Codeine, Pseudoephedrine and Pyrilamine

  • Generic Name or Active Ingridient: Codeine
Drug Class: Codeine, Pseudoephedrine And Pyrilamine > Codeine > Opiate > Opioids > Opioid Agonist > Analgesic.

Uses

Physicians prescribe codeine, pseudoephedrine and pyrilamine to treat symptoms associated with colds, upper respiratory infections and allergies. Symptoms include cough, sinus congestion, runny nose and sneezing. You might use this drug to reduce symptoms enough to allow you to sleep comfortably, go to work or attend school. Learn More About Codeine, Pseudoephedrine and Pyrilamine Uses

Other, off label uses for this medicine

Your physician may recommend you use codeine, pseudoephedrine and pyrilamine to treat long-term cough caused by asthma, emphysema or smoking.

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Administration/Dosage

Codeine, pseudoephedrine and pyrilamine syrup is available as a brand name, Neo AC. This medication may cause excitability in children.

Take codeine, pseudoephedrine and pyrilamine preparations with a full, 8 oz. glass of water. Continue to drink water while taking this drug to thin mucus congestion.

If your physician has recommended that you take codeine, pseudoephedrine and pyrilamine on a schedule and you miss a dose, take the missing dose as soon as you remember. If it is nearly time to take another dose and you can tolerate the symptoms, skip the missed dose and resume your regular schedule.

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Action

Codeine acts directly on the region of your brain responsible for the cough reflex. Codeine makes your brain unaware of the need to cough. Pseudoephedrine shrinks blood vessels inside the lining of your nasal passages to open airways. Pyrilamine reduces the action of histamines responsible for itchy, watery eyes and sneezing. More About How Codeine, Pseudoephedrine and Pyrilamine Works

Precautions

Anyone can suffer an allergic reaction to any medication. Allergic reaction is a serious medical condition that can deteriorate rapidly into a life-threatening emergency. Seek medical help immediately if you think you are suffering a reaction to codeine, pseudoephedrine and pyrilamine.

Symptoms of an allergic reaction include rash, hives, itching, difficulty breathing, tightness in your chest, swelling of your mouth, face, lips or tongue.

Tell your doctor about your medical history. She may change your dosage of codeine, pseudoephedrine and pyrilamine or switch you to a different medication if you have had a history of certain medical conditions. This medication may worsen your disease, or your medical condition may interfere with the way codeine, pseudoephedrine and pyrilamine works. Notify your physician if your existing medical conditions worsen while you are taking codeine, pseudoephedrine and pyrilamine.

Tell your physician about any significant illnesses or conditions, including:

  • Fast, Slow or Irregular Heartbeat.
  • Breathing Problems, Such as COPD and Asthma.
  • History of Adrenal Gland Disorders.
  • Heart Problems.
  • High or Low Blood Pressure.
  • Low Blood Volume.
  • Diabetes.
  • Blood Vessel Problems.
  • Stroke.
  • Glaucoma.
  • Blockage of Your Stomach, Bladder or Intestines.
  • Trouble Urinating.
  • Enlarged Prostate or Other Prostate Problems.
  • Mental or Mood Problems, Such as Depression.
  • Pancreas Problems, Such as Pancreatitis.
  • Thyroid Problems

Tell your doctor if you have a history of asthma or other breathing problems; this preparation may worsen these conditions. Discuss significant illnesses with your physician, including recent heat injury or brain tumor, increased cranial pressure, infections in your brain or nervous system, or seizure disorder. Let your physician know if you have had severe constipation, stomach problems like ulcers, bowel problems, gallbladder disorders or recent surgery on your stomach, bowel or urinary sytems.

This medication may make you dizzy or drowsy; furthermore, codeine, pseudoephedrine and pyrilamine may impair your decision-making. Do not operate heavy machinery, drive a vehicle or engage in behavior that requires you make quick decisions.

Do not drink alcohol while taking codeine, pseudoephedrine and pyrilamine. Alcohol increases your risk for side effects associated with codeine, pseudoephedrine and pyrilamine.

