- Generic Name or Active Ingridient: Oxycodone And Acetaminophen
- Excessive yawning
- Muscle aches
- Runny nose
- Watery eyes
- Stomach cramps
- Dilated pupils
- Goose bumps
- Nausea and vomiting
- Stomach cramps
- Appetite loss
- Upset stomach
- Have suffered an overdose
- Cannot receive treatment safely in an outpatient setting
- Are at risk for severe withdrawal symptoms or complications
- Have co-existing conditions that make outpatient detoxification unsafe
- Have not benefited from less restrictive programs
- Have psychiatric problems that prevent participation in outpatient treatment
- Suffer significant mental disorders, such as acute psychosis or depression with suicidal thoughts
- Exhibit behaviors that may cause danger to the individual or to others
Taxadone detoxification rids the body of toxins accumulated as the result of using Taxadone for a long time. Taxadone detoxification brings a drug-dependent body to a drug-free state.
Taxadone contains 5 mg of oxycodone and 500 mg of acetaminophen. Oxycodone is an opioid pain reliever synthesized from extracts of the opium poppy plant. Acetaminophen is a non-opioid pain reliever. Other names for acetaminophen include paracetamol and the brand name, Tylenol.
Doctors prescribe Taxadone to relieve a patient’s moderate to moderately severe pain. The oxycodone in Taxadone works like other opioids to relieve pain: oxycodone acts directly on the nervous system to change the way the brain interprets pain signals.
Opioids cause other neurological effects, the most immediately noticeable being sedation, relaxation and a pleasant, euphoric feeling. Opioids including the oxycodone in Taxadone work with other body systems to cause other effects, such as stiffening the muscles in the digestive and cardiovascular systems to cause constipation, high blood pressure, and a fast pulse.
With continuous use, some of these neurological changes become more permanent, altering how the consumer thinks, feels, and behaves. These alterations can have a profoundly negative impact on the person’s ability to work, go to school, take care of family, and interact with others. Without help, the effects of chronic drug use can cause job loss and financial hardship, separation or divorce, loss of child custody, homelessness, incarceration, overdose, and death.
The oxycodone and acetaminophen in Taxadone are common analgesics in the United States. Oxycodone is available by prescription only; acetaminophen is available without a prescription. In 2010, U.S. pharmacists dispensed 58.2 million prescriptions for drugs containing oxycodone. In 2005, Americans purchased more than 28 billion doses of products containing acetaminophen.
Someone might take Taxadone to relieve pain after a significant injury, illness, or invasive medical or dental procedure. Many patients are on long-term opioid therapy for chronic pain for cancer, arthritis and other conditions that cause persistent pain. Currently, more than three percent of American adults are receiving long-term opioid therapy for the treatment of chronic non-cancer pain.
Most patients take Taxadone as directed and dispose of unused doses when they no longer need the medication to relieve pain. Some people, however, use Taxadone non-medically to get high or to treat a different condition than the one the doctor had intended to treat when he wrote the prescription. About 5 million Americans use painkillers for non-medical use every year.
Opioid Dependence and Taxadone Detoxification
Anyone who uses Taxadone regularly for more than a few weeks can become physically dependent on oxycodone, whether he uses this drug for therapeutic purposes or for non-medical reasons. The human body accommodates the presence of some toxic substances, including the oxycodone in Taxadone, by adjusting its own physiology. With continued use, the body begins to depend on a certain level of oxycodone to feel normal - the body becomes opioid-dependent.
According to results from a 2011 National Survey on Drug Use and Health, about 1.9 million Americans are dependent on Taxadone and other prescription opioid pain relievers. This number has grown slightly since 2004, when there were 1.4 million opioid-dependent people in the United States.
When opioid levels fall drastically in an opioid-dependent person, his body struggle to regain stability and recover from the toxic neurological and physical effects of chronic oxycodone abuse. Doctors refer to this as Taxadone detoxification. An opioid-dependent person experiences Taxadone detoxification through unpleasant withdrawal symptoms.
