Codeine, Pseudoephedrine, and Triprolidine

  • Generic Name or Active Ingridient: Codeine
Drug Class: Codeine, Pseudoephedrine, And Triprolidine > Codeine > Opiate > Opioids > Opioid Agonist > Analgesic.


Codeine, pseudoephedrine and triprolidine work in unison to provide relief from symptoms of colds, upper respiratory infections and allergies. This drug combination stops coughing and relieves a stuffy nose. Physicians suggest codeine to relieve a dry cough, so that you can sleep or participate in daily activities without being interrupted by an annoying, non-productive cough. Pseudoephedrine shrinks swollen nose tissue, opening up nasal passages so you can breathe better. Doctors prescribe triprolidine to relieve watery eyes, runny nose and itching. Learn More About Codeine, Pseudoephedrine, and Triprolidine Uses


Codeine, pseudoephedrine and triprolidine combination therapy is sold under the brand name, Poly Hist NC.

This medicine comes in a liquid form. Take with or without food; take with food if taking without food makes you nauseated. This drug is not safe for children under the age of 6 years old. Safety and effectiveness has not been established for children; younger patients may be at greater risk for severe and possibly fatal breathing problems. Consult with your pediatrician to find out if codeine, pseudoephedrine and triprolidine drugs are appropriate to soothe your child's symptoms of cough, runny nose and congestion. Children may be more sensitive to the effects of this drug, especially excitability.

Clinicians should use caution when prescribing codeine, pseudoephedrine and triprolidine to elderly patients. Older patients may be more sensitive to certain effects, including especially confusion, dizziness, drowsiness, low blood pressure, excitability, dry mouth and trouble urinating.

A physician typically prescribes codeine, pseudoephedrine and triprolidine drugs to only be taken when you need relief from cough and stuffy nose, therefore missing doses is not an issue. Simply take this medication when you need relief from cough and stuffy nose, provided enough time has passed since your last dose. Read More About Codeine, Pseudoephedrine, and Triprolidine Administration and Dosage


Coughing is the body's way of expelling foreign objects and mucus. When something irritates your throat or lungs, your nervous system sends a message to the brain that it should cough. Codeine affects the signals in the brain that trigger the cough reflex; it "turns off" the urge to cough. Doctors prescribe codeine to relieve dry coughs, not productive coughs with a lot of phlegm; it is always important to cough up excess phlegm. The unpleasant sensation of a stuffy nose is caused by swelling in the lining of nasal passages and sinuses; this swelling is caused by inflammation of the blood vessels found deep within this lining. Pseudoephedrine works by acting directly on the alpha receptors in the walls of those blood vessels to reduce swelling in the lining of nasal passages and sinuses. Triprolidine blocks the allergic reaction which results in the unpleasant symptoms of runny nose, teary eyes and itching. It works by minimizing or preventing the body's reaction to the allergen. More About How Codeine, Pseudoephedrine, and Triprolidine Works


Do not use this drug if you are allergic to codeine, pseudoephedrine or triprolidine, or if you are allergic to any codeine- or morphine-related medicines, such as oxycodone. An allergic reaction is a serious medical condition that can result in death. Symptoms of allergic reactions usually appear soon after taking the drug, but allergic reactions may be delayed as long as 24 hours after exposure. Contact your physician or emergency room immediately if you think you are having an allergic reaction to this medication. Anaphylaxis, a sudden and severe form of allergic reaction, can lead to death within 15 minutes of exposure.

Symptoms of an allergic reaction include hives, itchiness, rashes and watery eyes. Symptoms of a severe reaction may include abdominal pain, difficulty breathing, anxiety, feeling lightheaded or nausea and vomiting.

Your doctor may choose another pain medication or change the dosage of & if you have a history of certain medical conditions. This medication may worsen certain disorders; some medical conditions can interfere with the way & works. Tell your doctor about any serious or chronic illnesses including you have, including severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, severe heart problems, or slow or shallow breathing. Do not take this medication if you are unable to urinate or are having an asthma attack.

Let your doctor know if you have a history of heart problems, especially angina, heart disease or fast, slow or irregular heartbeat. Before you take this drug, tell your doctor about any significant medical condition, such as adrenal gland problems, high or low blood pressure, liver or kidney problems. Tell your physician if you have had low blood volume, diabetes, blood vessel problems, a stroke, glaucoma or increased pressure in the eye, a curvature of the spine, pancreas problems or thyroid problems.

This product may not be suitable for you if you have a history of asthma, COPD or other lung or breathing problems, especially chronic bronchitis, emphysema, sleep apnea, slow or irregular breathing. Tell your doctor if you have a persistent cough, chronic cough or a cough that occurs with a large amount of mucus.

Your physician may order a different remedy if you have severe drowsiness, a recent head injury or brain injury, tumor or lesion. You may not be able to take codeine, pseudoephedrine and triprolidine products if you have suffered increased intracranial pressure, an infection of the brain or nervous system or a seizure disorder such as epilepsy.

This medication affects your central nervous system in a way that can make you drowsy. Do not operate heavy machinery or drive a car until you know how you react to this medication. Avoid engaging in risky behavior that requires you to be alert and awake or to make swift decisions. Alcohol and some medications, such as cold or allergy drugs, can enhance this effect.

