Hydrocodone, Brompheniramine, Pseudoephedrine

Drug Class: Hydrocodone, Brompheniramine, Pseudoephedrine > Hydrocodone > Semi Synthetic Opioid > Opioids > Opioid Agonist > Analgesic.


A doctor might prescribe hydrocodone, brompheniramine and pseudoephedrine to relieve symptoms of a common cold, allergies or respiratory infection caused by bacteria or viruses. This drug will not cure a cold or treat an infection but you can use it at night to sleep undisturbed or during the day so you can attend class or go to work. The combination, known as a polydrug, relieves coughing, sneezing, nasal congestion, runny nose and itchy, watery eyes. Learn More About Hydrocodone, Brompheniramine, Pseudoephedrine Uses


Hydrocodone, brompheniramine and pseudoephedrine polydrugs are available in generic form only.

Take hydrocodone, brompheniramine and pseudoephedrine preparations with a full glass of water. If this drug causes stomach upset, take with food or milk.

Talk with your child's pediatrician about administering this medication to your child. Hydrocodone, brompheniramine and pseudoephedrine is not approved for children under the age of 6 years.

People over the age of 60 may be more sensitive to hydrocodone, brompheniramine and pseudoephedrine products. Physicians should start with lower initial doses and observe older patients closely.

Take hydrocodone, brompheniramine and pseudoephedrine at regular intervals to provide complete coverage for symptoms. If you miss a dose, take the missed dose as soon as you can. If it is nearly time to take another dose, skip the missed dose and resume your normal schedule. Do not double up or take extra medicine in an effort to catch up. Tell the prescribing physician if you have trouble maintaining your schedule or if the prescribed dose does not relieve your symptoms. Tell your healthcare provider if this drug stops working for you; this could be a sign you are growing tolerant to the medication.

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Hydrocodone, brompheniramine and pseudoephedrine polydrugs combine a cough suppressant, antihistamine and decongestant. Each chemical acts in a different way to relieve your symptoms. Hydrocodone acts directly on the part of the brain responsible for the cough reflex; it makes your brain unaware of the need to cough. In animal studies, the cough-suppressing action of codeine takes effect about 15 minutes after oral administration, reaching peak effectiveness 45 minutes to an hour after ingestion. Cough-suppression wears off after about three hours.

Brompheniramine is an antihistamine. It reduces histamines that cause blood vessels to dilate and seep fluid into surrounding tissue, resulting in watery eyes and runny nose. Pseudoephedrine is a decongestant. It constricts blood vessels in the lining of nasal passages.

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An allergic reaction is a serious medical emergency that could quickly turn into a life-and-death crisis. Stop using this drug immediately and seek help at the first sign of an allergic reaction. Symptoms of an allergic reaction include hives, difficulty breathing and swelling of the face, lips or tongue.

Anaphylaxis is the most serious form of an allergic reaction and it usually occurs within minutes of exposure. Without expert medical intervention, death from anaphylaxis can occur within 15 minutes of contact.

Symptoms of a moderate or severe reaction, including anaphylaxis, include:

  • Abdominal Pain or Stomach Cramps.
  • Chest Discomfort or Tightness.
  • Difficulty Breathing or Wheezing.
  • Difficulty Swallowing.
  • Fear or Feeling of Apprehension or Anxiety.
  • Flushing or Redness of the Face.
  • Nausea, Vomiting or Diarrhea.
  • Palpitations.
  • Severe Dizziness or Severe Light-Headedness.
  • Swelling of the Face, Eyes or Tongue.
  • Unconsciousness.
  • Weakness.

The prescribing physician may alter the dose of hydrocodone, brompheniramine and pseudoephedrine polydrugs or switch you to a different medication if you have a history of certain medical disorders. Hydrocodone, brompheniramine and pseudoephedrine polydrugs may worsen these conditions or interfere with treatment for those illnesses. Conversely, these maladies may change the way hydrocodone, brompheniramine and pseudoephedrine polydrugs works in your system.