Taxadone Withdrawal Symptoms
Withdrawal symptoms begin a few hours after the last dose of Taxadone. Opioid withdrawal symptoms typically appear in two waves, with the first set of symptoms beginning a few hours after the final dose or inadequate dose of Taxadone.
Initially the patient might feel:
Later, the individual might develop:
Some patients develop clinically significant withdrawal symptoms, such as increase blood pressure and rapid pulse. Furthermore, the effects of chronic acetaminophen consumption can cause symptoms that mimic withdrawal symptoms. Without sufficient patient education, someone suffering acetaminophen overdose might attribute his discomfort to Taxadone detoxification and mistakenly take even more acetaminophen to control withdrawal.
Symptoms of acetaminophen overdose may not appear for 12 hours after consumption of a toxic dose. Acetaminophen overdose symptoms include:
It is important to note that Taxadone withdrawal and acetaminophen overdose share several common symptoms. Most notable are stomach cramps, diarrhea, nausea and vomiting, sweating, and irritability or agitation.
Acetaminophen and Taxadone Detoxification
Acetaminophen does not produce euphoria and, as a result, is not associated with recreational use. However, dependence on Taxadone causes the individual to consume high doses of acetaminophen. Acetaminophen can accumulate to toxic levels in the system, potentially resulting in dangerous or even fatal overdose. Acetaminophen overdose is one of the most common poisonings worldwide and is the leading cause of acute liver failure in the United States.
The body breaks acetaminophen down into a smaller toxic metabolite known as NAPQI. A certain protein binds to NAPQI and carries it to the liver. The liver then eliminates the metabolite from the system. These metabolites are quite toxic to the liver and can cause extensive damage to liver cells if not cleared from the body quickly enough. The liver might become overwhelmed with toxic metabolites and suffer damage after a single episode of acetaminophen overdose or as the result of acetaminophen accumulation resulting from Taxadone dependence.
Alcohol interferes with the uptake and elimination of NAPQI in a way that increases levels enough to cause liver damage or death. The extent of liver damage depends on the amount of toxic metabolites and the ability of the liver to remove this metabolite before it binds to the liver proteins. The antidote to NAPQI poisoning is acetylcysteine.
Anyone attempting Taxadone detoxification must take into account the effects of chronic acetaminophen use on the liver. Liver damage can change the way the body metabolizes nutrients and drugs, including medication the patient might receive during Taxadone detoxification.
Benefits of Taxadone Detoxification
Taxadone detoxification is just one part of the recovery process. Detoxification does little to change the behaviors associated with drug abuse that increase the risk for relapse. Most opioid-dependent patients benefit from some amount of rehabilitation to learn how to live without drugs. Rehabilitation frequently includes counseling and behavior modification that teaches the patient how to recognized situations that could potentially lead to drug abuse, and how to refuse Taxadone when offered.
Taxadone detoxification brings an opioid-dependent person to an opioid-free state and furthers his attempts at living without drugs. Detoxification addresses withdrawal symptoms and clarifies the patient’s thinking in a way that facilitates his entry into rehabilitation. Taxadone detoxification helps someone stay in rehabilitation long enough to reverse some of the adverse neurological effects of substance abuse. This helps the patient return to work, take care of family, and engage in healthy and meaningful interactions with others. In this way, Taxadone detoxification returns to the patient to as much of his former life as possible and improving his social and psychological well-being.
Detoxification promotes abstinence - the patient enjoys the restoration of physical health and mental clarity that only a drug-free state can bring. Taxadone detoxification also reduces the frequency of relapses and decreases the severity of drug use episodes when they do occur.
Taxadone detoxification also refers to a medical procedure that uses opioid or non-opioid drugs to control detoxification and withdrawal symptoms. The detoxification process can occur at home, through an outpatient clinic, at a hospital, or a specialty detoxification facility.
