Physicians prescribe Endocet to relieve moderate to severe pain. Learn More about Endocet Uses


Endocet is available in a tablet to be taken by mouth. Each tablet contains 5 mg, 7.5 mg or 10 mg of oxycodone hydrochloride and 325 mg, 500 mg or 650 mg of acetaminophen. The usual adult dosage is one Endocet tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4,000 mg in a 24-hour period.

Do not take more Endocet than you need. Stop taking this medication when recommended by a physician.

Doctors typically suggest you take Endocet only when you need it for pain, rather than taking it on a regular schedule, so missed doses are not usually a concern. If you are taking Endocet tablets on a schedule and miss a dose, take another tablet as soon as you remember unless it is almost time to take another dose. If it is nearly time for another dose and you can tolerate the pain, skip the missed dose and resume your normal schedule.

Read More about Endocet Administration and Dosage


The oxycodone in Endocet changes the way your brain perceives pain. When the cells of your body are injured or ill, they release chemicals that bind with pain receptors in nerve endings, which then send messages of pain to your brain. Endocet binds with those pain receptors in a way that prevents the pain chemicals from attaching to receptors in a way that interrupts the message of pain and replaces it with one of pleasure.

Furthermore, opioids such as oxycodone act directly on the brain in a way that causes euphoria and relaxation, which is the sensation of being "high."

The acetaminophen in Endocet eases pain and reduces fever by blocking the hormone responsible for inflammation, pain and fever.

Opioids like those in Endocet affect the respiratory and digestive systems. Endocet depresses the part of the brain responsible for breathing; taking too much of this medication can make the brain forget to breathe. Opioids also depress the cough center in the brain and reduce the urge to cough.

The opioids in Endocet act on smooth muscle organs, like those in your digestive tract, in a way that slows down the muscles in your intestines and causes constipation. Drink six to eight full glasses of water each day you take Endocet to soften stool and make it easier to move your bowels. Talk with your doctor or dietician about increasing your intake of dietary fiber, known to ease constipation. Do not use a laxative or stool softener without first discussing it with a doctor.

More about How Endocet Works


Tell your doctor if you are allergic to oxycodone, acetaminophen or any other medication. Go to the hospital or seek immediate medical help at the first sign of an allergic reaction, as this may turn into a serious or life-threatening condition quickly.

Symptoms of an allergic reaction include:

  • Hives
  • Difficulty Breathing
  • Swelling of the Face, Lips, Tongue or Throat

Your doctor may recommend a different medication or change your Endocet prescription if you have had a history of, or are currently suffering from, certain medical conditions. Your medical condition may interfere with the way Endocet works, or Endocet may make your condition worse.

Tell your physician about any significant illnesses or conditions, including:

  • Addison's Disease or Other Adrenal Gland Disorder
  • Any Breathing Disorders
  • Asthma
  • COPD
  • Curvature of the Spine
  • Enlarged Prostate
  • Epilepsy Or Other Seizure Disorder
  • History of Drug or Alcohol Addiction
  • History of Head Injury pr Brain Tumor
  • Liver or Kidney Disease
  • Low Blood Pressure
  • Mental Illness
  • Sleep Apnea
  • Stomach, Intestinal or Pancreas Disorder
  • Underactive Thyroid
  • Urination Problems

The oxycodone in Endocet causes dizziness or drowsiness and may affect your ability to make quick decisions. Do not drive a car or operate heavy machinery until you know how this medication affects you.

Do not drink alcoholic beverages while taking Endocet. Consuming alcohol while taking opioids may cause serious adverse reactions, such as damage to your liver or even death. Check the labels of foods, beverages and medications to determine if the product contains alcohol. Ask your pharmacist for help if you are not certain how to read a product's label.

Tell the prescribing physician if you typically consume more than three alcoholic beverages per day. Let your doctor know if you have ever had cirrhosis, sometimes called alcoholic liver disease. You may not be able to take Endocet or other medications containing acetaminophen. Chronic alcoholics should limit acetaminophen intake to less than 2000 mg per day.

It is possible to develop dependence on or addiction to opioids, especially if you take high doses or use Endocet for more than a few weeks. Uncomfortable and persistent symptoms associated with dependence or addiction makes it difficult to stop taking Endocet. Do not take a high dose or use Endocet more frequently than prescribed to reduce your risk for dependence and side effects.

