Oxycodone and Ibuprofen

Drug Class: Oxycodone And Ibuprofen > Oxycodone > Semi Synthetic Opioid > Opioids > Opioid Agonist > Analgesic.


Oxycodone and ibuprofen are the active ingredients in the brand name drug, Combunox. Doctors prescribe this drug combination to treat short-term acute, moderate to severe pain, with the prescription lasting no more than seven days. Ibuprofen effectively reduces mild pain and swelling.

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According to the package insert, Combunox contains 5 mg of hydrocodone HCL and 400 mg of ibuprofen. This brand name pain reliever comes in tablet form only.

Researchers have not yet confirmed the safety of using oxycodone and ibuprofen in children under the age of 14. Physicians should use extreme caution in prescribing this drug combination to young patients.

Doctors typically prescribe oxycodone and ibuprofen to be taken as needed for pain, rather than as a scheduled dose. If you are taking oxycodone and ibuprofen combination drugs as needed, do not worry if you miss a dose. Take another dose when you have pain, provided enough time has passed since the previous dose. If your doctor has requested you take these drugs on a regular basis and you miss a dose, take another dose as soon as you remember; however, if it is nearly time to take a regularly scheduled dose, skip the missed dose and resume your normal schedule.

Notify your physician if your current oxycodone and ibuprofen prescription stops working, or does not control the pain as well as it used to. Your tolerance to these drugs may be increasing. Do not take your medicine more frequently without first consulting your doctor.

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When the cells of your body are in distress due to illness or injury, they send a chemical message through the nervous system to your brain. Your brain then perceives pain and reacts appropriately to that pain. Hydrocodone works by binding to pain receptors in your nervous system, replacing messages of pain with messages of pleasure or euphoria. Hydrocodone, like other narcotics, changes the way your brain perceives pain.

The cells of your body produce a hormone known as prostaglandin. This hormone promotes inflammation, pain and fever. Ibuprofen blocks the enzymes responsible for producing prostaglandin, effectively reducing swelling, discomfort and fever. More About How Oxycodone and Ibuprofen Works


Give your doctor and pharmacist a list of your allergies, including allergies to oxycodone and ibuprofen. Get help right away at the first sign of an allergic reaction after taking oxycodone and ibuprofen. An allergic reaction is a serious medical emergency that can turn quickly into a life-threatening situation. Symptoms of an allergic reaction include rash, hives and difficulty breathing.

Your doctor may change your oxycodone and ibuprofen dosage, or switch you to a different pain reliever altogether, if you have a history of certain medical conditions. This medication may worsen these illnesses, or these medical conditions may interfere with the way oxycodone and ibuprofen work. Make sure your medical charts include a history of your serious illnesses such as head injuries, brain tumors, seizures, breathing problems such as asthma or COPD, bowel conditions such as paralytic ileus or have recently had heart bypass surgery. Do not take this medication if you have been experiencing diarrhea related to antibiotic use, are taking sodium oxybate or an MAO inhibitor.

Oxycodone and Ibuprofen can make you drowsy and less alert. Don't drive a car or operate heavy machinery until you know how this medication affects you. Alcohol and some prescription and over-the counter medications can worsen drowsiness associated with oxycodone and ibuprofen.

This medicine may make you dizzy when you stand up too fast. Alcohol, hot weather, fever or exercise can worsen this effect. To remedy this, put your feet on the floor and sit at the edge of the bed for a few minutes before standing. Rise slowly from the bed or chair. Sit down at the first sign of dizziness.

Your doctor may order laboratory tests while you take oxycodone and ibuprofen. Tests may include complete blood counts and liver and kidney function. These tests monitor your condition and alert your physician to any side effects.

Do not consume alcohol or take other medicines that cause drowsiness while taking oxycodone and ibuprofen. This medication will add to the effects of alcohol and other depressants. Check the labels of food, beverages and medicines to learn the alcohol content.

This drug can be habit-forming, especially if you take it for long periods of time. Tell your doctor if you have a history of dependence or addiction to drugs or alcohol. Your physician may choose a different course of treatment or adjust your dosage accordingly.

Elderly patients may be more sensitive to the effects of oxycodone and ibuprofen. Physicians should monitor older patients carefully for signs of breathing problems or stomach bleeding.

