Codeine, Chlorpheniramine, and Phenylephrine

  • Generic Name or Active Ingridient: Codeine
Drug Class: Codeine, Chlorpheniramine, And Phenylephrine > Codeine > Opiate > Opioids > Opioid Agonist > Analgesic.

Uses

Doctors prescribe codeine, chlorpheniramine and phenylephrine products to relieve symptoms associated with the common cold, allergies and hay fever. These symptoms include cough, sneezing, runny nose and itchy or watery eyes. Use codeine, chlorpheniramine and phenylephrine products to make it easier to sleep, go to work or attend class. Learn More About Codeine, Chlorpheniramine, and Phenylephrine Uses

Administration/Dosage

A combination codeine, chlorpheniramine and phenylephrine drug is available in a liquid, or syrup, form. Take this medication with or without food; if stomach upset occurs, take with a snack or meal.

Codeine, chlorpheniramine and phenylephrine should not be given to children under the age of six years without physician's approval. Children and elderly patients may be more sensitive to the effects of codeine, chlorpheniramine and phenylephrine. Children may be more excitable after using this preparation.

Doctors typically prescribe codeine, chlorpheniramine and phenylephrine preparations as you need it to control your symptoms, rather than on a strict schedule. This means you do not normally have to worry about missed doses - simply take a dose when you need it provided enough time has passed since your last dose. If your physician has requested you adhere to a schedule and you miss a dose, take the missed dose as soon as you remember. If it is nearly time to take another dose and you can tolerate the symptoms, skip the missed dose and resume your normal schedule.

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Action

Codeine, chlorpheniramine and phenylephrine syrup combines the power of a cough suppressant, antihistamine and decongestant. Codeine works directly on the part of your brain responsible for the cough reflex. Codeine makes your brain unaware of the need to cough. Chlorpheniramine is an antihistamine; it blocks the production of histamines that cause symptoms like watery eyes and sneezing. Phenylephrine works by constricting blood vessels and reducing swelling in your nasal passages so your nose feels less stuffy. More About How Codeine, Chlorpheniramine, and Phenylephrine Works

Precautions

Tell your doctor if you are allergic to this drug or to any other medication. Allergic reaction is a serious condition that can rapidly deteriorate into a medical emergency without warning.

Allergic drug reactions can cause:

  • Skin Rash or Hives
  • Itchy Skin
  • Wheezing or Other Breathing Problems
  • Swelling of Body Parts
  • Anaphylaxis: A Life-Threatening Allergic Reaction

You may not be able to take this medication if you have a history of certain medical conditions. This drug may worsen your condition, or your medical condition may interfere with the way this medication works. Your doctor may have to prescribe a different drug or change your dosage. Tell your physician about any significant illnesses or conditions, including a recent brain injury, trauma to your head, seizures, an infection in your brain or nervous system, brain tumor or lesions. Talk with your doctor if you have had adrenal gland problems, heart disease, trouble with your blood pressure, diabetes or liver problems. Tell your healthcare provider about any history of stroke, glaucoma, thyroid problems, excessive sleepiness or sleep problems. It is important that your doctor know about any problems with your digestive tract, such as constipation, ulcers, inflammation or ulceration of your bowels or diarrhea associated with antibiotic use. Tell your doctor if you have breathing problems, like asthma, COPD, sleep apnea, slow or irregular breathing or a chronic cough.

This product may make you drowsy or dizzy, or it may interfere with your ability to make quick decisions. Do not operate heavy machinery, drive a car or engage in potentially risky behavior until you know how this preparation affects you.

Do not consume alcohol while taking this drug. Drinking alcohol may worsen side effects associated with this medication.

This drug can be habit-forming, especially if you take high doses or use it for long periods of time. Tell your doctor if your codeine, chlorpheniramine and phenylephrine prescription stops working to control your symptoms - this could be a sign you are growing tolerant to the medication.

