Endocet Side Effects

Endo Pharmaceuticals produces Endocet in tablet form in various strengths. Each Endocet contains 5 mg, 7.7 mg or 10 mg of oxycodone. Every tablet also contains 325 mg, 500 mg or 650 mg of acetaminophen.
Physicians prescribe Endocet to relieve moderate to moderately severe pain. Recreational users consume Endocet because of the euphoric feeling it provides.

Oxycodone is a semi-synthetic opioid pain reliever. Pharmacologists create oxycodone from thebaine, extracted from the poppy plant, Papaver somniferum. Opioids such as oxycodone bind to special receptors at nerve endings to send messages of pleasure to the brain; oxycodone changes the way the brain perceives pain.

Oxycodone, as with other opioids, also acts directly on the breathing center in the brain to reduce cough. Opioids also work in the gastrointestinal tract to slow down digestion and ease diarrhea.

Acetaminophen is a less potent pain reliever that also reduces fever. Acetaminophen works by inhibiting the production of prostaglandin, a natural chemical that produces pain, inflammation and fever. Together, acetaminophen and oxycodone relieve pain more completely than either medication could alone.

Side Effect Information

All drugs, including Endocet, can cause side effects in some people. Many Endocet consumers experience no side effects or minor adverse reactions. Most commonly reported side effects are not serious and disappear after using Endocet as prescribed for a few days. Some people experience serious side effects, requiring the immediate medical attention.

The adverse reactions commonly associated with Endocet are typical of any opioids. Opioid use may cause respiratory depression, a serious breathing problem. Respiratory depression can lead to slowed breathing, stopped breathing, circulatory collapse, dangerously low blood pressure and shock. Symptoms of respiratory depression include slow or shallow breathing, unusual breathing patterns and a bluish color around the eyes, mouth and fingertips.

Most people tolerate acetaminophen at therapeutic doses.

Abuse, Addiction and Dependence

Oxycodone causes euphoria - recreational users abuse Endocet to get high. The U.S. Drug Enforcement Agency, or DEA, classifies substances according to its potential for abuse, and classifies the oxycodone in Endocet as a Schedule II narcotic, which means Endocet carries the same risk for abuse as opium or OxyContin.

Abusing a drug means to use it non-medically in hopes of getting high or to treat a condition other than the one for which it was prescribed. Non-medical use and repeated doses of Endocet can cause physical and psychic dependence, and an increased tolerance to oxycodone.
A doctor will diagnose an individual as being opioid-dependent if the patient suffers withdrawal symptoms when he stops using Endocet. An addicted person feels cravings and engages in drug-seeking behavior when his supplies run low. Increased tolerance means the individual must take stronger doses of Endocet more often to achieve the same pain-relieving or euphoric effect; lowered tolerance means a person is more sensitive to the effects of Endocet.

Withdrawal symptoms come in two phases, and last five or more days with the worst symptoms appearing on or about the fourth day.
Early symptoms of withdrawal include:

  • Agitation
  • Anxiety
  • Muscle aches
  • Increased tearing
  • Insomnia
  • Runny nose
  • Sweating
  • Yawning

Late symptoms of withdrawal include:

  • Abdominal cramping
  • Diarrhea
  • Dilated pupils
  • Goose bumps
  • Nausea
  • Vomiting

Most Frequently Observed Endocet Side Effects

The most frequently observed side effects associated with this drug include lightheadedness, dizziness, drowsiness or sedation, nausea and vomiting. These adverse reactions are most prominent in ambulatory patients, as compared to those confined to a wheelchair or bed. Lying down seems to alleviate these symptoms in most consumers. Other side effects include constipation, itching, euphoria and its emotional opposite, dysphoria.

Allergic Reaction

Anyone can suffer an allergic reaction to Endocet or to any other drug. Seek help immediately at the first signs of an allergic reaction after taking Endocet - an allergic reaction is a serious, potentially fatal medical emergency. Bring the Endocet container along with the rest of your medications to help physicians determine the cause of the reaction.

