Doctors prescribe Perloxx to relieve moderate to severe pain. Perloxx is only available by prescription. The U.S. Drug Enforcement Agency, or DEA, prohibits refills on this medication; physicians must write a new prescription when they determine a patient needs an opioid painkiller. Learn More about Perloxx Uses

Other, off label uses for this medicine

The acetaminophen in Perloxx is an effective fever-reducer. More Off-Label Uses for Perloxx


Perloxx is available in a tablet, capsule or as a solution. The active analgesic ingredients in Perloxx are oxycodone and acetaminophen.

The typical Perloxx dose for adults in one capsule every 6 hours as needed. Physicians may prescribe 5 mg dose of Perloxx solution every 6 hours as needed, not to exceed 60 ml in a 24-hour period. The usual adult dose for adults is one tablet every 6 hours as needed and not more than 6 to 12 tablets per day.

Studies have not yet determined the safety and efficacy of using Perloxx in children. Administer Perloxx to a child only under direct supervision of a pediatrician.

Do not take more Perloxx than you need to relieve your pain. Discontinue this medication when recommended by a physician.

Doctors typically prescribe Perloxx only when you need it for pain, rather than taking it on a regular schedule, so missing doses is not typically a problem. If your doctor told you to take Perloxx on a set schedule and you miss a dose, take another dose as soon as you can unless it is almost time to take another dose. If it is almost time for another dose and you can stand the pain, skip the missed dose and resume your normal schedule.

Read More about Perloxx Administration and Dosage


The oxycodone in Perloxx alters your perception of pain. When the cells of your body are injured or ill, the cells release chemicals that bind with pain receptors in nerve endings, called prostaglandin. These chemical messengers then send messages of pain to your brain. Perloxx interrupts prostaglandins from binding with pain receptors in a way that prevents the pain chemicals from attaching to receptors and interrupts the message of pain. Instead, opioids such as oxycodone send message of euphoria and relaxation, which is the sensation of being "high."

The acetaminophen in Perloxx eases pain and reduces fever by blocking the production of prostaglandins.

The oxycodone in Perloxx affects the respiratory system. Perloxx depresses the part of the brain responsible for breathing; taking too much of this medication can make the brain forget to breathe. Opioids also depress the cough center in the brain and reduce the urge to cough.

The oxycodone in Perloxx acts on smooth muscle organs, like those in your intestines, in a way that slows down your digestive tract to cause constipation. Drink six to eight full glasses of water each day you take Perloxx to soften stool and make moving your bowels easier. Discuss ways to increase your intake of dietary fiber, known to ease constipation, with your doctor or nutritionist. Do not use a laxative or stool softener without first talking it over with a healthcare provider.

More about How Perloxx Works


Tell your doctor if you are allergic to oxycodone, acetaminophen or any other medication, especially opioid painkillers. Go to the hospital or seek immediate medical help at the first sign of an allergic reaction.

Symptoms of an allergic reaction to Perloxx include rash, hives, itching, difficulty breathing and tightness in the chest. Other symptoms include swelling of the face, mouth, lips or tongue.

Your doctor may recommend a different medication or change your Perloxx prescription if you have ever had, or are currently suffering from, certain medical conditions. These medical conditions may interfere with the way Perloxx works, or Perloxx may make your condition worse.

Tell your physician about any significant illnesses or conditions, including:

  • Addison's Disease or Other Adrenal Gland Disorder
  • Any Breathing Disorders
  • Asthma
  • COPD
  • Curvature or The Spine
  • Enlarged Prostate
  • Epilepsy or Other Seizure Disorder
  • History or Brain Tumor
  • History or Drug or Alcohol Addiction
  • History or Head Injury
  • Kidney Disease
  • Liver Disease
  • Low Blood Pressure
  • Mental Illness
  • Sleep Apnea
  • Stomach, Intestinal or Pancreas Disorder
  • Underactive Thyroid
  • Urinary Problems

The oxycodone in Perloxx may cause dizziness or drowsiness and affect your ability to think clearly. Do not drive a motor vehicle or operate other heavy equipment until you determine how this medication affects you.

Do not consume alcohol while taking Perloxx. Drinking alcoholic beverages or taking products that contain alcohol while taking opioids may cause serious adverse reactions, such as damage to your liver or even death. Check the labels of foods, beverages and medications to learn if the preparation contains alcohol. Ask your pharmacist for help if you are not certain.