Tell the prescribing physician if your current Endocet dose stops relieving your pain, as this is a sign that your body is becoming tolerant to Endocet. She may adjust your dosing schedule or recommend a different medication to relieve your pain.

The oxycodone and acetaminophen in Endocet may affect the outcome of certain laboratory tests, including lowered blood sugar test results. Tell the phlebotomist or laboratory technician about using Endocet when submitting a blood or urine sample.

Read More about Endocet Precautions


Endocet is a pregnancy category C, which means scientists do not yet know how taking this medication during pregnancy may affect an unborn baby but it could cause breathing problems with withdrawal symptoms in a newborn. Tell your doctor if you are pregnant or plan to become pregnant while taking Endocet. If you become pregnant while taking Endocet, call your doctor immediately.

Oxycodone and acetaminophen passes from the mother to her breast milk. Do not take this medication while breastfeeding.

Do not stop taking Endocet suddenly, or change your dose drastically, unless a doctor tells you to do so. Discontinuing Endocet abruptly, or taking smaller doses than usual, may result in unpleasant withdrawal symptoms. Wean yourself from Endocet use by taking smaller doses increasingly further apart. If you find it difficult to stop using Endocet, you may be physically dependent and require the assistance of detoxification specialists.

Patients with known hypersensitivity to oxycodone or acetaminophen should not use Endocet.

Endocet is not appropriate for patients with significant respiratory depression in unmonitored settings or the absence of resuscitative equipment. Individuals with acute or severe bronchial asthma or hypercarbia should not use Endocet. Consumers with suspected or known paralytic ileus, a serious digestive problem, should not use Endocet.

More Warnings about Using Endocet

Drug Interactions

Endocet can interact with other medications or supplements in unexpected or unsafe ways. Give your prescribing physician and pharmacist filling the order with a list of all the prescriptions, over-the-counter drugs, vitamins and herbal remedies you take regularly

Do not start, stop or change the way you take any drug while taking Endocet without first consulting your healthcare provider, including over-the-counter preparations and supplements.

While using Endocet, avoid taking other medications that affect your breathing, like sleep aides, other pain relievers, tranquilizers or sedatives. Do not take cold or allergy medications while using this medication. You may experience dangerous side effects if you use Endocet along with muscle relaxers or medicines for seizures, depression or anxiety.

Tell the physician if you use Tell your doctor about all other medicines you use, especially:

  • Glycopyrrolate (Robinul)
  • Mepenzolate (Cantil)
  • Atropine (Donnatal and Others)
  • Benztropine (Cogentin)
  • Dimenhydrinate (Dramamine)
  • Methscopolamine (Pamine)
  • Scopolamine (Transderm-Scop)
  • Bladder or Urinary Medications such as Enablex, Urispas, Ditropan, Oxytrol, Detrol, Vesicare
  • A Bronchodilator such as Atrovent, Spiriva
  • Irritable Bowel Medications

Certain medications, such as naloxone, quickly lower Endocet levels in the body. This sudden decrease in Endocet levels causes dependent individuals to experience withdrawal symptoms More Drug Interactions

Side effects

Most people do not experience side effects while taking this medication but, as with all drugs, using Endocet cause adverse reactions. Most commonly reported side effects are not serious and go away on their own with continued use. Continue using Endocet but notify the prescribing physician if your side effects become intolerable or do not disappear by themselves. Common side effects include:

  • Constipation
  • Dizziness
  • Drowsiness
  • Flushing
  • Light-Headedness
  • Nausea
  • Vomiting

Some side effects can be serious or fatal. Stop taking Endocet and contact your physician if you experience any serious side effects, such as:

  • Burning, Numbness or Tingling
  • Change In Amount of Urine Produced
  • Confusion
  • Fainting
  • Fast, Slow or Irregular Heartbeat
  • Fever, Chills or Persistent Sore Throat
  • Hallucinations
  • Hearing Loss
  • Mental or Mood Changes, such as Agitation, Anxiety, Depression
  • Seizures
  • Severe or Persistent Constipation
  • Severe or Persistent Dizziness, Headache or Light-Headedness
  • Shortness of Breath
  • Slow or Difficult Breathing
  • Stomach or Back Pain
  • Symptoms of Liver Problems, such as Yellowing of the Skin or Eyes, Pale Stools, Dark Urine, Persistent Loss of Appetite
  • Tremors
  • Trouble Urinating
  • Unusual Bruising or Bleeding
  • Unusual Tiredness or Weakness
  • Vision Changes

Learn More about Endocet Side Effects


Overdose is a serious, potentially fatal medical emergency that requires immediate medical assistance. If you suspect you or someone you know is suffering from Endocet overdose, contact your local poison control center at 1-800-222-1222 or go to the nearest emergency room. Doctors and nurses will administer drugs such as naloxone to lower Endocet levels in the blood. They will also administer other emergency, life-saving treatments as necessary, such as establishing an airway, pumping the stomach or performing CPR as necessary.

