Doctors prescribe the opioid medicine Endocodone to relieve moderate to severe pain. The extended-release formula of Endocodone provides round-the-clock pain relief for chronic or acute medical conditions.

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Other, off label uses for this medicine

Physicians might also prescribe Endocodone to relieve dental pain or pain associated with postpartum delivery. Endocodone may be used to treat pain related to postoperative surgery if the patient used Endocodone prior to the procedure.

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Endocodone is a brand name preparation of the narcotic pain reliever, oxycodone. Endocodone comes in a liquid form and an extended-release pill form. The prescribing physician will base the dosage on your condition and response to treatment.

Take Endocodone with or without food. Taking this medication with food may reduce nausea associated with opioid use. If nausea persists, try lying down for an hour or two after taking Endocodone, moving your head as little as possible.

Take the pill form of Endocodone with a large glass of water; drink the entire glass to prevent the tablet from lodging in your throat. Swallow the pill whole; the medicine will enter the bloodstream slowly to provide maximum pain coverage for a long time. Do not crush or chew the tablet, as this will cause all of the medicine enter the bloodstream all at once. If your doctor has prescribed two tablets, take one pill at a time and make sure you have swallowed the first pill before taking the second one.

Never crush Endocodone tablets for intravenous injection. Doing so has resulted in death with the misuse of other oxycodone products.

Use an approved medical dosing spoon when administering liquid Endocodone - do not use a household tablespoon. Using an improper measuring device may lead to an inadequate dose or overdose.

Patients with liver or kidney damage may have trouble processing and removing Endocodone from their bodies. Physicians should start these patients on smaller initial doses and increase the strength as needed and tolerated.

If you have missed a schedule dose of Endocodone, take the missed dose as soon as you can, provided it is not almost time for another dose. If it is nearly time to take more Endocodone, and you can tolerate the pain, skip the missed dose and resume your normal schedule. Do not take extra Endocodone in an effort to catch up. Talk with your doctor if you have trouble maintaining your prescribed schedule; extended-release medications work best to relieve pain when they are taken on a regular schedule.

Endocodone, like other opioids, may cause constipation. Drink six to eight full glasses of water each day to soften stool and make it easier to pass. Talk with your doctor or dietician about increasing your intake of dietary fiber, known to be beneficial to your digestive tract. Do not use a stool softener or laxative without first discussing it with your doctor.

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When illness or trauma injures cells within the body, the cells release special chemicals that bind to pain receptors in your nerve endings. These chemicals send information about the pain, including the intensity and location, to your brain. Endocodone works by binding to pain receptors, sending signals of pleasure and euphoria to your brain while blocking pain signals. Endocodone changes the way your brain perceives pain.

Endocodone also causes feelings of relaxation and euphoria, making it a target for recreational opioid abusers.

Opioids such as Endocodone also work on smooth muscle organs in a way that slows the digestive tract, causing constipation.

More About How Endocodone Works


Notify the prescribing physician if you are allergic to Endocodone, another narcotic pain medication or to any other drug. Allergic reaction is a serious, potentially life threatening, condition. Seek medical help at the first sign of an allergic reaction.

Allergic drug reactions can cause:

  • Skin Rash or Hives
  • Itchy Skin
  • Wheezing or Other Breathing Problems
  • Swelling of Body Parts
  • Anaphylaxis: A Life-Threatening Allergic Reaction

Your doctor may recommend a different drug or change your Endocodone dosage if you have had a history of certain medical conditions. Your medical condition may interfere with the way Endocodone works, or Endocodone may worsen your condition. Liver or kidney disease may slow the rate at which your body processes and disposes of Endocodone, potentially leading to an accumulation or overdose of this opioid.

Talk with your doctor about any significant illnesses or conditions, including:

  • Asthma
  • Chronic Obstructive Pulmonary Disease (COPD)
  • Constipation
  • Diarrhea Due To Infection
  • Difficulty Urinating
  • Enlarged Prostate
  • Head Injury
  • Kidney Disease
  • Liver Disease
  • Mental or Mood Disorders such as Confusion or Depression
  • Personal or Family History of Drug or Alcohol Abuse
  • Seizures
  • Sleep Apnea
  • Stomach or Intestinal Blockage
  • Tumor

Opioids such as Endocodone can cause dizziness or drowsiness, and impair your ability to make quick decisions. Do not drive a car or operate other heavy machinery until you know how Endocodone affects you.

Do not consume alcohol while taking Endocodone. Drinking alcohol while taking opioids may cause serious side effects or even death. Check the labels of all prescription and over-the-counter medications to be sure the product does not contain alcohol. Ask your pharmacist if you are not sure if a product contains alcohol.

The liquid formulation of Endocodone may contain sugar, aspartame or alcohol. Notify the prescribing physicians if you have diabetes, alcohol dependence, liver disease or phenylketonuria, otherwise known as PKU. Tell your doctor if you have any other medical condition that prevent you from consuming products containing those substances.

Endocodone, like all opioids, can be habit-forming, especially if you take high doses or use Endocodone for a long time. Tell your doctor if your current prescription stops working to relieve your pain - this is a sign that your body is developing a tolerance to Endocodone. Your physician may recommend you take the medication more often, prescribe a higher dose or switch you to a different pain medication. Do not increase your own dosage or use Endocodone more frequently than prescribed to reduce your risk for dependence or overdose.

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Do not take Endocodone if you are having an asthma attack or other breathing problems. Endocodone may cause respiratory depression, a dangerous and common type of respiratory condition characterized by slow and shallow breathing.

