Doctors prescribe Roxicet to reduce moderate to severe pain. Learn More about Roxicet Uses

Other, off label uses for this medicine

The acetaminophen component in Roxicet reduces fever. More Off-Label Uses for Roxicet


Roxicet contains oxycodone and acetaminophen. This drug is available as a tablet or solution, and only with a doctor's prescription. Each Roxicet tablet or 5 ml of solution contains 5 mg oxycodone hydrochloride and 325 mg of acetaminophen. A 5 ml dose of Roxicet solution also contains 0.4 percent alcohol.

Take Roxicet as directed. Taking larger doses than prescribed can cause overdose of two important components of Roxicet, oxycodone and acetaminophen.

The usual Roxicet dosage is one pill or 5 ml every six hours as needed for pain. If your doctor suggested you take Roxicet to provide round-the-clock coverage of your chronic pain and you miss a dose, take the missed dose as soon as possible. If it is almost time for another dose and you can tolerate the pain, skip the missed dose and resume your normal schedule.

Drink a full glass of water with a Roxicet tablet to prevent choking.

Physicians should gradually reduce the doses for those patients who have taken Roxicet for more than a few weeks when the individual no longer needs the medication. Long-term Roxicet use puts consumers at special risk for withdrawal symptoms once they stop taking this medication.

Stop taking this drug when you no longer need it to relieve your pain or when a physician suggests you discontinue Roxicet.

Read More about Roxicet Administration and Dosage


Roxicet contains two active ingredients that work together to ease pain more efficiently than one medication could do alone. When you are sick or injured, the affected cells release chemicals, called prostaglandins, which bind with the pain receptors in nerve endings and send pain signals to your brain. Your brain reacts by perceiving pain.

The oxycodone in Roxicet acts on your central nervous system, or CNS, to change the way your brain receives these pain messages. Roxicet binds with pain receptors, blocking prostaglandins from binding with these receptors to send the message of pain. Instead of pain signals, the brain receives messages of euphoria and relaxation.

The acetaminophen in Roxicet eases pain and reduces fever by blocking the production of prostaglandins in the first place.

Roxicet causes other actions as well. The opioids in Roxicet affect the respiratory system and depress the part of the brain responsible for breathing. Roxicet can make the brain simply forget to breathe. Opioids also act directly on the cough center in the brainstem, reducing the urge to cough out excess phlegm or foreign objects.

Oxycodone also acts on smooth muscle organs, like those in your intestines, slowing down digestion and causing constipation. To soften stools and make it easier to move your bowels, drink six to eight full glasses of water every day you use Roxicet. Talk with a doctor or nutritionist about different ways to increase dietary fiber, thought to aide digestion. While taking Roxicet, do not use a laxative or stool softener without first talking it over with a healthcare professional.

More about How Roxicet Works


Do not take Roxicet if you are allergic to any component in this medication including oxycodone and acetaminophen. Tell the doctor prescribing Roxicet if you have ever experience an allergic reaction to other opioid medications, such as codeine or morphine. An allergic reaction can rapidly deteriorate into anaphylactic shock, which is a serious, life threatening medical emergency that requires immediate attention.

Symptoms of an allergic reaction include:

  • Rash
  • Hives
  • Itching
  • Difficulty Breathing
  • Swelling of the Face, Mouth, Lips or Tongue

Roxicet can make you dizzy or drowsy and affect your ability to make quick decisions. Do not drive a motor vehicle or operate other machinery until you know how this medication affects you.


Do not consume alcoholic drinks or use products containing alcohol while taking Roxicet. Using alcohol while taking opioids can result in serious adverse reactions, including liver damage or even death. Check the labels of all food, beverages and medications to determine if it contains alcohol. Consult with a pharmacist if you are not sure if an over-the counter product or prescription contains alcohol, as it is a common ingredient in many preparations.

Confide in your doctor if you normally drink more than three alcoholic beverages each day. Tell your healthcare provider if you have ever had cirrhosis, sometimes called alcoholic liver disease - it may be dangerous for you to take Roxicet or other medications containing acetaminophen. Chronic alcoholics should not exceed 2000 mg of acetaminophen in a 24-hour period.


Roxicet, like other opioid medications, is associated with abuse, dependence or addiction, especially if you take high doses or continually use this drug for more than a few weeks. Uncomfortable and constant withdrawal symptoms or cravings associated with addiction sometimes make it hard to stop using Roxicet. Avoid large doses or using Roxicet more often than prescribed to decrease the danger for dependence, addiction and other side effects.

Tell the prescribing physician if your current Roxicet dose stops relieving your pain, as this is a signal that your body is becoming tolerant to Roxicet. Your healthcare provider may tell you to take Roxicet more frequently or recommend a different treatment to relieve your pain.

Roxicet can change the results of certain laboratory tests, especially the urine glucose test. Tell the phlebotomist drawing your blood or laboratory technician making the appointment about your Roxicet use before submitting urine sample or getting your blood drawn. You may have to stop taking Roxicet for a short time or reschedule your laboratory appointment.

Medical History

Certain medical conditions can change the way Roxicet works in your body. Roxicet may worsen your illness or interfere with treatment.

