Hydrocodone, Guaiacolsulfonate

Drug Class: Hydrocodone, Guaiacolsulfonate > Hydrocodone > Semi Synthetic Opioid > Opioids > Opioid Agonist > Analgesic.


Doctors prescribe hydrocodone and guaiacolsulfonate to relieve cough plus throat and airway irritation caused by the common cold, flu or hay fever. Your physician may recommend hydrocodone and guaiacolsulfonate preparations, known as polydrugs, to reduce annoying symptoms so you can sleep at night and participate in work or school. This product will not cure your illness nor shorten its duration but it will make you feel better. Learn More About Hydrocodone, Guaiacolsulfonate Uses

Other, off label uses for this medicine

Healthcare providers may recommend hydrocodone and guaiacolsulfonate polydrugs to reduce cough and other symptoms caused by breathing illnesses such as bronchitis and sinusitis. While physicians do not normally prescribe hydrocodone and guaiacolsulfonate to treat coughs due to smoking, asthma or emphysema but your doctor may suggest you try this medication to treat those types of chronic coughs.

More Off-Label Uses for Hydrocodone, Guaiacolsulfonate


Hydrocodone and guaiacolsulfonate are available in a syrup form. Take hydrocodone and guaiacolsulfonate by mouth. Pharmacologists mix hydrocodone and guaiacolsulfonate with sugar to create syrup polydrugs; these syrups contain sugars.

Brand name preparations include Entuss and Mintuss NX.

The typical prescription for an adult calls for one dose every four to six hours as needed to reduce symptoms. Your prescription may vary - consult with the prescribing physician and pharmacist filling your prescription for instructions on how often to take your medicine.

Take hydrocodone and guaiacolsulfonate with an entire 8-ounce glass of water to help thin secretions and make them easier to cough up. Take this medication with or without food; take hydrocodone and guaiacolsulfonate with food if it upsets your stomach.

Use an approved medical dosing spoon or cup to measure liquid medicines. Do not use a household spoon, as dosing errors such as inadequate or overdose may occur. You can get a medical dosing device from your drug store or pharmacy.

Pharmacologists do not recommend hydrocodone and guaiacolsulfonate for children under the age of 3 years; some preparations may be suitable for children aged 2 years and older. Consult with your child's pediatrician to find out if hydrocodone and guaiacolsulfonate are right for your child. Always follow dosing instructions and talk with a pediatrician or pharmacist if you do not understand how to give hydrocodone and guaiacolsulfonate to your child.

Misuse of cough and cold preparations in very young children may result in death. Always use an approved measuring device when administering liquid preparations to children. Follow instructions closely; consult with your pediatrician or druggist if you do not understand how to give this medication to your child.

Doctors normally suggest you take hydrocodone and guaiacolsulfonate only when you need to relieve symptoms, rather than on a regular schedule throughout the day. If your prescribing physician suggested you take this polydrug at regular intervals and you miss a dose, take the missing dose as soon as you remember. If it is almost time to take another dose and you can tolerate your cough and congestion, skip the missed dose and resume your regular schedule.

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Hydrocodone and guaiacolsulfonate polydrugs combine a cough suppressant and expectorant. Hydrocodone acts directly on your medulla, the cough center of your brain. Hydrocodone makes your brain unaware of the need to cough. Guaiacolsulfonate is an expectorant that works by thinning secretions to make mucus easier to cough from the lungs. More About How Hydrocodone, Guaiacolsulfonate Works


Do not take hydrocodone and guaiacolsulfonate polydrugs if you are allergic to any active or inactive ingredient in the preparation. Do not use this drug if you are allergic to other opioids, such as codeine or morphine. Tell your doctor and pharmacist about all your allergies. An allergic reaction is a serious event that could deteriorate rapidly into a medical emergency. Seek medical assistance immediately upon the first symptoms of an allergic reaction. Symptoms of an allergic reaction include hives, itching, difficulty breathing and swelling of the face, lips and tongue.

Anaphylaxis is a severe, potentially fatal, form of allergic reaction that can occur within minutes of exposure. Without professional medical assistance, death can occur as soon as 15 minutes after contact with the allergen. About 82,000 cases of anaphylaxis occur in the United States every year. People with asthma have a greater risk for suffering anaphylaxis than are persons without a chronic breathing problem.