Overdose symptoms include:

  • Change in Consciousness
  • Chest Pain or Discomfort
  • Constricted, Pinpoint or Small Pupils
  • Decreased Awareness or Responsiveness
  • Extreme Drowsiness
  • Loss of Consciousness
  • No Muscle Tone or Movement
  • Severe Sleepiness
  • Slow or Irregular Heartbeat

Learn More about Endocet Overdose


Individuals abuse medicines such as Endocet because of the way one of the active ingredients, oxycodone, gets them high. Abusers purchase illicit oxycodone on the street, or get it by presenting fake prescriptions to pharmacies, getting prescriptions from multiple doctors or by stealing from friends, family members or even pharmacies and hospitals. The U.S. Drug Enforcement Agency, or DEA, calls this process "diversion" because of the way medicines are diverted from prescribed use.

Read More about Endocet Abuse


Withdrawal symptoms are a normal and predictable consequence of a sudden drop in the level of Endocet in the body of a person who is physically dependent on opioids. Withdrawal, or detoxification, presents itself in a variety of overpowering physical, flu-like symptoms that can last five or more days as the levels of Endocet toxins slowly decrease. The associated psychological symptoms of withdrawal may last much longer.

A human adjusts to the presence of foreign substances in the body, including Endocet, by adjusting its own chemical balance to accommodate those drugs. With continued use, the body grows dependent on the chemical, which means the person has to maintain a certain level of Endocet for his body to feel "normal." If his level of Endocet drops rapidly, his body struggles to maintain its chemical balance. This struggle shows itself through uncomfortable, flu-like withdrawal symptoms.

Withdrawal is a symptom of physiological process and is not an indicator a person's moral character. Your body can become physically dependent on Endocet whether you have been taking it according to a doctor's prescription or if you have purchased it illegally on the street.

The severity of withdrawal symptoms varies from person to person and is dependent on how long the person took Endocet and the dosages he would normally take. These withdrawal symptoms may be severe enough to prevent even the most determined and disciplined individuals from quitting Endocet without the help of a qualified rehabilitation specialist.

More about Endocet Withdrawal


Detoxification is the process of lowering opioid levels. Detoxification can occur either because the individual did not take enough Endocet, or because he has taken a medication to crash opioid levels quickly. Detoxification in a dependent person will cause uncomfortable or painful withdrawal symptoms, especially if the individual attempts self-detoxification without the help of medical professionals.

Dependence and addiction to Endocet is often hard to beat on your own, especially if you have been taking large doses or using these opioids for a long time. Detoxification can be a tough and extremely unpleasant experience, especially for those who attempt self-detoxification.

Rapid Detox is considered the most humane, efficient way to detoxify the body from Endocet. During rapid detox, board certified anesthesiologists administer sedatives and anesthesia alongside the standard medications to lower opioid levels. The patient dozes in a comfortable "twilight sleep" during detoxification, and then awakens without any memory of the withdrawal process.

Learn More about Endocet Detoxification Programs


Check your Endocet pills to make sure they look the same; ask your pharmacist to verify you have received the proper medication if your Endocet tablets look different.

Put Endocet in a secure location, at room temperature and away from moisture, heat and light. Keep Endocet away from children and pets. Put this opioid where adults cannot consume it by accident or on purpose. Count your pills frequently and account for all missing doses.

Flush unused or unwanted Endocet tablets down the toilet. This method of disposal is not appropriate for other medications but the FDA, working with the manufacturer, has determined flushing Endocet down the toilet presents the least risk to human safety.

Do not share Endocet with others, especially those with a history of drug or alcohol abuse, even if they complain of symptoms similar to your own. It is illegal to give a prescription drug to another individual.

Read More about Storing Endocet