Common symptoms of a mild allergic reaction include:

  • Hives, especially over the neck and face
  • Itching
  • Nasal congestion
  • Rashes
  • Watery, red eyes

Symptoms of a moderate to severe reaction include:

  • Abdominal pain
  • Abnormal or high-pitched breathing sound
  • Anxiety
  • Chest discomfort or tightness
  • Cough
  • Diarrhea
  • Difficulty breathing
  • Difficulty swallowing
  • Dizziness or light-headedness
  • Flushing or redness of the face
  • Nausea or vomiting
  • Palpitations
  • Swelling of the face, eyes or tongue
  • Unconsciousness
  • Wheezing

Anaphylaxis is a severe form of an allergic reaction. Anaphylaxis usually appears within moments of exposure, but anaphylaxis may start as late as a half an hour or longer after exposure to this drug. Seek help immediately if you think you or someone you know is suffering anaphylaxis.
Symptoms of anaphylaxis include:

  • Abdominal pain
  • Abnormal, high-pitched) breathing sounds
  • Anxiety
  • Chest discomfort or tightness
  • Cough
  • Diarrhea
  • Difficulty breathing
  • Difficulty swallowing
  • Dizziness or light-headedness
  • Hives, itchiness
  • Nasal congestion
  • Nausea or vomiting
  • Palpitations
  • Skin redness
  • Slurred speech
  • Swelling of the face, eyes, or tongue
  • Unconsciousness
  • Wheezing

Signs include:

  • Abnormal heart rhythm
  • Blue skin from lack of oxygen
  • Fluid in the lungs
  • Hives
  • Low blood pressure
  • Mental confusion
  • Pale skin from shock
  • Rapid pulse
  • Swelling in the throat
  • Swelling of the eyes or face
  • Weakness
  • Wheezing


Some people are hypersensitive to the effects of Endocet. Symptoms of hypersensitivity include allergic dermatitis, skin rash, hives, itching and swelling of the face.

Hypersensitivity to Endocet may cause hematologic reactions such as certain types of low blood platelet count, low white blood cell count and low red blood cell count. Rarely, high doses cause liver and kidney problems.

Serious Side Effects

Some adverse reactions are serious and require immediate medical attention including respiratory depression, stopped breathing, circulatory problems, low blood pressure and shock.

By body system

Body as a Whole

Endocet consumers can experience anaphylaxis or allergic reaction. Consumers have reported fatigue, malaise and weakness. Others report chest pain, fever, hypothermia, thirst, along with headache and increased sweating. Endocet use may result in accidental or non-accidental overdose.


Endocet use may cause low or high blood pressure, or changes in blood pressure when the patient stands up. This medication may cause slow or irregular heartbeat.

Central and Peripheral Nervous System

Endocet consumers have reported stupor, lethargy, confusion and dizziness. Others report anxiety, agitation, tingling or tremor. Serious nervous system side effects include loss of sensitivity, seizures or swelling of the brain.


Endocet use may affect the skin, causing rash, hives or flushing. Consumers have reported excessive sweating.

Fluid and Electrolyte

Using Endocet may cause dehydration, high potassium levels, high blood acid levels and low levels of carbon dioxide in the blood.


Endocet consumers have reported upset stomach along with abdominal pain and distention, diarrhea and gas. This product may cause dry mouth, taste disturbances, nausea and vomiting. Other digestive side effects include pancreatitis and intestinal obstruction.


Endocet use may cause hearing loss or ringing in the ears.


Endocet may cause dangerously low platelet counts.


Endocet use may cause temporary elevations of some liver enzymes and bilirubin. It is also associated with hepatitis, liver failure, a yellowing of the skin and eyes and liver disorders.


Some individuals are hypersensitive to the effects of Endocet. Hypersensitivity may result in hives, acute anaphylaxis, rapid swelling of the deep layers of skin, asthma and breathing problems. Hypersensitivity may cause swelling in the throat.


Endocet may cause changes in blood sugar; it may also cause an imbalance in the body's acid and base levels.


Some Endocet consumers have reported muscle pain or the breakdown of muscle tissue.


Endocet use may cause drug dependence or drug abuse. Some Endocet consumers report insomnia, confusion, anxiety and agitation, along with depressed level of consciousness, nervousness, hallucination and excessive sleepiness. Endocet use may cause depression or suicide.

Respiratory System

Endocet consumers have reported breathing problems such as bronchospasm, stopped breathing, rapid breathing, swelling of the heart and swelling of the throat.


Using Endocet may result in kidney problems and urinary retention.


Endocet use may cause visual disturbances, red eyes or pinpoint pupils.