Hydrocodone, Guaiacolsulfonate, Pseudoephedrine

Drug Class: Hydrocodone, Guaiacolsulfonate, Pseudoephedrine > Hydrocodone > Semi Synthetic Opioid > Opioids > Opioid Agonist > Analgesic.


Doctors prescribe guaiacolsulfonate, hydrocodone and pseudoephedrine combination products, known as polydrugs, to relieve symptoms associated with the common cold or respiratory infections caused by bacteria or viruses. This medication reduces cough and nasal congestion so you can sleep, work or go to school without annoying symptoms. This medication will not cure nor shorten the duration of your illness but it will lessen the severity of your symptoms.

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Guaiacolsulfonate, hydrocodone and pseudoephedrine come in a syrup form. Generic guaiacolsulfonate, hydrocodone and pseudoephedrine syrup is available.

Follow the advice of your child's pediatrician when administering medication to your child. Always use a medical dosing device, such as an approved spoon, syringe or cup when administering liquid medications, especially when giving medicine to a child. Do not use a household spoon, as this could lead to ineffective doses or dangerous overdose.

Take guaiacolsulfonate, hydrocodone and pseudoephedrine exactly as prescribed by your doctor. If she has suggested you use this medication on a regular schedule and you miss a dose, take the missed dose as soon as you can. If it is nearly time to take another dose, less than two hours, skip the missed dose and resume your normal schedule.

Take guaiacolsulfonate, hydrocodone and pseudoephedrine syrup with a full glass of water to help loosen and clear mucus from your throat. This medication may make your mouth dry. Drinking water will also prevent this from happening.

Patients over the age of 60 may be more sensitive to the effects of guaiacolsulfonate, hydrocodone and pseudoephedrine.

Guaiacolsulfonate, hydrocodone and pseudoephedrine may cause sleeplessness and nervousness that interferes with your ability to sleep. To avoid this effect, take this medication at least two hours before you plan to go to sleep. If your nervousness and sleeplessness continue to occur, consult with the prescribing physician.

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Guaiacolsulfonate, hydrocodone and pseudoephedrine work in tandem to provide more complete pain relief than either single medication. Guaiacolsulfonate is an expectorant. It thins secretions, making it easier to cough up mucus. Hydrocodone suppresses cough by acting directly on the part of your brain responsible for cough. Hydrocodone makes your brain apathetic about the need to cough. Pseudoephedrine is a decongestant that works by reducing the size of blood vessels lying deep within the lining of your nose. It shrinks these veins and capillaries inside the lining and allows more room for air to flow in your nasal passages. Together, this polydrug provides complete relief for your symptoms. More About How Guaiacolsulfonate, Hydrocodone, Pseudoephedrine Works


Do not take guaiacolsulfonate, hydrocodone and pseudoephedrine preparations if you are allergic to any active or inactive ingredient in the polydrug. Do not take this medication if you are allergic to any opioid, such as codeine or morphine. An allergic reaction is a serious medical crisis that can deteriorate rapidly into a life-or-death emergency. Symptoms of an allergic reaction include hives, itching, trouble breathing or swelling of the face, lips, tongue or throat. Seek professional medical help immediately at the first sign of an allergic reaction; take the bottle of guaiacolsulfonate, hydrocodone and pseudoephedrine with you to help emergency medical personnel understand your medical condition.

The prescribing doctor may change the dosage or frequency at which you take guaiacolsulfonate, hydrocodone and pseudoephedrine, order special medical laboratory tests or suggest a different medication to treat your symptoms if you have a history of or are currently experiencing certain medical conditions. Guaiacolsulfonate, hydrocodone and pseudoephedrine may exacerbate your condition or interfere with treatment of that disorder. Conversely, your illness or treatment for that illness may change the way guaiacolsulfonate, hydrocodone and pseudoephedrine works in your body.

Tell your physician about any significant illnesses or conditions, including:

  • A Recent Head Trauma.
  • Asthma, Emphysema or Other Breathing Problems.
  • Blood Vessel Disease.
  • Chronic Bronchitis.
  • Constipation or Diarrhea.
  • Diabetes.
  • Fever.
  • Glaucoma.
  • Heart Disease.
  • Heart Rhythm Problems.
  • High Blood Pressure.
  • Intestinal or Stomach Problems.
  • Kidney Disease.
  • Liver Disease.
  • Pain or Difficulty Passing Urine.
  • Peripheral Vascular Disease.
  • Prostate Trouble.
  • Thyroid Problems.