Types of Detox
Each person arrives at an opioid-dependent state in a slightly different way and, consequently, everyone experiences Taxadone detoxification in a slightly different way. Some people require a high degree of medical care and supervision while others can reach an opioid-free state without any help whatsoever.
Of all opioid-dependent people, only about 10 percent received help during detoxification from a specialty facility, such as an inpatient hospital, inpatient or outpatient rehabilitation facility or mental health centers. The vast majority of opioid-dependent people engages in self-help, work with a private doctor, get treatment in an emergency room, quit opioids while incarcerated, or do not attempt detoxification at all. Any treatment that brings the patient to an opioid-free state in a safe and effective manner is an appropriate approach to Taxadone detoxification.
When it comes time for a patient to stop taking Taxadone after using this opioid for more than a few weeks, a physician will suggest the individual taper Taxadone use rather than stopping abruptly - sudden cessation may cause withdrawal symptoms in these patients, complicating ongoing care for the patient’s chronic condition. The patient takes a smaller dose each day - just enough to prevent withdrawal symptoms - until he reaches an opioid-free state.
Self-detoxification is appropriate for those who have been opioid-dependent for only a short time, suffer mild withdrawal symptoms, and do not have any underlying conditions that might complicate Taxadone detoxification.
Lingering withdrawal symptoms prevent some people from completing Taxadone detoxification through tapering. These individuals might try quitting cold turkey by discontinuing Taxadone abruptly. While quitting cold turkey does bring the person to an opioid-free state, withdrawal symptoms can be intense.
Taxadone withdrawal symptoms are responsive to a variety of treatments. Acupuncture, massage, meditation, and yoga relax the body, easing the severity of symptoms. Herbal supplements, such as ginger or peppermint to relieve nausea, provide immediate relief.
The Thomas Recipe is a homemade treatment plan that uses prescription and non-prescription drugs to ease the Taxadone detoxification process. This plan calls for a benzodiazepine such as Valium or Xanax to calm nerves and help with sleep, vitamin B6 with hot baths for muscle aches, and Imodium for diarrhea.
Sometimes called medical detoxification, medication-assisted detoxification is a professional treatment plan that uses opioid replacement drugs to manage the onset of detoxification or control the severity of symptoms. Methadone and buprenorphine are the most commonly used drugs in medical detoxification.
Many people associated methadone and buprenorphine with maintenance programs, where patients use these opioids to delay the onset of detoxification while they engage in rehabilitation. Methadone and buprenorphine are opioids, so they prevent withdrawal symptoms. When administrated properly at therapeutic doses, methadone and buprenorphine do not get the patient high. Once the participant learns how to lead a drug-free life, he weans himself from the replacement drug.
Outpatient Taxadone Detoxification
Outpatient clinics now use methadone and buprenorphine as “step down” drugs to ease withdrawal symptoms in patients attempting detoxification at home. Patients start out on a high dose of the replacement drug during the induction phase and gradually reduce the daily dosage over the course of several days or weeks during the tapering phase.
Outpatient Taxadone detoxification is appropriate for anyone who has been opioid-dependent longer than one year and who cannot spend time at an inpatient facility because of work or family responsibilities.
A German chemist first synthesized methadone as a pain reliever in 1939. Physicians around the world prescribe methadone as an analgesic but U.S. doctors usually order methadone as a treatment for dependence on opioids such as Taxadone and heroin.
About 100,000 Americans use a methadone maintenance program. These patients come to an outpatient clinic each day to receive a dose of methadone. The effects of one dose of methadone last 24 to 36 hours.
An increasing number of people use methadone as an aid to the tapering process. Doctors start these patients on 10 to 15 mg of methadone and increase dosages by 10 mg each day until the patient no longer feels withdrawal symptoms. The patient remains on this induction dose for a few days as his condition stabilizes then decreases daily dosages by 10 mg each day until he completes detoxification.
Some patients use buprenorphine as part of medically supervised withdrawal. While there is no set tapering schedule, some patients can complete detoxification in as little as one week, spending the first one to three days in the induction phase and tapering during days four through seven.