Symptoms of a serious allergic reaction include:

  • Stomach Cramps or Abdominal Pain.
  • Chest Discomfort or Tightness.
  • Difficulty Breathing or Wheezing.
  • Difficulty Swallowing.
  • Dizziness or Light-Headedness.
  • Fear or Feeling of Apprehension or Anxiety.
  • Flushing or Redness of the Face.
  • Nausea, Vomiting or Diarrhea.
  • Palpitations.
  • Swelling of the Face, Eyes or Tongue.
  • Weakness.
  • Unconsciousness.

Your healthcare provider may alter the dosage of your hydrocodone and guaiacolsulfonate prescription or choose a different medication to treat your symptoms if you have a history of certain medical conditions. Taking hydrocodone and guaiacolsulfonate polydrugs may worsen your condition or interfere with treatment. Alternately, your ailment may change the way your system deals hydrocodone and guaiacolsulfonate. Tell your physician about any significant illnesses or conditions, including:

  • Addison's Disease.
  • Asthma.
  • Enlarged Prostate.
  • Gallbladder Disease.
  • Head Injury.
  • Kidney Disease.
  • Liver Disease.
  • Seizures or Epilepsy.
  • Thyroid Disorder.
  • Urination Problems.

Hydrocodone and guaiacolsulfonate preparations may make you dizzy or drowsy. This polydrug may impair decision-making. Do not drive a car, ride a bike, operate heavy machinery or engage in potentially risky behavior requiring alertness until you know how this medication affects you. Alcohol and some medications enhance this effect.

Hydrocodone and guaiacolsulfonate may be habit forming. Do not take larger doses of hydrocodone and guaiacolsulfonate or use this medicine longer than recommended by your doctor to reduce your risk for developing a drug habit. To have a drug habit means you are developing physical or mental dependence to that drug.

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Do not take hydrocodone and guaiacolsulfonate if you have recently experienced diarrhea resulting from the use of antibiotics. Do not use hydrocodone and guaiacolsulfonate polydrugs or other cough suppressants to treat a cough with a lot of mucus; hydrocodone makes your brain unaware of the serious need to cough these secretions from your lungs.

The Food and Drug Administration, or FDA, has classified hydrocodone and guaiacolsulfonate polydrugs as pregnancy Category C, which means taking this drug during pregnancy may harm an unborn child. Tell the prescribing physician if you are pregnant or plan to become pregnant while taking this medication. If you discover you are pregnant while taking this medication, consult with your doctor to weigh the benefits of this medication against the potential risk to your unborn baby. Hydrocodone and guaiacolsulfonate pass into breast milk and onto a nursing child. Do not breastfeed a baby while taking this medication.

Do not stop taking hydrocodone and guaiacolsulfonate abruptly unless warned to do so by a physician. Sudden cessation may cause flu-like withdrawal symptoms, especially if you have taken high doses to relieve acute pain or have been using this product for a long time to treat a chronic illness. When your doctor suggests you stop taking hydrocodone and guaiacolsulfonate, wean yourself from this opioid by taking successively smaller doses further apart to lower the amount of narcotics in your system.

More Warnings About Using Hydrocodone, Guaiacolsulfonate

Drug Interactions

Give a list of all your prescription drugs, non-prescription medicines, vitamins and herbal remedies. Do not start, stop or change the way you take any medication while you are using hydrocodone and guaiacolsulfonate without first consulting a doctor or pharmacist. Notify the prescribing physician if hydrocodone and guaiacolsulfonate stops working for you; this may be a sign of increased tolerance to opioids. Some drugs may interact with hydrocodone and guaiacolsulfonate polydrugs in unsafe or unfavorable ways. Cimetidine may increase the risk for side effects associated with hydrocodone and guaiacolsulfonate. Barbiturates and sodium oxybate, commonly known as GHB, increases the risk for severe drowsiness and breathing problems associated with hydrocodone and guaiacolsulfonate. Naltrexone may reduce the efficacy of hydrocodone.

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Side effects

Consumers have reported side effects from hydrocodone and guaiacolsulfonate preparations. Reduce your risk for side effects by taking hydrocodone and guaiacolsulfonate exactly as directed. Most of these side effects are not serious and go away on their own. Contact the prescribing doctor if your side effects become intolerable.

