minor withdrawal symptoms.
Lingering withdrawal symptoms prevent some people from completing Tylox detoxification. These individuals might try quitting cold turkey by discontinuing Tylox abruptly. Quitting cold turkey causes severe withdrawal symptoms but it does bring the patient to an opioid-free state.
Natural remedies can take the punch out of withdrawal symptoms. Some people use ginger or peppermint to soothe nausea, while others use chamomile or cayenne to slow diarrhea. Acupuncture, meditation, yoga, and massage help relax patients and reduce body aches.
Others take a scientific approach and incorporate prescription and non-prescription drugs into a homemade treatment plan designed to reduce withdrawal symptoms associated with Tylox detoxification. The Thomas Recipe is a well-known remedy that calls for a benzodiazepine such as Xanax or Librium to calm nerves and help with sleep. Vitamin B6 and hot baths ease muscle aches and Imodium works on diarrhea.
Medication-assisted detoxification, sometimes called medical detoxification, calls for opioid and non-opioid drugs to control the onset of Tylox detoxification and manage withdrawal symptoms. Medication-assisted detoxification is appropriate for patients who were unsuccessful at self-detoxification, have underlying conditions that make self-detoxification unsafe, or are likely to develop severe withdrawal symptoms or complications during treatment. Medical detoxification can occur through an outpatient clinic or in an inpatient hospital or specialized detoxification facility.
An outpatient clinic usually administers opioid replacement drugs, such as methadone or buprenorphine, to control Tylox detoxification. Methadone and buprenorphine are opioids that mimic the effects of oxycodone and therefore reduce the occurrence of withdrawal symptoms. When administered properly at therapeutic doses, methadone and buprenorphine do not get the consumer high.
Outpatient clinicians start patients on a high induction dose to stop withdrawal symptoms. The patient then takes smaller doses of the replacement drugs throughout the tapering phase - just enough to control withdrawal symptoms - until the patient reaches an opioid-free state.
Outpatient detoxification is appropriate for those patients that have been dependent on opioids for more than a year, require little supervision, and have been unable to reach an opioid-free state through self-detoxification.
A chemist first synthesized methadone in a German laboratory in 1939 in a quest to develop a safe and effective pain reliever. Doctors around the world still prescribe methadone as an analgesic but healthcare providers in the United States usually reserve methadone for the treatment of opioid dependence.
Today, about 100,000 Americans use a methadone maintenance program to control dependence on oxycodone, heroin and other opioids. Patients come to an authorized methadone clinic once a day to drink a beverage containing methadone. The effects of one dose of methadone lasts about 24 to 36 hours.
Many doctors now prescribe methadone as a “step down” drug during detoxification. Patients start out on 10 to 15 mg of methadone daily. Doctors will increase dosages by 10 mg each day until the patient no longer experiences withdrawal symptoms. Once the physician determines a safe and effective induction dose, the clinician decreases subsequent doses by 10 mg each day until the patient reaches an opioid-free state.
Buprenorphine works like methadone as an opioid replacement drug, either as a part of a drug maintenance program or as an aid to tapering. The patient places a buprenorphine tablet under his tongue, where it dissolves and enters the bloodstream at the appropriate rate.
It is possible to abuse buprenorphine through intravenous use where the consumer dissolves the tablet before injecting the solution into a vein. One drug maker, Reckitt Benckiser, adds naloxone to the brand name buprenorphine, Suboxone. Naloxone has little effect on the patient when taken as directed under the tongue but intravenous administration causes naloxone to neutralize the effects of buprenorphine so that the consumer does not get high. Furthermore, intravenous naloxone use causes withdrawal symptoms in opioid-dependent patients.
In September of 2012, Reckitt Benckiser voluntarily replaced buprenorphine tablets with film to discourage abuse and accidental exposure to children. Tablets are still available upon request.
Inpatient Tylox Detoxification
Hospitals and other inpatient detoxification facilities use powerful non-opioid drugs to lower oxycodone levels and relieve withdrawal symptoms. Additionally, inpatient detoxification usually includes prescreening for co-existing medical conditions that may cause complications during Tylox detoxification, professional treatment plans, and close patient supervision. These healthcare professionals take special care to address any liver problems caused by chronically high acetaminophen levels associated with Tylox abuse.
