Codeine, Diphenhydramine, and Phenylephrine

  • Generic Name or Active Ingridient: Codeine
Drug Class: Codeine, Diphenhydramine, And Phenylephrine > Codeine > Opiate > Opioids > Opioid Agonist > Analgesic.

Uses

Pharmacologists combined codeine, diphenhydramine and phenylephrine into one single dose to treat symptoms of allergies, influenza or upper respiratory infections that cause cough, runny or stuffy nose and sneezing. This drug combination is not indicated for the treatment of cough caused by smoking, asthma or emphysema. Learn More About Codeine, Diphenhydramine, and Phenylephrine Uses

Administration/Dosage

Endal CD, Airacof are brand name codeine, diphenhydramine and phenylephrine preparations. This medicine is available in syrup form.

Codeine, diphenhydramine and phenylephrine preparations are not recommended for children under two years old; death can occur in improper use in children.

If you miss a dose of your medication, take another dose as soon as you can. If it is nearly time to take another dose, skip the missed dose and resume your normal schedule. Do not take extra medicine in an effort to make up for a lost dose. Never take two doses at one time, as serious overdose can occur.

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Action

Codeine, diphenhydramine and phenylephrine work in concert to relieve cough that interferes with sleep or activities of daily living. Codeine affects the signals in the brain that trigger the cough reflex; it reduces the urge to cough. Codeine works to relieve dry coughs, not productive coughs with a lot of phlegm. Diphenhydramine is an antihistamine that relieves itching, sneezing, watery eyes and runny nose. Phenylephrine is a decongestant. It works by shrinking blood vessels in nasal passages. More About How Codeine, Diphenhydramine, and Phenylephrine Works

Precautions

Do not take codeine, diphenhydramine and phenylephrine preparations if you are allergic to any component. An allergic reaction is a serious medical condition that can result in death.

Symptoms of an allergic reaction include hives, itchiness, rashes and watery eyes. Symptoms of a severe reaction may include abdominal pain, difficulty breathing, anxiety, feeling lightheaded or nausea and vomiting.

Your doctor may choose another cough medication or change the dosage of codeine, diphenhydramine and phenylephrine if you have a history of certain medical conditions, including severe high blood pressure or other blood vessel disease, rapid heartbeat, stomach ulcer, trouble urinating, glaucoma or are having an asthma attack. This medication may worsen certain disorders; some medical conditions can interfere with the way codeine, diphenhydramine and phenylephrine works. Tell your doctor about any serious or chronic illnesses including:

  • Asthma, Emphysema or Other Breathing Problems.
  • Heart Disease or High Blood Pressure.
  • History of Head Injury or Brain Tumor.
  • Glaucoma.
  • Diabetes.
  • Liver or Kidney Disease.
  • An Enlarged Prostate or Urination Problems.
  • Seizure Disorders.
  • Severe Constipation, Intestinal Blockage or Stomach Ulcer.
  • Pancreas Disorders.
  • Adrenal Gland Disorder Such as Addison's Disease.
  • Thyroid Disorders.
  • History of Depression, Mental Illness or Drug or Alcohol Addiction.

Your doctor may order laboratory tests to measure the effectiveness of treatment and look for signs of serious side effects. Keep all doctor and laboratory appointments and alert your physician or laboratory technician to any problems you have with side effects or with codeine, diphenhydramine and phenylephrine.

Codeine, diphenhydramine and phenylephrine affect your central nervous system in a way that can make you drowsy or dizzy, or make your vision blurry. This medication may also make you dizzy when you stand up suddenly. Hot weather, fever, alcohol and illness may intensify this effect. Do not take other cold medicines along with codeine, diphenhydramine and phenylephrine preparations unless directed to do so by your physician.

Do not drink alcohol or consume other products that contain codeine, diphenhydramine and phenylephrine. Read the labels of all products before using. Consult with your doctor or pharmacist if you are not certain.

Do not use this product if you have a cough with a lot of mucus. Coughing is your body's way of removing the mucus from your lungs so you can breathe better. Codeine suppresses cough.

This drug is intended to be used for short periods of time. Narcotics, including codeine, can be habit-forming. Tell your doctor if you have a history of dependence or addiction to drugs or alcohol before taking this preparation. Your physician may choose a different course of treatment or adjust your dosage accordingly. Talk with your doctor if you have difficulty trying to quit codeine, diphenhydramine and phenylephrine.

