Hydrocodone, Pseudoephedrine, Triprolidine

Drug Class: Hydrocodone, Pseudoephedrine, Triprolidine > Hydrocodone > Semi Synthetic Opioid > Opioids > Opioid Agonist > Analgesic.


Hydrocodone, pseudoephedrine and triprolidine combination are effective for reducing symptoms associated with the common cold, allergies or upper respiratory bacterial or viral infections. Symptoms include coughing, sneezing, runny nose, congestion and itchy, watery eyes. Use this medication at night to prevent symptoms from awakening you or during the day so you can go to work or attend school. Learn More About Hydrocodone, Pseudoephedrine, Triprolidine Uses


Pharmacologists combine hydrocodone, pseudoephedrine and triprolidine into one single medication, known as a polydrug. Hydrocodone, pseudoephedrine and triprolidine is sold under the brand name Zymine HC. This polydrug is available in a liquid form to be taken by mouth.

Take hydrocodone, pseudoephedrine and triprolidine as directed. Use an approved medical dosing spoon to administer this medication; a household spoon is inaccurate and may result in dosing errors or overdose.

Follow the pediatrician's recommendations when administering hydrocodone, pseudoephedrine and triprolidine to a child between the ages of 6 and 12 years.

Children, elderly people or debilitated patients may be more sensitive to the effects of this drug. This medication may cause excitability in some children. Physicians should prescribe smaller initial doses and observe these patients closely until tolerance is established.

You may or may not have to take this medication on a regular basis; the prescribing physician may have recommended you take hydrocodone, pseudoephedrine and triprolidine only when you need relief from symptoms. If your healthcare provider prescribed this polydrug to be taken on a schedule and you miss a dose, take the missed dose as soon as possible. If it is almost time to take another dose and you can tolerate the symptoms, skip the missed dose and resume your normal schedule. Contact the prescribing physician if you have trouble maintaining the dosing schedule.

Take hydrocodone, pseudoephedrine and triprolidine with or without food. Consume this drug with food if this medication causes stomach upset.

Do not take more than the recommended dose, or take the medication more frequently than prescribed, in an effort to relieve symptoms; doing so may result in a dangerous drug overdose. Contact the prescribing physician if the prescribed hydrocodone, pseudoephedrine and triprolidine does not work or if it stops working to relieve your symptoms - you may have developed an increased tolerance to opioids. Your physician can adjust the prescribed dosage or choose a different medication.

Stop taking this medication when your doctor recommends you discontinue use. Continuing to use medications that contain opioids such as hydrocodone on a long-term basis may cause dependence on that drug.

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Hydrocodone, pseudoephedrine and triprolidine is a polydrug containing a cough suppressant, a decongestant and an antihistamine. Hydrocodone is a cough suppressant. It works directly on the medulla, the part of your brain responsible for the cough reflex. Hydrocodone makes your brain unaware of the need to cough. Pseudoephedrine is a decongestant. It works by constricting the blood vessels inside the lining of the nasal cavity to clear nasal congestion. Triprolidine is an antihistamine that relieves a runny nose, sneezing and itchy, watery eyes. Your body reacts to invading allergens, like pollen and dust, by producing histamines. Histamines cause small blood vessels to widen, allowing fluid to pass from the bloodstream into the surrounding tissues in a way that causes nasal symptoms, watery eyes, runny nose and sometimes hives. Histamines also indirectly stimulate the production of thick, sticky mucus. Antihistamines such as triprolidine reduce the level of symptom-causing histamines.

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Do not take hydrocodone, pseudoephedrine and triprolidine polydrugs if you are allergic to any active or inactive ingredient. Do not take this drug if you are allergic to another narcotic, such as morphine. Get immediate medical assistance at the onset of symptoms of an allergic reaction; a person's condition can worsen quickly and without warning. Common symptoms of a mild allergic reaction include hives, especially over the face and neck, nasal congestion, itching, rashes and watery, red eyes.

Anaphylaxis is a very serious, potentially deadly, type of an allergic reaction that usually occurs within minutes of exposure. Without professional medical intervention, death from anaphylaxis can occur within 15 minutes of contact.