Confide in your doctor about your alcohol use, and tell her if you typically consume more than three alcoholic beverages per day. Let your doctor know if a physician has told you that you have cirrhosis, sometimes called alcoholic liver disease. You may not be able to take Perloxx or other medications containing acetaminophen. Chronic alcoholics should not take more than 2000 mg of acetaminophen per day.

It is possible to develop dependence on or addiction to opioids, especially if you take high doses or use Perloxx for more than a few weeks. Uncomfortable and persistent symptoms associated with dependence or addiction makes it difficult to stop taking Perloxx. Do not take a high dose or use Perloxx more frequently than prescribed to reduce your risk for dependence and side effects.

Tell the prescribing physician if your current Perloxx dose stops relieving your pain, as this is a sign that your body is becoming tolerant to Perloxx. She may adjust your dosing schedule or recommend a different medication to relieve your pain.

The oxycodone and acetaminophen in Perloxx may affect the outcome of certain laboratory tests, including lowered blood sugar test results. Tell the phlebotomist or laboratory technician about using Perloxx when submitting a blood or urine sample.

Read More about Perloxx Precautions


The FDA has classified Perloxx as a pregnancy category C, which means doctors do not yet know how taking Perloxx during pregnancy may affect an unborn baby. This medication might cause breathing problems and withdrawal symptoms in a newborn. Notify the prescribing physician if you are pregnant or intend on become pregnant while taking Perloxx. If you become pregnant while taking Perloxx, call your doctor immediately.

The oxycodone and acetaminophen in Perloxx passes from the mother to her breast milk. Do not take Perloxx while breastfeeding.

Do not stop taking Perloxx abruptly, or change your dose drastically, unless a doctor tells you to. Discontinuing Perloxx suddenly, or consuming smaller doses than normal, might result in unpleasant withdrawal symptoms. Taper off slowly from Perloxx use by taking smaller doses further apart. If you find it difficult to discontinue Perloxx use, you might have grown physically dependent to this products and require the assistance of detoxification specialists.

Patients with known hypersensitivity or allergies to oxycodone or acetaminophen, or to opioids in general, should not use Perloxx.

Perloxx use is inappropriate in those with significant respiratory depression in unmonitored settings or the absence of resuscitative equipment. People with acute or severe bronchial asthma or hypercarbia should not use Perloxx. Those who have suspected or known paralytic ileus, a serious digestive problem, should avoid Perloxx use. More Warnings about Using Perloxx

Drug Interactions

Perloxx may interact with other medications in unfavorable or unsafe ways. Supply the prescribing physician and pharmacist filling the order with a complete list of all the medications you take, including prescriptions, over-the-counter preparations, vitamins, supplements and herbal remedies. Do not begin, stop or change the way you take any drug, including non-prescription medications and supplements, without first discussing it with the prescribing physician. Certain drugs interact with Perloxx, including:

  • Glycopyrrolate (Robinul)
  • Mepenzolate (Cantil)
  • Atropine (Donnatal and Others)
  • Benztropine (Cogentin)
  • Dimenhydrinate (Dramamine)
  • Methscopolamine (Pamine)
  • Scopolamine (Transderm-Scop)
  • Darifenacin (Enablex)
  • Flavoxate (Urispas)
  • Oxybutynin (Ditropan and Oxytrol)
  • Tolterodine (Detrol)
  • Solifenacin (Vesicare)
  • Ipratropium (Atrovent)
  • Tiotropium (Spiriva)
  • Dicyclomine (Bentyl)
  • Hyoscyamine (Anaspaz, Cystospaz, Levsin and Others)
  • Propantheline (Pro-Banthine)

More Drug Interactions

Side effects

Most people do not experience side effects while taking this medication. Perloxx, like all medications, may cause unwanted side effects. Most of the more common side effects are not serious and go away with continued use.

Continue taking Perloxx but contact the prescribing physician if you experience side effects such as:

  • Blurred Vision
  • Constipation
  • Dizziness or Drowsiness
  • Dry Mouth
  • Mild Nausea
  • Upset Stomach
  • Vomiting

Some consumers experience serious adverse reactions while taking Perloxx. Discontinue this medication and contact a physician if you experience serious side effects such as:

  • Clay-Colored Stools
  • Confusion
  • Dark Urine
  • Fainting
  • Itching
  • Lightheadedness
  • Loss of Appetite
  • Nausea
  • Seizure
  • Shallow Breathing
  • Slow Heartbeat
  • Unusual Thoughts or Behavior
  • Upper Stomach Pain
  • Urinary Trouble
  • Yellowing of the Skin or Eyes

Learn More about Perloxx Side Effects


It is possible to overdose on both the acetaminophen and oxycodone contained in Perloxx. Symptoms of opioid overdose are different from symptoms of acetaminophen overdose.

