Codeine, Phenylephrine and Chlorcyclizine

  • Generic Name or Active Ingridient: Codeine
Drug Class: Codeine, Phenylephrine And Chlorcyclizine > Codeine > Opiate > Opioids > Opioid Agonist > Analgesic.


Physicians prescribe codeine, phenylephrine and chlorcyclizine to treat symptoms associated with allergies, the common cold or the flu. Symptoms include runny or stuffy nose, coughing, sneezing, itchy or watery eyes and sinus congestion. Doctors prescribe this medication to help you sleep, go to work or attend school free from annoying symptoms. Learn More About Codeine, Phenylephrine and Chlorcyclizine Uses


Codeine, phenylephrine and chlorcyclizine combinations are available in the liquid brand name formula, Nasotuss. This preparation contains 10 mg of codeine, 10 mg of phenylephrine and 25 mg of chlorcyclizine in each 5 ml teaspoon.

The recommended dose for adults and children 12 years and older is one 5 ml teaspoon every 6 to 8 hours, not to exceed 3 teaspoonfuls in a 24-hour period. The dosage for children aged 6 to 11 years is a half teaspoon, or 2.5 ml, every 6 to 8 hours. Do not exceed one and a half teaspoons in a 24-hour period in these children. This medication is not recommended for children under the age of 6 years unless prescribed by a pediatrician.

Take this medication exactly as prescribed; do not take larger or smaller doses than recommended by your physician. Do not use codeine, phenylephrine and chlorcyclizine preparations for more than seven days. Talk with your doctor if your symptoms are not relieved within one week or if you develop a fever with a headache or skin rash.

Do not give codeine, phenylephrine and chlorcyclizine to a child under the age of six unless directed to do so by her pediatrician. Improper use of cough and cold medicine in very young children may result in death.

Codeine, phenylephrine and chlorcyclizine preparations are usually taken only when you need relief from your symptoms, so missed doses are not a concern. If your physician has recommended that you take codeine, phenylephrine and chlorcyclizine preparations on a rigid schedule and you miss a dose, take the missing dose as soon as you remember, as long as it is not nearly time to take another dose.

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Codeine works directly on the part of your brain responsible for the cough reflex. Codeine makes your brain unaware of the need to cough. Phenylephrine is a decongestant that works by constricting the blood vessels inside the lining of your nasal passages. Chlorcyclizine is an antihistamine, which means it works against histamines that cause itchy, watery eyes, sneezing and runny nose. Together, these drugs provide complete coverage for symptoms associated with colds and allergies.

More About How Codeine, Phenylephrine and Chlorcyclizine Works


Stop taking codeine, phenylephrine and chlorcyclizine and seek immediate help if you experience symptoms of an allergic reaction after taking this medication. An allergic reaction is a serious condition. Symptoms of an allergic reaction include hives, difficulty breathing and swelling of your face, lips, tongue or throat.

You may not be able to take this medication if you have a history of certain medical conditions, or your doctor may alter your dosage or suggest laboratory blood tests to monitor your condition. This medication may worsen your disease, or your medical condition may interfere with the way codeine, phenylephrine and chlorcyclizine works. Contact your doctor right away if you notice a change in your pre-existing medical condition while you are taking codeine, phenylephrine and chlorcyclizine.

Tell your physician about any significant illnesses or conditions, including:

  • Blockage in Your Digestive Tract.
  • Colostomy or Ileostomy.
  • Diabetes.
  • Liver or Kidney Disease.
  • Epilepsy or Other Seizure Disorder.
  • Cough with Mucus or Cough Caused By Smoking, Emphysema or Chronic Bronchitis.
  • Enlarged Prostate or Urination Problems.
  • Adrenal Gland Tumor or Disorder, Such as Addison's Disease.
  • If You Take Potassium.

This medication may make you feel dizzy or drowsy, or blur your vision. Avoid operating heavy equipment, driving a car or engaging in behavior that requires you see clearly while taking codeine, phenylephrine and chlorcyclizine.

