• Generic Name or Active Ingridient: Oxymorphone
Drug Class: Oxymorphone > Semi Synthetic Opioid > Opioids > Opioid Agonist > Analgesic.


Doctors prescribe oxymorphone instant release to control moderate to severe pain. The extended-release formula of this medication provides round-the-clock protection against chronic pain, like that caused by cancer. Oxymorphone is not indicated for pain relief postoperatively unless the patient was already taking oxymorphone to control pain before surgery.

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Oxymorphone is available only in an oral form. Oxymorphone may be prescribed as needed for pain or on a regular schedule. Taking oxymorphone on a regular basis will control persistent pain more effectively than when taken only as necessary. If you miss a regularly scheduled dose and it is nearly time to take another dose, skip the missed dose. Never take two doses in an effort to catch up.

Initial doses of oxymorphone IR for people who are not accustomed to taking opioids is 10 to 20 mg every four to six hours. The typical prescription for extended-release oxymorphone is 5 mg ever 12 hours. Older people and patients with liver or kidney impairment may be more sensitive to the affects of oxymorphone.

Oxymorphone should be taken on an empty stomach. Wait for at least two hours after eating before you take a dose of oxymorphone. Do not eat for at least one hour after taking oxymorphone. Read More About Oxymorphone Administration and Dosage


Oxymorphone works by binding with pain receptors in a way that change the way your brain perceives pain. More About How Oxymorphone Works


Tell your doctor if you are allergic to Oxymorphone or any other medication, especially if you have ever suffered an allergic reaction to narcotics. Seek emergency medical services if you have an allergic reaction after taking oxymorphone. Symptoms of an allergic reaction include:

  • Rash.
  • Hives.
  • Itching.
  • Difficulty Breathing.
  • Tightness in the Chest.
  • Swelling of the Mouth, Face, Lips or Tongue.

Bring a list of medications with you to the doctor's office to be placed in your patient file. This list should include all prescription drugs, over-the-counter medicines and herbal remedies. Supply your pharmacist with a copy of the list.

Do not use oxymorphone if you have severe liver disease or are having an asthma attack. Tell your doctor if you have ever had the digestive disease, paralytic ileus. You may not be able to take oxymorphone if you have ever had the following diseases or medical conditions:

  • Respiratory Conditions like Asthma, COPD or Sleep Apnea
  • Liver or Kidney Disease.
  • Pancreas Disorders.
  • Underactive Thyroid.
  • Curvature of the Spine.
  • Brain Tumor.
  • Seizures, Epilepsy.
  • Head Injuries.
  • Enlarged Prostate.
  • Urinary Disorders.
  • Adrenal Gland Disorders, such as Addison's.
  • Mental Illness.
  • Drug or Alcohol Addiction.

Do not consume alcohol while taking oxymorphone. Drinking alcohol while taking oxymorphone may cause serious side effects or even death.

Oxymorphone may impair your thinking. Be careful when driving a car or performing other actions that require decision making and quick reflexes.

This drug can be habit-forming, especially if you take it for long periods of time. Tell your doctor if you feel agitated when it is nearly time to take another dose. Notify your physician if your current dose does not adequately control your pain; this may be a sign of dependence.

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Do not use oxymorphone if you are having trouble breathing. Forms of respiratory distress include asthma attacks, high levels of carbon dioxide in your blood, history of severe asthma or a having an asthma attack. Tell your doctor if you have a history of COPD, emphysema or bronchitis.

Tell your doctor if you are pregnant, breastfeeding or planning to become pregnant while taking oxymorphone. Do not use oxymorphone during labor.

Stopping oxymorphone use suddenly may cause unpleasant withdrawal symptoms. Whenever possible, wean yourself from oxymorphone by taking smaller doses further apart. If you cannot comfortably stop using oxymorphone, consult with your doctor or qualified in-patient or out-patient rehabilitation center. More Warnings About Using Oxymorphone

Drug Interactions

Some drugs interact in unfavorable or even dangerous ways with oxymorphone.