Narcotics can be habit-forming, especially if you take them for long periods of time. Tell your doctor if you have a history of dependence or addiction to drugs or alcohol. Your physician may choose a different course of treatment or adjust your dosage accordingly. Talk with your doctor if you have difficulty trying to quit codeine, pseudoephedrine and triprolidine preparations.

Read More About Codeine, Pseudoephedrine, and Triprolidine Precautions


The FDA classifies codeine as a pregnancy Category C, which means scientists do not yet know how it affects your unborn child. Taking codeine in the last three months of pregnancy may result in your baby experiencing withdrawal symptoms after delivery. Tell your doctor if you are pregnant or plan to become pregnant while taking this medication. Codeine is found in breast milk; do not breast feed your baby while taking this medication.

More Warnings About Using Codeine, Pseudoephedrine, and Triprolidine

Drug Interactions

Tell your physician or pharmacist if you take droxidopa or sodium oxybate, otherwise known as GHB. It may be dangerous to take this medication if you have taken furazolidone or a monoamine oxidase inhibitor, especially phenelzine, within the last 14 days. This medication may interact in an unfavorable or even dangerous way with other prescriptions, over-the-counter medications and herbal remedies. Give your doctor and pharmacist a complete and updated list of all the prescriptions, remedies and vitamins you take regularly.

Do not take diet pills or appetite control while taking codeine, pseudoephedrine and triprolidine.

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Side effects

You may experience side effects while taking codeine, pseudoephedrine and triprolidine. If the more common side effects become intolerable or don't go away on their own, talk with your doctor. Common side effects include:

  • Constipation.
  • Dizziness.
  • Drowsiness.
  • Dry Mouth, Nose or Throat.
  • Excitability.
  • Headache.
  • Loss of Appetite.
  • Nausea.
  • Nervousness or Anxiety.
  • Trouble Sleeping.
  • Upset Stomach.
  • Vomiting.
  • Weakness.

Some side effects can be severe or life-threatening. Seek medical assistance immediately if you experience severe side effects such as:

  • Confusion.
  • Fainting.
  • Fast, Slow or Irregular Heartbeat.
  • Fever, Chills, or Persistent Sore Throat.
  • Hallucinations.
  • Loss of Coordination.
  • Mental or Mood Changes, Especially Irritability.
  • Persistent Trouble Sleeping.
  • Ringing in the Ears.
  • Seizures.
  • Severe Dizziness, Lightheadedness, or Headache.
  • Severe Drowsiness.
  • Shallow Breathing.
  • Tremor.
  • Trouble Urinating or Inability to Urinate.
  • Uncontrolled Muscle Movements.
  • Unusual Bruising or Bleeding.
  • Unusual Weakness or Tiredness.
  • Vision Changes or Blurred Vision.

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Codeine, pseudoephedrine and triprolidine overdose is a serious, life-threatening medical emergency. If you suspect that you or someone you know has taken an overdose of codeine, pseudoephedrine and triprolidine, seek emergency assistance immediately by going to the emergency room or calling an ambulance. If you need immediate help, contact your local poison control center at 1-800-222-1222. Overdose symptoms include:

  • Blurred Vision.
  • Cold and Clammy Skin.
  • Coma.
  • Confusion.
  • Hallucinations.
  • Seizures.
  • Severe Dizziness.
  • Lightheadedness.
  • Headache.
  • Severe Drowsiness.
  • Shallow Breathing.
  • Unusually Fast, Slow, or Irregular Heartbeat.
  • Vomiting.

Learn More About Codeine, Pseudoephedrine, and Triprolidine Overdose


Pseudoephedrine and triprolidine are not typically abused. The DEA classifies codeine as a Schedule II drug, which means it has a high potential for abuse that might result in severe psychological or physical dependence. Prolonged abuse, lasting three or more weeks, may result in dependence or addiction. Recreational users and abusers obtain codeine by going to multiple doctors, telephoning in or presenting bogus prescriptions to pharmacies or by stealing the drugs. Read More About Codeine, Pseudoephedrine, and Triprolidine Abuse


Recreational and prescription use of codeine, pseudoephedrine and triprolidine does not always lead to physical dependency and addiction but quitting codeine can lead to withdrawal symptoms. Withdrawal is not necessarily a sign of criminal activity or willful abuse; it is a normal, predictable, physical sign of chemical dependency. Withdrawal symptoms may appear after you stop taking codeine, especially if you have been taking high doses or using the opioid for a long period of time. Withdrawal symptoms and duration vary from person to person. Withdrawal symptoms may be so intense that they prevent you from quitting codeine without medical assistance. Speak with your physician if withdrawal symptoms prevent you from quitting codeine. More About Codeine, Pseudoephedrine, and Triprolidine Withdrawal


Qualified professionals can free you from your dependence on codeine. Some in-patient programs offer rapid detox, where you are sedated and anesthetized during the worst parts of the withdrawal syndrome. When you wake up, you do not remember experiencing the withdrawal symptoms that prevented you from quitting codeine on your own. Talk with your physician or qualified rehabilitation specialist to find out if rapid detox is for you, or if there are other, more conventional treatment centers available in your area.

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Put codeine, pseudoephedrine and triprolidine in a secure location where children and pets cannot accidentally consume it. Be aware of any adults who might take it accidently or on purpose. Do not share this medication with anyone, especially those with a known history of drug or alcohol abuse. Keep track of this narcotic and all your medications. Store this product at room temperature, away from excessive heat, humidity and light.

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