Oxycodone and Aspirin

Drug Class: Oxycodone And Aspirin > Oxycodone > Semi Synthetic Opioid > Opioids > Opioid Agonist > Analgesic.


Pharmacologists combine oxycodone and aspirin in a single tablet that provides relief from moderate to moderately severe pain. Percodan and Endodan are two brand name preparations that contain this combination. Aspirin is also known as acetylsalicylic acid or ASA. Learn More About Oxycodone and Aspirin Uses


Oxycodone and aspirin come in a tablet form to be taken by mouth. Each tablet contains 325 mg of aspirin and 4.8355 mg of oxycodone.

The effectiveness and safety of oxycodone use in young children has not been established. Children and teenagers are at increased risk for toxicity associated with aspirin, so the use of combination drugs including aspirin is not recommended for this age group.

Oxycodone and aspirin preparations are normally prescribed to be taken as needed for pain; do not worry if you miss a dose. Simply take another dose when you have pain, provided enough time has passed since your last dose. If you are taking oxycodone and aspirin on a regular schedule and miss a dose, take another dose as soon as you remember. If it is nearly time to take a regularly scheduled dose, skip the missed dose and resume your normal schedule. If you miss several consecutive doses, or if you have trouble maintaining the prescribed schedule, talk with your doctor.

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Oxycodone is an opioid, part of the narcotic family. It works to reduce discomfort by binding to nerve endings to send messages of pleasure and euphoria instead of messages of pain. Oxycodone, like other narcotics, change the way your brain perceives pain. Oxycodone suppresses cough by depressing the cough reflex directly in the medulla, the part of your brain responsible for breathing. Aspirin works on the immune system to reduce swelling. Damaged body cells produce large quantities of the enzyme, cylooxygenase-2, or COX-2. This enzyme, in turn, releases prostaglandin which sends a message to the brain that a specific part of the body is in pain. Aspirin adheres to COX-2 and prevents it from producing prostaglandin. As a result, the brain receives only a partial pain message. Prostaglandin also signals wounded cells to release fluids, causing swelling and inflammation. Aspirin reduces swelling and inflammation by reducing prostaglandin production. Aspirin also impacts the hypothalamus, which is the area of your brain known responsible for regulating body temperature, in a way that reduces fever. More About How Oxycodone and Aspirin Works


Tell your doctor if you are allergic to oxycodone, aspirin or to any other medication, over-the-counter drug or herbal preparation. An allergic reaction is a serious, potentially life-threatening medical emergency. Seek immediate help if you experience an allergic reaction shortly after taking oxycodone and aspirin. Symptoms of an allergic reaction include hives, trouble breathing and swelling of the face, lips, tongue or throat.

You may not be able to take oxycodone and aspirin if you have a history of certain medical conditions. Talk with your physician about any history of kidney disease, liver disease, bleeding and blood-clotting disorders, such as hemophilia, vitamin K deficiency or low platelet count. Tell your professional heath care provider about any serious or chronic illnesses including intestinal or bowel disorders such as paralytic ileus, infectious diarrhea, colitis and blockage. Oxycodone may worsen asthma, chronic obstructive pulmonary disease-COPD, breathing problems such as slow or shallow breathing, sleep apnea and nasal polyps. You may not be able to take oxycodone and aspirin if you have certain stomach problems, such as ulcers, heartburn and stomach pain. Be sure your physician is aware of significant chronic illnesses, such as diabetes, gout, spinal problems, and heart problems such as low blood pressure or irregular heartbeat, underactive thyroid, pancreas problems, gallbladder disease, difficulty urinating, adrenal gland problems or enzyme deficiencies. You may not be able to take oxycodone if you have a personal or family history of alcohol or drug abuse, seizures, head injury, tumor, increased intracranial pressure or mental and mood disorders.

Oxycodone and aspirin can impair decision making and cause you to feel you drowsy. Do not operate heavy machinery or drive a car until you know how you feel after taking oxycodone. Avoid engaging in risky behavior that requires you to be alert and awake. Alcohol and some medications can enhance this effect. Aspirin does not cause drowsiness.

Do not consume alcohol while taking oxycodone and aspirin. Drinking alcohol may worsen side effects, especially stomach ulcers and bleeding associated with aspirin.

Older patients are more likely to have liver or kidney problems. Physicians should use caution in prescribing preparations containing aspirin to geriatric patients, adjusting dosages as necessary.

This drug can be habit-forming, especially if you take it for long periods of time. Tell your doctor if you have a history of dependence or addiction to drugs or alcohol. Your physician may choose a different course of treatment or adjust your dosage accordingly.