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Warnings

Do not take codeine, chlorpheniramine and phenylephrine preparations if you have uncontrolled or very high blood pressure, severe heart blood vessel disease, fast heart beat, severe heart problems or increased pressure in your brain. Do not take this drug if you are having an asthma attack or slow or shallow breathing. Avoid taking codeine, chlorpheniramine and phenylephrine if you are having trouble urinating.

Talk with your doctor if you are pregnant or plan to become pregnant while taking codeine, chlorpheniramine and phenylephrine. Researchers have not yet determined if this drug will harm your unborn baby. Codeine passes into breast milk. Do not breastfeed your baby while taking this product.

Do not stop using codeine, chlorpheniramine and phenylephrine suddenly unless your doctor tells you to do so. Sudden cessation may cause withdrawal symptoms. Whenever possible, wean yourself from a codeine, chlorpheniramine and phenylephrine preparation by taking smaller doses further apart. If you cannot comfortably stop using a codeine, chlorpheniramine and phenylephrine preparation, consult with your doctor or qualified in-patient or outpatient rehabilitation center.

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Drug Interactions

Do not take codeine, chlorpheniramine and phenylephrine if you have taken MAO inhibitors in the past 14 days. Taking this medication while MAO inhibitors are still in your system can have serious, even fatal, consequences. Do not take this medication if you are taking droxidopa or GHB, otherwise known as sodium oxybate.

Some medications may interact with codeine, chlorpheniramine and phenylephrine preparations in unsafe or unfavorable ways. Tell your doctor if you are taking anti-cholinergic medications, especially if you are taking scopolamine, as using these medications along with codeine, chlorpheniramine and phenylephrine increases your risk for the serious bowel disorder, paralytic ileus. Digoxin and droxidopa may increase your risk for an irregular heartbeat or even heart attack.

Some drugs increase the risk for side effects associated with codeine, chlorpheniramine and phenylephrine. Tell your doctor if you are taking:

  • Barbiturates , Especially Phenobarbital.
  • Beta-Blockers , Especially Propranolol.
  • Cimetidine.
  • Catechol-O-Methyltransferase (COMT) Inhibitors , Especially Tolcapone.
  • HIV Protease Inhibitors, Especially Ritonavir.
  • Muscle Relaxants, Especially Cyclobenzaprine.
  • Opioid Analgesics, Especially Hydrocodone.
  • Phenothiazines , Especially Chlorpromazine.
  • Sodium Oxybate (GHB) or Tricyclic Antidepressants, Especially Amitriptyline.

Quinidine or rifamycins, especially rifampin, decrease the effectiveness of codeine, chlorpheniramine and phenylephrine preparations. Naltrexone not only decreases the effectiveness of codeine, it may even cause withdrawal symptoms in patients who are physically dependent on opioids. Codeine, chlorpheniramine and phenylephrine syrup may decrease the effectiveness of guanadrel, guanethidine, mecamylamine, methyldopa and reserpine.

Do not take diet or appetite control pills while taking codeine, chlorpheniramine and phenylephrine.

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Side effects

You may experience side effects while taking this drug. Speak with your physician if these common side effects become intolerable or if they do not go away on their own. Common side effects include: Anxiety; constipation; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; loss of appetite; nausea; trouble sleeping; upset stomach; vomiting; weakness.

Some side effects can be serious. Seek medical help if you experience any of these serious side effects:

  • Confusion.
  • Difficulty Urinating or Inability to Urinate.
  • Fainting.
  • Fast, Slow or Irregular Heartbeat.
  • Fever, Chills or Persistent Sore Throat.
  • Hallucinations.
  • Loss of Coordination.
  • Mental or Mood Changes, Especially Depression.
  • Nervousness.
  • Persistent Trouble Sleeping.
  • Restlessness.
  • Ringing in the Ears.
  • Seizures.
  • Severe or Persistent Constipation.
  • Severe or Persistent Dizziness, Light-Headedness or Headache.
  • Severe or Persistent Drowsiness.
  • Slow or Shallow Breathing.
  • Tremor.
  • Uncontrolled Muscle Movements.
  • Unusual Bruising or Bleeding.
  • Unusual Tiredness or Weakness.
  • Vision Changes or Blurred Vision.

