Hydrocodone, Brompheniramine, Guaifenesin

Drug Class: Hydrocodone, Brompheniramine, Guaifenesin > Hydrocodone > Semi Synthetic Opioid > Opioids > Opioid Agonist > Analgesic.


You may use hydrocodone, brompheniramine and guaifenesin preparations to relieve symptoms associated with the common cold, allergies or a respiratory infection caused by bacteria or virus. Symptoms include coughing, sneezing and runny nose. Hydrocodone, brompheniramine and guaifenesin preparations do not cure cold, allergies or respiratory infection but they do relieve your symptoms so you can sleep, attend classes or go to work.

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Hydrocodone, brompheniramine and guaifenesin are sold as a single-dose preparation, known as a polydrug, in a liquid form. It is available under the brand name, Tusnel-HC.

Take hydrocodone, brompheniramine and guaifenesin by mouth with or without food. Take with food if this medication upsets your stomach.

Use a measuring device intended for dosing medicine. Do not use a household tablespoon; using an inaccurate measuring device may result in an insufficient dose or overdose. Proper medicine measuring spoons are available at any pharmacy, often at little or no cost.

Children and the elderly are more sensitive to the effects of hydrocodone, brompheniramine and guaifenesin preparations. Administer this medication with caution to very young or very old patients, especially in the initial doses.

If you miss a dose of this drug, take the missed dose as soon as possible. If it is almost time to take another dose, skip the missed dose and resume your normal schedule. Never take more than one dose in an effort to make up for missed doses. Contact the prescribing physician if you have trouble taking your doses on time.

Call the prescribing physician if this medication does not control your symptoms or if it stops working. Do not take extra medicine in an effort to relieve your symptoms. Contact the prescribing physician if your symptoms do not get better within five to seven days, or if they get worse.

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Hydrocodone, brompheniramine and guaifenesin is a polydrug containing a cough suppressant, a decongestant and expectorant. Hydrocodone works directly on the medulla, the part of the brain responsible for the cough reflex; hydrocodone makes your brain unaware of the need to cough. Brompheniramine is a decongestant that eases a stuffy nose by shrinking blood vessels in the lining of the nasal passages. Guaifenesin is an expectorant which thins mucus, making it easier to cough congestion up and out of the lungs.

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Do not take hydrocodone, brompheniramine and guaifenesin preparations if you are allergic to any component in this drug. Tell the prescribing physician about all your allergies, especially if you are allergic to any opioid such as codeine or morphine.

Do not take this medication if you are allergic to any active or inactive ingredient. Do not take this drug if you are allergic to other opioids, such as morphine or oxycodone. Seek immediate medical assistance at first onset of symptoms of an allergic reaction; a person's condition can deteriorate quickly and unexpectedly after exposure to a drug allergen. Common symptoms of a mild allergic reaction include hives, especially over the face and neck, nasal congestion, itching, rashes and watery, red eyes.

Anaphylaxis is a very serious, potentially deadly form of an allergic reaction that usually occurs within minutes of exposure to the drug. Without medical help, a person can die from anaphylaxis within 15 minutes of contact.

Symptoms of a moderate or severe reaction include:

  • Abdominal Cramps or Pain.
  • Chest Discomfort or Tightness.
  • Difficulty Breathing or Wheezing.
  • Difficulty Swallowing.
  • Feeling Dizzy.
  • Feeling Light-Headed.
  • Fear or Feeling of Apprehension or Anxiety.
  • Flushing or Redness of the Face.
  • Nausea, Vomiting or Diarrhea.
  • Palpitations.
  • Swelling of the Face, Eyes or Tongue.
  • Weakness.
  • Unconsciousness.

The prescribing physician may recommend a different drug to control your symptoms or she may adjust your dose of hydrocodone, brompheniramine and guaifenesin if you have had a history of certain medical disorders. This medication may worsen your condition or interfere with treatment. Your ailment or therapy may change the way hydrocodone, brompheniramine and guaifenesin works in your body.

Tell your physician about any significant illnesses or conditions, including:

  • Asthma or Lung Disease.
  • Diabetes.
  • Glaucoma.
  • Head Injury.
  • Heart Problems.
  • High Blood Pressure.
  • Heart Disease.
  • Intestinal Problems.
  • Kidney or Liver Disease.
  • Systemic Lupus Erythematosus.
  • Pain or Difficulty Passing Urine.
  • Prostate Trouble.
  • Vision Problems.

Hydrocodone, brompheniramine and guaifenesin medications may cause dizziness, drowsiness or blurred vision. Do not operate a motor vehicle or perform hazardous tasks until you know how your body reacts to this medication. Alcohol and some other medications may worsen this effect.

Hydrocodone is habit-forming. To have a drug habit means to take a substance differently than the manufacturer intended or to continue taking a medication after a physician has suggested you stop. Symptoms of a drug habit include feeling irritable or agitated when it is nearly time to take another dose. You may find yourself watching the clock, waiting anxiously for the next dose even though you are not having symptoms.

Do not take appetite suppressants or other diet aides while taking hydrocodone, brompheniramine and guaifenesin without the consent of a physician.

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Contraindications Medical researchers do not yet know if hydrocodone, brompheniramine and guaifenesin polydrugs harm an unborn child. Tell the prescribing physician if you are pregnant or plan to become pregnant while taking this drug; notify your healthcare provider immediately if you become pregnant while taking this medication. Hydrocodone is known to pass into breast milk and onto a nursing baby. Do not take this medication while breastfeeding a baby.