Tell your physician about any significant illnesses or conditions, including:

  • Asthma
  • Diabetes
  • Drug Abuse or Addiction
  • Glaucoma
  • High Blood Pressure
  • Stomach Ulcer
  • Urinary Problems

Hydrocodone, brompheniramine and pseudoephedrine polydrugs can make you dizzy or drowsy, or may even impair your ability to make decisions. Avoid operating heavy machinery or driving a car until you know how this medication affects you. Alcohol and some medications, such as cold or allergy drugs, sleep aides, tranquilizers, sedatives and antidepressants can enhance this effect.

Hydrocodone is habit-forming. Do not use higher doses or take doses more frequently than recommended. Stop using this medication when advised to by a physician. Do not share this medication with another person, especially those with a history of alcohol or drug abuse.

Hydrocodone, brompheniramine and pseudoephedrine may cause constipation. Drink six to eight glasses of water each day while taking this medication to soften stools and reduce constipation. Try to have a bowel movement at least once every three days but do not take laxatives or stool softeners unless directed to do so by a physician who knows you are taking hydrocodone, brompheniramine and pseudoephedrine. If you do not have a bowel movement for three days, contact the prescribing physician.

This medication may make your mouth dry. Suck on hard candy, drink water or chew sugarless gum to relieve this symptom. Call your doctor if your dry mouth become intolerable or won't go away on its own.

Hydrocodone, brompheniramine and pseudoephedrine polydrugs may cause dry eyes and blurred vision; this may be uncomfortable for contact lens wearers. Try lubricating drops. Wear glasses instead of contact lenses as necessary. Contact your doctor if your dry eyes are intolerable or if they don't get better by themselves.

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Do not use opioids like those contained in this preparation if you have asthma or other lung diseases. This drug may cause respiratory depression, meaning airflow is too inadequate to allow for the proper exchange of oxygen and carbon dioxide. Symptoms of respiratory depression include slow and shallow breathing.

Medical research has not yet established if this medication harms an unborn baby. Tell the prescribing physician if you are pregnant or intend on becoming pregnant while taking hydrocodone, brompheniramine and pseudoephedrine. Call your doctor if you become pregnant while taking this preparation. Hydrocodone passes into breast milk and onto a nursing baby. Do not breast feed while taking this medication.

Sudden cessation may cause flu-like withdrawal symptoms. Do not stop taking this drug abruptly unless directed to do so by a physician. Wean yourself from hydrocodone by taking successively smaller doses increasingly further apart. Talk with your doctor if withdrawal symptoms prevent you from quitting this opioid.

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Drug Interactions

Hydrocodone, brompheniramine and pseudoephedrine polydrugs may interact with other medications in unsafe or unfavorable ways. Do not start, stop or change the way you take any medication, even over-the-counter drugs, vitamins and herbal remedies without first consulting with a doctor or druggist.

Do not take hydrocodone, brompheniramine and pseudoephedrine preparations if you have taken and MAO inhibitor, such as Carbex, Eldepryl, Marplan, Nardil and Parnate, in the past 14 days. Taking this drug while an MAO inhibitor is still in your system can cause a dangerous, even fatal, drug interaction.

Give the prescribing physician and pharmacist filling the prescription a complete list of all your medications, including prescriptions, over-the-counter drugs, vitamins and herbal remedies, especially:

  • Barbiturates
  • Blood Pressure Medicine
  • Colds or Allergy Medicine
  • Diet Aides
  • Heart Medicines
  • Mecamylamine
  • Medicines for Depression, Anxiety, or Psychotic Disturbances
  • Pain Relievers
  • Parkinson's Disease Medication
  • Reserpine
  • Sleep Aides
  • Some Herbal or Nutritional Supplements

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Side effects

Patients have reported some common side effects while taking hydrocodone, brompheniramine and pseudoephedrine polydrugs. Most of these common side effects are not serious; contact the prescribing physician if your common side effects become intolerable or do not subside on their own.

Common side effects include:

  • Constipation.
  • Feeling Excessively Drowsy or Tired.
  • Dry Mouth.
  • Headache.
  • Loss of Appetite.
  • Upset Stomach, Nausea.
  • Insomnia.