Do not drink alcohol while taking codeine, phenylephrine and chlorcyclizine. Alcohol increases your risk for side effects associated with codeine, phenylephrine and chlorcyclizine. Tell your doctor if you drink more than three alcoholic beverages in a day. Check the labels of all food, beverages and medications for the presence of alcohol.

Do not take other cough and cold remedies while using codeine, phenylephrine and chlorcyclizine preparations. Doing so may result in a dangerous drug overdose. Cough suppressants, antihistamines and decongestants are common ingredients in many over-the-counter and prescription drugs.

Codeine, like other opioids, can be habit-forming, especially if you have been taking high doses or using it for a long time. Tell your doctor if your prescription stops working to relieve your symptoms - you may be developing a tolerance to codeine. Your physician may adjust your dosage or switch you to a different cold and allergy medication. Do not take higher doses or use preparations containing codeine or other opioids more frequently in an effort to relieve your symptoms. Stop using this medication when recommended by your doctor. Tell your physician if you experience withdrawal symptoms when you stop using this product.

Read More About Codeine, Phenylephrine and Chlorcyclizine Precautions


Do not use codeine, phenylephrine and chlorcyclizine if you have severe liver disease, severe constipation, severe colitis or toxic megacolon. Do not use this preparation if you are having trouble urinating, have been sick with severe diarrhea, have recently drank a large quantity of alcohol or a recent head injury or brain tumor. Do not use cough and cold medicines if you have untreated or uncontrolled diseases such as asthma or COPD, glaucoma, heart disease, high blood pressure or overactive thyroid.

Tell your doctor if you are pregnant or plan on becoming pregnant while taking codeine, phenylephrine and chlorcyclizine products. Researchers have not yet determined whether taking this product can harm your unborn child but scientists do know nursing mothers should not take this medication. Codeine passes into breast milk and that it can have profound, if not fatal, effects on your nursing baby. Small infants, newborns and premature infants in particular, have a higher risk for intolerance to antihistamines. Tell your doctor if you are breastfeeding a baby or planning to become pregnant while taking this medication.

Do not quit taking codeine, phenylephrine and chlorcyclizine suddenly unless directed to do so by your physician. Stopping the use of codeine abruptly may cause unpleasant withdrawal symptoms. Wean yourself from this medication by taking smaller doses less frequently.

More Warnings About Using Codeine, Phenylephrine and Chlorcyclizine

Drug Interactions

This medication may interact with other drugs in unsafe or unfavorable ways. Supply your doctor and pharmacist with a complete and updated list of all your prescriptions, over-the-counter drugs and herbal remedies. Do not start or stop any medication without telling your physician, including non-prescription preparations.

Do not take codeine, phenylephrine and chlorcyclizine preparations if you have taken MAO inhibitors in the previous 14 days. Taking this product while MAO inhibitors are still in your system may have serious, even fatal, consequences. Examples of band name MAO inhibitors include Furoxone, Marplan, Nardil, Azilect, Eldepryl, Emsam, Zelapar and Parnate.

Your doctor may alter the dosage of codeine, phenylephrine and chlorcyclizine or switch you to a different prescription if you already take certain medications to treat other illnesses. Tell your doctor if you are taking:

  • Narcan.
  • Topamax.
  • Ultram or Ultracet.
  • Zonegran.
  • A Diuretic.
  • An Antidepressant.
  • Anti-Nausea Medications.
  • Bladder or Urinary Medications.
  • Bowel Cleansing Preparations.
  • Bronchodilators.
  • Irritable Bowel Medications.
  • Ulcer Medicine.

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Side effects

There are some non-serious side effects associated with codeine, phenylephrine and chlorcyclizine. Tell your doctor if these side effects interfere with the quality of your life or if they don't go away on their own. Common side effects include:

  • Dizziness, Drowsiness, Problems with Memory or Concentration.
  • Dry Mouth, Nose, or Throat.
  • Increased Sweating or Urination.
  • Mild Stomach Pain, Diarrhea or Constipation.
  • Sleep Problems Such as Insomnia.
  • Blurred Vision.
  • A Warmth, Redness or Tingly Feeling.