Tell your physician about any significant illnesses or conditions, including:

  • Asthma
  • Breathing Disorders
  • COPD
  • Curvature of the Spine
  • Enlarged Prostate
  • Epilepsy or Other Seizure Disorder
  • History of Drug or Alcohol Addiction
  • History of Head Injury or Brain Tumor
  • Intestinal Disorder
  • Kidney Disease
  • Liver Disease
  • Low Blood Pressure
  • Mental Illness
  • Pancreas Disorder
  • Sleep Apnea
  • Stomach Disorder
  • Underactive Thyroid
  • Urinary Problems

Roxicet may cause dizziness or drowsiness or affect your ability to make quick decisions. Do not drive a motor vehicle or operate heavy equipment until you know how this medication affects you.


The U.S. Drug Enforcement Agency, or DEA, classifies drugs according to the risk they pose for abuse, physical dependence or addiction, and has classified Roxicet as a schedule II narcotic. This means Roxicet use poses a significant risk for abuse and dependence. As a schedule II, Roxicet is available only by prescription and the DEA prohibits refills.

Read More about Roxicet Precaution


The acetaminophen component of Roxicet is associated with cases of acute liver failure, sometimes resulting in liver transplant and death. Most cases of liver damage was associated with high doses of 4000 mg of acetaminophen or more per day, and frequently involved more than one acetaminophen-containing product.

A person with significant respiratory depression should not use Roxicet in unmonitored settings or without resuscitative equipment nearby. Individuals experiencing acute or severe bronchial asthma or other breathing problems should not use Roxicet. Individuals who have suffered paralytic ileus, a serious digestive disease, should not use Roxicet.

Roxicet is an FDA pregnancy category C, which means medical researchers have not yet established the harm this medication may cause to an unborn child. Tell the prescribing physician if you are pregnant or plan to become pregnant while taking Roxicet.

Two components of Roxicet, oxycodone and acetaminophen, can pass into breast milk and harm a nursing baby. Do not breastfeed a baby while taking Roxicet.

Patients with known hypersensitivity or allergies to opioids or any component of Roxicet should not use this medication.

Do not stop taking Roxicet abruptly or change your dose significantly unless a doctor tells you to do so. Discontinuing Roxicet all of a sudden, or using significantly less Roxicet than normal, will result in unpleasant withdrawal symptoms in a person dependent upon opioids. Slowly wean yourself from Roxicet by taking smaller doses increasingly further apart. If you experience withdrawal symptoms when you try to stop taking Roxicet, you may be dependent on opioids and require the help of detoxification professionals. More Warnings about Using Roxicet

Drug Interactions

Do not take Roxicet with any other opioid drugs, sedatives, tranquilizers, sleeping pills, muscle relaxers, or medicines that could make you sleepy or slow your breathing. Dangerous adverse reactions may result.

Roxicet can interact with other medications in unexpected or unfavorable ways. Supply the prescribing physician and pharmacist with a complete list of all your medications including prescriptions, over-the-counter preparations, vitamins, supplements and herbal products. Do not start, stop or change the way you take any prescription or non-prescription drug while you take Roxicet without first talking it over with your doctor.

It is especially important that the prescribing physician and pharmacist know if you are taking:

  • Glycopyrrolate (Robinul)
  • Mepenzolate (Cantil)
  • Atropine (Donnatal and Others)
  • Benztropine (Cogentin)
  • Dimenhydrinate (Dramamine)
  • Methscopolamine (Pamine)
  • Scopolamine (Transderm-Scop)
  • Darifenacin (Enablex)
  • Flavoxate (Urispas)
  • Oxybutynin (Ditropan and Oxytrol)
  • Tolterodine (Detrol)
  • Solifenacin (Vesicare)
  • Ipratropium (Atrovent)
  • Tiotropium (Spiriva)
  • Dicyclomine (Bentyl)
  • Hyoscyamine (Anaspaz, Cystospaz, Levsin and Others)
  • Propantheline (Pro-Banthine)

More Drug Interactions

Side effects

All drugs may cause adverse reactions in some consumers. Most side effects associated with Roxicet are not serious and disappear after continued use, while some side effects are serious medical emergencies.

Continue using Roxicet but contact the prescribing physician if the following side effects become intolerable or if they do not go away:

  • Blurred Vision
  • Constipation
  • Dizziness
  • Drowsiness
  • Dry Mouth
  • Mild Nausea or Vomiting
  • Upset Stomach

Some side effects associated with Roxicet use are serious medical emergencies. Stop taking Roxicet and consult a physician immediately if you experience the following serious side effects:

  • Clay-Colored Stools
  • Confusion, Unusual Thoughts or Behavior
  • Dark Urine
  • Feeling Light-Headed or Fainting
  • Itching
  • Jaundice
  • Loss of Appetite
  • Nausea
  • Problems With Urination
  • Seizure
  • Shallow Breathing
  • Slow Heartbeat
  • Upper Stomach Pain

Learn More about Roxicet Side Effects


An individual can overdose on either the oxycodone or acetaminophen in Roxicet, or both. Symptoms of oxycodone overdose differ from acetaminophen overdose symptoms.

