Tylox

  • Generic Name or Active Ingridient: Oxycodone Hydrochloride And Acetaminophen
Drug Class: Tylox > Oxycodone Hydrochloride And Acetaminophen > Oxycodone > Fully Synthetic Opioid > Opioids > Opioid Agonist > Analgesic.

Physicians prescribe Tylox to treat moderate to moderately severe pain. Tylox contains the powerful opioid painkiller oxycodone hydrochloride and the moderate analgesic, acetaminophen.

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Other, off label uses for this medicine

The oxycodone in Tylox soothes a cough while the acetaminophen reduces fever.

A doctor may prescribe Tylox to treat breakthrough pain associated with cancer or other chronic illnesses.

More Off-Label Uses for Tylox

Administration/Dosage

Tylox is available in capsule form. Each Tylox capsule contains 5 mg of oxycodone hydrochloride and 500 mg of acetaminophen. The usual dose for adults is one capsule every six hours as needed to control pain.

The usual Tylox prescription calls for one tablet every six hours as needed. Your doctor based your dosage on your condition and response to treatment. Take Tylox exactly as directed; do not increase your dosage unless a doctor tells you to do so.

Doctors normally suggest you take Tylox as need for pain, rather than on a regular schedule. If your physician told you to take Tylox on a regular schedule and you miss a dose, take the missed dose as soon as possible. If it is nearly time to take another dose, skip the missed dose and resume your normal schedule.

Administer Tylox to children exactly as prescribed by his pediatrician.

Take Tylox with a full glass of water to prevent choking. Take Tylox with or without food. Take with food if Tylox upsets your stomach or makes you nauseated.

Drink 6 to 8 full glasses of water each day you take Tylox to reduce constipation.

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Action

Tylox works with the chemistry and nervous system to change the way your brain perceives pain.

Injured or ill body cells produce prostaglandin, a chemical messenger, that binds to pain receptors and sends messages about the pain to your brain. Your brain responds to the information prostaglandins send by perceiving pain and taking appropriate action. For example if your pain were caused by touching your finger to a flame, your brain would respond by telling your mouth to say "Ouch" and pulling your finger away from the fire.

Tylox binds to pain receptors, preventing prostaglandins from attaching there. The opioid component of Tylox then sends messages of euphoria and relaxation. Instead of perceiving pain or distress, opioids fool your brain into believing your body is healthy and happy.

The acetaminophen in Tylox eases pain and reduces fever by blocking the production of prostaglandins.

The oxycodone in Tylox acts on your respiratory system; it depresses the part of the brain responsible for breathing. Tylox can make your brain simply forget to breathe. The oxycodone in Tylox also acts directly on the cough center in your brain, making you unaware of the need to cough out excess phlegm or foreign objects from your lungs.

The opioid oxycodone found in Tylox acts on smooth muscle organs, such as the muscles in your intestines, in a way that result in constipation. Soften stools to make it easier to move your bowels: drink six to eight full glasses of water each day you take Tylox. You may want to increase your dietary fiber intake, thought to reduce constipation. Do not use a laxative or stool softener while on Tylox without first discussing it with a doctor.

More about How Tylox Works

Precautions

Do not take Tylox if you are allergic to oxycodone or acetaminophen or to any other opioid medications, such as codeine. Seek medical help immediately if you think you are suffering an allergic reaction.

Symptoms of an allergic reaction include:

  • Rash
  • Hives
  • Itching
  • Difficulty Breathing
  • Swelling of the Face, Mouth, Lips or Tongue

Tylox may cause dizziness or drowsiness and impair thinking. Do not operate a motor vehicle or other heavy equipment until you know how this medication affects you.

The DEA has classified Tylox as a schedule II controlled substance, which means it is associated with a high risk for abuse. Do not use large doses or use this medication more often than prescribed to reduce your risk for dependence, addiction and other side effects.

Tell your healthcare provider if your current Tylox prescription stops working, as this is a sign that your body is becoming tolerant to Tylox. The physician might change your dose or recommend a different treatment.

Consuming alcohol while taking Tylox can cause dangerous side effects, liver damage or death. Read the labels of foods, beverages and medications, especially over-the-counter preparations, to determine if it contains alcohol.

Discuss alcohol use with your doctor, especially if you normally drink more than three alcoholic beverages each day. It may be dangerous for you to take Tylox or other medications containing acetaminophen if you have ever had cirrhosis, commonly called alcoholic liver disease.