Inpatient Tylox detoxification is appropriate for anyone who could not reach an opioid-free state through self-detoxification, have co-existing illnesses or substance abuse issues that make self-detoxification unsafe, and who are likely to suffer severe withdrawal symptoms.
Anyone recovering from an overdose must engage in inpatient Tylox detoxification, as must those with serious medical conditions that make outpatient care unsafe. Inpatient Tylox detoxification is necessary for those with serious mood disorders, especially acute psychosis or depression with suicidal thoughts, and for those who may cause harm to themselves or to others.
Rapid detox is a technically advanced procedure that brings a person to an opioid-free state in hours rather than days, weeks, or months. Specially trained doctors anesthetize and sedate the patient before administering the usual detoxification and anti-withdrawal drugs so that the patient dozes in a comfortable “twilight sleep” during Tylox detoxification. Patients awaken a few hours later, unaware of the uncomfortable and demoralizing withdrawal symptoms that had prevented them from completing Tylox detoxification in the past.
Our detoxification center: Who we are and what we do
We are a group of board-certified anesthesiologists and other medical professionals who receive advanced training in detoxification procedures. We have helps thousands of people reach an opioid-free state since opening the doors of our fully accredited hospital more than a decade ago.
We prescreen every patient for any medical condition that could undermine his success, including the presence of acute liver failure caused by chronic acetaminophen overdose caused by Tylox dependence. We then create a personalized treatment plan that often includes rapid detox. After we help the patient complete Tylox detoxification and stabilize his condition, we invite him to continue his recovery in our qualified aftercare center.
Comparisons of the Various Approaches to Treatment
Dependence on Tylox is a confusing time, and choosing the right treatment approach is sometimes confusing. Some people find it helpful to compare the various approaches to Tylox detoxification to highlight the advantages and disadvantages to each.
Without the expense of anti-withdrawal medications and professional treatment, self-detoxification is the least costly approach to Tylox detoxification but this lack of medical care makes self-detoxification likely to produce severe withdrawal symptoms and complications.
Outpatient detoxification uses opioids to produce fewer withdrawal symptoms during Tylox detoxification, but the use of these opioids tends to prolong the detoxification process. Some patients remain in treatment for months or years.
Medical grade anti-withdrawal drugs, professional treatment plans, and close patient monitoring reduce the risk for severe withdrawal symptoms and complications. Inpatient care tends to bring the patient to an opioid-free state much quicker than outpatient care: the average length of stay for detoxification is 4 days, compared with 197 days for medication-assisted therapy.
Rapid detox is the most efficient and humane approach to Tylox detoxification, bringing the patient to an opioid-free state in just hours while sparing him the demoralizing aspect of withdrawal. Rapid detox puts the patient in the optimal physical and emotional state for rehabilitation.
Possible Complications during Tylox Detoxification
Tylox detoxification is painful and demoralizing but it is not normally a life-threatening procedure. However, pre-existing medical conditions including liver failure from acetaminophen abuse, co-existing alcohol or drug problems, acute or extremely long-term Tylox abuse, and pregnancy can cause complications.
Relapse is the primary complication associated with all approaches to Tylox detoxification. Relapse reverses the therapeutic effects of detoxification and returns the individual to an opioid-dependent state. Some people take more Tylox to stop severe withdrawal symptoms. Others relapse sometime after completing the detoxification process.
Relapse greatly increases the risk for toxic, sometimes fatal oxycodone overdose. The detoxification process decreases the body’s tolerance of opioids, making the individual more sensitive to the effects of oxycodone. Someone who relapses soon after detoxification can potentially overdose on a weaker dose of Tylox than he used to take before experiencing even minor withdrawal symptoms. In 2008, 14,800 Americans died from opioid overdoses. For the first time that year, prescription drug overdoses killed more people than overdose from cocaine and heroin combined.
Self Detoxification Possible Complications
Self-detoxification poses a great risk for complications, especially for individuals with other medical conditions and co-existing substance abuse issues. Uncontrolled withdrawal symptoms can complications. For example, severe and prolonged vomiting and diarrhea can cause dehydration and electrolyte imbalances.