Some side effects can be serious, even fatal. Contact your doctor or go to local emergency room right away if you experience serious side effects such as:

  • Fast or Pounding Heartbeat.
  • Confusion, Hallucinations, Unusual Thoughts or Behavior.
  • Severe Dizziness, Anxiety, Restless Feeling, or Nervousness.
  • Urinating Less Than Usual or Not At All.
  • Easy Bruising or Bleeding, Unusual Weakness, Fever, Chills, Body Aches, Flu Symptoms.
  • Dangerously High Blood Pressure

Learn More About Codeine, Phenylephrine and Chlorcyclizine Side Effects


Do not take more codeine, phenylephrine and chlorcyclizine than prescribed or take it more often than recommended, as this may result in overdose. Overdose of codeine, phenylephrine and chlorcyclizine is a serious, life-threatening condition. If you think you or someone you know has taken an overdose, contact poison control center at 1-800-222-1222 or go to the emergency room. Overdose symptoms include:

  • Confusion.
  • Extreme Weakness.
  • Pinpoint Pupils.
  • Cold and Clammy Skin.
  • Weak Pulse.
  • Slow Breathing.
  • Fainting.
  • Breathing That Stops.

Learn More About Codeine, Phenylephrine and Chlorcyclizine Overdose


Research shows about 9 percent of the American population have misused opioids over the course of their lifetimes, including illegal and prescription drugs. The codeine in this medication, like other opioids, is a favorite among recreational users because it gets them high. Abusers can buy codeine from drug dealers on the street, present forged prescriptions at pharmacies, go to multiple doctors or steal it from pharmacies, friends or family.

Read More About Codeine, Phenylephrine and Chlorcyclizine Abuse


If you take high doses of codeine, or if you use this opioid for an extended period, your body may grow physically dependent to the drug. Dependence means your body relies on codeine to prevent symptoms of withdrawal. You may experience unpleasant, flu-like symptoms when you stop taking codeine as your body chemistry returns to normal. Withdrawal symptoms are a predictable, normal physiological reaction to your body's dependence on a chemical and not necessarily an indication of illicit or recreational drug abuse. Not all people experience withdrawal in exactly the same way. Sometimes people who had been given opioids in the hospital don't realize they are suffering from withdrawal and attribute the unpleasant physical symptoms to the flu. Since they don't associate their symptoms with codeine, they usually ride out the unpleasant withdrawal symptoms and never become addicted to drugs. A person who has associated his symptoms with withdrawal might start craving codeine because he knows using the drug will stop the withdrawal symptoms. Withdrawal symptoms may be so strong in some individuals that the physical discomfort prevents them from quitting drug use. Learn More About Codeine, Phenylephrine and Chlorcyclizine Withdrawal


Rehabilitation specialists combine supportive care and medications to detoxify your body from codeine use and improve your chances for success. Some medications ease withdrawal symptoms while others cleanse the opioid from your body to speed restoration of your chemical balance. Supportive care typically involves counseling and other social services to increase your chances for success. Rapid detox is a new, humane way method of detoxifying your system. Physicians administer sedatives and anesthesia along with the regular detoxification medications so that you are sedated during withdrawal, unaware of the pleasant flu-like symptoms that prevented you from quitting on your own. You awaken refreshed and stabilized, already finished with the physically demanding part of rehabilitation. Learn More About Codeine, Phenylephrine and Chlorcyclizine Detoxification Programs


Codeine, phenylephrine and chlorcyclizine should be stored at room temperature, between 68 and 77 degrees Fahrenheit. Do not freeze. Keep codeine, phenylephrine and chlorcyclizine away from excessive heat, light and moisture. Put this and all medications out of the reach of children and pets. Do not share codeine, phenylephrine and chlorcyclizine with others. Keep this opioid away from adults who might mistakenly or purposefully take this drug. Monitor your medications and account for all doses.

Read More About Storing Codeine, Phenylephrine and Chlorcyclizine