Opana is a brand name preparation of oxymorphone hydrochloride. Opana is used to treat moderate to severe pain. Extended-release Opana is intended to provide round-the-clock relief from chronic pain. Opana is not generally prescribed for post-operative use unless you had been already taking Opana before your surgery. The generic form of this drug is oxymorphone. Learn More About Opana Uses


Opana is available in regular- and extended-release. It is available in 5 mg to 10 mg tablets to be taken by mouth. Your doctor will probably start you out on a low dose and then increase the strength until your pain is under control.

Take Opana on an empty stomach, at least one to two hours after a meal. Regular Opana is to be taken once every four to six hours; extended-release Opana is usually taken once every 12 hours.

Regular Opana is frequently prescribed on an as-needed basis to control pain and, as such, there is no problem if you miss a dose. Simply take another dose when you feel pain, provided enough time has passed since your last Opana tablet. Speak with your doctor if your current Opana dose and schedule do not relieve your pain.

Your doctor may have prescribed extended-release Opana to be taken on a regular schedule. If you miss a dose of extended-release Opana, simply take another tablet as soon as you remember. If it is nearly time to take a regularly scheduled dose and you are not in significant pain, wait until it is time to take another Opana tablet and resume your normal schedule. Talk with your doctor if you have trouble staying on schedule.

Read More About Opana Administration and Dosage


Opioids like Opana work by changing the way your brain perceives pain. When you are sick or injured, special receptors throughout your body send a message to your brain that it should perceive pain in that part of the body. The active ingredient in Opana, oxymorphone, works by binding with these receptors and sending a message of pleasure or euphoria instead of pain. More About How Opana Works


Tell your doctor if you are allergic to Opana or any other medication, especially if you had suffered an allergic reaction to another narcotic, like codeine or morphine. Go to the emergency room immediately if you experience symptoms of an allergic reaction.

Tell your doctor if you are allergic to Norco or any other medication, especially if you have suffered an allergic reaction to other narcotic medications. An allergic reaction is a serious, life-threatening medical condition.

Seek immediate medical attention if you notice any of these signs of an allergic reaction:

  • Hives.
  • Difficulty Breathing
  • Swelling of the Face, Lips, Tongue or Throat.

Give your doctor a detailed list of your medical history. Based upon your medical history, your physician may choose a different narcotic to relieve your pain. Tell caregiver about any respiratory conditions, including respiratory depression, severe asthma or hypercarbia, which is a medical condition marked by excessive levels of carbon in the bloodstream. Let your doctor know if you have ever suffered from certain bowel diseases like infectious diarrhea or paralytic ileum, a disease that causes severe constipation.

Opana may make you drowsy, dizzy or lightheaded. Do not operate a car or other heavy machinery until you know how your body reacts to Opana. You may get dizzy if you get up too quickly from a lying position. To avoid this, put your feet on the floor and sit on the side of the bed for a minute or two before standing up.

Do not consume alcohol while taking Opana. Drinking alcohol may worsen side effects. Talk openly with your physician about your alcohol use. Alcohol is a known CNS depressant, which means alcohol depresses your central nervous system or breathing patterns.

Older adults may be more sensitive to the effects of Opana. A physician may choose to start elderly patients on a lower dose or begin pain management therapy under medical supervision until she is certain how the senior citizen's system will handle Opana.

This drug can be habit-forming, especially if you take it for long periods of time. Tell your doctor if you worry you are growing dependent on Opana. Tell your physician if your Opana stops working – this is a sign of increased tolerance to the medication. Do not take more pills than your doctor prescribed and do not take them more frequently than recommended.

Read More About Opana Precautions


Opana may not be right for you, especially if you have experienced certain medical conditions. Your doctor may choose a pain reliever other than Opana, or adjust your dose of this narcotic, if you have ever had:

  • Respiratory Conditions like Asthma, COPD or Sleep Apnea
  • Liver, Pancreas or Kidney Disease.
  • Underactive Thyroid.
  • Curvature of the Spine.
  • Brain Tumor or Head Injuries.
  • Adrenal Gland Disorders, such as Addison's.
  • Enlarged Prostate.
  • Mental Illness.
  • Drug or Alcohol Addiction.

Opana may pass into breast milk; do not breastfeed your baby while taking Opana. This drug may cause damage to your unborn child. Do not take Opana if you are pregnant or plan to become pregnant while taking this narcotic. Taking this pain reliever while pregnant may cause your infant to suffer breathing problems along with symptoms of dependency and withdrawal. Contact your doctor if your baby has symptoms of withdrawal associated with Opana. Symptoms of neonatal withdrawal include:

  • Abnormal Sleep Pattern.
  • Diarrhea.
  • High-pitched Cry.
  • Irritability.
  • Shakiness or Tremors.
  • Weight Loss.
  • Vomiting.
  • Failure to Gain Weight.

