Tussionex is used to treat runny nose, itching, watering eyes and cough associated with the common cold. Learn More About Tussionex Uses


Tussionex is available in a liquid form. Each 5 ml teaspoon of Tussionex contains the equivalent of 10 mg of hydrocodone and 8 mg of chlorpheniramine. Shake the bottle before dispensing medicine into an approved measuring spoon. Do not mix Tussionex with other substances. You may take Tussionex with or without food.

Tussionex is normally prescribed to be taken as needed for pain; do not worry if you miss a dose. Simply take another dose when you have pain, provided enough time has passed since your last dose. If you are taking Tussionex on a regular schedule and miss a dose, take another dose as soon as you remember. If it is nearly time to take a regularly scheduled dose, skip the missed dose and resume your normal schedule. If you miss several consecutive doses, or if you have trouble maintaining the prescribed schedule, talk with your doctor. Read More About Tussionex Administration and Dosage


Chlorpheniramine is an antihistamine that reduces symptoms of sneezing, itching, runny nose and watery eyes. Hydrocodone is a narcotic cough suppressant. Together, these medications reduce the symptoms of the common cold. More About How Tussionex Works


Tell your doctor if you are allergic to Tussionex or any other medication. An allergic reaction is a serious, potentially life-threatening medical emergency. Seek immediate help if you experience an allergic reaction shortly after taking Tussionex. Symptoms of an allergic reaction include hives, difficulty breathing and swelling of your face, lips, tongue or throat.

You may not be able to take Tussionex if you have a history of certain medical conditions. Tell your doctor about any serious or chronic illnesses including asthma or another breathing disorder, a history of head injury or brain tumor, stomach or intestinal problems, liver or kidney disease, glaucoma, urination problems or an enlarged prostate, Addison's disease, or underactive thyroid.

Tussionex can make you drowsy. Do not operate heavy machinery or drive a car until you know how Tussionex affects you. Avoid engaging in risky behavior that requires you to be alert and awake. Alcohol and some medications can enhance this effect. Do not consume alcohol while taking Tussionex. Drinking alcohol may worsen side effects.

This drug can be habit-forming, especially if you take it for long periods of time. Tell your doctor if you have a history of dependence or addiction to drugs or alcohol. Your physician may choose a different course of treatment or adjust your dosage accordingly.

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It is not known how taking Tussionex can affect your unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while taking Tussionex. If you become pregnant while taking Tussionex, call your doctor immediately. Tussionex is found in breast milk. Do not take Tussionex while breastfeeding.

Don't stop taking Tussionex suddenly; doing so may cause unpleasant withdrawal symptoms. Try weaning yourself from Tussionex by taking smaller doses less frequently. If withdrawal symptoms prevent you from quitting Tussionex, talk with your doctor or qualified in-patient or out-patient rehabilitation center. More Warnings About Using Tussionex

Drug Interactions

Tussionex may interact in an unfavorable or even dangerous way with other prescriptions, over-the-counter medications and herbal remedies. Give your doctor a complete and updated list of medicines. Be sure to tell your doctor if you take any of the following drugs:

  • Atropine.
  • Benztropine.
  • Dramamine.
  • Bronchodilators.
  • Bladder or Urinary Medications.
  • Irritable Bowel Medications.
  • MAO Inhibitors.

More Drug Interactions

Side effects

You may experience side effects while taking Tussionex. If side effects become acute or don't go away on their own, talk with your doctor. Common side effects include dizziness, drowsiness, trouble concentrating, mood changes or anxiety. Other side effects include blurred vision, constipation, nausea, vomiting or loss of appetite. Talk with your doctor if your dry mouth or throat worsens or if you have uncomfortable sweating, mild itching or skin rash.

Some side effects can be severe or life-threatening. Seek medical assistance immediately if you experience severe side effects such as weak or shallow breathing, chest tightness, painful urination, urinating less than usual or not at all or confusion, hallucinations or unusual behavior.

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Tussionex overdose is a serious, life-threatening medical emergency. If you suspect that you or someone you know has taken an overdose of Tussionex, seek emergency assistance immediately by going to the emergency room or calling an ambulance. If you are a very long distance from professional help, contact your local poison control center at 1-800-222-1222. Overdose symptoms include dry mouth, cold and clammy skin, flushing, large pupils, nausea, vomiting, severe dizziness or drowsiness, seizure, shallow breathing, slow heart rate, blue colored skin, feeling light-headed or fainting.

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Tussionex is a Schedule III drug, which means abuse may lead to moderate or low physical dependence or high psychological dependence. Pharmaceutical companies legally manufacture Tussionex for licit use as a pain reliever but abusers obtain Tussionex through forged prescriptions, bogus prescription call-ins to pharmacies, "doctor shopping" as well as theft from pharmacies and friends. Read More About Tussionex Abuse


Withdrawal is not necessarily a sign of willful substance abuse. Withdrawal is a normal, predictable, physical sign of dependency. Withdrawal symptoms may appear after you stop taking Tussionex, especially if you have been taking high doses or using the opioid for a long period of time. Withdrawal symptoms and duration vary from person to person. Withdrawal symptoms may be so intense that they prevent you from quitting Tussionex without medical assistance. Speak with your physician if withdrawal symptoms prevent you from quitting Tussionex.


You may need the help of qualified professionals to help you detoxify your body from Tussionex. Strong withdrawal symptoms may make dependency and addiction to Tussionex difficult to overcome on your own. Quitting may be more difficult if you have been taking large doses or using opioids for a long time. Talk with your doctor or seek in-patient and out-patient treatment facilities where trained professionals can minimize withdrawal symptoms, detoxify your body and give you the tools you need to live drug-free. Detoxification, rehabilitation and counseling are effective therapies to treat addiction to Tussionex and other opiates.

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Keep Tussionex in a safe place, away from children, pets and adults who might consume this product willfully or accidentally. Store Tussionex away from excessive heat and moisture. Never share Tussionex or other opioids with others, especially with people with a history of alcohol or drug abuse. Keep track of your medication, taking note of any missing doses.

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