This opioid can be habit-forming, especially if you have been taking high doses or using codeine for a long time. Tell your doctor if your prescription stops working to relieve your symptoms; this may be a sign you are developing a tolerance to codeine. Your physician may adjust your dosage or switch you to a different pain medication. Do not take higher doses or use codeine, pseudoephedrine and pyrilamine more frequently in an effort to relieve your symptoms. Stop using codeine, pseudoephedrine and pyrilamine when recommended. Tell your physician if you have trouble quitting this medication.

This medication may cause you to sunburn more easily. Avoid exposure to the sun, sun lamps or tanning booths until you know how you react to this medication. Use sunscreen or use protective clothing whenever outdoors for extended periods of time.

Codeine, pseudoephedrine and pyrilamine preparations may interfere with allergy skin tests. Tell your doctor if you are using this drug a few days before allergy testing. You may need to stop taking this medication a few days before your scheduled test.

Tell your surgeon or dentist that you are taking codeine, pseudoephedrine and pyrilamine before you have any operations or dental procedures.

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Warnings

Do not use this medication if you have a history of severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, severe heart problems, stomach ulcer, certain types of glaucoma, difficulty urinating or you are having an asthma attack. Do not take codeine, pseudoephedrine and pyrilamine preparations if you have taken MAO inhibitors in the previous 14 days. Taking this product while MAO inhibitors are still in your system may have serious, even fatal, consequences. Examples of band name MAO inhibitors include Furoxone, Marplan, Nardil, Azilect, Eldepryl, Emsam, Zelapar and Parnate.

Do not take codeine, pseudoephedrine and pyrilamine if you have a cough with a lot of mucus. Codeine suppresses your body's cough reflex.

MAO inhibitors also enhance the drying effect of antihistamines such as pyrilamine. Antihistamine may also add to the effects with alcohol and other central nervous system depressants, such as hypnotics, sedatives, tranquilizers and anti-anxiety agents.

Healthcare professionals have not yet determined if this drug can harm an unborn child. Tell your doctor if you are pregnant or plan to become pregnant while taking this medication. Codeine can pass into breast milk; do not breastfeed your baby while taking this drug.

Do not quit taking codeine, pseudoephedrine and pyrilamine suddenly unless directed to do so by your physician. Stopping the use of codeine, pseudoephedrine and pyrilamine abruptly may cause unpleasant withdrawal symptoms. Wean yourself from this medication by taking smaller doses less frequently.

More Warnings About Using Codeine, Pseudoephedrine and Pyrilamine

Drug Interactions

This medication may interact with other drugs in unsafe or unfavorable ways. Give your doctor and pharmacist a complete and updated list of all your prescriptions, over-the-counter drugs and herbal remedies. Do not start or stop any medication without telling your physician.

Your doctor may alter the dosage of codeine, pseudoephedrine and pyrilamine or switch you to a different prescription if you already take certain medications to treat other illnesses. Tell your doctor if you are taking beta-blockers, COMT inhibitors, cimetidine, furazolidone, HIV protease inhibitors, linezolid, MAOIs, muscle relaxants, opioid analgesic, phenothiazines, sodium oxybate, or tricyclic antidepressants because they may increase the risk of side effects associated with codeine, pseudoephedrine and pyrilamine.

Digoxin or droxidopa increase the risk for irregular heart beat and heart attack. Naltrexone, quinidine, or rifamycins decrease the effectiveness of codeine, pseudoephedrine and pyrilamine. This preparation may increase the likelihood of side effects associated with bromocriptine or hydantoins. This medication reduces the efficacy of guanadrel, guanethidine, mecamylamine, methyldopa or reserpine.

Do not take appetite suppressants or diet aides while taking codeine, pseudoephedrine and pyrilamine without the approval of your physician. More Drug Interactions

Side effects

Patients report some common side effects after taking codeine, pseudoephedrine and pyrilamine. Tell your doctor if these side effects become unbearable or if they don't go away on their own. Common side effects include:

  • Anxiety or Nervousness.
  • Constipation or Diarrhea.
  • Dizziness.
  • Drowsiness.
  • Dry Mouth, Nose or Throat.
  • Excitability.
  • Headache.
  • Loss of Appetite, Nausea or Vomiting.
  • Trouble Sleeping.
  • Upset Stomach.
  • Weakness.