Withdrawal symptoms can aggravate underlying medical conditions. Tylox detoxification may increase blood pressure and pulse in a way that worsens some heart problems. The detoxification process may cause pain to return in patients who take Tylox to control discomfort from a chronic condition.
A patient may unwittingly take an acetaminophen overdose during Tylox detoxification in an attempt to calm withdrawal symptoms. Acetaminophen is a common ingredient in many prescription and over-the-counter drugs, including Tylox. In fact, Americans purchased more than 28 billion doses of products containing acetaminophen in 2005. While some people intentionally take an acetaminophen overdose in a suicide attempt, many people unwittingly take a toxic dose. These individuals may be unaware a product contains acetaminophen, or take very large doses to reduce discomfort associated with withdrawal symptoms or other painful conditions.
Consuming more than 4,000 mg of acetaminophen can result in serious liver injury. Doses greater than 7,000 mg can cause death.
Outpatient Detoxification Possible Complications
Opioid replacement drugs reduce the severity of withdrawal symptoms to lessen the likelihood of complications, but outpatients can still struggle to overcome obstacles during Tylox detoxification. Using opioids during detoxification lengthens the amount of time someone is opioid-dependent, so outpatient care may not bring the patient to an opioid-free state as quickly as with other treatments. Furthermore, a patient may become dependent on the replacement drug and have trouble quitting at the appropriate time. Some people remain on methadone or buprenorphine for months or years.
Methadone is not entirely safe. The number of methadone overdoses has been steadily climbing for the past decade: in 2009, there were 5.5 times as many deaths associated with methadone as there were in 1999. Methadone now accounts for about one-third of all opioid pain reliever deaths, even though methadone accounts for only about 2 percent of sales on the painkiller market.
While considered safer than methadone, buprenorphine is associated with risk for abuse. It is possible to die from a buprenorphine overdose, especially when the consumer takes buprenorphine along with benzodiazepines like those used in The Thomas Recipe.
Inpatient Detox Possible Complications
Inpatient detoxification provides a great amount of protection from complications through adequate prescreening, safe and effective anti-withdrawal drugs, and close patient monitoring but complications can occur even in an inpatient setting. One major complication is withdrawal from multiple substances, especially alcohol, benzodiazepines, sedatives and anti-anxiety drugs.
Rapid Detox Possible Complications
It is rare, but someone could suffer an allergic reaction to the drugs used in rapid detox. Strong sedatives may complicate breathing, blood pressure and pulse. Anesthesia patients may experience bruising, swelling, or infection at the injection site.
Myths about Tylox Detoxification
Self Detoxification Myths
Myth: Anyone can perform self-detoxification if he wants to badly enough.
Fact: While it takes a lot of desire and commitment to reach an opioid-free state, Tylox detoxification is an intense physiological process that can cause real discomfort and dangerous complications. Self-detoxification may be unsafe for individuals with other ailments, co-existing substance abuse issues, and serious mental health issues.
Myth: Using prescription and over-the-counter drugs like those called for in The Thomas Recipe make self-detoxification safe.
Fact: Combining prescription and non-prescription medications may result in dangerous drug interactions. Furthermore, consuming any product containing acetaminophen increases the risk for acute liver failure.
Outpatient Detox Myths
Myth: Tossing drug addicts in prison to dry out is cheaper than providing treatment.
Fact: Treatment is less expensive than imprisonment. A year of prison costs about $24,000 per inmate while 12 months of methadone runs about $4,700 per patient.
Myth: Methadone causes bone rot.
Fact: Inadequate methadone doses cause withdrawal symptoms, most notably achy bones. A patient should discuss dosage increases with his clinician.
Inpatient Tylox Detoxification Myths
Myth: Treating drug addicts is a waste of a good hospital bed as drug addiction is incurable.
Fact: Drug addiction is a chronic disease but patients do respond to treatment. Relapse rates for drug addiction are similar to those of other chronic diseases, such as high blood pressure, diabetes or asthma.
Myth: Communities cannot afford to waste money on drug treatment programs in this tough economy.