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It is not known how taking oxycodone and aspirin can affect your unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while taking oxycodone and aspirin. If you become pregnant while taking oxycodone and aspirin, call your doctor immediately. Taking oxycodone in the last three months of pregnancy may cause your baby to experience withdrawal symptoms after birth, including irritability, persistent crying, vomiting or diarrhea. Oxycodone is found in breast milk. Do not take oxycodone and aspirin while breastfeeding.

Don't stop taking oxycodone and aspirin suddenly; doing so may cause unpleasant withdrawal symptoms. Try weaning yourself from oxycodone and aspirin by taking smaller doses less frequently. If withdrawal symptoms prevent you from quitting oxycodone and aspirin, talk with your doctor or qualified in-patient or out-patient rehabilitation center. More Warnings About Using Oxycodone and Aspirin

Drug Interactions

Oxycodone and aspirin may interact in an unfavorable or even dangerous way with other prescriptions, over-the-counter medications and herbal remedies. Give your doctor a complete and updated list of medicines. Be sure to tell your doctor if you take any of the following drugs

  • Antidepressants.
  • Anti-platelet Drugs.
  • Blood Thinners.
  • Certain Cancer Drugs.
  • Corticosteroids.
  • Diabetes Drugs.
  • Herbal Products such as Ginkgo Biloba.
  • High Blood Pressure Medication.
  • Non-steroidal Anti-inflammatory Drugs such as Ibuprofen.

Talk with your doctor if you take other pain medications. She may suggest you take oxycodone and aspirin less frequently or switch you to a different pain reliever.

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Side effects

You may experience side effects while taking oxycodone and aspirin. If side effects become acute or don't go away on their own, talk with your doctor. Common side effects include drowsiness, sleepiness and constipation.

Some side effects can be severe or life-threatening. Seek medical assistance immediately if you experience severe side effects such as:

  • Black, Bloody or Tarry Stools.
  • Coughing Up Blood.
  • Vomit that Looks Like Coffee Grounds.
  • Shallow Breathing.
  • Slow Heartbeat.
  • Fast Heart Rate;
  • Feeling Light-headed.
  • Fainting.
  • Confusion.
  • Hallucinations.
  • Easy Bruising or Bleeding Easily.
  • Problems with Urination.

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Contact your local poison control center at 1-800-222-1222 or go to the closest emergency room if you suspect that you or someone you know has taken an overdose of oxycodone and aspirin. Overdose is a serious, life-threatening medical emergency. Overdose symptoms include:

  • Ringing in the Ears.
  • Fever.
  • Slow or Shallow Breathing.
  • Severe Drowsiness.
  • Slow Heartbeat.
  • Severe Dizziness.
  • Pinpoint Pupils.
  • Cold or Clammy Skin.
  • Limp or Weak Muscles.
  • Loss of Consciousness.

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Oxycodone is a Schedule II drug, which means it carries a significant risk for abuse and physical as well as psychological dependence. While the majority of people take oxycodone and aspirin by prescription to reduce pain, there are some who will abuse the drug for recreational purposes. They get oxycodone and other narcotics by forging or calling in bogus prescriptions, visiting multiple doctors or by theft. Read More About Oxycodone and Aspirin Abuse


When used to relieve pain, you are not likely to develop a mental dependence on oxycodone but you may suffer physical manifestations of narcotic withdrawal. The symptoms of withdrawal are sometimes acutely unpleasant, appearing after you stop taking oxycodone. This is especially true if you have been taking high doses of oxycodone or using narcotic pain relievers for a long period of time. Withdrawal symptoms may be so intense that they prevent you from quitting oxycodone and aspirin without medical assistance. Withdrawal symptoms include anxiety, sweating, trouble sleeping, shakiness, nausea, tremors, diarrhea, or hallucinations.

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Qualified drug rehabilitation specialists can detoxify your body and help overcome dependence or addiction to oxycodone. These professionals use special drugs and techniques that minimize withdrawal symptoms, detoxify your body and give you the tools you need to live drug-free. Talk to your doctor or rehabilitation specialist to learn how detoxification, rehabilitation and counseling therapies can treat addiction to oxycodone and aspirin and other opiates.

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Put oxycodone and aspirin in a safe place where children, pets and adults who might consume this product willfully or accidentally cannot access it. Protect oxycodone and aspirin from excessive heat, moisture and light. Do not allow this medication to freeze. Never share oxycodone and aspirin or other opioids with others, especially with people with a history of alcohol or drug abuse. Keep track of your medication, taking note of any missing doses. Flush unused medication down the toilet.

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