Overdose is a serious, potentially fatal medical emergency that requires immediate medical assistance. If you suspect you or someone you know is suffering from Perloxx overdose, contact your local poison control center at 1-800-222-1222 or go to the nearest emergency room. Doctors and nurses will administer drugs such as naloxone to lower Perloxx levels in the blood. They will also administer other emergency, life-saving treatments as necessary, such as establishing an airway, pumping the stomach or performing CPR as necessary.

Opioid overdose symptoms include:

  • Bluish Lips or Skin
  • Change in Consciousness
  • Cold, Clammy Skin
  • Extreme Sleepiness
  • General Feeling of Discomfort or Illness
  • Loss of Consciousness
  • No Blood Pressure or Pulse
  • No Pulse
  • Not Breathing
  • Unconsciousness

A person may overdose on the acetaminophen component of Perloxx. Symptoms of acetaminophen overdose come in two waves. The first symptoms of acetaminophen overdose include:

  • Confusion
  • Loss of Appetite
  • Nausea
  • Stomach Pain
  • Sweating
  • Vomiting
  • Weakness

Later symptoms may include:

  • Dark Urine
  • Upper Abdominal Pain
  • Yellowing of the Skin or Eyes

Learn More about Perloxx Overdose


Individuals abuse painkillers such as Perloxx because of the way oxycodone gets them high. Abusers purchase illicit opioids on the street, or get this substance by presenting phony prescriptions to pharmacies, visiting multiple doctors or by stealing from friends, family members or even pharmacies and hospitals. The U.S. Drug Enforcement Agency, or DEA, calls this process "diversion" because of the way medicines are diverted from their prescribed use as a therapeutic medicine.

Read More about Perloxx Abuse


Withdrawal symptoms are a predictable and normal outcome of a sudden drop in the level of Perloxx in a person physically dependent on opioids. Withdrawal, or detoxification, causes a variety of flu-like symptoms that can last five or more days as the levels of Perloxx toxins gradually subside. Psychological symptoms of withdrawal may last much longer and be more devastating.

A human body adapts to foreign substances, including opioids such as Perloxx, by adjusting its own chemical balance. With prolonged use, the body becomes dependent on the drug, which means the person has to maintain a certain level of Perloxx in order for his body to feel "normal." If the level of Perloxx plummets quickly, his body struggles to maintain chemical balance, resulting in uncomfortable, flu-like withdrawal symptoms.

Rehabilitation specialists recognize withdrawal symptoms as physiological process and not as an indicator of a person's moral character. You might grow physically dependent on Perloxx whether you have been taking it according to a doctor's prescription or if you have been using it illegally to get high.

Withdrawal symptoms vary in severity and duration from person to person and are dependent on the length of time the person took Perloxx and the dosages he took. Withdrawal symptoms are frequently severe enough to prevent even the most determined and disciplined individuals from discontinuing this medication by themselves.

Withdrawal symptoms include:

  • Abdominal Cramps
  • Agitation
  • Anxiety
  • Blurred Vision
  • Goose Bumps
  • Insomnia
  • Restlessness
  • Sweating
  • Tremor
  • Vomiting

More about Perloxx Withdrawal


Perloxx detoxification is the process of reducing the level of opioids in an individual's body. Detoxification occurs either because the individual did not take enough Perloxx, or because he has taken a medication to reduce opioid levels quickly. Detoxification in an individual dependent on opioids causes uncomfortable withdrawal symptoms, especially if the individual attempts self-detoxification without the aid of rehabilitative professionals.

Most consider rapid detox the most efficient and humane way to detoxify the body dependent on Perloxx. During the rapid detox procedure, board certified anesthesiologists administer sedatives and anesthesia to the patient alongside the standard medications to lower his opioid levels. The individual dozes in a comfortable "twilight sleep" during detoxification before awakening without any memory of the withdrawal process.

Learn More about Perloxx Detoxification Programs


Keep Perloxx in a tightly closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Do not store this medication in your bathroom.

Keep out of the reach of children and pets. Do not allow adults to take Perloxx, either on purpose or by accident. Giving this medication to others is illegal, even if their symptoms are similar to your own.

Do not keep outdated medicine or medicine no longer needed. Flush any unused Perloxx capsules, liquid, or tablets down the toilet.

Read More about Storing Perloxx


  • Perloxx