- Generic Name or Active Ingridient: Oxycodone And Aspirin
- Adrenal Gland Disorder, especially Addison's Disease
- Curvature of the Spine
- Enlarged Prostate
- Gallbladder Disease
- Heart Rhythm Disorder
- History of Drug or Alcohol Addiction
- History of Head Injury or Brain Tumor
- History of Stomach Ulcer or Bleeding
- Kidney Disease
- Liver Disease
- Low Blood Pressure
- Mental Illness
- Nasal Polyps
- Serious Breathing Disorder
- Severe Constipation
- Stomach or Intestinal Blockage
- Stomach or Intestinal Disorder
- Underactive Thyroid
- Urinary Problems
- Rheumatrex, Trexall
- Dry Mouth
- Upset Stomach
- Black, Bloody or Tarry Stools
- Coughing up Blood or Vomit that Looks like Coffee Grounds
- Decreased Hearing
- Easy Bruising or Bleeding
- Fast or Slow Heartbeats
- Feeling like You Might Pass Out
- Ringing in the Ears
- Severe Stomach Pain or Constipation
- Weak or Shallow Breathing
- Extreme Drowsiness
- Pinpoint Pupils
- Ringing in the Ears
- Cold, Clammy Skin
- Muscle Weakness
- Weak Pulse
- Slow Heart Rate
- Blue Lips
- Shallow Breathing or No Breathing
- Trouble Sleeping
Physicians prescribe Roxiprin to relieve moderate to severe pain.
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Other, off label uses for this medicine
The aspirin in Roxiprin reduces pain, fever and inflammation while the oxycodone in this medication soothes cough.
More Off-Label Uses for Roxiprin
Roxiprin is available in a tablet form for oral administration. Each tablet contains 325 mg of aspirin, 4.5 mg oxycodone hydrochloride and oxycodone 0.38 mg terephthalate.
Take Roxiprin with a full glass of water to prevent choking. Take Roxiprin with or without food; take with food if Roxiprin upsets your stomach.
Do not give Roxiprin or other preparations containing aspirin to a child or teenager with a fever, especially if the child also has flu symptoms or chicken pox. Aspirin may cause Reye's syndrome, a serious and sometimes fatal condition.
Healthcare providers normally prescribe Roxiprin only as needed, rather than on a regular schedule. If you are supposed to take Roxiprin on a regular schedule and miss a dose, take the missed dose as soon as possible. If it is nearly time for another dose and you can tolerate the pain, skip the missed dose and resume your normal schedule.
Read More about Roxiprin Administration and Dosage
Body cells damaged by injury or illness produce large quantities of the enzyme, cylooxygenase-2, or COX-2. This enzyme, in turn, releases prostaglandin, which binds to nerve endings and then sends messages about the illness or injury through the nervous system to the brain. The brain responds by perceiving pain and taking appropriate action, like saying "ouch" or recoiling from the source of pain.
The oxycodone in Roxiprin reduces discomfort by binding to nerve endings to send messages of pleasure and euphoria instead of messages of pain. Oxycodone, like other opioids, changes the way your brain perceives pain.
Oxycodone suppresses cough by depressing the cough reflex directly in the medulla, the part of your brain responsible for breathing. This opioid also works on smooth muscles, like those in your intestines, in a way that can slow processes such as digestion.
The aspirin in Roxiprin adheres to COX-2 and prevents it from producing prostaglandin. As a result, the brain receives only a partial pain message.
Prostaglandin also signals wounded cells to release fluids, causing swelling and inflammation. Aspirin reduces swelling and inflammation by reducing prostaglandin production.
Aspirin also affects the hypothalamus, which is the area of your brain known responsible for regulating body temperature, in a way that reduces fever.
More about How Roxiprin Works
Do not use Roxiprin if you are allergic to aspirin, oxycodone or any non-steroidal anti-inflammatory drug, or NSAID, such as Advil, Aleve, Indocin and Motrin. An allergic reaction is a serious, potentially fatal medical condition that requires immediate professional attention.
Symptoms of an allergic reaction include hives, rash, difficulty breathing and swelling of the face, lips, tongue or throat.