Some side effects can be serious, even life-threatening. Contact your doctor or local emergency room right away if you experience serious side effects such as:

  • Confusion.
  • Difficulty Urinating or Inability To Urinate.
  • Fast, Slow or Irregular Heartbeat.
  • Hallucinations.
  • Loss of Coordination.
  • Mental or Mood Changes, Especially Irritability.
  • Ringing in the Ears.
  • Seizures.
  • Severe Dizziness, Lightheadedness or Headache.
  • Severe Drowsiness.
  • Shallow Breathing.
  • Tremor.
  • Trouble Sleeping.
  • Uncontrolled Muscle Movements.
  • Unusual Bruising or Bleeding.
  • Unusual Weakness or Tiredness.
  • Vision Changes or Blurred Vision.

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Overdose

Do not take more codeine, pseudoephedrine and pyrilamine than prescribed or take it more often than recommended, as this may result in overdose. Overdose of codeine, pseudoephedrine and pyrilamine is a serious, life-threatening condition. If you think you or someone you know has taken an overdose, contact poison control center at 1-800-222-1222 or go to the emergency room. Overdose symptoms include:

  • Blurred Vision.
  • Cold and Clammy Skin.
  • Coma.
  • Confusion or Hallucinations.
  • Seizures.
  • Severe Dizziness, Lightheadedness or Headache.
  • Severe Drowsiness.
  • Shallow Breathing.
  • Unusually Fast, Slow or Irregular Heartbeat.
  • Vomiting.

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Abuse

Experts believe about 9 percent of the population have misused opioids over the course of their lifetimes, including illegal and prescription drugs. This medication, like other opioids, is a favorite among recreational users because it gets them high. Abusers can buy codeine, pseudoephedrine and pyrilamine on the street, present phony prescriptions to pharmacies, go to multiple doctors or steal it from pharmacies, friends or family.

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Withdrawal

If you take high doses of codeine, pseudoephedrine and pyrilamine, or you use this drug for a long time, your body may grow physically dependent on this opioid. Dependence means your body relies on codeine, pseudoephedrine and pyrilamine to prevent symptoms of withdrawal. You may experience unpleasant, flu-like symptoms when you stop taking codeine, pseudoephedrine and pyrilamine. It takes some time for your body chemistry to return to normal. Withdrawal symptoms are a predictable, normal physiological reaction to your body's dependence on a chemical and not necessarily an indication of illicit or recreational drug abuse. Not everyone experiences withdrawal in exactly the same way. Sometimes people who had been given opioids in the hospital don't realize they are suffering from withdrawal and attribute the unpleasant physical symptoms to the flu. A person who has associated his symptoms with withdrawal might start craving codeine, pseudoephedrine and pyrilamine because he knows using the drug will ease his discomfort. Withdrawal symptoms may be so strong in some individuals that the physical discomfort prevents them from quitting codeine, pseudoephedrine and pyrilamine. More About Symptoms of Withdrawal from Codeine, Pseudoephedrine and Pyrilamine

Detox

Rehabilitation specialists combine supportive care and medications to detoxify your body from codeine, pseudoephedrine and pyrilamine use. Medications ease withdrawal symptoms and cleanse the opioid from your body to speed restoration of your chemical balance. Supportive care typically involves counseling and other social services to increase your chances for success. Rapid detox is a new, humane way method of detoxifying your system. Physicians administer sedatives and anesthesia along with the regular detoxification medications so that you are sedated during withdrawal, unaware of the pleasant flu-like symptoms that prevented you from quitting on your own. You awaken refreshed and stabilized, already finished with the physically demanding part of rehabilitation. Learn More About Codeine, Pseudoephedrine and Pyrilamine Detoxification Programs

Storage

This drug should be stored at room temperature, between and degrees Fahrenheit. Keep codeine, pseudoephedrine and pyrilamine away from excessive heat, light and moisture. Put this and all medications out of the reach of children and pets. Do not share codeine, pseudoephedrine and pyrilamine with others. Keep this opioid away from adults who might mistakenly or purposefully take this drug. Monitor your medications and account for all doses.

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