Guaiacolsulfonate, hydrocodone and pseudoephedrine may make you feel drowsy or dizzy, especially during initial doses. Use caution when operating motor vehicles or heavy machinery until dizziness and drowsiness dissipate. Stand or sit up slowly to reduce dizziness and the risk for fainting. Drowsiness should decrease after a few days. Alcohol and some medications may enhance this effect.

Do not consume alcohol while taking guaiacolsulfonate, hydrocodone and pseudoephedrine. Alcohol is a common ingredient in food, beverages or medicine. Read all labels to learn if a product contains alcohol. Consult with a pharmacist if you are not certain.

Hydrocodone may be habit forming. Do not take higher doses than prescribed or take your doses more frequently than recommended. Stop using guaiacolsulfonate, hydrocodone and pseudoephedrine when your doctor tells you to. Talk with your doctor if you are unable to quit using guaiacolsulfonate, hydrocodone and pseudoephedrine on your own.

Tell your health care professional if your cough does not improve after seven days. Contact the prescribing physician if you develop a high fever, skin rash or persistent headache while taking guaiacolsulfonate, hydrocodone and pseudoephedrine polydrugs.

Guaiacolsulfonate, hydrocodone and pseudoephedrine may cause dry eyes and blurry vision. This may be uncomfortable for contact wearers. Use lubricating drops to reduce dry eyes. Consult with an optometrist if the problem persists or grows intolerable.

Guaiacolsulfonate, hydrocodone and pseudoephedrine may cause constipation. Drink six to eight full glasses of water each day to soften stool. Try to have a bowel movement at least every two to three days. Consult with your healthcare provider or nutritionist about increasing your intake of dietary fiber, known to benefit digestive regularity. Your physician may suggest using an enema or suppository to promote bowel movements.

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Consult with the prescribing doctor if you are pregnant or plan to become pregnant while taking guaiacolsulfonate, hydrocodone and pseudoephedrine to discuss the benefits and risks for taking this medication while pregnant. Contact your doctor immediately if you become pregnant while taking this drug. Do not breastfeed a child while using guaiacolsulfonate, hydrocodone and pseudoephedrine.

Do not stop taking guaiacolsulfonate, hydrocodone and pseudoephedrine suddenly unless directed to do so by a physician. Abrupt cessation may lead to uncomfortable withdrawal symptoms, especially if you have taken high doses of guaiacolsulfonate, hydrocodone and pseudoephedrine or have used this medication for long time to treat a chronic illness. When it is almost time to discontinue guaiacolsulfonate, hydrocodone and pseudoephedrine, start taking successively smaller doses further apart to reduce the amount of opioids in your system. If you cannot wean yourself from guaiacolsulfonate, hydrocodone and pseudoephedrine, consult with your healthcare provider or rehabilitation specialist.

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Drug Interactions

Some drugs interact with guaiacolsulfonate, hydrocodone and pseudoephedrine in dangerous or adverse ways. Tell the prescribing physician and druggist filling the order about all your medications. Include your prescription and non-prescription medications, vitamins, supplements and herbal remedies. Do not start, stop or change the way you take any medicine, remedy or supplement while taking guaiacolsulfonate, hydrocodone and pseudoephedrine products.

The following drugs interact in unsafe or unfavorable ways with guaiacolsulfonate, hydrocodone and pseudoephedrine:

  • Bicarbonate, Citrate, or Acetate Products, Such As Sodium Bicarbonate, Sodium Acetate, Sodium Citrate, Sodium Lactate, and Potassium Citrate.
  • Caffeine or Stimulant Drugs.
  • Certain Medicines Used for Parkinson's Disease.
  • Chloroquine.
  • Cimetidine.
  • Depression or Psychosis Medications.
  • Diabetes Medications.
  • Diarrhea Medications.
  • Furazolidone.
  • Linezolid.
  • Mao Inhibitors.
  • Procarbazine.
  • Quinacrine.
  • Rifabutin.
  • Rifampin.
  • Ritonavir.
  • Seizure Medications.
  • Sleep or Anxiety Medicines.
  • Some Antihistamines.
  • Some Medicines for Chest Pain, Heart Disease, High Blood Pressure or Heart Rhythm Problems.
  • Some Pain Killers
  • Some Weight Loss Medications.
  • St. John's Wort.
  • Theophylline.
  • Thyroid Hormones.

