Combunox Side Effects

  • Generic Name or Active Ingridient: Oxycodone Hydrochloride And Ibuprofen

General information about this drug

Combunox contains 5 mg oxycodone and 400 mg ibuprofen. Forest Laboratories, Inc. manufactures Combunox in a tablet form to be taken by mouth.

Physicians prescribe Combunox to treat moderate to severe pain. Recreational users take Combunox to get high.

Oxycodone is a semi-synthetic opioid pain reliever; drug manufacturers make oxycodone from thebaine extracted from the opium poppy plant. Oxycodone works in the nervous system to change the way the brain perceives pain. This opioid also acts on smooth muscle groups, like those in the digestive system, to slow diarrhea. Oxycodone also depresses the respiratory centers to reduce cough. As a result, Combunox side effects are typically associated with the nervous system, respiratory system and digestive tract.

Ibuprofen is a non-steroidal anti-inflammatory drug, or NSAID. Ibuprofen relieves mild pain and reduces fever and swelling.

Side Effect Information

Most people do not experience side effects while taking Combunox but, as with all medication, this drug may cause non-serious and serious adverse reactions. Most commonly reported side effects ease up or go away after using Combunox as prescribed for a few days. Some side effects are serious and require immediate medical attention.

The adverse reactions associated with Combunox are typical of other opioids. Opioid use may cause respiratory depression, a serious breathing problem in which the lungs do not adequately exchange oxygen for toxic gases. Respiratory depression may result in slowed breathing, stopped breathing, circulatory problems, dangerously low blood pressure and shock. Symptoms of respiratory depression include slow or shallow breathing, unusual breathing patterns, noisy breathing like gasping, wheezing or grunting, and a bluish color around the victim's eyes, mouth and fingertips.

Abuse, Addiction and Dependence

People abuse opioids such as Combunox to get high. Long-term abuse of opioid driugs
The U.S. Drug Enforcement Agency, or DEA, classifies substances according to their relative potential for abuse. Schedule I narcotics, such as heroin and cocaine, pose the greatest threat while schedule V drugs are rarely associated with abuse. An example of a schedule V is Robitussin AC, a cough remedy.

Potential for abuse, physical dependence or addiction are potential side effects associated with this drug. The U.S. Drug Enforcement Agency, or DEA, classifies substances according to its potential for abuse, and classifies this drug as a Schedule II narcotic. This means this drug carries a relatively high potential for abuse and mental or physical dependence.

A person who is physical dependent on this drug will suffer withdrawal symptoms after he stops it.

Early symptoms of withdrawal include:

  • Agitation
  • Anxiety
  • Muscle aches
  • Increased tearing
  • Insomnia
  • Runny nose
  • Sweating
  • Yawning

Late symptoms of withdrawal include:

  • Abdominal cramping
  • Diarrhea
  • Dilated pupils
  • Goose bumps
  • Nausea
  • Vomiting

Adverse reactions to this drug are similar to side effects associated with most opioids. These side effects usually become less severe or stop altogether with continued use at proper doses. The most serious side effect is respiratory problems that may lead to stopped breathing, circulatory depression, dangerously low blood pressure and shock. Physicians should expect side effects and treat patients accordingly.

Respiratory depression is a dangerous medical problem associated with opioid use. Respiratory depression is a serious breathing problem that is sometimes fatal. During respiratory depression, your lungs do not adequately exchange oxygen for carbon dioxide and other toxins. Symptoms of respiratory depression include slow or shallow breathing, unusual breathing patterns, gasping or wheezing, and a bluish tint around the eyes, mouth and fingertips.

Most Frequently Observed Combunox Side Effects

The most frequently observed side effects associated with this drug affect the nervous system and digestive system, and may affect the skin. In clinical trials, more than 80 percent of Combunox consumers reported nausea and 49 percent vomited. Less than 10 percent of trial participants reported flatulence.

Nervous system side effects include sleepiness and dizziness. Combunox may also cause sweating.

Allergic Reaction

An allergic reaction is a serious, sometimes fatal, medical emergency. Anyone could suffer an allergic reaction to Combunox or any other drug. Seek immediate medical help at the first sign of an allergic reaction including difficulty breathing, hives, itching, rash and swelling of the face, lips or tongue. Anyone can suffer an allergic reaction to this or any other drug. Seek help immediately if you suffer any symptoms of an allergic reaction after taking this drug - an allergic reaction is a serious, potentially fatal medical emergency. Bring the bottle of this drug with the rest of your medications to help physicians determine the cause of the reaction.

Anaphylaxis

Anaphylaxis is a serious type of allergic reaction that can occur the first time someone takes Combonox. Anaphylaxis usually appears within moments of exposure, but anaphylaxis may start as late as a half an hour or longer after consuming Combunox. Get medical help immediately in cases of suspected anaphylaxis.

Anaphylaxis symptoms include hives, itching, flushed or pale skin. Other symptoms include a sensation of warmth, feeling like the throat is closing or tongue is swelling, or of a lump in the throat. The victim's pulse may be weak and fast. She may complain of nausea or vomit. Some people become dizzy or faint. Others express a feeling of impending doom.