You may not be able to take Roxiprin if you currently suffer from or have a history of certain medical conditions. Roxiprin may worsen your condition or interfere with treatment. Do not take Roxiprin if you are currently or have recently been sick with diarrhea.
Tell your physician about any significant illnesses or conditions, including:
Roxiprin may make you dizzy or drowsy, or impair with decision-making. Do not operate a motor vehicle or other heavy machinery until you know how Roxiprin affects you.
The DEA classifies Roxiprin as a schedule II controlled substance, which means this painkiller has an increased potential for abuse. Do not use larger doses than prescribed, or use this medication more often than prescribed to reduce your risk for dependence, addiction and other side effects.
Tell the prescribing physician if your current Roxiprin prescription stops working to relieve your pain, as this is a sign that you are becoming tolerant to opioids. Your healthcare provider may recommend you take Roxiprin more frequently or suggest a different treatment.
Avoid drinking alcohol or consuming products that contain alcohol while using Roxiprin. Alcohol may increase your risk of stomach bleeding.
Tell your surgeon or dentist about your Roxiprin use before scheduling an operation or procedure. She may instruct you to stop using Roxiprin before the procedure to reduce your risk for bleeding.
The oxycodone in Roxiprin is habit-forming. This medication should only be used by the person for whom it was prescribed. Never share prescription medication with another person, even if she expresses symptoms similar to your own.
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Do not take Roxiprin if you have a bleeding disorder, or a recent history of stomach or intestinal bleeding. Do not use Roxiprin if you use a blood thinner such as warfarin, sold under the brand name Coumadin or Jantoven.
Do not take Roxiprin if you have taken an MAO inhibitor in the prior 14 days. Doing so may result in dangerous, potentially fatal, side effects. Examples of MAO inhibitors include furazolidone, isocarboxazid phenelzine, rasagiline, selegiline, or tranylcypromine. Brand name preparations include Parnate, Furoxone, Marplan, Nardil, Azilect, Eldepryl, Emsam and Zelapar.
The FDA classifies Roxiprin as a pregnancy category D: Roxiprin may cause harm to an unborn baby, and breathing problems or withdrawal symptoms in newborns. Taking products containing aspirin late in the pregnancy increases the risk for bleeding in the mother or baby during delivery. Do not take products containing aspirin during pregnancy unless a doctor tells you to.
Tell the prescribing physician if you are pregnant or plan to become pregnant while taking Roxiprin. Use an effective form of birth control while using this medication. Tell your doctor if you become pregnant while using Roxiprin.
Both the aspirin and oxycodone components of Roxiprin can pass into breast milk and onto a nursing baby. Do not use Roxiprin while breastfeeding.
Do not stop using Roxiprin abruptly, especially if you have been taking high doses or using this medication for a long time. Quitting suddenly may cause unpleasant withdrawal symptoms. Wean yourself from Roxiprin by taking increasingly smaller doses further apart. Consult with your doctor or rehabilitation professional if withdrawal symptoms prevent you from discontinuing Roxiprin.
More Warnings about Using Roxiprin
Roxiprin may interact with other medications in unsafe or unintended ways. Give the prescribing physician and pharmacist filling the order a complete list of all your medications including prescriptions, over-the-counter preparations, vitamins, supplements and herbal remedies. Do not start, stop or change the way you take any medications, including non-prescription drugs, while taking Roxiprin without first discussing it with your doctor.
Tell the prescribing physician if you take any of the following brand name drugs:
Do not take Roxiprin while using antiviral medicines such as adefovir or cidofovir, available under the brand names Hepsera and Vistide.
Avoid medications containing aspirin or other salicylates including Pepto-Bismol, Kaopectate, Pamprin Cramp Formula and others.
Do not use bowel-cleansing preparations such as Evac-Q-Kwik, Fleet Prep Kit, GoLytely, Half Lytely, and Supraprep while taking Roxiprin.
Tell the prescribing physician if you use glaucoma medication such as acetazolamide, sold under the brand name Diamox, or methazolamide, available under the brand names Glauctabs and Neptazane.
Do not use Roxiprin alongside drugs that prevent blood clots, such as dalteparin (Fragmin), enoxaparin (Lovenox), fondaparinux (Arixtra), tinzaparin (Innohep), and others.