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Overdose

An overdose is a serious situation that can deteriorate into a medical emergency, or even death, quickly and without warning. If you suspect you or someone you know has taken an overdose of a codeine, chlorpheniramine and phenylephrine preparation, seek emergency assistance immediately. Contact your local poison control center at 1-800-222-1222 or go to the emergency room. While at the hospital, you can expect doctors and nurses to perform emergency, life-saving treatments including using activated charcoal, artificial respiration, fluids, laxatives, medicine to lower drug levels in the blood, medicine to reverse the effect of the narcotic or a tube through inserted the mouth into the stomach to pump out the contents of your stomach. Overdose symptoms include:

  • Blurred Vision.
  • Cold and Clammy Skin.
  • Coma.
  • Confusion.
  • Hallucinations.
  • Seizures.
  • Severe Dizziness, Light-Headedness or Headache.
  • Severe Drowsiness.
  • Slow or Shallow Breathing.
  • Unusually Fast, Slow or Irregular Heartbeat.
  • Vomiting.

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Abuse

Codeine is frequently used for recreational purposes because of the euphoric feeling associated with consumption of this opioid. Abusers use codeine to get high. While many abusers buy codeine on the street, others get this narcotic by presenting fake prescriptions to pharmacies, getting prescriptions from multiple doctors or by stealing from friends, family members or even pharmacies and hospitals. Read More About Codeine, Chlorpheniramine, and Phenylephrine Abuse

Withdrawal

You may experience unpleasant withdrawal symptoms when you stop taking codeine products, especially if you have been using high doses or taking the opioid for a long time. Symptoms may be slightly different from person to person, and the intensity of withdrawal varies as well. One person may be able to stop taking opioids on her own while another may need the assistance of rehabilitation professionals to overcome withdrawal symptoms. Withdrawal is a normal, predictable, physical sign of dependency, not necessarily a sign of willful or criminal abuse. Confide in your doctor or seek out the help of a qualified rehabilitation center if withdrawal symptoms prevent you from stopping a codeine, chlorpheniramine and phenylephrine preparation on your own. Withdrawal symptoms include:

  • Anxiety.
  • Diarrhea.
  • Fever, Runny Nose, or Sneezing.
  • Goose Bumps and Abnormal Skin Sensations.
  • Nausea.
  • Vomiting.
  • Pain.
  • Rigid Muscles.
  • Rapid Heartbeat.
  • Seeing, Hearing or Feeling Things that are not There.
  • Shivering or Tremors.
  • Sweating.
  • Trouble Sleeping.

Detox

Addiction to codeine or other drugs is a complex medical condition. Successful rehabilitation depends on the skill of thoughtful professionals who address each patient's medical, psychological and social needs. The most advanced rehabilitation treatment option today is rapid detox, in which you are sedated and anesthetized during the withdrawal period. While you are asleep, doctors administer other medicines to facilitate rapid detoxification of codeine and from your body. You will not remember the withdrawal process after you awaken. After the detoxification process, you can regain your physical and mental strength with the help of specially trained doctors, nurses and counselors. Other rehabilitative options are available to help you stop using codeine. Talk with your doctor or contact a qualified rehabilitation center. Learn More About Codeine, Chlorpheniramine, and Phenylephrine Detoxification Programs

Storage

Keep this drug and all medicines out of the reach of children, pets and adults who might consume this product accidentally or on purpose. Store this drug at room temperature, between and degrees Fahrenheit. Keep this medicine away from excessive heat, humidity and light; do not store in your bathroom or car. Track your medicine and account for all doses.

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Miscellaneous information

Codeine, chlorpheniramine and phenylephrine may cause you to sunburn easily. Wear sunscreen and protective clothing whenever you are out in the sun for long periods of time. Miscellaneous Information About Codeine, Chlorpheniramine, and Phenylephrine