Healthcare providers prescribe Magnacet to relieve moderate to moderately severe pain.

Learn More about Magnacet Uses

Other, off label uses for this medicine

Magnacet contains acetaminophen, sometimes used to reduce a fever.

More Off-Label Uses for Magnacet


Each Magnacet tablet contains oxycodone hydrochloride and acetaminophen. Magnacet is available in several strengths, including 400 mg of acetaminophen and varying amounts of oxycodone HCl.

The typical dose for Magnacet containing 5 mg of oxycodone is one tablet every six hours as needed for pain, not to exceed 10 tablets in one 24-hour period. The usage dose for Magnacet containing 7.5 mg of oxycodone is one tablet every six hours as needed for pain, not to exceed eight tablets in one day. The normal dose for Magnacet containing 10 mg of oxycodone is one tablet every six hours as needed for pain, not to exceed 6 tablets in a single 24-hour period.

Magnacet is available by prescription only. The U.S. Drug Enforcement Agency, or DEA, forbids refills of Magnacet; the prescribing physician must write a new prescription when the patient needs more medicine.

Doctors typically suggest you only take Magnacet when you need it for pain, rather than on a fixed schedule. If your physician recommends you take Magnacet on a schedule to provide round-the-clock pain relief and you miss a dose, take the missed dose as soon as you can. If it is nearly time to take another tablet and you can tolerate the pain, skip the missed dose and resume your normal schedule.

Take Magnacet with a large glass of water to prevent the tablet from sticking in your throat.

Drink six to eight glasses of water each day you take Magnacet to reduce constipation. Talk to your doctor or a nutritionist about other ways to reduce constipation, such as increasing your intake of dietary fiber. Do not use a laxative or stool softener without first checking with the prescribing physician.

Read More about Magnacet Administration and Dosage


When cells are injured by trauma or illness, they release the chemical prostaglandin. This chemical binds to special nerve endings that transmit the message to the brain that something has gone wrong. After the brain receives and interprets the message, it responds by perceiving pain, creating inflammation at the site of injury and increasing your body temperature.

The oxycodone in Magnacet relieves pain by binding to the nerve endings, sending messages of pleasure and euphoria to the brain in such a way that overrides any signals of pain.

The acetaminophen in Magnacet slows the production of prostaglandins. Acetaminophen is a less potent pain reliever than oxycodone but the two medicines work better together than either drug could alone.

Along with pain relief, opioids such as Magnacet calm anxiety and cause feelings of relaxation and euphoria - they get you high.

The opioids in Magnacet cause respiratory depression, which is slow and shallow breathing, by acting directly on respiratory centers in the brain. Magnacet depresses your cough reflex by directly affecting your cough center in the brain stem.

The oxycodone in Magnacet also acts on smooth muscle organs, including those in your intestines, in a way that slows down bowel movements and causes constipation.

More about How Magnacet Works


Magnacet and other opioids may mask symptoms in patients with acute abdominal conditions. The oxycodone in Magnacet may aggravate or induce seizures in those with convulsive disorders.

Tell your doctor and pharmacist about any allergies to oxycodone, acetaminophen, another opioid such as morphine or codeine, or any other medication. An allergic reaction is a serious and potentially fatal medical emergency that requires immediate professional care. If you think you are having an allergic reaction to Magnacet, seek medical assistance immediately.

Symptoms of an allergic reaction include rash, hives, itching, difficulty breathing and tightness in the chest. Other symptoms include swelling of the face, mouth, lips or tongue.

Magnacet, like other opioids, can cause constipation. Drink six to eight full glasses of water each day you take Magnacet to soften stool. Ask your healthcare provider or dietician about ways to increase your intake of dietary fiber, known to ease constipation. Do not use a laxative or stool softener without first discussing it with a doctor.

You may not be able to take Magnacet, or the prescribing physician may adjust your Magnacet dose, if you have a history of certain medical conditions. Your condition may change the way Magnacet works for you, or this medication may worsen your illness or interfere with treatment.

Tell your physician about any significant illnesses or conditions, including:

  • Addison's Disease or Other Adrenal Gland Disorder
  • Asthma
  • Breathing Disorders
  • COPD
  • Curvature of the Spine
  • Enlarged Prostate
  • Epilepsy or Other Seizure Disorder
  • History of Drug or Alcohol Addiction
  • History of Head Injury or Brain Tumor
  • Liver or Kidney Disease
  • Low Blood Pressure
  • Mental Illness
  • Sleep Apnea
  • Stomach, Intestinal or Pancreas Disorder
  • Underactive Thyroid
  • Urinary Problems

Magnacet can make you dizzy or drowsy, or impair your ability to make decisions. Do not drive a motor vehicle or operate heavy equipment until you know how Magnacet affects you.

Do not drink alcoholic beverages or use products that contain alcohol while taking Magnacet. Consuming alcohol while taking opioids may cause serious side effects, liver damage or even death. Read the labels of foods, beverages and medications to determine if the product contains alcohol. Ask your pharmacist for help if you are not sure if a product contains alcohol.