Overdose is a serious, potentially fatal medical emergency. If you think you or someone you know has taken an overdose of Roxicet or any other drug, contact poison control center at 1-800-222-1222 or go to the nearest emergency room. Emergency department doctors and nurses administer drugs such as naloxone to lower Roxicet levels in the blood. They will also administer other emergency, life-saving treatments as necessary, such as establishing an airway to help the patient breathe, pumping excess medication from the stomach or performing CPR as necessary. Symptoms of acetaminophen overdose come in two phases. The first wave of acetaminophen overdose symptoms include:

  • Confusion
  • Loss of Appetite
  • Nausea
  • Stomach Pain
  • Sweating
  • Vomiting
  • Weakness

The second wave of acetaminophen overdose symptoms may include:

  • Dark Urine
  • Upper Abdominal Pain
  • Yellowing of the Skin or Eyes

Opioid overdose symptoms include:

  • Bluish Lips or Skin
  • Change in Consciousness
  • Cold, Clammy Skin
  • Extreme Sleepiness
  • General Feeling of Discomfort or Illness
  • Loss of Consciousness
  • No Blood Pressure or Pulse
  • No Pulse
  • Not Breathing
  • Unconsciousness

Learn More about Roxicet Overdose


The oxycodone in Roxicet is a favorite among recreational users because of the way oxycodone gets them high. Abusers buy opioids such as Roxicet from drug dealers, by filing phony prescriptions with pharmacies or "doctor shopping." Some abusers steal oxycodone from friends, family members or even pharmacies and hospitals. Sometimes friends or family members willingly supply the drug abuser with opioids. The DEA, calls this process "diversion" because of the way it diverts legal prescription drugs to illegal use.

Recreational users rarely abuse acetaminophen because it provides no pleasant euphoric effect. However, since acetaminophen is a common ingredient in many opioid preparations and over-the-counter medications, unintentional acetaminophen abuse may cause dangerous liver disease and overdose.

Long-term Roxicet abuse increases the risk for opioid dependence or addiction in some people, especially for those individuals who use large doses to get high or administer the drugs intravenously.

Read More about Roxicet Abuse


It is normal for a dependent person to experience withdrawal symptoms if his level of opioids suddenly drops. Withdrawal is characterized by uncomfortable, flu-like physical symptoms that can last five or more days as the individual's body gradually adjusts to lower opioid levels. Psychological withdrawal symptoms last much longer and can be more devastating to the individual's attempt at recovery.

Your body adapts to the occurrence of certain foreign substances, including the opioids in Roxicet, by altering its own chemical balance. With continued use, the body starts to rely on a certain level of the drug in order to feel "normal." If the level of Roxicet drops, the dependent body battles to maintain chemical balance. This battle for chemical stability manifests itself in uncomfortable symptoms associated with withdrawal.

Rehabilitation specialists and most medical professionals recognize withdrawal symptoms as a physiological process rather than as an indicator of moral character. A person might grow physically dependent on Roxicet whether he has been taking it legally or illegally.

Withdrawal symptoms vary in severity and duration between individuals. The intensity and length of the withdrawal process also depends on how long the person took the drug and the dosages he normally used. Many times, withdrawal symptoms are overpowering, preventing even the most determined and disciplined people from quitting opioid use without the help of trained professionals.

Withdrawal symptoms include:

  • Abdominal Cramps
  • Agitation
  • Anxiety
  • Blurred Vision
  • Goose Bumps
  • Insomnia
  • Restlessness
  • Sweating
  • Tremor
  • Vomiting

More about Roxicet Withdrawal


Detoxification is the process of reducing the level of opioids in a person's body; detoxification results in withdrawal symptoms. The detoxification process occurs either because the individual took a lower dose of Roxicet than usual or because he took a medication to reduce opioid levels.

Standard detoxification treatments in inpatient facilities usually use naloxone to reduce opioid levels, and include medications to treat the ensuing withdrawal symptoms. Physicians administer drugs to calm anxiety, ease diarrhea, quiet tremors and help the patient sleep. While standard detoxification methods shorten withdrawal time and relieve physical withdrawal symptoms, the patient still endures the demoralizing psychological symptoms that often impede recovery efforts.

Authorities agree that rapid detox is the most efficient and humane way to detoxify a body dependent on Roxicet. During the gentle rapid detox procedure, board certified anesthesiologists administer sedatives and anesthesia to the individual alongside those standard medications that lower his opioid levels. The rapid detox patient rests in a comfortable "twilight sleep" during the detox process. She then awakens refreshed, with no memory of the withdrawal process.

Learn More about Roxicet Detoxification Programs


Keep Roxicet at room temperature, away from excessive heat, light and moisture. Do not allow Roxicet to freeze.

Put Roxicet out of the reach of children and pets. Do not allow adults to take your Roxicet - it is illegal to share prescription drugs with another individual, even if they express symptoms similar to your own.

Flush unused Roxicet down the toilet when you no longer need it to treat your pain or when a doctor tells you to stop using it.

Read More about Storing Roxicet