More Drug Interactions

Side effects

Consumers have reported side effects associated with guaiacolsulfonate, hydrocodone and pseudoephedrine use. Most side effects are not serious and go away on their own. Continue taking your medication but tell the prescribing physician if your non-serious side effects become intolerable or do not go away by themselves.

Common side effects include:

  • Diarrhea or Constipation.
  • Drowsiness.
  • Dry Mouth.
  • Itching.
  • Mild Headache.
  • Stomach Upset or Nausea.

Some side effects can be serious, even life threatening. Discontinue guaiacolsulfonate, hydrocodone and pseudoephedrine use and contact a doctor or emergency department immediately if you experience serious side effects.

Serious side effects:

  • Anxiety or Nervousness.
  • Blurred Vision.
  • Chest Pain or Palpitations.
  • Confusion.
  • Excessive Sweating.
  • Fainting Spells, or Dizziness Which Does Not Go Away.
  • Fast, Slow or Irregular Heartbeat.
  • Increased Blood Pressure.
  • Insomnia.
  • Labored Breathing.
  • Numbness or Tingling in the Hands or Feet.
  • Persistent or Unusual Rash.
  • Severe, Persistent, or Worsening Headache.
  • Tremor.
  • Trouble Passing Urine or No Urine Output.
  • Vomiting.

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Drug overdose is a serious, potentially fatal, medical emergency. Deaths from drug overdose are a growing problem in the United States, with the number of drug overdose deaths tripling between the years of 1990 and 2008. More than 36,000 people died from drug overdose in 2008, and more of these deaths resulted from prescription drugs overdose than from cocaine and heroin combined.

If you suspect that you or someone you know has taken too much guaiacolsulfonate, hydrocodone and pseudoephedrine or any other drug, immediately contact poison control center at 1-800-222-1222 or go to the emergency room.

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Drug abuse is a growing problem in the United States. American physicians are compassionate and prescribe pain relievers to those who need it most. Unfortunately, many people divert medically necessary prescription pain relievers to get high, use an old prescription to treat new symptoms or to use someone else's prescription. Hydrocodone is the most frequently prescribed painkillers in the United States, and it is one of the most widely diverted and abused drug.

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Withdrawal is a normal, predictable physiological result of taking opioids and other medications for a long time and then suddenly stopping. When you become dependent on a drug, your body needs to maintain a certain level of that drug to feel normal. When your blood level of that drug drops, your body quickly reacts to stabilize your system.

Withdrawal symptoms are a manifestation of that physiological struggle. Withdrawal is not necessarily an indication of criminal drug abuse. You may experience withdrawal after discharge from a hospital stay, where doctors prescribed painkillers to treat a severe or chronic condition. When you get home, you may attribute your flu-like symptoms to having caught a bug while in the hospital when they are, in fact, withdrawal symptoms. If you do not associate your symptoms with drug use, you will not crave the drug and develop other addictive behaviors because you do not know that taking the medication will make you feel better.


Dependence on opioids is a complex condition requiring an equally multifaceted approach for recovery. The first phase of rehabilitation includes reducing withdrawal symptoms to tolerable levels and detoxifying the body from the effects of drug use. During this first phase, doctors and nurses administer medications to reduce the symptoms of withdrawal and detoxify the body. This initial step may take five days or more. Potent withdrawal symptoms may impede your progress. After doctors stabilize your body, you may participate in the second step, including counseling and other social services to address any family or legal issues that contributed to or were the result of dependence on drugs. Rapid detox is a new, humane treatment plan that improves your chances of rehabilitative success by reducing both the severity and duration of the symptoms of withdrawal. Along with the standard anti-withdrawal and detoxification medications, physicians administer anesthesia and sedatives so that you sleep comfortably through the worst parts of withdrawal. When you awaken, refreshed and revitalized, you will have no memory of the physical discomfort of withdrawal. This new rapid detox method shortens detox time down to just a few hours rather than days. Learn More About Guaiacolsulfonate, Hydrocodone, Pseudoephedrine Detoxification Programs


Put guaiacolsulfonate, hydrocodone and pseudoephedrine in a safe location, where children, pets and other adults cannot access it. Keep guaiacolsulfonate, hydrocodone and pseudoephedrine at room temperature, between 59 and 86 degrees Fahrenheit, away from light. Do not freeze. Throw away unused medication.

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