Doctors prescribe Taxadone to relieve moderate to moderately severe pain. Taxadone contains a potent opioid pain reliever, oxycodone, and a non-narcotic analgesic, acetaminophen.

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Other, off label uses for this medicine

The acetaminophen in Taxadone reduces fever, while the oxycodone represses the urge to cough.

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Taxadone is available in capsule form. There is 5 mg of oxycodone hydrochloride and 500 mg of acetaminophen in every capsule.

Take the capsule whole - do not open the capsule. Drink a large glass of water with your Taxadone capsule to prevent choking.

Take Taxadone exactly as prescribed. The maximum daily dose for oxycodone is 60 mg; do not take more than 4000 mg of acetaminophen in a 24-hour period.

Physicians normally suggest you take Taxadone when you need it to relieve pain, rather than on a schedule. If you are taking oxycodone and acetaminophen tablets on a regular schedule and miss a dose, take the missed dose as soon as possible. If it is almost time for another dose and you can tolerate the pain, skip the missed dose and resume your normal schedule. Do not take two or more doses at once.

When the patient no longer needs the medication, physicians should gradually reduce dosage for patients who have taken Taxadone longer than a few weeks. Taking opioids such as Taxadone continually for a long time puts a person at special risk for withdrawal symptoms if he were to stop taking Taxadone abruptly.

Wean yourself from Taxadone when you no longer need it to relieve your pain, or when a doctor suggests you stop using it. Take increasingly smaller doses further apart to avoid withdrawal symptoms.

Taxadone is available only with a doctor's prescription. The U.S. Drug Enforcement Agency, or DEA, does not allow refills on Taxadone - the physician must write a new prescription each time he determines the patient needs this medication.

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Taxadone works with the chemistry and central nervous system, or CNS, to change the way your brain perceives pain.

When you are injured or ill, the affected cells of your body produce prostaglandin, a chemical messenger. Prostaglandin binds to pain receptors and sends messages about the pain to your brain. Your brain responds by perceiving pain and taking appropriate action, such as saying "Ouch" or pulling away from the source of pain.

Taxadone binds to pain receptors, preventing prostaglandins from docking there. The opioid component of Taxadone sends messages of euphoria and relaxation. Instead of perceiving pain or distress, your brain is calm and happy.

The acetaminophen in Taxadone eases pain and reduces fever by blocking the production of prostaglandins.

The opioid component of Taxadone affects the respiratory system. Taxadone depresses the part of the brain responsible for breathing in a way that can make the brain simply forget to breathe. Opioids also depress the cough center in the brain, reducing the urge to cough out excess phlegm or foreign objects.

The opioid oxycodone found in Taxadone acts on smooth muscle organs, like those in your intestines, in a way that slows down digestion and causes constipation. Ease constipation and soften stools by drinking six to eight full glasses of water each day you take Taxadone. Increase your dietary fiber intake, known to aide digestion. Do not use a laxative or stool softener without first discussing it with a healthcare provider.

More about How Taxadone Works


Do not take Taxadone if you are allergic to any component of Taxadone, especially oxycodone or acetaminophen. Tell the prescribing doctor if you have ever suffered an allergic reaction to other opioid medications, such as codeine. Seek medical help immediately if you think you are suffering an allergic reaction.

Symptoms of an allergic reaction include:

  • Rash
  • Hives
  • Itching
  • Difficulty Breathing
  • Swelling of the Face, Mouth, Lips or Tongue

Taxadone can cause dizziness or drowsiness and impair thinking. Do not operate a motor vehicle or other machinery until you know how this medication affects you.

The DEA has classified Taxadone as a schedule II controlled substance, which means it is associated with a high risk for abuse. Uncomfortable and relentless withdrawal symptoms or cravings associated with addiction makes it difficult to stop using opioids such as Taxadone. Do not use large doses or use this medication more often than prescribed to reduce your risk for dependence, addiction and other side effects.

Tell the prescribing physician if your current Taxadone prescription stops working, as this is a sign that your body is growing tolerant to Taxadone. The doctor might change your dosing schedule or recommend a different treatment for your pain.

Avoid alcoholic beverages and products that contain alcohol while taking Taxadone. Consuming alcohol while taking opioids may cause dangerous side effects, such as liver damage or death. Read the labels of foods, beverages and medications, especially over-the-counter preparations, to determine if it contains alcohol. Consult with your pharmacist if you are not sure if a product contains alcohol. Talk with your doctor about your alcohol use, especially if you normally drink more than three alcoholic beverages each day. It may be dangerous for you to take Taxadone or other medications containing acetaminophen if you have ever had cirrhosis, commonly called alcoholic liver disease. Chronic alcoholics should not consume more than 2000 mg of acetaminophen in a single day.