Sudden cessation of hydrocodone, brompheniramine and guaifenesin may cause unpleasant symptoms of withdrawal. Do not stop taking this drug abruptly unless directed to do so by a physician. If you suffer flu-like symptoms when you do not take this drug, try taking successively smaller doses further apart to wean yourself from hydrocodone.

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Drug Interactions

Do not take hydrocodone, brompheniramine and guaifenesin preparations if you have taken an MAO inhibitor within the previous 14 days. Doing so may result in a dangerous drug interaction. Furazolidone, sodium oxybate and some antidepressants may increase side effects associated with hydrocodone, brompheniramine and guaifenesin polydrugs. Hydrocodone, brompheniramine and guaifenesin increase the side effects associated with hydratoins, especially phenytoin.

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Side effects

Some patients have reported side effects associated with hydrocodone, brompheniramine and guaifenesin. Contact the prescribing physician if these common side effects become troublesome or if they don't disappear. Common side effects include constipation or diarrhea, dizziness, drowsiness and excitability, nervousness or anxiety. Other common side effects include headache, loss of appetite, upset stomach, nausea and vomiting, trouble sleeping or weakness.

Some side effects can be serious. Discontinue use immediately and contact a physician if you suffer from serious side effects

Serious side effects include:

  • Severe Allergic Reactions.
  • Difficulty Urinating or Inability to Urinate.
  • Fast or Irregular Heartbeat.
  • Hallucinations.
  • Seizures.
  • Severe Dizziness, Lightheadedness or Headache.
  • Severe Drowsiness.
  • Tremor.
  • Trouble Sleeping.
  • Vision Changes.

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Overdose from prescription drugs have reached epidemic proportions and the numbers of overdoses continues to rise each year. According to the Centers for Disease Control, more than 36,000 people died from drug overdoses in 2008 - most of these deaths were caused by prescription drugs. If you fear that you or someone you know has overdosed on any prescription pain reliever or illegal substance, immediately contact poison control center at 1-800-222-1222 or go to the emergency room. Emergency department staff will perform a variety of life-saving measures, including stomach pumping, the administration of medicines to reduce the amount of hydrocodone or brompheniramine in your body and IV fluids to restore fluid balance. Specially-trained staff will administer CPR as necessary. Overdose symptoms include:

  • Extreme Dizziness or Drowsiness.
  • Confusion.
  • Restlessness.
  • Nervousness
  • Cold and Clammy Skin.
  • Warmth or Tingly Feeling.
  • Nausea or Vomiting.
  • Slow or Shallow Breathing.
  • Slow Heart Rate.
  • Pinpoint Pupils.
  • Fainting.
  • Convulsions.
  • Coma.

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Hydrocodone is a target for abuse among recreational drug users because it imparts a feeling of euphoria; in fact, hydrocodone is one of the most widely abused drugs today. A drug abuser can get hydrocodone by visiting multiple doctors under assumed names, presenting or phoning in bogus prescriptions to pharmacies, by stealing it or buying the drug on the streets.

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Medical professionals recognize withdrawal as a normal physiological response to taking high doses of opioids or using these drugs for a long time, and not necessarily a sign that a person has taken committed criminal drug abuse. A person may experience physical dependence and the resulting withdrawal symptoms after receiving powerful pain relievers in a hospital after a devastating accident or illness and being discharged home without proper drug detoxification. These former patients may even think they caught the flu while hospitalized, unaware of the cause of their symptoms. You feel withdrawal symptoms as your body tries to regain a normal chemical balance. Sometimes these powerful withdrawal symptoms prevent even the most disciplined person from quitting drug use. Withdrawal symptoms include:

  • Anxiety.
  • Diarrhea.
  • Fever, Runny Nose or Sneezing.
  • Goose Bumps and Abnormal Skin Sensations.
  • Hallucinations.
  • Nausea and Vomiting.
  • Pain.
  • Rapid Heartbeat.
  • Rigid Muscles.
  • Shivering.
  • Sweating.
  • Tremors.
  • Trouble Sleeping.


Drug dependence frequently requires the help of highly trained rehabilitation specialists to overcome. Rehabilitative treatment programs address each facet of the complex syndrome of drug dependence, including overcoming withdrawal symptoms, cleansing the substance from your body and tackling any social issues that add to drug dependence. During the earliest stage of rehabilitation, physicians administer medication to detoxify and decontaminate your system while easing your withdrawal symptoms. Once detoxified, you may opt to participate in a counseling program or other social services to resolve issues that contributed to or is the result of your dependence on drugs, such as personal issues or legal problems. Rapid detox is the most state-of-the-art, humane and effective way to overcome physical withdrawal. During rapid detox, specially trained physicians and staff administer anesthesia and sedatives along with detoxification drugs. You slumber through the withdrawal process, oblivious to the objectionable withdrawal symptoms. When you wake up, you will have no memory of the withdrawal process.

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Keep hydrocodone, brompheniramine and guaifenesin liquid at room temperature, between the temperatures of 59 and 86 degrees Fahrenheit. Do not store this drug in the bathroom. Do not expose this medication to extreme heat, humidity or light. Keep out of the reach of children and pets. Do not allow adults to mistakenly or purposefully consume this medication.

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