Fact: Communities cannot afford to ignore the financial benefits of investing in drug treatment programs. For every dollar invested in drug treatment, experts estimate a community can expect to see a return of $4 to $7 in reduced drug-related crime rates, criminal justice costs and theft. Factor in savings to the local healthcare system and these yields skyrocket to a gain of $12 for every dollar spent.
Rapid Detox Myths
Myth: Pain and humiliation are important features of Tylox detoxification as they punish the individual for drug abuse.
Fact: Suffering is never a part of any humane treatment plan. In fact, the discomfort of withdrawal symptoms actually prevents some people from completing Tylox detoxification. Rapid detox is the most humane approach to medical detoxification in that it spares an already struggling person the discomfort and despair associated with opioid dependence and detoxification. Rapid detox patients enjoy a pleasant twilight sleep instead of enduring endless days of detoxification.
Myth: It takes days or weeks to complete Tylox detoxification.
Fact: A reputable expert can perform rapid detox in one to two hours.
Tylox Detoxification and Pregnancy
Dependence on Tylox or other opioids increases a woman’s risk for developing anemia, blood infections, heart conditions, mood disorders, pneumonia, HIV/AIDS, tuberculosis and other diseases that can cause complications during pregnancy. Complications can affect the health and well-being of both the mother and baby, and can include hemorrhage, separation of the membrane surrounding the fetus, slowed fetal growth, spontaneous abortion, premature labor and delivery, and fetal death.
Methadone reduces these complications and is currently the only approved treatment plan for opioid-dependent pregnant women. A recent study published in the New England Journal of Medicine, however, calls buprenorphine “an acceptable treatment for opioid dependence in pregnant women.”
Using any opioid during pregnancy, including buprenorphine, methadone and Tylox, can result in the development of neonatal abstinence syndrome, or NAS, in a newborn baby. A baby with NAS struggles with withdrawal symptoms in the first weeks or months of life, suffering from irritability, vomiting and excessive stools, tremors, and hyperactive reflexes. NAS babies have lower birth weights than other babies, and can experience seizures, breathing problems, feeding difficulties and even death.
Self Detoxification during Pregnancy
Detoxification can be unsafe for pregnant women and their unborn babies. A pregnant woman should consult with a doctor before attempting even tapering. The Thomas Recipe is not safe for pregnant women.
Inpatient Induction to Methadone Maintenance during Pregnancy
A doctor will likely admit a pregnant woman to a hospital to start methadone maintenance treatments where he can monitor her response to treatment and adjust dosages more conveniently. A clinician would typically start with 10 mg to 20 mg of methadone on the first day of treatment and increase subsequent daily dosages by 5 - 10 mg of methadone until establishing a safe maintenance dose. The maximum methadone for a pregnant woman is 60 mg daily. Most inpatient facilities offer fetal monitoring to determine the baby’s response to treatment.
A woman will usually stay in the hospital for about three days before the doctor discharges her to outpatient care, where she continues methadone treatments until the birth of her baby. Babies born to women taking methadone during pregnancy will remain under close observation in the hospital for 72 hours after delivery.
Outpatient Induction to Methadone for Pregnant Women
A woman may be unable to start methadone treatments as an inpatient, perhaps because she works or takes care of other children. She may start methadone maintenance treatments as an outpatient. She will come to the clinic twice daily during induction to treatment, once in the morning for a daily methadone dose and again later for evaluation. The patient will continue twice-daily visits until establishing a safe maintenance dose when she reduces visits to just once a day.
What is the best method to detox from Tylox?
Each person becomes opioid-dependent in a slightly different way, and every individual has slightly different needs when it comes to Tylox detoxification. One person may be opioid-dependent for only a short time and can reach an opioid-free state through detoxification. Another person might have a chronic battle with opioid dependence and require the help of trained professionals.
When deciding between the various forms of treatment, the individual should assess the extent of his own dependence, his likelihood for withdrawal symptoms and complications, and his ability to turn down drugs when offered. The individual should then choose the least restrictive form of treatment that is still likely to bring him to an opioid-free state in a safe and effective manner.
Please contact us for more information on what approach to Tylox detoxification may be right for you or for someone you love.
- Tylox Detox