More Drug Interactions
Most people use Roxiprin without experiencing side effects but, as with all medications, Roxiprin may cause some side effects. The most common side effects are not serious and disappear by themselves after continued use. Continue using Roxiprin but contact the prescribing physician if these non-serious side effects become intolerable or if they do not disappear by themselves:
Some side effects can be serious and require professional attention. Stop using Roxiprin and contact your doctor right away if you experience serious side effects such as:
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An overdose of Roxiprin is a serious, life-threatening emergency that requires immediate professional treatment. If you worry you or someone else has taken an overdose, contact poison control center at 1-800-222-1222 or go to the nearest hospital, emergency department, urgent care clinic, doctor's office or fire department. Call an ambulance if it is the fastest way to get medical help.
When you or the patient arrives at the hospital, emergency department personnel will administer naloxone or other drugs to drop Roxiprin to non-toxic levels quickly. Doctors and nurses will establish an airway to help the patient breathe and pump excess Roxiprin from the stomach. They will also perform other emergency, life-saving treatments such as CPR as necessary to counteract toxic levels of Roxiprin.
Overdose symptoms include:
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Recreational users target the oxycodone component in Roxiprin because of the way opioids gets them high. Abusers purchase opioids such as oxycodone illegally on the streets, by giving phony prescriptions to pharmacies or seeking multiple prescriptions from several doctors in a practice the DEA calls "diversion." Some recreational users divert opioids from friends, family members or even pharmacies and hospitals.
Abusing Roxiprin for a long time increases the risk for physical dependence and opioid addiction in some individuals, especially if they use large doses to get high. Physical dependence results in uncomfortable withdrawal symptoms while opioid addiction causes craving and drug-seeking behaviors.
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Any person who takes Roxiprin for more than a few weeks can experience withdrawal symptoms when they stop using this drug. Withdrawal symptoms are a predictable and normal physiological process, and not necessarily a sign of illegal drug abuse.
The body adapts to the presence of certain foreign substances, such as opioids, by altering its own chemical balance. With continuous use, the body starts to depend on a certain level of the drug in order to feel "normal." If opioid levels plunge, the dependent body struggles to maintain chemical balance. The individual experiences this struggle, known as detoxification, through the uncomfortable, flu-like withdrawal symptoms.
The physical withdrawal symptoms associated with Roxiprin detoxification can last five days or more as the body slowly adjusts to lower opioid levels. Withdrawal also causes powerful psychological symptoms, such as depression and anxiety; these psychological symptoms may be as devastating to recovery and usually last longer than physical withdrawal symptoms.
Withdrawal symptoms differ in severity and duration from person to person; symptoms can be dose-dependent, which means they are worse for individuals who took high doses or used Roxiprin for a long time.
Withdrawal symptoms include:
More about Roxiprin Withdrawal
Detoxification is the process of reducing the level of opioids in the body of an individual who is physically dependent upon Roxiprin. The detoxification process occurs either because the person consumed less Roxiprin than usual or because he took a medication such as naloxone to decrease the level of opioids in his body.
Detoxification is a lengthy and challenging process, especially if you attempt self-detoxification without specially trained professionals to develop a treatment plan or drugs that ease your withdrawal symptoms. During standard detoxification treatment, doctors administer drugs such as naloxone to decrease opioid levels and more medications to ease the resulting withdrawal symptoms. Then the patient receives a variety of medications, including drugs to calm anxiety, slow diarrhea, soothe tremors and help the patient sleep.
While the standard detoxification treatments usually reduce withdrawal time and relieve uncomfortable physical symptoms to a certain degree, many individuals find the demoralizing psychological symptoms associated with the detoxification process impede a successful recovery.
For these patients and for many more, rapid detox is the most humane way to detoxify a body dependent on opioids. During rapid detox, board certified anesthesiologists administer anesthesia and sedatives along with the usual detoxification drugs to rid the body of the oxycodone in Roxiprin. The patient dozes in a pleasant "twilight sleep. " When she awakens, she will have no memory of the grueling and demoralizing withdrawal process.
Learn More about Roxiprin Detoxification Programs
Store Roxiprin at room temperature, away from heat, moisture and light.
Flush Roxiprin down the toilet when you no longer use it for pain or when a doctor instructs you to stop using it.
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