The acetaminophen in Magnacet may cause false values in medical laboratory tests, such as the urine test for the presence of sugar. If you are a diabetic and notice a change in your glucose levels while taking Magnacet, talk with a physician.

Tell the prescribing physician if you normally drink more than three alcoholic beverages each day. Let your healthcare provider know if you have ever had cirrhosis, sometimes called alcoholic liver disease. You may not be able to use Magnacet or other drugs that contain acetaminophen. Chronic alcoholics should limit acetaminophen intake to less than 2000 mg per day.

Tell your surgeon or dentist that you use Magnacet before you have any procedures done. They may request you stop taking Magnacet for a short time before the procedure.

Using opioids such as Magnacet poses a risk for the development of dependence or addiction, especially if you use Magnacet for more than a few weeks or if you take high doses. The severity and duration of withdrawal symptoms and the behavioral manifestations of addiction makes it difficult to stop taking Magnacet. To reduce your risk for dependence or addiction, take only as much Magnacet as you need to relieve your pain. Stop using this medication when you no longer need it or when a physician recommends you stop.

Notify the prescribing physician if your current dose of Magnacet stops working to relieve your pain, as this is a sign that your body is becoming tolerant to the effects of Magnacet. To avoid dangerous overdose, side effects, dependence and addiction, do not increase your dose or take Magnacet more frequently without the consent of the prescribing physician. Your healthcare provider may adjust your dosing schedule or recommend a different analgesic.

The oxycodone in Magnacet may be habit-forming. Tell your doctor if you experience flu-like symptoms or cravings when you do not take Magnacet: these may be a sign of dependence or addiction.

Read More about Magnacet Precautions


Acetaminophen use is associated with cases of acute liver failure, sometimes resulting in liver transplant and death. Most of these cases are associated with taking more than 4,000 mg of acetaminophen per day and frequently involve using multiple products containing acetaminophen.

Patients with significant respiratory depression should not use Magnacet in an unmonitored setting or in a location without lifesaving resuscitation equipment. Those with bronchial asthma or other breathing problems should not take Magnacet. Do not use Magnacet where the use of opioids is not recommended, such as in people with suspected or confirmed paralytic ileus, a dangerous digestive disorder.

The FDA has categorized Magnacet as a pregnancy category C, which means doctors do not yet know how Magnacet may affect an unborn child. Taking Magnacet during pregnancy may result in breathing problems and withdrawal symptoms in a newborn.

Before you take Magnacet, tell your doctor if you are pregnant or plan to become pregnant while using this medication; she will discuss with you the risks and benefits of taking Magnacet during pregnancy.

The oxycodone and acetaminophen in Magnacet passes into breast milk and could harm a nursing baby. Do not use this medication while breastfeeding.

When it is time to stop using Magnacet, wean yourself from this medication gradually by taking your doses further apart. Sudden cessation will cause withdrawal symptoms in patients whose bodies have grown dependent on Magnacet. More Warnings about Using Magnacet

Drug Interactions

Magnacet may interact with other drugs in unsafe or unfavorable ways. Do not take Magnacet with any other opioid painkillers, sedatives, tranquilizers, sleeping pills, muscle relaxers or other medicines that can cause drowsiness or slow your breathing. Dangerous adverse reactions may result. Tell your doctor about all other medicines you use. It is especially important to tell the prescribing physician if you use glycopyrrolate (Robinul) or mepenzolate (Cantil). Notify your healthcare provider if you use atropine (Donnatal), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine) or scopolamine (Transderm-Scop). Make sure the prescribing physician knows if you are taking any bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare). Talk about your use of a bronchodilator such as ipratropium (Atrovent) or tiotropium (Spiriva). It is important the doctor knows about your use of irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), or propantheline (Pro-Banthine).

Give the prescribing physician and pharmacist filling the order a complete list of everything you take, including prescriptions, over-the-counter preparations, vitamins, supplements and herbal remedies. Do not start, stop or change the dosage of any medications while you are taking Magnacet, including all prescription and non-prescription drugs.

More Drug Interactions

Side effects

Most people do not experience side effects while taking Magnacet but, as with all medications, some individuals suffer non-serious and serious adverse reactions to this medication. Most non-serious side effects subside after continued use.

Continue taking Magnacet but tell your physician if any of the non-serious side effects become intolerable or if they do not go away on their own.

Common side effects include:

  • Dizziness
  • Drowsiness or Sedation
  • Lightheadedness
  • Mild Nausea and Vomiting
  • Upset Stomach
  • Constipation
  • Blurred Vision
  • Dry Mouth

Some side effects are serious and require the immediate attention of a medical professional. Stop taking Magnacet and talk to a doctor right away if you experience any serious adverse reactions while taking Magnacet.