  • Phenothiazines, especially chlorpromazine, used to treat various mental disorders may increase the risk for low blood pressure.
  • Barbiturate anesthetics, the ulcer medication cimetidine, or narcolepsy medication sodium oxybate increase the risk for risk of severe drowsiness, coma, confusion, or slowed or difficult breathing when taken with oxymorphone.
  • Anti-spasmodic medication used to treat illnesses like COPD may cause constipation or trouble urinating when taken with oxymorphone.
  • Taking oxymorphone with MAO inhibitors prescribed to treat depression increase the risk for severe reaction including fever, seizures, and coma.
  • Certain analgesics decrease oxymorphone's effectiveness and increase the risk for experiencing withdrawal symptoms.

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Side effects

You may experience side effects while taking oxymorphone. These side effects range from common and not serious to life-threatening.

Seek medical assistance immediately if you suffer from serious side effects, including confusion, fainting, fever, severe or persistent headache, vomiting or unusual swelling. Go to the emergency room if you experience trouble breathing, a fast, slow or irregular heartbeat or problems urinating. Mood changes and hallucinations are serious side effects that warrant immediate medical attention.

Other side effects are less serious and more common. These side effects include anxiety, constipation, dizziness or drowsiness, dry mouth, gas, headache, lightheadedness, nausea and vomiting or perspiring. Talk with your doctor if these side effects become uncomfortable or if they don't disappear on their own

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Oxymorphone overdose is a serious, life-threatening medical condition. If you suspect that you or someone you know has taken an overdose of oxymorphone, seek emergency assistance immediately. Contact your local poison control center at 1-800-222-1222 or go to the emergency room. Overdose symptoms include:

  • Bluish Skin.
  • Chest Pain.
  • Cold, Clammy Skin.
  • Coma.
  • Difficult or Slow Breathing.
  • Limp Muscles.
  • Numbness of an Arm or Leg;.
  • Pinpoint Pupils.
  • Severe Drowsiness.
  • Severe Dizziness.
  • Slow or Irregular Heartbeat.

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Oxymorphone is a Schedule II drug, which means it carries a significant risk for abuse and physical as well as psychological dependence. Pharmaceutical companies legally manufacture oxymorphone for licit use as a pain reliever but abusers obtain oxymorphone through forged prescriptions, bogus prescription call-ins to pharmacies, "doctor shopping" as well as theft from pharmacies and friends. Dispose of any unused oxymorphone when you no longer have pain. Tell your health care provider if you have trouble stopping oxymorphone use even after your pain has subsided. You may need the assistance of a rehabilitation specialist to help you stop using oxymorphone. Read More About Oxymorphone Abuse


You may experience a variety of withdrawal symptoms when you stop taking oxymorphone, especially if you take high doses or have been taking oxymorphone for a while. Symptoms vary in intensity. Withdrawal is a normal, predictable, physical sign of dependency; withdrawal is not necessarily a sign of willful abuse. Withdrawal symptoms may make quitting oxymorphone difficult without the assistance of rehabilitative professionals. Withdrawal symptoms include:

  • Anxiety.
  • Diarrhea.
  • Fever.
  • Runny Nose or Sneezing.
  • Goose Bumps and Abnormal Skin Sensations.
  • Nausea and Vomiting.
  • Pain.
  • Rigid Muscles.
  • Seeing, Hearing, or Feeling Things that are not There.
  • Shivering or Tremors.
  • Sweating.
  • Trouble sleeping.


Dependency and addiction to oxymorphone is often difficult to overcome. This is especially true if you have been taking large doses of oxymorphone or using these opioids for a long period of time. In-patient and out-patient treatment facilities can minimize withdrawal symptoms, detoxify your body and give you the tools you need to live without oxymorphone.

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Oxymorphone should be stored at 77 degrees Fahrenheit. Protect oxymorphone from exposure to excessive heat, moisture and light. Do not keep this drug in the bathroom or in your car. Keep Oxymorphone away from children, pets and adults who might accidently or purposefully take this narcotic. Do not share Oxymorphone with other people, especially with people who have abused drugs or alcohol in the past. Keep track of your medication, taking note of any missing doses.

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