Medical History

Tell your physician about any significant illnesses or conditions, including:

  • Addison's Disease or Other Adrenal Gland Disorder
  • Asthma
  • Breathing Disorders
  • COPD
  • Curvature of the Spine
  • Enlarged Prostate
  • Epilepsy or Other Seizure Disorder
  • History of Drug or Alcohol Addiction
  • History of Head Injury or Brain Tumor
  • Intestinal Disorder
  • Kidney Disease
  • Liver Disease
  • Low Blood Pressure
  • Mental Illness
  • Pancreas Disorder
  • Sleep Apnea
  • Stomach Disorder
  • Underactive Thyroid
  • Urinary Problems

Tylox may make you dizzy or drowsy. This opioid painkiller can also impair your thinking or reactions - do not operate a motor vehicle or other heavy machinery until you know how Tylox affects you.

Do not drink alcohol while taking Tylox. Consuming alcohol while using products that contain acetaminophen increases your risk for liver damage.

Tylox may cause false-positive results on certain laboratory tests, especially urine glucose tests. Notify your doctor if you have diabetes and find unexpected high levels of blood glucose while taking Tylox.

Tell your surgeon or dentist that you use Tylox before you undergo any operations or procedures. She may suggest you stop using Tylox for a short time or reschedule your procedure.

Tylox may be habit-forming.

Read More about Tylox Precautions

Warnings

Each Tylox capsule contains 500 mg of acetaminophen. Many other products contain acetaminophen, including a variety of over-the-counter preparations. Taking too much acetaminophen may cause serious liver damage. Do not consume more than 4,000 mg of acetaminophen in a 24-hour period. Check the labels of all medications for the presence of acetaminophen.

Taking Tylox along with other narcotic analgesics, general anesthetics, phenothiazines, other tranquilizers, sedative-hypnotics or alcohol increases depression of the central nervous system, or CNS. CNS depression may result in decreased breathing rate, decrease heart rate and loss of consciousness potentially leading to coma or death.

Using Tylox along with some anticholinergics, used for a variety of illnesses, may cause a dangerous digestive condition known as paralytic ileus. Acetaminophen is associated with cases of acute liver failure, at times resulting in liver transplant and death. Most cases of liver damage were associated with using more than 4000 mg of acetaminophen in a single day. These cases often involve the use of multiple products containing acetaminophen.

People who are allergic to oxycodone, acetaminophen or to other opioids should not use Tylox.

Those with significant respiratory depression should not use Tylox. Respiratory depression is a serious breathing problem, where the lungs do not adequately exchange oxygen and other gases.

Individuals with bronchial asthma or other serious breathing problems should not use Tylox. Do not use Tylox if you have ever suffered the serious digestive problem, paralytic ileus.

Pregnancy

Tylox is an FDA pregnancy category C, which means researchers have not yet established how this drug affects an unborn baby. Oxycodone can cause breathing problems and withdrawal symptoms in a newborn. Tell your doctor if you are pregnant or thinking of becoming pregnant while taking Tylox. If you become pregnant while using this medication, notify your healthcare provider immediately.

Oxycodone and acetaminophen pass from the mother to her breast milk and onto a nursing baby. Do not take Tylox while breastfeeding.

Sudden Cessation

Do not discontinue Tylox suddenly or decrease your dose unless your doctor instructs you to do so. A drop in opioid levels may cause unpleasant withdrawal symptoms. Wean yourself from Tylox by taking smaller doses increasingly further apart.

More Warnings about Using Tylox

Drug Interactions

Tell your doctor if you take other narcotic analgesics, general anesthetics, phenothiazines, other tranquilizer, sedative-hypnotic or other CNS depressants including alcohol. Taking these medications alongside Tylox may cause additional CNS depression.

Using Tylox with certain drugs known as anticholinergics may cause a serious digestive condition known as paralytic ileus.

More Drug Interactions

Side effects

All drugs may cause side effects in some individuals. Most of the commonly reported side effects are not serious and go away by themselves. Some side effects are serious, requiring immediate medical attention.

Continue using Tylox but talk to your doctor if the following side effects are intolerable or if they persist:

  • Blurred Vision
  • Constipation
  • Dizziness
  • Drowsiness
  • Dry Mouth
  • Mild Nausea
  • Upset Stomach
  • Vomiting

Discontinue Tylox and consult a physician immediately if you experience serious side effects:

  • Clay-Colored Stools
  • Confusion
  • Dark Urine
  • Fainting
  • Itching
  • Lightheadedness
  • Loss of Appetite
  • Seizure
  • Severe Nausea
  • Shallow Breathing
  • Slow Heartbeat
  • Unusual Thoughts or Behavior
  • Upper Stomach Pain
  • Urinary Problems
  • Yellowing of the Skin or Eyes

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Overdose

Overdose of Tylox is a life-threatening emergency requiring the immediate help of qualified medical professionals. If you suspect you or someone else is experiencing Tylox overdose, contact poison control center at 1-800-222-1222 or go to the nearest hospital, emergency department, urgent care clinic, doctor's office or fire department. Call an ambulance if it results in the quickest medical care possible.