Buprenorphine is available under the brand name, Subutex. The patient places a buprenorphine tablet under his tongue where it dissolves before entering the bloodstream.
It is possible to abuse buprenorphine by dissolving the tablet before injecting the solution into a vein. Drug makers discourage abuse by adding naloxone to the buprenorphine preparation, Suboxone. Taken under the tongue, naloxone has no effect. When taken intravenously, however, naloxone counteracts buprenorphine so the consumer does not get high. Additionally, intravenous naloxone use causes withdrawal symptoms in opioid-dependent users.
Inpatient Taxadone Detoxification
Inpatient Taxadone detoxification offers a professional treatment plan that includes prescreening for underlying conditions that may cause complications, non-opioid detoxification and anti-withdrawal drugs, and close patient supervision.
Inpatient treatment is appropriate for those who:
Rapid detox brings a patient to an opioid-free state in hours, rather than days, weeks or months. Rapid detox specialists sedate and anesthetize patients before administering the usual detoxification and anti-withdrawal drugs. Rapid detox patients rest in a comfortable “twilight sleep” during Taxadone detoxification, avoiding the discomfort and demoralization resulting from detoxification.
Our detox center: Who we are and what we do
We are a group of board-certified anesthesiologists and other dedicated professionals who have received advanced training in detoxification procedures, specializing in rapid detox. We have helped thousands of people reach an opioid-free state since opening the doors of our fully accredited facility more than a decade ago.
We prescreen patients in our state-of-the-art facility for any underlying conditions that may cause complications. We then create an individualized treatment plan that may include rapid detox. After completing detoxification, patients may continue recovery in our qualified aftercare center.
Opioid dependence is a difficult diagnosis and choosing a treatment plan can be confusing, so it is helpful to compare the various treatment approaches to highlight the benefits and drawbacks of each.
Without the expense of professional guidance and anti-withdrawal drugs, self-detoxification is the least costly approach. However, without the benefits of prescreening, a proven treatment plan, anti-withdrawal drugs and patient supervision, the patient faces a high risk for developing severe withdrawal symptoms and dangerous complications. This is especially true for anyone with undiagnosed acute liver failure caused by chronic acetaminophen consumption - those attempting self-detoxification may increase acetaminophen levels even further by taking this over-the-counter drug to ease withdrawal symptoms.
Outpatient reduces the risk for severe withdrawal symptoms and complications associated with self-detoxification, but medication-assisted detoxification can actually prolong the opioid-dependent state with some patients remaining on methadone or buprenorphine for years.
Inpatient care brings the patient to an opioid-free state in an average of only 4 days, compared with 197 days for medication-assisted therapy. Inpatient care also provides greater protection from withdrawal symptoms, complications and relapse.
Rapid detox brings the patient to an opioid-free state in the shortest possible time in a safe manner - just hours instead of days, weeks or months. Rapid detox spares the patient from all withdrawal symptoms.
Possible Complications to Taxadone Detoxification
Taxadone detoxification is not usually life-threatening but severe withdrawal symptoms, underlying conditions, and co-existing drug or alcohol problems can cause complications that could become dangerous or even fatal.
The primary complication to any approach to Taxadone detoxification is relapse. Uncomfortable and prolonged withdrawal symptoms cause some to take more Taxadone, while others relapse sometime after completing detoxification.
Relapse increases the risk for toxic overdose. Taxadone detoxification decreases the body’s tolerance to oxycodone, making the individual more sensitive to its effects. This decrease in tolerance makes it possible for someone to overdose on a smaller amount of Taxadone than he used to take before experiencing even moderate withdrawal symptoms.
Approximately 14,800 Americans died after overdose from Taxadone or other opioid analgesics in 2008. That year, for the first time in U.S. history, deaths from prescription opioids killed more Americans than cocaine and heroin combined.