Serious side effects include:

  • Shallow Breathing
  • Slow Heartbeat
  • Feeling Light-Headed or Fainting
  • Confusion, Unusual Thoughts or Behavior
  • Seizure
  • Problems Urinating
  • Upper Stomach Pain
  • Itching
  • Loss of Appetite
  • Dark Urine
  • Clay-Colored Stools
  • Yellowing of the Skin or Eyes

Learn More about Magnacet Side Effects


An overdose of Magnacet is a serious, life threatening medical emergency. If you think you or someone you know is suffering from Magnacet overdose, call local poison control center at 1-800-222-1222 or go to the nearest emergency department.

Emergency department doctors and nurses administer drugs such as naloxone to lower Magnacet levels in the blood and perform other emergency, life-saving treatments, like establishing an airway, pumping the stomach or performing CPR as necessary. Medical personnel will monitor the patient's condition, as the effects of the opioids in Magnacet sometimes outlast the therapeutic effect of naloxone.

An individual may overdose on the opioid or the acetaminophen contained in Magnacet. Overdose of either substance is a serious medical emergency. Acetaminophen overdose and opioid overdose cause different sets of symptoms.

The symptoms of acetaminophen overdose come in two waves. The first symptoms of acetaminophen overdose include:

  • Confusion
  • Loss of Appetite
  • Nausea
  • Stomach Pain
  • Sweating
  • Vomiting
  • Weakness

Later symptoms may include:

  • Dark Urine
  • Upper Abdominal Pain
  • Yellowing of the Skin or Eyes

Symptoms of opioid overdose include extreme drowsiness, muscle weakness, fainting, weak pulse, slow heart rate and coma. Other opioid overdose symptoms include pinpoint pupils, cold and clammy skin, blue lips, shallow breathing or no breathing at all.

Learn More about Magnacet Overdose


Oxycodone, one active ingredient in Magnacet, is a favorite among recreational users because of the way this opioid gets them high. Abusers purchase opioids such as Magnacet on the street, by presenting fake prescriptions to pharmacies, getting prescriptions from multiple doctors or by stealing from friends, family members or even pharmacies and hospitals in a process the U.S. Drug Enforcement Agency, or DEA, calls "diversion."

Recreational users rarely abuse acetaminophen because it provides no pleasant euphoric effect. However, acetaminophen is a common ingredient in many opioid preparations and over-the-counter medications; abuse can lead to dangerous acetaminophen overdose

Long-term Magnacet abuse leads to physical dependence and addiction to opioids in some people.

Read More about Magnacet Abuse


If you have taken Magnacet for a long time, or have used high doses, you may feel unpleasant withdrawal symptoms when you stop taking Magnacet.

Withdrawal is a normal and predictable sign of physical dependency and not necessarily a sign of unlawful abuse. The appearance of withdrawal symptoms is a normal, physiological consequence of a sudden drop in the level of Magnacet in the body of a person who is physically dependent on opioids.

Your body adapts to the presence of foreign substances, including Magnacet, by altering its own chemical balance to accommodate those drugs. The body may eventually become tolerant of these substances, which means a person must take an ever-increasing amount of opioids to relieve pain or get high. With continued use, the body may grow dependent on the chemical, meaning the person must maintain a certain level of Magnacet for his body to feel "normal." If the individual's level of Magnacet drops rapidly, his body struggles to maintain its chemical balance. This chemical struggle manifests itself through uncomfortable, flu-like withdrawal symptoms.

Uncomfortable physical withdrawal symptoms can last five or more days as the levels of Magnacet toxins slowly decrease; psychological symptoms of withdrawal may last much longer. Symptoms vary in intensity, depending on the duration of use and dosage strength. These withdrawal symptoms may be severe enough to keep some individuals from quitting Magnacet without the help of a qualified rehabilitation specialist.

Withdrawal symptoms include:

  • Agitation
  • Goosebumps
  • Nausea, Vomiting and Diarrhea
  • Runny Nose
  • Sweating

More about Magnacet Withdrawal


Detoxification is the medical process of lowering opioid levels in a person who is physically dependent upon this class of drugs. Detoxification happens either because the dependent person did not take enough Magnacet or because he has taken a medication to reduce opioid levels. Detoxification in a dependent person will cause painful withdrawal symptoms, especially in those who attempt self-detoxification without the help of medical professionals.

Magnacet dependence and addiction is often difficult to overcome alone, especially if you have been taking large doses of Magnacet or using this opioid analgesic for a long time. Rapid Detox is the most humane and efficient way to cleanse the body of opioids such as the oxycodone found in Magnacet. During rapid detox, board certified anesthesiologists administer sedatives and anesthesia along with the other drugs that bring opioids to safe levels. The patient dozes comfortably in a "twilight sleep" during rapid detox and awakens without any recollection of the withdrawal process. Learn More about Magnacet Detoxification Programs


Store Magnacet at temperatures between 68 degrees and 77 degrees Fahrenheit it its original tight, light resistant container with a child-resistant lid.

Put Magnacet where children and pets cannot access it. Keep Magnacet in a safe location, where adults cannot consume this medication by accident or on purpose.

It is illegal to share prescription medication such as Magnacet, even if the other person has symptoms similar to your own.

Flush unused Magnacet down the toilet when you no longer need the medication or when a doctor suggests you stop using it.

Read More about Storing Magnacet