Percolone is an opioid pain reliever that acts similarly to the narcotic, morphine. Doctors prescribe Percolone to relieve moderate to severe pain.

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Other, off label uses for this medicine

A surgeon may prescribe Percolone to treat post-operative pain if the patient was taking this medication before the procedure.

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Percolone contains the opioid analgesic, oxycodone hydrochloride. Endo Pharmaceuticals manufacture Percolone. This medication is available in a 5 mg tablet by prescription only.

Take Percolone with a full glass of water to prevent the tablet from sticking in your throat. If you are supposed to take two pills for a single dose, take one pill at a time.

Take Percolone with or without food; take with food to avoid stomach upset.

Percolone may cause nausea, especially with the initial doses. Try lying down for an hour or two while keeping your head after taking Percolone still to reduce nausea.

If you are on a dosing schedule and miss a dose, take the missed dose as soon as possible providing it is not nearly time for another dose. Never take two doses at once unless directed to do so by a physician.

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Percolone changes the way your brain perceives pain. When the cells of your body are injured or ill, they release chemicals that bind with pain receptors in nerve endings, which then send messages of pain to your brain. Percolone binds with those pain receptors in a way that blocks the chemicals associated with pain - the brain is unaware of pain.

Furthermore, the opioids in Percolone act directly on the brain in a way that causes euphoria and relaxation: the sensation of being "high."

Opioids also affect the respiratory and digestive systems. Percolone and other opioids depress the part of the brain responsible for breathing; taking too much opioid may make the brain apathetic about breathing. Many opioids depress the cough center in the brain to reduce the cough reflex in a way that makes the brain ignore the need to cough.

Percolone and other opioids also act on smooth muscle organs, like those in your digestive tract. The action of opioids slows down the muscles in your intestines in a way that causes constipation. Drink six to eight full glasses of water each day to soften stool and make it easier to move your bowels. Talk with your doctor or dietician about increasing your intake of dietary fiber, known to be beneficial to your digestive tract. Do not use a stool softener or laxative without first discussing it with your healthcare provider.

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Tell your doctor if you are allergic to Percolone, another opioid drug or to any other medication. Allergic reaction is a serious condition. Anaphylaxis is a serious, life threatening form of allergic reaction that may occur suddenly and without warning. Seek medical help at the first sign of an allergic reaction.

Allergic drug reactions can cause:

  • Skin Rash or Hives
  • Itchy Skin
  • Wheezing or Other Breathing Problems
  • Swelling of the Lips, Tongue or Face

Your doctor may recommend a different medication or change your Percolone prescription if you have had a history of, or are currently suffering from, certain medical conditions. Your medical condition may interfere with the way Percolone works, or Percolone may make your condition worse. Tell the prescribing physician about any significant illnesses or conditions, including:

  • Addison's Disease or Other Adrenal Gland Disorders
  • Asthma
  • Brain Tumor
  • COPD
  • Curvature of the Spine
  • Enlarged Prostate or Urination Problems
  • Epilepsy or Other Seizure Disorder
  • Gallbladder Disease
  • Head Injury
  • History of Drug or Alcohol Addiction
  • Liver or Kidney Disease
  • Low Blood Pressure
  • Mental Illness
  • Other Breathing Disorders
  • Sleep Apnea
  • Stomach or Intestinal Blockage
  • Trouble Swallowing
  • Underactive Thyroid

Oxycodone can cause dizziness or drowsiness and affect your ability to make quick decisions. Do not drive a car or operate heavy machinery until you know how Percolone affects you.

Do not drink alcoholic beverages while taking Percolone. Consuming alcohol while taking opioids may cause serious adverse reactions or even death. Check the labels of all prescription and over-the-counter preparations to determine if the product contains alcohol. Ask your pharmacist if you are uncertain.

It is possible to develop physical dependence upon or an addiction to opioids, especially if you take high doses or use Percolone for a long time. Overwhelming symptoms associated with dependence or addiction makes it difficult to stop taking Percolone. Do not take a high dose or use Percolone more frequently than prescribed to reduce your risk for dependence.

Tell the prescribing physician if your current prescription stops relieving your pain, as this is a sign that your body is becoming tolerant to Percolone. She may adjust your dosing schedule or recommend a different medication.

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Do not take Percolone if you are having an asthma attack or other breathing problems. Percolone may cause respiratory depression, a dangerous and common type of respiratory condition characterized by slow and shallow breathing. Respiratory depression means the individual is not breathing well enough to exchange oxygen for carbon dioxide.

Percolone use during pregnancy may cause harm to the unborn baby, and could cause addiction or withdrawal symptoms in a newborn. Notify your doctor if you are pregnant or plan to become pregnant while taking Percolone so you and your healthcare provider can weigh the benefits and risks of taking this medication while pregnant. Percolone can pass into breast milk and may harm a nursing baby; do not take Percolone while breastfeeding your baby.

Do not stop taking Percolone abruptly, or reduce your dose drastically, unless a doctor directs you to do so. Discontinuing Percolone suddenly, or taking smaller doses than usual, may cause unpleasant withdrawal symptoms. Try weaning yourself from Percolone use by taking smaller doses further apart. If you have trouble discontinuing Percolone, you may be physically dependent and require the assistance of detoxification specialists.