The maximum daily dosage for oxycodone is 60 mg while the maximum acetaminophen dosage is 4,000 mg in any 24-hour period. Taking more than the recommended total daily dose of 4,000 mg of acetaminophen can lead to serious liver injury in some people; acetaminophen doses exceeding 7,000 mg may result in death.
Acetaminophen overdoses kill about 500 deaths per year in the United States, with about half of these deaths associated with accidental overdose rather than suicide. Acetaminophen is a common ingredient in prescription and non-prescription drugs, so some patients sometimes combine medications to cause unintentional overdose. Others take an unintentional overdose when consuming extra doses to relieve stubborn pain - like that experienced during Taxadone detoxification.
Self-Detoxification Possible Complications
Uncontrolled vomiting and diarrhea can cause dehydration and imbalances in potassium and other electrolytes. Withdrawal symptoms can aggravate underlying medical conditions to complicate treatment. Withdrawal from Taxadone can increase blood pressure, for example, in a way that can worsen some types of heart conditions.
Possible Complications to Outpatient Detoxification
A patient may have trouble establishing a methadone or buprenorphine dose, feeling either over-medicated or suffering withdrawal symptoms. It is possible to become dependent on the replacement drug and remain on methadone or buprenorphine for months or years.
Methadone abuse is associated with an increasing number of overdose deaths: in 2009, there were 5.5 times as many deaths associated with methadone as there were in 1999. Even though it represents only about 2 percent of prescription painkiller sales, it now accounts for about a third of all prescription analgesic overdose deaths.
While doctors consider buprenorphine safer than methadone, there is still risk for fatal overdose with intravenous injection, especially when combined with benzodiazepines like those used in The Thomas Recipe.
Inpatient Detox Possible Complications
Inpatient care provides the greatest protection from complications but withdrawal from multiple substances, especially alcohol, benzodiazepines, sedatives and anti-anxiety drugs can interfere with this approach to detoxification.
Rapid Detox Possible Complications
It is rare, but a patient may suffer an allergic reaction to the medications used in rapid detox procedures. He might experience infection, swelling, or bruising at the anesthesia injection site. Strong sedatives may complicate breathing, blood pressure, and pulse.
Myths about Taxadone Detoxification
Despite decades of research and mountains of clinical evidence gathered from actual doctors and opioid-dependent people, myths shrouding Taxadone prevent an untold number of people from seeking the help they need.
Self Detox Myths
Myth: Self-detoxification is always safe - the individual can always take acetaminophen or other over-the-counter drugs to relieve withdrawal symptoms.
Fact: Untreated withdrawal symptoms can aggravate undiagnosed conditions to produce dangerous complications. Consuming acetaminophen during detoxification can cause dangerously high levels of the metabolite, NAPQI, potentially resulting in liver damage or acute liver failure.
Myth: Using prescription and non-prescription drugs, such as those outlined in The Thomas Recipe, makes self-detoxification safe for everyone.
Fact: Self-detoxification can be unsafe for those with severe withdrawal symptoms, underlying conditions and co-existing substance abuse problems, pregnancy, and other issues even if the patient uses safe and effective medications. Combining medications may cause dangerous drug interactions.
Outpatient Detox Myths
Myth: Imprisonment is cheaper than treatment.
Fact: Treatment is less expensive than treatment. A year of methadone costs about $4,700 per patient, whereas a year of imprisonment costs about $24,000 per inmate.
Myth: Methadone causes bone rot.
Fact: Inadequate methadone doses cause withdrawal symptoms, especially bone ache. Any methadone patient suffering achy bones should consult with the prescribing clinician to discuss a dosage increase.
Inpatient Detox Myths
Myth: It is a waste of space to treat drug addicts in a hospital because drug dependence is incurable.
Fact: Any person with a medical disorder, including Taxadone, deserves treatment. Opioid dependence is a chronic condition and, as such, has relapse rates similar to other chronic conditions, such as high blood pressure, diabetes or asthma - 40 to 60 percent.
Myth: Communities cannot afford to waste money on drug treatment during this bad economy.