When you or the patient arrives at the hospital, emergency department personnel will administer naloxone or other drugs to lower Tylox to safe levels rapidly. Doctors and nurses will work quickly to establish an airway to help the patient breathe and pump excess medication from the stomach. They will also perform other emergency, life-saving treatments as necessary to counteract the ingredients in Tylox.

It is possible to overdose on either the acetaminophen or the oxycodone components of Tylox, or a combination of the two. Opioid overdose symptoms are different from those associated with acetaminophen overdose.

Opioid overdose symptoms include:

  • Bluish Lips or Skin
  • Change in Consciousness
  • Cold, Clammy Skin
  • Extreme Sleepiness
  • General Feeling of Discomfort or Illness
  • Loss of Consciousness
  • No Blood Pressure or Pulse
  • No Pulse
  • Not Breathing
  • Unconsciousness

Symptoms of acetaminophen overdose occur in two phases. The first wave of acetaminophen overdose symptoms includes:

  • Confusion
  • Loss of Appetite
  • Nausea
  • Stomach Pain
  • Sweating
  • Vomiting
  • Weakness

The second set of acetaminophen overdose symptoms may include:

  • Dark Urine
  • Upper Abdominal Pain
  • Yellowing of the Skin or Eyes

Learn More about Tylox Overdose

Abuse

Recreational users target one active ingredient in Tylox, oxycodone, because of the way it gets them high. Abusers purchase opioids such as oxycodone illegally on the streets, by giving phony prescriptions to pharmacies or seeking multiple prescriptions from several doctors. Some recreational users steal opioids from friends, family members or even pharmacies and hospitals in a process the DEA calls "diversion."

Recreational users rarely target acetaminophen because it does not get them high but, since acetaminophen is a common ingredient in many opioid preparations and over-the-counter medications, incidental acetaminophen abuse may cause dangerous liver disease or overdose.

Abusing Tylox for a long time increases the risk for physical dependence and addiction to opioids in some consumers, especially if they use large doses to get high or administer the drugs intravenously.

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Withdrawal

Anyone who takes Tylox for a long time can experience withdrawal symptoms when they discontinue the medication. Withdrawal symptoms are a predictable and normal physiological process, and not necessarily a sign of criminal drug abuse.

The human body adapts to the presence of certain foreign substances, such as the oxycodone in Tylox, by altering its own chemical balance. With continuous use, the body begins to rely on a certain level of the drug to feel "normal." If the level of oxycodone plummets, the dependent body struggles to maintain chemical balance. The individual experiences this chemical imbalance, known as detoxification, through the uncomfortable, flu-like withdrawal symptoms.

Physical withdrawal symptoms can last five days or more as the body gradually adjusts to lowered opioid levels. Withdrawal may cause psychological symptoms, such as depression and anxiety; these psychological symptoms may be as devastating and may even last longer than physical withdrawal symptoms.

Withdrawal symptoms vary in severity and duration from person to person; symptoms can be worse for individuals taking high doses or using Tylox for a long time. Withdrawal symptoms include:

  • Abdominal Cramps
  • Agitation
  • Anxiety
  • Blurred Vision
  • Goose Bumps
  • Insomnia
  • Restlessness
  • Sweating
  • Tremor
  • Vomiting

More about Tylox Withdrawal

Detox

Detoxification is the process of reducing the level of opioids in the body of an individual who is opioid-dependent. This detoxification process occurs either because the person used a smaller dose than usual or because he took a medication such as naloxone to reduce the level of opioids dramatically.

Detoxification is a long and difficult process, especially if you attempt self-detoxification without specially trained professionals to chart a treatment plan or medicines to reduce withdrawal symptoms. Rehabilitation specialists administer drugs such as naloxone to decrease opioid levels and more medications to ease the resulting withdrawal symptoms. These physicians prescribe a variety of medications, including drugs to soothe anxiety, treat diarrhea, calm tremors and help the patient sleep.

While standard detoxification treatments typically reduce withdrawal time and relieve uncomfortable physical withdrawal symptoms somewhat, many patients still struggle with the demoralizing psychological symptoms that may prevent successful recovery.

Experts think rapid detox is the most humane way to detoxify a body dependent on opioids, such as the oxycodone in Tylox. During rapid detox, board certified anesthesiologists administer anesthesia and sedatives along with the usual detoxification drugs. The individual rests in a comfortable "twilight sleep" before awakening with no recollection of the grueling withdrawal process.

Learn More about Tylox Detoxification Programs

Storage

Flush unused Tylox down the toilet to reduce the risk for diversion or overdose. This advice applies to only a small number of medications; ask your pharmacist how to dispose of medications you no longer need.

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Facts

  • Tylox

Programs