Oxycodone and Acetaminophen

Drug Class: Oxycodone And Acetaminophen > Oxycodone > Semi Synthetic Opioid > Opioids > Opioid Agonist > Analgesic.


Doctors prescribe oxycodone and acetaminophen to relieve moderate to moderately severe pain. There are several brand name oxycodone and acetaminophen preparations, including Endocet, Percocet, Tylox and Xolox, among others.

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One tablet may contain 2.5 mg to 10 mg of oxycodone and up to 325 mg of acetaminophen. The typical prescription for an adult is one to two tablets every six hours as needed for pain. The maximum daily dose for oxycodone is 60 mg; do not take more than 4000 mg of acetaminophen in a 24-hour period.

Children may take up to 5 mg of oxycodone per dose every 4 to 6 hours as needed for pain.

Physicians normally prescribe oxycodone and acetaminophen combinations to be taken as needed for pain rather than on a regular schedule. If you are taking oxycodone and acetaminophen tablets on a regular schedule and miss a dose, take another tablet as soon as you remember unless it is almost time to take a regularly scheduled dose. Read More About Oxycodone and Acetaminophen Administration and Dosage


Acetaminophen eases pain and reduces fever by blocking the hormone responsible for inflammation, pain and fever. Oxycodone binds with nerve endings to change the way your brain perceives pain. More About How Oxycodone and Acetaminophen Works


Tell your doctor if you are allergic to oxycodone, acetaminophen or any other medication. Go to the hospital or seek immediate medical help at the first sign of an allergic reaction, as this may turn into a serious or life-threatening condition quickly. Symptoms of an allergic reaction include swelling of the face, mouth and throat, respiratory distress, hives, rash, itching and vomiting.

Some serious medical conditions may prevent you from taking oxycodone and acetaminophen. Tell your doctor about any significant illnesses including Addison's disease or other adrenal gland problem, alcohol or drug abuse, history of brain tumor, COPD or enlarged prostate. Tell your doctor if you have ever had a head injury, history of underactive thyroid, curvature of the spine, trouble passing urine, asthma or the bowel problem, paralytic ileus. Report any history of very slow breathing, low blood pressure, pancreatitis, liver or kidney disease.

Oxycodone can make you drowsy. Do not operate heavy machinery or drive a car until you know how oxycodone affects you. Avoid engaging in any activities that requires you to be alert and awake. Alcohol and some medications, like other pain relievers and over-the-counter cold medicines, can enhance this effect.

Do not consume alcohol while taking oxycodone. Drinking alcohol may increase drowsiness. Chronic alcoholics should limit acetaminophen intake to less than 2000 mg per day.

Acetaminophen is not habit-forming but taking large doses or using this drug for long periods of time may cause serious liver damage. Oxycodone can be habit-forming, especially if you take it for long periods of time. Tell your doctor if you have a history of dependence or addiction to drugs or alcohol. Your physician may choose a different course of treatment or adjust your dosage accordingly.

Oxycodone and acetaminophen combination therapy drugs may affect the outcome of certain laboratory tests, including lowered blood sugar test results. Tell the phlebotomist or laboratory technician about using oxycodone and acetaminophen when submitting a blood or urine sample.

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It is not known how taking oxycodone and acetaminophen can affect your unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while taking oxycodone and acetaminophen. If you become pregnant while taking oxycodone and acetaminophen, call your doctor immediately. Oxycodone and acetaminophen is found in breast milk. Do not take oxycodone and acetaminophen while breastfeeding.

Don't stop taking oxycodone and acetaminophen suddenly; doing so may cause unpleasant withdrawal symptoms. Try weaning yourself from oxycodone and acetaminophen by taking smaller doses less frequently. If withdrawal symptoms prevent you from quitting oxycodone and acetaminophen, talk with your doctor or qualified in-patient or out-patient rehabilitation center.

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Drug Interactions

Oxycodone and acetaminophen may each interact in an unfavorable or even dangerous way with other prescriptions, over-the-counter medications and herbal remedies. Give your doctor a complete and updated list of medicines. Be sure to tell your doctor if you drink alcohol or take over-the-counter medicines such as allergy or cold remedies. Tell your doctor if you take anti-seizure drugs, such as phenobarbital, medicine for sleep or anxiety, muscle relaxants, other narcotic pain relievers and psychiatric medicine. Your physician may alter the dosage or switch you to another pain reliever. Other medications, such as antifungals, antibiotics and certain HIV medications, can affect the removal of oxycodone from your body, which may affect how oxycodone works.

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Side effects

You may experience side effects while taking oxycodone and acetaminophen. If side effects become acute or don't go away on their own, talk with your doctor. Serious side effects are uncommon but can result in very serious medical conditions. Seek medical assistance immediately if you experience severe side effects such as mental or mood changes, severe stomach or abdominal pain, or difficulty urinating. Other rare but serious side effects include fainting, seizure, slow or shallow breathing, or unusual drowsiness or difficulty waking up.

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Oxycodone and acetaminophen overdose is a serious, life-threatening medical emergency. Go to the emergency room or call for an ambulance if you suspect that you or someone you know has overdosed. If you are a very long distance from professional help, contact your local poison control center at 1-800-222-1222. Overdose symptoms include slow breathing, slow heartbeat or loss of consciousness.

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There is little risk for acetaminophen dependence but oxycodone is a Schedule II drug, which means it carries a significant risk for abuse and physical as well as psychological dependence. Abusers often get oxycodone and acetaminophen combination drugs by forging prescriptions, calling in bogus prescriptions to pharmacies, getting prescriptions from multiple doctors or stealing drugs from pharmacies, friends and family. Read More About Oxycodone and Acetaminophen Abuse


Acetaminophen does not cause withdrawal symptoms when you stop taking it, but you may experience unpleasant withdrawal symptoms when you quit using oxycodone. Going through withdrawal does not necessarily mean you have abused oxycodone for recreational purposes. In fact, medical experts recognize that withdrawal is a normal, predictable, physical sign of dependency. Withdrawal symptoms may appear after you stop taking oxycodone, especially if you have been taking high doses or using the opioid for a long period of time. Withdrawal symptoms may be so intense that they prevent you from quitting oxycodone without medical assistance. Speak with your physician if withdrawal symptoms prevent you from quitting oxycodone. Withdrawal symptoms include restlessness, teary eyes, runny nose, yawning, perspiration, chills, muscle pain and dilated pupils. Other withdrawal symptoms include irritability, anxiety, backache, joint pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhea, or increased blood pressure, respiratory rate or heart rate.

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Withdrawal symptoms may become severe enough to prevent you from quitting oxycodone use without the help of qualified professionals. Quitting may be more difficult if you have been taking large doses of oxycodone or using narcotics for a long period of time. Consult with your doctor or seek in-patient and out-patient treatment facilities in your area; trained professionals can minimize withdrawal symptoms, detoxify your body and give you the tools you need to live without oxycodone or other drugs.

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Oxycodone and acetaminophen are best kept between 59 degrees and 86 degrees Fahrenheit, in a place away from excessive heat and moisture. Keep oxycodone and acetaminophen in a safe place away from children and pets. Be aware of any adults that may consume oxycodone accidentally or purposefully.

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