• Generic Name or Active Ingridient: Oxycodone Hydrochloride And Aspirin
Drug Class: Percodan > Oxycodone Hydrochloride And Aspirin > Oxycodone > Fully Synthetic Opioid > Opioids > Opioid Agonist > Analgesic.


Doctors prescribe Percodan to control moderate to severe pain. Percodan contains two pain relievers, oxycodone and aspirin. Oxycodone is a narcotic pain reliever. Aspirin is a less potent pain reliever that also reduces fever. Learn More About Percodan Uses


Percodan is available in a yellow, round tablet. Each Percodan contains 4.8 mg of oxycodone and 325 mg of aspirin.

The usual Percodan prescription calls for one table every six hours as needed for pain. In this case, take Percodan at the first sign of pain, provided enough time has passed since your last dose. Waiting until the pain has worsened may reduce the effectiveness of Percodan. Percodan may be given on a schedule to control chronic pain. The maximum daily dose of Percodan should not exceed 4 grams, or 12 tablets.

Your doctor decides how much Percodan you should receive by assessing your body weight, other medical conditions and the medications you are currently taking. Do not take more Percodan than your doctor recommends and do not take Percodan more often than prescribed.

Take Percodan with an eight ounce glass of water. To prevent stomach upset, take Percodan with food or milk. If you suffer from nausea after taking Percodan, lie down for one to two hours and avoid head movements.

Percodan is not recommended for children under the age of six. Doctors calculate the proper dose of Percodan for children with an equation of 0.1 mg to 0.2 mg of oxycodone per kilogram of body weight per dose. Products containing aspirin, like Percodan, should not be given to children to treat viral infections with or without fever. Giving aspirin to children with certain viral infections can increase the risk for Reye syndrome.

It is important to take Percodan exactly as your doctor has prescribed. Do not stop taking Percodan suddenly or you may experience unpleasant withdrawal symptoms such as anxiety, sweating, trouble sleeping, shakiness, nausea, tremors, diarrhea, or hallucinations.

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When the cells of the body are injured through illness or trauma, they secrete a natural substance known as prostaglandin. The prostaglandin binds to pain receptors in nerve endings which transmit a signal to the brain that something is wrong. The brain then perceives pain and gains other information, like the location and nature of the injury. Aspirin blocks the production of prostaglandin so that less of this substance binds to nerve endings. Oxycodone works by binding with pain receptors and, instead of sending a message of pain to the brain, sends a message of pleasure and euphoria. Combined, aspirin and Percodan provide complete pain relief because they change the way the brain perceives pain. More About How Percodan Works


Tell your doctor if you are allergic to Percodan or any other medication. Allergic reaction can be a life-threatening situation – seek immediate medical help if you think you are suffering an allergic reaction to Percodan or any other medication. Signs of an allergic reaction include hives, trouble breathing and swelling of the face, lips, tongue or throat.

Do not take aspirin or products like Percodan that contain aspirin if you have a history of asthma, rhinitis and nasal polyps. Aspirin may cause hives, swelling just under the skin or an asthma attack. Tell your doctor about any respiratory problems.

Tell your doctor if you have ever had the intestinal obstructive disorder, paralytic ileum. Oxycodone may worsen this condition.

Percodan may make you drowsy or dizzy. Do not operate a car or heavy machinery until you know how you react to Percodan. Avoid risky behavior or activities that require you to be alert and awake.

Do not consume alcohol or smoke cigarettes while taking Percodan. Drinking alcohol may worsen side effects. Alcohol and tobacco use increase the risk for stomach bleeding associated with Percodan.

This drug can be habit-forming, especially if you take high doses or use it for more than a few weeks.

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You may not be able to take Percodan if you have a history of certain medical disorders, including intestinal or bowel disorders such as paralytic ileus, infectious diarrhea, colitis and blockage. Tell your physician if you have ever had kidney disease, liver disease, bleeding and blood-clotting disorders, such as hemophilia, vitamin K deficiency or low platelet count. Percodan may worsen certain lung diseases such as asthma, chronic obstructive pulmonary disease-COPD, breathing problems such as slow or shallow breathing, sleep apnea and nasal polyps. Certain stomach problems, such as ulcers, heartburn and stomach pain may prevent you from taking Percodan. Talk with your doctor if you have diabetes, gout, spinal problems, and heart problems such as low blood pressure or irregular heartbeat, underactive thyroid, pancreas problems, gallbladder disease, difficulty urinating, adrenal gland problems or enzyme deficiencies. You may not be able to take Percodan if you have a personal or family history of drug or alcohol abuse, brain disorders such as seizures, head injury, tumor, increased intracranial pressure or mental and mood disorders.