Medical History

You may not be able to take this drug if you have ever had certain medical conditions. Your illness or treatment for that illness might affect how Taxadone works for you. Additionally, taking this medication may worsen your pre-existing condition or affect your treatment.

Tell your physician about any significant illnesses or conditions, including:

  • Addison's Disease or Other Adrenal Gland Disorder
  • Asthma
  • Breathing Disorders
  • COPD
  • Curvature of the Spine
  • Enlarged Prostate
  • Epilepsy or Other Seizure Disorder
  • History of Drug or Alcohol Addiction
  • History of Head Injury or Brain Tumor
  • Intestinal Disorder
  • Kidney Disease
  • Liver Disease
  • Low Blood Pressure
  • Mental Illness
  • Pancreas Disorder
  • Sleep Apnea
  • Stomach Disorder
  • Underactive Thyroid
  • Urinary Problems

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Acetaminophen is associated with cases of acute liver failure, at times resulting in liver transplant and death. Most cases of liver damage were associated with using more than 4000 mg of acetaminophen in a single day. These cases often involve the use of multiple products containing acetaminophen.

Patients with known allergies or hypersensitivities to oxycodone, acetaminophen or to other opioids should not use Taxadone.

Individuals with significant respiratory depression should not use Taxadone in unmonitored settings or the absence of resuscitative equipment. Respiratory depression is a serious breathing problem, where the lungs do not adequately exchange oxygen and other gases.

Individuals experiencing acute or severe bronchial asthma or other breathing problems should not use Taxadone. Taxadone is not recommended for individuals who have suffered the serious digestive problem known as paralytic ileus.


Taxadone is an FDA pregnancy category C, which means medical scientists do not yet know how this drug affects an unborn baby. The oxycodone in this drug can cause breathing problems and withdrawal symptoms in a newborn. Tell your doctor if you are already pregnant or plan to get pregnant while taking Taxadone. If you become pregnant while taking Taxadone, notify your healthcare provider immediately. She will discuss the benefits and risks of using opioid pain relievers while pregnant.

Oxycodone and acetaminophen pass from the mother to her breast milk and onto a nursing baby. Do not take Taxadone while breastfeeding.

Sudden Cessation

Do not quit taking Taxadone abruptly or change your dose drastically unless your doctor instructs you to do so. A sudden decrease in opioid levels will cause unpleasant withdrawal symptoms in a person who has grown dependent upon opioids. Wean yourself from Taxadone by taking smaller doses increasingly further apart. If withdrawal symptoms prevent you from discontinuing Taxadone, you may be physically dependent on opioids.

More Warnings about Using Taxadone

Drug Interactions

The oxycodone and acetaminophen in Taxadone might interact in an unfavorable or unsafe ways with other medicines. Give your doctor a complete and updated list of your prescriptions, over-the-counter preparations, vitamins, supplements and herbal remedies.

Avoid alcohol or over-the-counter medicines such as allergy or cold remedies while taking Taxadone. Tell the prescribing physician if you take anti-seizure drugs, such as phenobarbital, medicine for sleep or anxiety, muscle relaxants, other narcotic pain relievers and psychiatric medicine; your physician may alter the dosage or switch you to another pain reliever. Antifungals, antibiotics and certain HIV medications may affect the removal of oxycodone from your body, changing the way Taxadone works for you.

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Side effects

All drugs, including Taxadone, may cause side effects in some individuals. Most side effects are not serious and disappear with continued use at proper doses. Some side effects are serious, requiring immediate medical attention. Continue using Taxadone but talk to the prescribing doctor if the common side effects become unbearable or if they persist. Common side effects include:

  • Blurred Vision
  • Constipation
  • Dizziness
  • Drowsiness
  • Dry Mouth
  • Mild Nausea
  • Upset Stomach
  • Vomiting

Some side effects are serious medical emergencies. Discontinue Taxadone and consult a physician immediately if you experience serious side effects. Serious side effects include:

  • Clay-Colored Stools
  • Confusion
  • Dark Urine
  • Fainting
  • Itching
  • Lightheadedness
  • Loss of Appetite
  • Seizure
  • Severe Nausea
  • Shallow Breathing
  • Slow Heartbeat
  • Unusual Thoughts or Behavior
  • Upper Stomach Pain
  • Urinary Problems
  • Yellowing of the Skin or Eyes

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Taxadone overdose is a serious, life-threatening emergency. If you think you or someone you know is experiencing symptoms of overdose, contact poison control center at 1-800-222-1222 or go to a nearby emergency department.

Emergency department personnel will administer naloxone or other drugs to rapidly lower Taxadone to safe levels. Doctors and nurses will establish an airway to help the patient breathe, pump excess medication from the stomach. They will also perform other emergency, life-saving treatments as necessary.