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Ibuprofen use may increase your risk for serious heart and blood vessel problems, sometimes resulting in heart attacks or strokes. The risk increases if you have a history of heart problems or if you have been taking ibuprofen for a long time. Do not use oxycodone and ibuprofen after heart surgery. Ibuprofen and drug combinations including ibuprofen increase your risk for developing sudden and serious stomach problems, including fatal ulcers and bleeding. Taking oxycodone and ibuprofen with food will not reduce your risks for stomach problems. Life-threatening stomach problems may happen suddenly and without warning. Seek emergency medical help if you have severe stomach pains, throw up what looks like blood or coffee grounds, tarry stools or unusual weight gain or swelling. Tell your doctor if you are pregnant or plan to become pregnant while taking oxycodone and ibuprofen. Taking this drug combination in the last three months of pregnancy or during labor and delivery may harm an unborn child. Do not breastfeed your baby while taking oxycodone and ibuprofen as these drugs is found in breast milk.

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Drug Interactions

Do not take aspirin while taking oxycodone and ibuprofen unless your doctor has knowingly recommended you do so.

Oxycodone and Ibuprofen may interact in an unfavorable or even dangerous way with other prescriptions, over-the-counter medications and herbal remedies. Give your doctor a complete and updated list of medicines.

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Side effects

You may experience side effects while taking oxycodone and ibuprofen. If side effects become acute or don't go away on their own, talk with your doctor. Common digestive side effects include constipation, diarrhea, indigestion, nausea, stomach pain, upset stomach and vomiting. You may also notice an increase in weakness, anxiety, nervousness, sleeplessness, dizziness, drowsiness, tiredness and headaches while taking this drug combination.

Some side effects can be severe or life-threatening. Seek medical assistance immediately if you experience severe side effects such as:

  • Black, Tarry or Bloody Stools.
  • Blurred Vision.
  • Chest Pain.
  • Dark urine.
  • Fainting.
  • Fast or irregular heartbeat.
  • Fever.
  • Flu-like Symptoms.
  • Increased or Decreased Urination.
  • Irregular or Difficult Breathing.
  • Mental or Mood Changes.
  • Red, Swollen, Blistered or Peeling Skin.
  • Severe or Persistent Dizziness.
  • Severe or Persistent Nausea or Stomach Pain.
  • Shortness of Breath.
  • Slurred speech.
  • Stiff Neck.
  • Swelling of the Arms or Legs.
  • Unusual Tiredness or Weakness.
  • Unusual Weight Gain.
  • Vomit that Looks like Coffee Grounds.
  • Yellowing of the Skin or Eyes.

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Oxycodone and Ibuprofen overdose is a serious, life-threatening medical emergency. If you suspect that you or someone you know has taken an overdose of oxycodone and ibuprofen, seek emergency assistance immediately by going to the emergency room or calling an ambulance. If you are a very long distance from professional help, contact your local poison control center at 1-800-222-1222. Overdose symptoms include blurred vision or cold and clammy skin. Seek medical help immediately if you notice confusion, severe dizziness, drowsiness, or coma, severe muscle weakness, slow, shallow, or difficult breathing.

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Oxycodone and Ibuprofen is a Schedule II drug, which means it carries a significant risk for abuse and physical as well as psychological dependence. Pharmaceutical companies legally manufacture oxycodone and ibuprofen for licit use as a pain reliever but abusers obtain oxycodone and ibuprofen through forged prescriptions, bogus prescription call-ins to pharmacies, "doctor shopping" as well as theft from pharmacies and friends. Read More About Oxycodone and Ibuprofen Abuse


You may experience withdrawal symptoms when you stop taking oxycodone and ibuprofen, whether you used this drug combination by prescription or for recreational purposes. The withdrawal process is a normal, predictable, physical sign of dependency and not necessarily a sign of willful substance abuse. Withdrawal symptoms may appear soon after your last dose of oxycodone and ibuprofen, especially if you have been taking high doses or using Combunox for more than seven days. If your withdrawal symptoms are so intense that they prevent you from quitting oxycodone and ibuprofen, call your doctor or contact professional rehabilitation specialists in your area. Withdrawal symptoms include anxiety, diarrhea, fever, runny nose, or sneezing. You may also experience goose bumps and abnormal skin sensations, nausea, vomiting, pain, rigid muscles or a rapid heartbeat. Seek qualified help if you begin seeing, hearing or feeling things that are not there. Talk with your physician if your shivering or tremors, sweating and trouble sleeping prevent you from quitting oxycodone and ibuprofen.

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You may need the help of qualified professionals to help you detoxify your body from oxycodone and ibuprofen. Strong withdrawal symptoms may make dependency and addiction to oxycodone and ibuprofen difficult to overcome on your own. Quitting may be more difficult if you have been taking large doses or using opioids for a long time. Talk with your doctor or seek in-patient and out-patient treatment facilities where trained professionals can minimize withdrawal symptoms, detoxify your body and give you the tools you need to live drug-free. Detoxification, rehabilitation and counseling are effective therapies to treat addiction to oxycodone and ibuprofen and other opiates.

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