More Warnings about Using Percolone

Drug Interactions

Percolone may interact with other drugs in unexpected or unsafe ways. Supply the prescribing physician and pharmacist filling the order with a list of all your prescriptions, over-the-counter drugs, vitamins and herbal remedies. Do not start, stop or change the way you take any drug without first consulting your physician - this includes over-the-counter preparations and supplements.

While taking Percolone, avoid other medications that affect your breathing, like sleep aides, other narcotics, tranquilizers and sedatives. Do not take cold or allergy medications while using Percolone. Dangerous side effects may result if you use Percolone along with muscle relaxers or medicines for seizures, depression or anxiety.

Tell the physician if you use pentazocine or nalbuphine, known by their brand names Talwin and Nubain. Notify your physician if you use Stadol, Buprenex or Subutex.

Certain medications, such as naloxone, quickly lower Percolone levels in the body. This rapid drop in Percolone levels will cause dependent individuals to experience withdrawal symptoms.

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Side effects

Most people do not suffer adverse reactions while taking Percolone but, as with all medication, some side effects may occur. Most of these side effects are not serious but let your doctor know if common side effects become intolerable or do not go away on their own. Common side effects include difficulty having a bowel movement, drowsiness, loss of strength, relaxed and calm feeling, sleepiness or unusual drowsiness.

Some side effects can be serious or even fatal. Seek medical help if you experience any of these serious side effects:

  • Shallow Breathing or Slow Heartbeat
  • Seizure
  • Cold, Clammy Skin
  • Confusion
  • Severe Weakness or Dizziness
  • Feeling Like You Might Pass Out

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Percolone overdose is a serious, potentially fatal medical emergency. If you suspect you or someone you know is suffering from Percolone overdose, contact your local poison control center at 1-800-222-1222 or go to the nearest emergency room. Doctors and nurses will administer drugs such as naloxone to lower Percolone levels in the blood, along with other emergency, life-saving treatments, like establishing an airway, pumping the stomach or performing CPR as necessary.

Overdose symptoms include:

  • Change in Consciousness
  • Chest Pain or Discomfort
  • Constricted, Pinpoint or Small Pupils
  • Decreased Awareness or Responsiveness
  • Extreme Drowsiness
  • Loss of Consciousness
  • No Muscle Tone or Movement
  • Severe Sleepiness
  • Slow or Irregular Heartbeat

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The active ingredient in Percolone, oxycodone, is a favorite among recreational users because of the euphoric feeling associated with narcotic use. Abusers use prescription opioids such as Percolone to get high. Abusers get oxycodone on the street, by presenting fake prescriptions to pharmacies, getting prescriptions from multiple doctors or by stealing from friends, family members or even pharmacies and hospitals in a process the U.S. Drug Enforcement Agency, or DEA, calls "diversion."

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Withdrawal symptoms are a natural and expected result of a sudden drop in the level of Percolone in the body of a person who is physically dependent on opioids. Withdrawal presents itself in a variety of overpowering physical, flu-like symptoms that can last five or more days as the levels of Percolone toxins slowly decrease; psychological symptoms of withdrawal may last much longer. Rehabilitation professionals call this process detoxification.

The human body adapts to the presence of foreign substances in the body, including Percolone, by adjusting its own chemical balance to accommodate those drugs. The body even becomes tolerant of these substances, which means a person must take an ever-increasing amount of opioids to relieve pain or get high. With continuous use, the body may become dependent on the chemical, which means the individual must maintain a certain level of Percolone for the body to feel "normal." If the level of Percolone drops rapidly, the body struggles to maintain its chemical balance. This struggle manifests itself through uncomfortable, flu-like withdrawal symptoms.

Withdrawal is a symptom of physical dependence; withdrawal symptoms do not represent a person's moral character. Your body can become physically dependent on Percolone whether you have been taking it legally or illegally. You may experience unpleasant withdrawal symptoms when you stop taking Percolone, especially if you have been using high doses or taking the opioid for a long time. Withdrawal symptoms vary from person to person and are dependent on how long you have been using Percolone and how frequently you take it. Withdrawal symptoms may be severe enough to prevent you from quitting Percolone without the help of a qualified rehabilitation specialist.


Detoxification is the process of lowering opioid levels. Detoxification can occur either because the individual did not take enough Percolone, or because he has taken a medication to crash opioid levels quickly. Detoxification in a dependent person will cause uncomfortable or painful withdrawal symptoms, especially if the individual attempts self-detoxification without the help of medical professionals.

Dependence and addiction to Percolone is often hard to beat on your own, especially if you have been taking large doses or using these opioids for a long time. Detoxification can be a tough and extremely unpleasant experience, especially for those who attempt self-detoxification.

Rapid Detox is considered the most humane, efficient way to detoxify the body from Percolone. During rapid detox, board certified anesthesiologists administer sedatives and anesthesia alongside the standard medications to lower opioid levels. The patient dozes in a comfortable "twilight sleep" during detoxification, and then awakens without any memory of the withdrawal process.

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Store Percolone at room temperature, away from moisture, heat and light. Keep Percolone away from children and pets. Put this opioid where adults cannot consume it by accident or on purpose.

Discard unused or unwanted Percolone in an appropriate manner. Ask your pharmacist how to dispose of unused or unwanted medication; do not flush it down the toilet unless directed to do so by a pharmacist.

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