Individuals with a history of angioedema, or who are currently suffering from "aspirin triad," should not take NSAIDS, including Combunox. The triad typically occurs in people with asthma, rhinitis and nasal polyps. Taking aspirin or other NSAIDS may cause potentially fatal bronchospasms. Symptoms of rhinitis include a runny or stuffy nose.

Hypersensitivity

Some people are hypersensitive to the effects of Combunox. Symptoms of hypersensitivity include allergic dermatitis, skin rash, hives, itching and swelling of the face.

Side effects associated with ibuprofen

Ibuprofen and other NSAIDs may cause non-serious and serious side effects. Continue taking Combunox but notify the prescribing physician if the following non-serious side effects become intolerable or do not disappear with continued use at therapeutic doses:

  • Stomach pain
  • Constipation
  • Diarrhea
  • Gas
  • Heartburn
  • Nausea
  • Vomiting
  • Dizziness

Serious side effects associated with NSAID use include:

  • Heart attack
  • Stroke
  • High blood pressure
  • Heart failure from fluid retention
  • Kidney problems including kidney failure
  • Bleeding and ulcers in the stomach and intestine
  • Anemia
  • Life-threatening skin reactions
  • Life-threatening allergic reactions
  • Liver problems including liver failure
  • Asthma attack in those with asthma

Seek emergency medical help if you experience symptoms such as:

  • Shortness of breath or trouble breathing
  • Slurred speech
  • Chest pain
  • Swelling of the face or throat
  • Weakness in one part or side of your body

Stop using Combunox and contact the prescribing physician if you have symptoms such as:

  • Nausea
  • Blood in the stool or black, tarry stool
  • Unusual fatigue
  • Itching
  • Yellowing of the eyes or skin
  • Unusual weight gain
  • Stomach pain
  • Skin rash or blisters with fever
  • Flu-like symptoms
  • Swelling of the arms and legs, hands and feet
  • Vomiting blood

By body system

Gastrointestinal

Combunox may affect the digestive tract. Combunox may cause nausea in 8 to 25 percent of consumers; 4 to 5 percent of Combunox users report vomiting. Like other opioids Combunox may cause constipation. Other gastrointestinal side effects include upset stomach, diarrhea and gas.

Ibuprofen may rarely cause serious gastrointestinal side effects including blood loss, ulcer, hemorrhage, pancreatitis and intestinal disorders. Ibuprofen overdose may result in bloody vomiting. Gastrointestinal blood loss associated with ibuprofen is dose-related, meaning high doses are more likely to result in increased blood loss.

Individuals with a history of serious gastrointestinal conditions or alcohol abuse are at increased risk for severe gastrointestinal side effects and should use ibuprofen with caution.

Nervous system

The oxycodone in Combunox acts on the nervous system to produce pain relief and euphoria; opioid use may cause side effects in the nervous system including sleepiness and dizziness. Other nervous system side effects include headache, dry mouth and lightheadedness. Some Combunox consumers rarely report abnormal thinking patterns or feeling anxious.
Nervous system side effects have included somnolence (7.3% to 17.4%) and dizziness (5.1% to 19.2%). Abnormal thinking, anxiety, hyperkinesia, and hypertonia have been reported rarely.

Hepatic

NSAIDs like the ibuprofen in Combunox can cause elevated results on liver function tests. NSAIDs may cause jaundice, or a yellowing of the skin and eyes, and fatal hepatitis.

Respiratory

Combunox may cause respiratory depression, stopped breathing and circulatory collapse. Elderly and debilitated patients may be more vulnerable to respiratory depression, especially when receiving large doses of Combunox or receiving other medication that depresses respiratory centers.

Renal

Combunox may cause adverse reactions in the renal system, affecting the kidneys. Side effects include renal insufficiency, kidney problems and kidney failure.

Metabolic

Combunox may cause low blood potassium levels.

Cardiovascular

NSAIDs may increase blood pressure or interfere with blood pressure medications.

Hypersensitivity

Some individuals may be hypersensitive to the ibuprofen in Combunox. Hypersensitivity side effects include rash, swelling beneath the skin, breathing problems and anaphylaxis.

Hematologic

Combunox may cause blood problems such as anemia, clotting problems and low hemoglobin and hematocrit.

Dermatologic

Combunox may cause itching and rash.

Musculoskeletal

Musculoskeletal side effects are rare but may include arthritis.

Genitourinary

Combunox may rarely cause urinary frequency.

Other

Combunox may cause other side effects including weakness, sweating, abdominal pain, chest pain and enlarged abdomen.

Dependence and Withdrawal

Chronic Combunox use may cause opioid dependence; an opioid-dependent person will suffer withdrawal symptoms when he stops taking Combunox. Withdrawal symptoms include agitation, restlessness, anxiety, insomnia, tremor, abdominal cramps, blurred vision, vomiting, goose bumps and sweating. Oxycodone withdrawal may cause psychosis.

Psychiatric

Both the ibuprofen and oxycodone components of Combunox are associated with psychiatric side effects, such as paranoia, psychosis and hallucinations.

Ocular

Combunox may rarely cause amblyopia, or a "lazy eye." Other side effects include blurry vision, double vision and a dark spot in the field of vision.