The Food and Drug Administration, or FDA, has classified Endocodone as a pregnancy category C. Endocodone may be harmful to an unborn baby, and could cause addiction or withdrawal symptoms in a newborn. Notify your doctor if you are pregnant or plan to become pregnant while taking Endocodone. Endocodone can pass into breast milk and may harm a nursing baby; do not take Endocodone while breastfeeding your baby.

Do not stop taking Endocodone abruptly unless a doctor directs you to do so. Discontinuing Endocodone suddenly may cause unpleasant withdrawal symptoms. Try weaning yourself from Endocodone use by taking smaller doses further apart.

More Warnings About Using Endocodone

Drug Interactions

Endocodone may interact with other drugs in an unexpected or unsafe manner. Give the prescribing physician and pharmacist a list of all your prescriptions, over-the-counter drugs, vitamins and herbal remedies. Do not start or stop taking any drug, including vitamins and other supplements, without first consulting your physician.

Do not take Endocodone with other medications that affect your breathing, like sleeping pills, other narcotics, tranquilizers and sedatives. Do not take cold or allergy medications while using Endocodone. Dangerous side effects may result if you use Endocodone along with muscle relaxers or medicines for seizures, depression or anxiety. Talk with a pharmacist if you are unsure how Endocodone will interact with over-the-counter medications you wish to take.

Some drugs may affect the removal of oxycodone from your body in a way that can influence how oxycodone works for you. Tell the prescribing physician if you are taking azole antifungals, such as ketoconazole, macrolide antibiotics such as erythromycin or HIV medications such as ritonavir.

Certain medications, such as naloxone, quickly lower Endocodone levels in the body. This rapid drop in Endocodone levels will cause dependent individuals to experience withdrawal symptoms.

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Side effects

Most consumers do not suffer side effects after taking Endocodone, but side effects are possible with all medications. Most of these side effects are not serious but let your doctor know if common side effects become unbearable or do not go away on their own. Common side effects include nausea or vomiting, constipation, lightheadedness, dizziness and drowsiness.

Tell your doctor if you experience mental or mood changes, such as agitation, confusion or hallucinations. Contact the prescribing physician immediately if you suffer severe stomach or abdominal pain, or difficulty urinating.

Some side effects can be serious or even fatal. Seek medical help if you experience serious side effects, such as fainting, seizure, slow or shallow breathing, unusual drowsiness or difficulty waking up

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Endocodone overdose is a serious, potentially life-threatening medical emergency. If you suspect you or someone you know has taken an overdose of Endocodone, contact your local poison control center at 1-800-222-1222 or go to the emergency room. Doctors and nurses will administer drugs such as naloxone to lower Endocodone levels in the blood, along with other medications that reverse the effect of the Endocodone. They will also perform emergency, life-saving treatments, like establishing an airway, pumping the stomach or performing CPR as necessary.

Overdose symptoms include:

  • Change in Consciousness
  • Chest Pain or Discomfort
  • Constricted, Pinpoint or Small Pupils
  • Decreased Awareness or Responsiveness
  • Extreme Drowsiness
  • Loss of Consciousness
  • No Muscle Tone or Movement
  • Severe Sleepiness
  • Slow or Irregular Heartbeat

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Recreational users abuse Endocodone to get high. They buy Endocodone on the street, or get it by presenting fake prescriptions to pharmacies. Some get prescriptions from multiple doctors or by stealing from friends, family members or even pharmacies and hospitals.

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Withdrawal symptoms are a natural and expected result of a sudden drop in the level of Endocodone in the body of a person who is physically dependent on opioids, in a process known as detoxification. Withdrawal presents itself in a variety of overpowering physical symptoms that can last five or more days as the levels of Endocodone toxins slowly decrease; psychological symptoms of withdrawal may last much longer.

The human body adapts to the presence of certain substances in the body, including Endocodone, by adjusting its own chemical balance to accommodate the presence of those drugs. The body even becomes tolerant of these drugs, which means a person must take an ever-increasing amount of opioids to relieve pain or get high. With continuous use, the body may become dependent on the chemical, which means the individual must maintain a certain level of Endocodone for the body to feel normal. If the level of Endocodone drops rapidly, the body struggles to maintain its chemical balance. This struggle manifests itself through uncomfortable, flu-like withdrawal symptoms.

Withdrawal is a symptom of physiological process; withdrawal symptoms do not represent a person's moral character. Your body can become physically dependent on Endocodone whether you have been taking it legally or illegally. You may experience unpleasant withdrawal symptoms when you stop taking Endocodone, especially if you have been using high doses or taking the opioid for a long time. Withdrawal symptoms vary from person to person. Withdrawal symptoms may be severe enough to prevent you from quitting Endocodone without the help of a rehabilitative professional.

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Detoxification is the process of lowering opioid levels. Detoxification can occur either because the individual did not take enough Endocodone, or because he has taken a medication to drop opioid levels rapidly. Detoxification in a dependent person will cause unpleasant withdrawal symptoms, especially if the individual attempts self-detoxification, without the help of medical professionals.

Dependence and addiction to Endocodone is often difficult to overcome on your own, especially if you have been taking large doses or using these opioids for a long time. Detoxification can be a challenging and extremely unpleasant experience, especially for those who attempt self-detoxification.

Rapid Detox is considered the most humane, efficient way to detoxify the body from Endocodone. During rapid detox, board certified anesthesiologists administer the standard medications to lower opioid levels alongside sedatives and anesthesia. The patient rests in a comfortable "twilight sleep" during detoxification, and awakens with no memory of the withdrawal process.

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Store Endocodone at temperatures between 59 and 86 degrees Fahrenheit. Do not store Endocodone in the bathroom. Keep this medication away from light and moisture. Prevent children and pets from accessing this medication. Put this opioid where adults cannot consume it by accident or on purpose.

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  • Endocodone