Common side effects include:

  • Blurred Vision.
  • Constipation.
  • Dizziness or Drowsiness.
  • Dry Mouth.
  • Nausea, Vomiting, Upset Stomach.
  • Sweating.

Some side effects associated with hydrocodone and guaiacolsulfonate can be severe. Stop taking this drug and call a doctor immediately if you experience serious side effects.

Serious Side Effects Include:

  • Slow Heart Rate, Weak or Shallow Breathing.
  • Feeling Like You Might Pass Out.
  • Confusion, Fear, Unusual Thoughts or Behavior.
  • Seizure.
  • Urinating Less Than Usual or Not At All.

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Deaths from drug overdose are on the rise. In 2008, there were three times as many deaths from drug overdoses than in 1990. An increasing number of these deaths are from prescription medicines rather than illegal drugs. In 2008, there were more deaths from prescription drugs than from cocaine and heroin combined. If you or someone you know has taken too much hydrocodone and guaiacolsulfonate or any other drug, immediately contact poison control center at 1-800-222-1222 or go to the nearest emergency room. Overdose symptoms include:

  • Blurred Vision.
  • Confusion or Hallucinations.
  • Seizures.
  • Severe Dizziness, Lightheadedness or Headache.
  • Severe Drowsiness Progressing to Stupor or Coma.
  • Unusually Fast, Slow or Irregular Heartbeat.
  • Vomiting.
  • Hypotension.
  • Cold and Clammy Skin.
  • Respiratory Depression.
  • Skeletal Muscle Flaccidity.
  • Breathing that stops.
  • Cardiac Arrest.
  • Death.

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To abuse hydrocodone and guaiacolsulfonate means to use this drug in a different way than recommended or for recreational purposes. The Drug Enforcement Agency, or DEA, states that hydrocodone is the most frequently prescribed opioid in the United States, and it is the most widely abused drug in that country. Abusers get drugs through a process the DEA calls diversion, which means to use a prescription drug for recreational purposes. Three out of four people who misuse prescription drugs abuse a medicine prescribed to someone else. Approximately 55 percent of all prescription drug abusers get free drugs from friends or family, according to the Centers for Disease Control and Prevention, or CDC.

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You may experience unpleasant withdrawal symptoms when you stop taking hydrocodone and guaiacolsulfonate, especially if you have been taking high doses or using this medication for a long time. Withdrawal is a normal and predictable physiological response to sudden cessation of a drug after gaining physical dependence to that drug. Experiencing withdrawal symptoms is not necessarily an indicator of illegal substance abuse; a person can suffer withdrawal after using medically-necessary drugs exactly as prescribed by a doctor. Withdrawal symptoms include:

  • Dilated Pupils.
  • Fast Heartbeat.
  • Goose Bumps.
  • Irritability.
  • Loss of Appetite.
  • Muscle or Bone Pain
  • Restlessness.
  • Runny Nose.
  • Shakiness.
  • Sweating.


Dependence on drugs is a complex condition requiring advanced rehabilitative treatment. During detox, doctors administer medications to ease withdrawal symptoms and other drugs to detoxify your system, restoring your chemical balance to healthy levels. The most acute withdrawal symptoms typically last five days to a week and post acute withdrawal symptoms can last for several weeks more. After successful detoxification, counseling and other social services to address any family, legal or employment issues that may have lead to or compounded by dependence on drugs.

Rapid detox is the newest, most humane detoxification therapy available. During rapid detox, physicians administer anesthetics and sedatives along with the usual anti-withdrawal and cleansing medications. You sleep lightly and comfortably through the unpleasant withdrawal phase and awaken refreshed, unaware of any physical discomfort associated with withdrawal.

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Keep hydrocodone and guaiacolsulfonate at room temperature, between 59 and 86 degrees Fahrenheit, away from excessive heat, moisture and light. Keep this and all medication out of the reach of children and pets. Do not allow adults to take this medication, even if they have symptoms similar to your own. Monitor the amount of hydrocodone and guaiacolsulfonate and account for any missing doses. Hydrocodone is a favorite among drug abusers and is widely diverted from use as a prescription pain reducer to use as a recreational drug.

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