Stopping Opana use suddenly may cause unpleasant withdrawal symptoms. Whenever possible, wean yourself from Opana by taking smaller doses further apart. If you cannot comfortably stop using Opana, consult with your doctor or qualified in-patient or out-patient rehabilitation center.

More Warnings About Using Opana

Drug Interactions

Give your doctor a list of all your medications, including prescription or over-the-counter drugs and herbal remedies. It is very important that your doctor know if you are taking certain medications before you use Opana. These medications include antidepressants, antihistamines, ulcer medication known as cimetidine or Tagamet, or the respiratory drug ipratropium, otherwise known as Atrovent. Be sure to mention any medications for anxiety, irritable bowel disease, mental illness, motion sickness, nausea, Parkinson's disease, seizures, ulcers, or urinary problems. It is important that your physician and pharmacist know if you are taking narcotic pain relievers, sedatives, sleeping pills; or tranquilizers.

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Side effects

You may experience side effects after taking Opana; some side effects are serious. Seek medical assistance if you have the following side effects:

  • Slow or Difficult Breathing.
  • Seizures.
  • Hives.

Opana may commonly cause less serious side effects. Consult with your doctor if these side effects become acute, uncomfortable or don't go away on their own:

  • Constipation.
  • Nausea.
  • Vomiting.
  • Loss of Appetite.
  • Dry Mouth.
  • Stomach Pain.
  • Headache, Dizziness, Confusion.
  • Extreme Tiredness, Difficulty Falling or Staying Asleep.
  • Fever.
  • Itching.

Learn More About Opana Side Effects


If you suspect that you or someone you know has taken an overdose of Opana, seek emergency assistance immediately. Contact your local poison control center at 1-800-222-1222 or go to the emergency room. While at the hospital, you can expect emergency, life-saving treatments including activated charcoal, artificial respiration, fluids, laxatives, medicine to lower Opana levels in the blood, medicine to reverse the effect of the Opana or a tube through inserted the mouth into the stomach to wash out the stomach. Overdose symptoms include:

  • Difficulty Breathing or Breathing that has Slowed or Stopped.
  • A Blue Tint around the Eyes, Lips, or Fingernails.
  • Cold, Clammy Skin.
  • Change in Pupil Size.
  • Limp or Weak Muscles.
  • Extreme Sleepiness.
  • Loss of Consciousness, Coma.

Learn More About Opana Overdose


Opana is a Schedule II drug, which means it carries a significant risk for abuse and physical as well as psychological dependence. Pharmaceutical companies legally manufacture Opana for licit use as a pain reliever but abusers obtain Opana through forged prescriptions, bogus prescription call-ins to pharmacies, "doctor shopping" as well as theft from pharmacies and friends. Read More About Opana Abuse


You might experience uncomfortable withdrawal symptoms after you stop taking Opana, especially if you have been using high doses or taking this narcotic pain reliever for a long time. Symptoms vary in intensity from person to person. Withdrawal is a normal, predictable, physical sign of chemical dependency and not necessarily a sign of willful abuse. Withdrawal symptoms may prevent you from successfully quitting Opana without medical assistance. Talk with your doctor or professional rehabilitation specialist to learn how to successfully stop Opana dependence by minimizing withdrawal symptoms. Withdrawal symptoms include:

  • Restlessness.
  • Watery Eyes,
  • Runny Nose.
  • Yawning.
  • Sweating.
  • Chills.
  • Muscle, Joint or Back Pain.
  • Enlarged Pupils.
  • Irritability.
  • Anxiety.
  • Weakness.
  • Stomach Cramps.
  • Difficulty Falling Asleep or Staying Asleep.
  • Nausea.
  • Vomiting.
  • Diarrhea.
  • Loss of Appetite.
  • Fast Heartbeat.
  • Fast Breathing.


Dependency and addiction to Opana is often difficult to overcome on your own, especially if you have been taking large doses or using these opioids for a long time. Fortunately, there are in-patient and out-patient treatment facilities where trained professionals can minimize withdrawal symptoms, detoxify your body and give you the tools you need to live drug-free. Detoxification, rehabilitation and counseling are effective therapies to treat addiction to Opana and other opiates. Learn More About Opana Detoxification Programs


Keep Opana in a tightly sealed container, away from excessive heat and moisture. Do not keep this drug in your bathroom or car. Store Opana where children or pets cannot accidently consume the product. Keep Opana where adults cannot take the drug accidentally or on purpose. Do not give Opana to another person, especially to a person who has had a history of substance abuse. Keep track of your medication, taking note of any missing doses.

Read More About Storing Opana