Some side effects are serious or life-threatening. Stop using hydrocodone, brompheniramine and pseudoephedrine and call your doctor immediately if you experience any of these serious side effects:

  • Anxiety or Nervousness.
  • Trouble Breathing.
  • Vision Changes.
  • Feeling Dizzy or Lightheaded.
  • Fast or Irregular Heartbeat.
  • Hallucinations.
  • High Blood Pressure.
  • Seizure.
  • Urinary Trouble or Changes in Amount of Urination.
  • Unusually Weak.
  • Vomiting.

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According to the Centers for Disease Control and Prevention, or CDC, deaths from drug overdoses have tripled since 1990. Most of these deaths are the result of prescription drug overdose rather than from illicit drugs such as heroin or cocaine. In fact, the CDC reports that there are now more overdoses from prescription opioids than from heroin and cocaine combined. While many of these deaths occur among the patients for whom the narcotic was prescribed, a large percentage of these deaths occurred after consuming drugs diverted from their intended, prescribed use. If you think you or someone you know has taken an overdose of this or any other medication, call poison control center at 1-800-222-1222 or go to the emergency room. Overdose symptoms include:

  • Blurred Vision.
  • Confusion.
  • Fast, Slow or Irregular Heartbeat.
  • Hallucinations.
  • Seizures.
  • Severe Drowsiness, Dizziness, Lightheadedness or Headache.
  • Vomiting.

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Drug abuse is a growing problem. Abusing a drug means to use it for non-medical purposes - many abuse drugs to get high. The CDC reports that in 2010, 12 million Americans age 12 and older admit to using a drug for non-medical purposes within the prior year. Hydrocodone is the second most widely abused prescription drug, in part because it was the most frequently prescribed pain reliever.

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Withdrawal is a normal, predictable physiological result of taking very high doses of opioids or using them for a long time. When you are physically dependent on a drug, your body needs the drug to feel normal. If you do not take the drug, you experience potent and unpleasant withdrawal symptoms as your body craves the chemical. Experiencing withdrawal symptoms does not necessarily indicated illegal drug use; a person who takes an opioid exactly as prescribed may suffer these symptoms if they are not well-instructed on how to stop taking them. Withdrawal symptoms include:

  • Anxiety.
  • Fast Pulse.
  • Fever.
  • Goose Bumps, Abnormal Skin Sensations.
  • Hallucinations.
  • Nausea, Vomiting and Diarrhea.
  • Pain.
  • Rigid Muscles.
  • Runny Nose or Sneezing.
  • Shivering or Tremors.
  • Sweating.
  • Trouble Sleeping.


Detoxification and rehabilitation programs are increasingly successful in helping people overcome drug dependence. Detoxification includes medicine to decrease powerful withdrawal symptoms and cleanse the drug from your body. Depending on the intensity of the withdrawal symptoms and the degree of dependence, withdrawal symptoms can last for several days or even weeks. Rapid detox is a new, state-of-the-art detoxification process that allows patients to virtually skip the withdrawal symptoms. During rapid detox, qualified professionals give the standard medicines to cleanse the drug from your body and reduce withdrawal symptoms, but they also administer anesthesia and sedatives so that you sleep through the withdrawal process. You will have no recollection of the unpleasant withdrawal symptoms when you awaken. After detoxification and cleansing, you may choose to participate in counseling or other social programs to increase your chances of success. Learn More About Hydrocodone, Brompheniramine, Pseudoephedrine Detoxification Programs


Keep hydrocodone, brompheniramine, pseudoephedrine at room temperature, between 59 and 86 degrees Fahrenheit, away from excessive heat, light and moisture. Do not keep this preparation in your bathroom. Put this medication out of the reach of children and pets. Do not allow other adults to willfully or mistakenly consume this product. Do not share this medication with others, even if their symptoms are just like yours. Throw away this and all unused medication when you are finished with it. Ask your druggist about proper disposal.

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