• Generic Name or Active Ingridient: Levorphanol
Drug Class: Levorphanol > Fully Synthetic Opioid > Opioids > Opioid Agonist > Analgesic.


Levorphanol is a powerful opioid prescribed to control moderate to severe pain. This drug is also used for pain management before surgery. The brand name of levorphanol is Levo-dromoran.

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Levorphanol is available in tablet, solution and injection forms. Each 1 ml ampul, milliliter in a 10 mL vial and tablet contain 2 mg of levorphanol tartrate. Levorphanol is normally injected at your doctor's office, hospital or clinic. If you are authorized to administer levorphanol tablets, solution or injections in your home, follow the instructions taught to you by your doctor or health care provider. If you miss a dose, take another dose as soon as you think of it. Do not use two doses in an effort to catch up.

Elderly patients may be more sensitive to the effects of levorphanol. Levorphanol is not recommended for children under the age of 18. It is not known if levorphanol will harm your unborn child. Do not take levorphanol while breastfeeding; it is unknown if levorphanol is excreted in breast milk.

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Levorphanol reduces pain by binding to receptors in the brain and nervous system, changing the way you perceive pain. More About How Levorphanol Works


Tell your doctor if you are allergic to levorphanol or any other medication. Do not take levorphanol if you have taken MAO inhibitors within the previous 14 days. Taking levorphanol before MAO inhibitors clear your system can have severe consequences. Do not use levorphanol if you take GHB or a narcotic agonist/antagonist medicine like pentazocine. Avoid using levorphanol if you are having an asthma attack, suffer severe asthma or have severe diarrhea caused by antibiotic use.

Levorphanol may impair your thinking. Do not operate heavy machinery, drive a car or perform risky tasks until you know how your system reacts to levorphanol. Avoid activities that require you to be alert and awake.

This drug can be habit-forming, especially if you take it for long periods of time.

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Seek emergency medical care if you suffer an allergic reaction to levorphanol or similar drugs, like morphine. Symptoms include hives, difficulty breathing and swelling of your face, lips, tongue or throat. Tell your doctor about your medical history. Be sure to include severe breathing problems, especially respiratory depression, severe or acute asthma and certain bowel diseases like paralytic ileus or toxic megacolon. Discuss any history you may have of intoxication with medications that slow the nervous system or your breathing or central nervous system and respiratory depressants such as alcohol, tranquilizers or sedatives.

Do not consume alcohol while taking levorphanol. Drinking alcohol may worsen side effects associated with levorphanol or even cause death. Check food and medicine labels to make sure they do not contain alcohol.

Stopping levorphanol use suddenly may cause unpleasant withdrawal symptoms. Whenever possible, wean yourself from levorphanol by taking smaller doses further apart. If you cannot comfortably stop using levorphanol, consult with your doctor or qualified in-patient or out-patient rehabilitation center.

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Drug Interactions

Some drugs may interact with levorphanel. Tell your doctor about all prescription drugs, over the counter medicines and herbal remedies you are taking. Cimetidine, MAO inhibitors GHB may increase levorphanol side effects. Naltrexone or narcotic agonist/antagonists may decrease the effectiveness of levorphanol. Antihistamines, barbiturates, muscle relaxants, other narcotic pain medicines , phenothiazines, sleeping medicines, or tricyclic antidepressants may cause severe side effects, such as severe drowsiness, low blood pressure or trouble breathing.

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Side effects

You may experience side effects while taking levorphanol. Seek medical treatment right away if you experience serious side effects. Contact your physician if mild side effects become acute or don't go away on their own. Serious side effects include:

  • Shallow Breathing.
  • Slow Heartbeat.
  • Seizure.
  • Cold, Clammy Skin.
  • Confusion.
  • Severe Weakness or Dizziness.
  • Feeling Light-headed, Fainting.

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If you suspect that you or someone you know has taken an overdose of levorphanol, seek emergency assistance immediately. Overdose is a serious and potentially life-threatening situation. Contact your local poison control center at 1-800-222-1222 or go to the emergency room. Overdose symptoms include:

  • Cold and Clammy Skin.
  • Deep Sleep.
  • Dizziness.
  • Drowsiness.
  • Lightheadedness.
  • Loss of Consciousness.
  • Slowed Breathing.
  • Slowed Heartbeat.

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Levorphanol is a Schedule II drug, which means it carries a significant risk for abuse and physical as well as psychological dependence. Pharmaceutical companies legally manufacture Levorphanol for licit use as a pain reliever but abusers obtain levorphanol through forged prescriptions, bogus prescription call-ins to pharmacies, "doctor shopping" as well as theft from pharmacies and friends. Tell your doctor if levorphanol stops relieving your pain – your tolerance to levorphanol may be rising. Do not take extra doses in an attempt to relieve pain, as this may cause physical and psychological dependence leading to addiction. Read More About Levorphanol Abuse


You may experience unpleasant withdrawal symptoms when you stop taking levorphanol, especially if you have been using high doses or taking the opioid for a long period of time. Symptoms vary in intensity. Withdrawal is a normal, predictable, physical sign of dependency, not necessarily a sign of willful abuse. Withdrawal symptoms may prevent you from quitting levorphanol without medical assistance. Withdrawal symptoms include:

  • Anxiety.
  • Diarrhea.
  • Fever.
  • Runny Nose or Sneezing.
  • Goose Bumps and Abnormal Skin Sensations.
  • Nausea.
  • Vomiting.
  • Pain.
  • Rigid Muscles.
  • Rapid Heartbeat.
  • Hallucinations.
  • Shivering or Tremors.
  • Sweating.
  • Trouble Sleeping.


Dependency and addiction to levorphanol is often difficult to overcome on your own, especially if you have been taking large doses or using these opioids for a long time. Fortunately, there are in-patient and out-patient treatment facilities where trained professionals can minimize withdrawal symptoms, detoxify your body and give you the tools you need to live drug-free. Detoxification, rehabilitation and counseling are effective therapies to treat addiction to levorphanol and other opiates.

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Keep levorphanol away from excessive heat and moisture. Do not keep this drug in your bathroom or car. Store levorphanol away from children, pets and adults who might accidently or purposeful consume the drug. Do not share levorphanol with others, especially with individuals with a history of alcohol or drug abuse. Keep track of your medication, taking note of any missing doses.

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