Do not take Percodan while pregnant, as this opioid may cause harm to your unborn baby. Taking Percodan in the last three months of pregnancy may cause your baby to experience withdrawal symptoms after birth, including irritability, persistent crying, vomiting or diarrhea. Do not take Percodan while breast feeding.

You may experience unpleasant withdrawal symptoms if you stop taking Percodan suddenly, especially if you have taken this pain medicine for a long time or have taken very large doses. Try weaning yourself from Percodan by taking smaller doses. Wait as long as you can before taking another tablet. If withdrawal symptoms prevent you from quitting Percodan, consult with your doctor or qualified in-patient or out-patient rehabilitation center. More Warnings About Using Percodan

Drug Interactions

Tell your doctor about all drugs, including prescriptions, over-the-counter and herbal remedies. Percodan may interact unfavorably with other medicines. Some of the drugs that may interact with Percodan include certain antidepressants, anti-platelet drugs, blood thinners, certain cancer drugs corticosteroids, diabetes drugs, herbal products such as ginkgo biloba, high blood pressure medication, non-steroidal anti-inflammatory drugs such as ibuprofen. Talk with your doctor if you take other pain medications. More Drug Interactions

Side effects

You may experience side effects while taking Percodan. Talk with your doctor immediately if you experience any of these side effects:

  • Black, Bloody or Tarry Stools.
  • Coughing Up Blood.
  • Vomit that Looks Like Coffee Grounds.
  • Shallow Breathing.
  • Slow Heartbeat.
  • Fast Heart Rate;
  • Feeling Light-headed.
  • Fainting.
  • Confusion.
  • Hallucinations.
  • Easy Bruising or Bleeding Easily.
  • Problems with Urination.

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Percodan overdose is a serious, potentially life-threatening medical condition. If you think that you or someone you know has taken too much Percodan, contact your local emergency room immediately. You can also call poison control at 1-800-222-1222. Overdose symptoms include:

  • Ringing in the Ears.
  • Fever.
  • Slow or Shallow Breathing.
  • Severe Drowsiness.
  • Slow Heartbeat.
  • Severe Dizziness.
  • Pinpoint Pupils.
  • Cold or Clammy Skin.
  • Limp or Weak Muscles.
  • Loss of Consciousness.

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Percodan poses a high risk for abuse and physical dependence. Pharmaceutical companies legally manufacture Percodan as a prescription pain reliever. Abusers and recreational users get Percodan by forging prescriptions, faking doctor phone calls to pharmacies, "doctor shopping" as well as theft from pharmacies and stealing from friends. Read More About Percodan Abuse


Stopping Percodan suddenly may cause unpleasant withdrawal symptoms, especially if you have been taking high doses or using the opioid for a long time. Withdrawal is not necessarily a sign of willful abuse but a normal, predictable, physical sign of dependency. Symptoms vary in intensity from person to person. Withdrawal symptoms may be unpleasant and overwhelming, preventing you from quitting Percodan without qualified help. Withdrawal symptoms include anxiety, sweating, trouble sleeping, shakiness, nausea, tremors, diarrhea, or hallucinations.


It can be difficult to stop taking Percodan, especially if you have been taking large doses or using this narcotic for more than a few weeks. In-patient and out-patient treatment facilities are staffed with qualified professionals who can minimize withdrawal symptoms, provide detoxification and the tools necessary to live drug-free. Talk with your doctor or contact a rehabilitation specialist if you have developed a dependence on Percodan and are finding it difficult to stop taking this drug.

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Keep Percodan at room temperature, ideally 77 degrees Fahrenheit. Do not keep this drug in your bathroom or car. Put Percodan in a safe location, away from children, pets and adults who might accidently or purposefully take it. Do not share Percodan with another person, especially with people you know have suffered a drug or alcohol addiction in the past. Count your Percodan tablets, taking note of any missing doses.

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Miscellaneous information

Miscellaneous Information About Percodan