Fact: Communities cannot afford to ignore the financial rewards of drug treatment. For every dollar spent on treatment, a community can expect a return of $4 to $7 in reduced drug-related crime rates and criminal justice costs. Factor in savings to the local healthcare system and these yields leap to $12 gained for every dollar invested.
Rapid Detox Myths
Myth: Pain and humiliation are important features of Taxadone detoxification as they serve as a punishing reminder about drug abuse.
Fact: Not everyone arrives at opioid dependence through abuse - many become dependent after using Taxadone as part of a long-term treatment plan. Furthermore, suffering is never an appropriate part of any treatment plan and it can actually make it more difficult to complete the detoxification process. Rapid detox removes most of the physical and psychological discomfort associated with detoxification.
Myth: It takes weeks or months to complete Taxadone detoxification.
Fact: A well-trained, board-certified anesthesiologist can perform rapid detox in one to two hours, bringing the patient to an opioid-free state in as little time possible.
Detoxification and Pregnancy
Dependence on Taxadone and other opioids increases a woman’s risk for developing certain medical conditions, such as heart disease, mood disorders, anemia and blood infections, hepatitis, and pneumonia. Opioid-dependence makes these women more vulnerable to contracting infectious diseases, such as tuberculosis, sexually transmitted diseases, and HIV/AIDS.
Opioid abuse increases the risk for gestational diabetes, a condition marked by wildly fluctuating blood sugar levels during pregnancy. Opioid dependence also increases the risk to a pregnant woman and her unborn baby for complications during pregnancy, labor, and delivery. Complications include hemorrhage, separation or inflammation of the membranes surrounding the fetus, slowed fetal growth, spontaneous abortion, premature labor and delivery, and fetal death.
Methadone reduces these complications and is currently only approved treatment plan for opioid-dependent pregnant women. However, a recent study published in the New England Journal of Medicine calls buprenorphine “an acceptable treatment for opioid dependence in pregnant women.”
A baby born to a woman who uses opioids regularly during pregnancy may be born with neonatal abstinence syndrome, otherwise known as NAS. Along with suffering withdrawal symptoms in the first weeks or months of life, NAS babies may suffer low birth weight, seizures, breathing problems, feeding difficulties and death.
Self-Detoxification and Pregnancy
Self-detoxification may be unsafe for a pregnant woman, even using the tapering method. A pregnant woman should not attempt self-detoxification without first consulting a physician.
Inpatient Induction to Methadone Maintenance for Opioid-Dependent Pregnant Women
A pregnant woman should start methadone maintenance as an inpatient where doctors can properly evaluate the response of the patient and the unborn baby to treatment. Physicians will typically start the woman on 10 mg to 20 mg of methadone on the first day of treatment and, based on her response, increase dosages by 5 - 10 mg until establishing a safe and effective dose, with the maximum daily dose of 60 mg. The patient usually remains in the hospital about three days before discharge to outpatient care, where she will continue maintenance until at least delivery. A baby born to a woman on methadone maintenance will stay in the hospital for 72 hours after delivery for close observation for signs of NAS.
Outpatient Induction to Methadone Maintenance for Opioid-Dependent Pregnant Women
An opioid-dependent woman may start methadone maintenance as an outpatient. She must visit the clinic twice each day, once to receive a daily dose and again for evaluation. These twice-daily visits continue until the clinician establishes an appropriate dose.
Women using methadone to maintain opioid dependence may suffer withdrawal symptoms late in pregnancy and require larger doses of methadone; outpatient clinicians will manage dosage increases.
What is the best method to detox from this drug?
Detoxification is a highly personal experience - some people are able to complete detoxification at home, with no medications, while others require the benefits of hospitalization. The individual should assess his likelihood of severe withdrawal symptoms and complications, his need for structure, and his ability to refrain from drug use. He should then choose the least restrictive form of treatment that is still likely to bring him to an opioid-free state in a safe and effective manner.
- Taxadone Detox