Symptoms of a moderate or severe allergic reaction include:

  • Abdominal Pain
  • Chest Discomfort or Tightness.
  • Difficulty Breathing or Wheezing.
  • Difficulty Swallowing.
  • Dizziness or Light-Headedness.
  • Fear or Feeling of Apprehension or Anxiety.
  • Flushing or Redness of the Face.
  • Nausea, Vomiting or Diarrhea.
  • Palpitations.
  • Stomach Cramps.
  • Swelling of the Face, Eyes or Tongue.
  • Unconsciousness.
  • Weakness.

Tell your physician about any significant illnesses or conditions, including glaucoma, kidney disease, an enlarged prostate or problems with urination. Hydrocodone, pseudoephedrine and triprolidine polydrugs may worsen these conditions or interfere with treatment. These ailments may change the way hydrocodone, pseudoephedrine and triprolidine polydrugs work in your system.

Hydrocodone, pseudoephedrine and triprolidine polydrugs may make you dizzy or drowsy, or impair decision-making. Do not drive a car, operate heavy machinery or engage in potentially risky behavior until you know how this drug affects you. Some medications, such as cold and allergy drugs, sedatives, sleep aides, muscle relaxers and antidepressants may enhance this effect. Alcohol can add to drowsiness associated with antihistamine use.

Hydrocodone is known to be habit-forming. Do not take this medication longer than 5 to 7 days, or take doses larger than prescribed to avoid developing a drug habit.

Avoid becoming dehydrated or over-heated during exercise or hot weather while taking medications containing triprolidine.

Hydrocodone, pseudoephedrine and triprolidine may affect the outcome of certain allergy skin tests. Tell the ordering physician or allergist performing the skin tests that you have taken hydrocodone, pseudoephedrine and triprolidine when you make the appointment. You may have to stop taking this medication for a few days or reschedule the skin test.

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Research has not yet established the harm this preparation may do to an unborn child. Tell the prescribing physician if you are pregnant or plan to become pregnant while taking hydrocodone, pseudoephedrine and triprolidine polydrugs. Contact your doctor immediately if you become pregnant while taking this drug. Hydrocodone can pass into breast milk and onto a nursing baby. Do not breast feed a baby while taking this medication.

Do not stop taking this medication suddenly unless warned to do so by a physician. Quitting abruptly may cause unpleasant withdrawal symptoms, especially if you have been taking high doses of hydrocodone or using this drug for a long time. Try weaning yourself from this opioids by taking successively smaller doses further apart.

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Drug Interactions

Hydrocodone, pseudoephedrine and triprolidine polydrugs may interact with other medications in unsafe or unfavorable ways. Give the prescribing physician and pharmacist filling the prescription a list of all your medications, including all prescriptions, vitamins, over-the-counter preparations and herbal remedies. Do not start, stop or change the way you take any drug while taking hydrocodone, pseudoephedrine and triprolidine without first consulting a doctor.

It is especially important that the practitioner and druggist know if you are already taking an antidepressant or a diuretic, commonly known as a water pill. Tell your healthcare team if you are taking medication to treat irritable bowel syndrome or bladder or urinary medications such as oxybutynin or tolterodine, known by the brand names Ditropan, Oxytrol and Detrol. Let your healthcare providers know if you are taking aspirin or salicylates such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others. Do not take hydrocodone, pseudoephedrine and triprolidine polydrugs if you have taken an MAO inhibitor in the previous 14 days. Examples of generic MAO inhibitors include isocarboxazid, phenelzine, rasagiline, selegiline and tranylcypromine. Brand names of these medications include Marplan, Nardil, Azilect, Eldepryl, Emsam and Parnate.

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Side effects

Some patients report side effects when taking hydrocodone, pseudoephedrine and triprolidine polydrugs. Most of the commonly reported side effects are not serious. Tell the prescribing physician if your common side effects become intolerable or if they don't go away.