It is possible to overdose on either the acetaminophen or the oxycodone components of Taxadone, or both. The symptoms of opioid overdose are different from symptoms of acetaminophen overdose.

Opioid overdose symptoms include:

  • Bluish Lips or Skin
  • Change in Consciousness
  • Cold, Clammy Skin
  • Extreme Sleepiness
  • General Feeling of Discomfort or Illness
  • Loss of Consciousness
  • No Blood Pressure or Pulse
  • No Pulse
  • Not Breathing
  • Unconsciousness

Symptoms of acetaminophen overdose occur in two phases. The first wave of acetaminophen overdose symptoms includes:

  • Confusion
  • Loss of Appetite
  • Nausea
  • Stomach Pain
  • Sweating
  • Vomiting
  • Weakness

The second set of acetaminophen overdose symptoms may include:

  • Dark Urine
  • Upper Abdominal Pain
  • Yellowing of the Skin or Eyes

Learn More about Taxadone Overdose


Oxycodone, one ingredient in Taxadone, is a favorite among recreational users because of the way the opioid gets them high. Abusers purchase opioids illegally from drug dealers, by presenting fake prescriptions at pharmacies or getting prescriptions from multiple doctors. Some steal opioids from friends, family members or even pharmacies and hospitals in a process the DEA calls "diversion."

Recreational users rarely target acetaminophen because it does not get them high but, since acetaminophen is a common ingredient in many opioid preparations and over-the-counter medications, incidental acetaminophen abuse may cause dangerous liver disease or overdose.

Abusing Taxadone for a long time increases the risk for physical dependence and addiction to opioids in some consumers, especially if they use large doses to get high or administer the drugs intravenously.

Read More about Taxadone Abuse


Withdrawal symptoms are a predictable and normal result of a drop in opioid levels in an opioid-dependent person, and not necessarily a sign of illegal abuse. Your body adapts to the presence of certain foreign chemicals, including the oxycodone in Taxadone, by altering its own chemical balance. With continuous use, the body starts to rely on certain level of the drug to feel "normal." If the level of Taxadone drops suddenly, the dependent body struggles to maintain chemical balance. The individual feels this battle, known as detoxification, through the uncomfortable, flu-like symptoms known as withdrawal.

Physical withdrawal symptoms can last five or more days as the individual's body gradually adjusts to lowered opioid levels. Psychological symptoms of withdrawal can be more devastating and last much longer than physical symptoms.

Rehabilitation specialists recognize withdrawal symptoms as a physiological process, not an indicator of moral character. Any person can become physically dependent on Taxadone whether he uses it with a prescription or abuses Taxadone to get high.

Withdrawal symptoms vary in severity and duration from person to person, and can be worse for those taking high doses or using Taxadone for a long time. Sometimes overpowering withdrawal symptoms prevent even the strongest, most determined people from quitting opioid use without medical help.

Withdrawal symptoms include:

  • Abdominal Cramps
  • Agitation
  • Anxiety
  • Blurred Vision
  • Goose Bumps
  • Insomnia
  • Restlessness
  • Sweating
  • Tremor
  • Vomiting

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Detoxification is the long and difficult process of reducing the level of opioids in the opioid-dependent body. Detoxification occurs either because the individual took a weaker dose of Taxadone than usual or because he took a medication such as naloxone to reduce opioid levels drastically.

Detoxification is especially lengthy and painful if you attempt self-detoxification without the aid of medicine and highly trained professionals. Rehabilitation specialists use naloxone and other drugs to reduce opioid levels and then administer medications to treat the ensuing withdrawal symptoms. These doctors give the patient a variety of medications, including drugs to calm anxiety, ease diarrhea, quiet tremors and help the patient sleep.

While standard detoxification treatments usually shorten withdrawal time and relieve uncomfortable physical withdrawal symptoms, the patient still battles demoralizing psychological symptoms that often interfere with a successful recovery.

Rapid detox is now the most efficient, humane way to detoxify a body dependent on the opioids in Taxadone. During rapid detox, board certified anesthesiologists administer sedatives and anesthesia alongside the standard detoxification medications. The individual dozes in a comfortable "twilight sleep" before awakening with no memory of the withdrawal process.

Learn More about Taxadone Detoxification Programs


Store Taxadone away from excessive heat and moisture. Keep this and all drugs out of the reach of children and pets. Do not give this medication to others, even if they express symptoms similar to your own. It is illegal to share prescription medication with others. To reduce illegal use and diversion, do not tell people other than your caregivers that you are taking Taxadone.

Dispose of Taxadone when you no longer need it for pain or when your doctor tells you to stop using it. Ask your pharmacist how to dispose of medications.

Read More about Storing Taxadone

Miscellaneous information

Major Pharmaceuticals, Inc. manufactures Taxadone.

Learn More Miscellaneous Information about Taxadone


  • Taxadone