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Warnings

The FDA classifies codeine, diphenhydramine and phenylephrine as a pregnancy Category C, which means scientists do not yet know how codeine, diphenhydramine and phenylephrine affects your unborn child. Tell your doctor if you are pregnant or plan to become pregnant while taking codeine, diphenhydramine and phenylephrine. If you become pregnant while taking codeine, diphenhydramine and phenylephrine, call your doctor immediately. Codeine is found in breast milk. Do not take this medication while breastfeeding.

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Drug Interactions

Codeine, diphenhydramine and phenylephrine preparations may interact in an unfavorable or even dangerous way with other prescriptions, over-the-counter medications and herbal remedies. Give your doctor and pharmacist a complete and updated list of all the prescriptions, remedies and vitamins you take regularly. It is especially important to tell your doctor if you have taken MAO inhibitors in the previous two weeks. MAO inhibitors are frequently prescribed to treat depression and Parkinson's disease. Dangerous side effects, including death, can occur if you take codeine, diphenhydramine and phenylephrine while MAO inhibitors are still present in your system. MAO inhibitors include isocarboxazid, phenelzine, rasagiline, selegilin and tranylcypromine. Brand names for these drugs include Marplan, Nardil, Azilect, Eldepryl, Emsam and Parnate.

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Side effects

You may experience side effects while taking codeine, diphenhydramine and phenylephrine. If the more common side effects become intolerable or don't go away on their own, talk with your doctor. Common side effects include constipation, diarrhea, dizziness, drowsiness or dry mouth, nose or throat. Other common side effects include excitability, headache, loss of appetite, nausea, nervousness or anxiety, trouble sleeping, upset stomach, vomiting or weakness.

Some side effects can be severe or life-threatening. Seek medical assistance immediately if you experience severe side effects such as confusion, difficulty urinating or inability to urinate, fast or irregular heartbeat. Hallucinations, mental or mood changes, persistent trouble sleeping, restlessness, seizures, severe dizziness, lightheadedness, or headache, severe drowsiness, tremor, vision changes or blurred vision are also serious side effects.

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Overdose

Codeine, diphenhydramine and phenylephrine overdose is a serious, life-threatening medical emergency. If you suspect that you or someone you know has taken an overdose of codeine, diphenhydramine and phenylephrine, seek emergency assistance immediately by going to the emergency room or calling an ambulance. If you need immediate help, contact your local poison control center at 1-800-222-1222. Overdose symptoms include blurred vision, cold and clammy skin, coma, confusion, hallucinations, seizures, severe dizziness, lightheadedness, or headache, severe drowsiness, unusually fast, slow, or irregular heartbeat or vomiting.

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Abuse

The DEA classifies codeine, diphenhydramine and phenylephrine as a Schedule II drug, which means it has a high potential for abuse. Over time, this abuse may lead to severe psychological or physical dependence. Codeine, like other narcotics, gives the user a pleasant feeling of euphoria. It is this "high" that abusers find so enticing. Read More About Codeine, Diphenhydramine, and Phenylephrine Abuse

Withdrawal

You may experience withdrawal when you stop using codeine, diphenhydramine and phenylephrine preparations. These withdrawal symptoms may be so intense that they prevent you from quitting this medication on your own. If you experience sever withdrawal symptoms, contact your doctor or talk with a qualified rehabilitation specialist. Withdrawal symptoms include anxiety, irregular heartbeat, irritability, restlessness, trouble sleeping, and unusual sweating. More About Codeine, Diphenhydramine, and Phenylephrine Withdrawal

Detox

Qualified professionals can free you from your dependence on codeine. Some in-patient programs offer rapid detox, where you are sedated and anesthetized during the worst parts of the withdrawal syndrome. When you wake up, you do not remember experiencing the withdrawal symptoms that prevented you from quitting codeine, diphenhydramine and phenylephrine on your own. Talk with your physician or qualified rehabilitation specialist to find out if rapid detox is for you, or if there are other, more conventional treatment centers available in your area.

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Storage

Put codeine, diphenhydramine and phenylephrine in a secure location where children and pets cannot accidentally consume it. Be aware of any adults who might take it accidently or on purpose. Do not share this medication with anyone, especially those with a known history of drug or alcohol abuse. Keep track of this narcotic and all your medications. Store this product at room temperature, away from excessive heat, humidity and light.

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