  • Abdominal Pain.
  • Constipation
  • Decreased Sweating.
  • Difficulty Urinating.
  • Drowsiness.
  • Dry Mouth, Nose or Throat.
  • False Sense of Well-Being.
  • Feeling Dizzy or Light-Headed.
  • Increased Sensitivity of Skin to Sun.
  • Insomnia.
  • Nausea or Vomiting.
  • Nightmares.
  • Thickening Of Mucus.
  • Unusual Excitement, Nervousness, Restlessness or Irritability.
  • Unusual Tiredness or Weakness.

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Drug overdose is a serious, potentially fatal medical emergency. Deaths from drug overdoses are on the rise in the United States; overdose deaths have more than tripled since 1990. Most of these deaths were the result of prescription drug overdoses, claiming the lives of more than 36,000 people in 2008. If you think you or someone you know has taken a drug overdose, you must act quickly. Contact poison control center at 1-800-222-1222 or go directly to the emergency room. Overdose symptoms include:

  • Cold, Clammy Skin.
  • Limpness.
  • Pinpoint Pupils of Eyes.
  • Seizures.
  • Severe Confusion.
  • Severe Drowsiness or Dizziness.
  • Severe Nervousness or Restlessness.
  • Sleepier than Usual.
  • Slow Heartbeat.
  • Slow or Difficulty Breathing.

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Drug abuse means to habitually take addictive or illegal drugs. You can abuse drugs by taking medication for recreational purposes or by continuing to take a drug after your physician has discontinued the prescription. You can also abuse drugs by taking large doses of a drug or taking it more often than prescribed. Hydrocodone is one of the most abused recreational drugs in the United States because of the way it gets recreational users high and because it is one of the most widely prescribed pain medication today. Abusers get hydrocodone and other drugs by filing bogus prescriptions at pharmacies, visiting multiple practitioners, buying it on the street or by stealing it.

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Withdrawal is not necessarily an indication of criminal drug abuse or weak moral character. Overcoming withdrawal is not a matter of discipline or strength. Withdrawal is a normal, predictable result of using some types of medications, especially opioids. Consult with your healthcare provider or contact a rehabilitation clinic if your withdrawal symptoms prevent you from quitting hydrocodone use.

Withdrawal symptoms include:

  • Anxiety.
  • Diarrhea.
  • Fever, Runny Nose or Sneezing.
  • Goose Bumps and Abnormal Skin Sensations.
  • Hallucinations.
  • Nausea and Vomiting.
  • Pain.
  • Rapid Heartbeat.
  • Rigid Muscles.
  • Shivering.
  • Sweating.
  • Tremors.
  • Trouble Sleeping.


Drug dependence is a complicated condition, often requiring the aid of qualified rehabilitation professionals to overcome. The most successful rehabilitative treatment programs attend to each aspect of the complex syndrome of drug dependence, including overcoming overpowering withdrawal symptoms, detoxifying your body from the effects of the drug and then addressing any social issues that contribute to drug dependence. During the initial stages of rehabilitation, practitioners administer drugs to detoxify and cleanse your system while easing your withdrawal symptoms. Once you are physically stabilized, you may participate in counseling or other social programs to work on any issues that lead to or is the result of your dependence on drugs, such as family problems or legal issues. Rapid detox is state-of-the-art, humane and extremely effective way to overcome withdrawal from opioids. During rapid detox, physicians administer anesthesia and sedatives alongside medicine to detoxify your system. You slumber through the withdrawal procedure, oblivious to the unpleasant withdrawal symptoms. When you wake up, you will have no recollection of withdrawal. Learn More About Hydrocodone, Pseudoephedrine, Triprolidine Detoxification Programs


Store hydrocodone, pseudoephedrine and triprolidine polydrugs at room temperature, away from excessive heat, light and moisture. Do not keep this drug in your bathroom or car. Put hydrocodone, pseudoephedrine and triprolidine out of the reach of children and animals. Do not allow adults to willfully or mistakenly consume this produce. Hydrocodone is a favorite among drug abusers who may be tempted to steal your medicine - do not tell anyone but your healthcare providers that you have this drug in your home. Do not share this medicine with others, even if their symptoms are similar to yours.

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