Codeine and Brompheniramine

  • Generic Name or Active Ingridient: Codeine
Drug Class: Codeine And Brompheniramine > Codeine > Opiate > Opioids > Opioid Agonist > Analgesic.


Doctors recommend codeine and brompheniramine preparations to reduce symptoms associated with colds, upper respiratory infections and allergies. Symptoms include runny nose, sneezing and cough. This combination drug is an antihistamine and cough suppressant. Learn More About Codeine and Brompheniramine Uses


Codeine and brompheniramine are sold under the brand name, Nalex AC. It is sold as syrup. Take codeine and brompheniramine with or without food. Take with food if codeine and brompheniramine upsets your stomach.

If your doctor told you to take codeine and brompheniramine on a regular schedule and you miss a dose, take a dose as soon as you remember. If it is nearly time to take another dose and you can tolerate the cough and congestion, skip the missed dose and resume your normal schedule. Do not take extra doses in an attempt to catch up. Read More About Codeine and Brompheniramine Administration and Dosage


When mucus or debris irritates your throat or lungs, a message is sent to the medulla, the part of your brain responsible for the cough reflex. Codeine works directly on your medulla to block the cough impulse; your brain is not aware of the need to cough. Suppressing your cough helps you sleep through the night or participate in daily activities. Brompheniramine is an antihistamine. When your body is exposed to allergens, it releases histamines which attach to cells and cause them to leak fluids. The result is watery eyes, runny nose and an itchy feeling in the nose and throat. Antihistamines block the production of histamines, reducing unpleasant symptoms.

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Do not use this product if you are allergic to codeine or brompheniramine. An allergic reaction is a serious and potentially life-threatening medical condition. Contact your local emergency room or physician if you think you are suffering an allergic reaction to codeine or brompheniramine.

Do not use codeine and brompheniramine if you have severe high blood pressure, severe heart blood vessel disease, glaucoma or peptic ulcers. You may not use codeine if you are unable to urinate or are having an asthma attack. Do not take this medication if you are taking GHB or have taken an MAO inhibitor in the last 14 days.

You may not be able to take this medication if you have a history of certain medical conditions, including high blood pressure, diabetes, liver or kidney problems, stroke, sleep apnea and slow or irregular breathing. Tell your doctor about any head or brain injuries, brain tumors, increased pressure in your brain, seizure disorder or brain infection.

This medication may make you drowsy. Do not operate heavy machinery until you know how codeine and brompheniramine affect you. Alcohol and some drugs enhance this effect.

Narcotics can be habit-forming. Do not take codeine and brompheniramine for more than one week unless otherwise directed by your physician.

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The FDA classifies codeine as a pregnancy Category C, which means scientists do not yet know how it affects your unborn child. Taking codeine in the last three months of pregnancy may result in your baby experiencing withdrawal symptoms after delivery. Tell your doctor if you are pregnant or plan to become pregnant while taking codeine and brompheniramine. If you become pregnant while taking codeine, call your doctor immediately. Codeine can be passed through breast milk. Do not take codeine and brompheniramine while breast feeding.

Don't stop taking codeine products suddenly unless directed to do so by a physician. Sudden cessation may cause unpleasant withdrawal symptoms. Try weaning yourself from this drug by taking smaller doses less frequently. If you cannot stop taking codeine and brompheniramine products because the withdrawal symptoms are too strong, consult with your doctor or qualified in-patient or out-patient rehabilitation center. More Warnings About Using Codeine and Brompheniramine

Drug Interactions

Your doctor may suggest a different medication to relieve your cough and reduce congestion if you are taking certain drugs. Tell your doctor if you are taking anticholinergics because serious bowel problems may occur. Some drugs may increase side effects associated with codeine and brompheniramine; tell your doctor if you are taking Cimetidine, furazolidone, HIV protease inhibitors, MAOIs, sodium oxybate, or tricyclic antidepressants. Do not take narcotic pain medicines, especially hydrocodone, because codeine and brompheniramine increases the risk of side effects associated with narcotic pain medicine. Naltrexone, quinidine and rifamycins decrease the effectiveness of codeine and brompheniramine syrup. More Drug Interactions

Side effects

You may experience side effects while taking codeine and bromopheniramine. If the more common side effects become intolerable or don't go away on their own, talk with your doctor. Common side effects include:

  • Constipation.
  • Diarrhea.
  • Dizziness.
  • Drowsiness.
  • Dry Mouth, Nose or Throat.
  • Excitability.
  • Headache.
  • Loss of Appetite.
  • Nausea.
  • Thickening of Mucus Secretions.
  • Upset Stomach.
  • Vomiting.

Some side effects can be severe or life-threatening. Seek medical assistance immediately if you experience severe side effects such as blurred vision, double vision, or other vision changes, confusion, difficulty urinating or inability to urinate, fast, slow, or irregular heartbeat. Go to the emergency room if you suffer loss of coordination, mood or mental changes, nervousness, ringing in the ears, seizures, severe dizziness, lightheadedness, or headache, severe drowsiness, shallow breathing, tremor, trouble sleeping, uncontrolled muscle movements, unusual bruising or bleeding, unusual weakness or tiredness.

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Overdose of codeine is a serious, even fatal, medical condition. If you think you are suffering from an allergic reaction, contact your local emergency room immediately. Overdose symptoms include blurred vision, confusion, hallucinations, seizures, severe dizziness, lightheadedness, or headache, severe drowsiness, shallow breathing, unusually fast, slow, or irregular heartbeat or vomiting.

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Codeine may make you feel relaxed and euphoric, making it a target for recreational use. Using this drug for recreational rather than medicinal purposes can lead to physical dependence and addictive behavior. Recreational users obtain codeine preparations through bogus prescriptions, going to multiple doctors or by stealing the drug. Read More About Codeine and Brompheniramine Abuse


Withdrawal symptoms are a predictable and normal response to abruptly quitting an opioid, especially if you have been taking the drug for a long period of time or using high doses to control symptoms. Withdrawal symptoms are not necessarily indicative of recreational or illegal drug use. Withdrawal symptoms can vary in intensity between people. Withdrawal symptoms may be intense, prohibiting you from quitting codeine use without the help of a rehabilitative professional.

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Substance abuse programs usually include detoxification and behavioral counseling. Rapid detox is a humane way to get through the peak discomfort associated with codeine withdrawal. During rapid detox, you are given a combination of sedatives and anesthesia, so that you sleep while medical professionals cleanse codeine from your system. You awaken unaware of the unpleasant symptoms of withdrawal. Other types of treatment plans are effective, whether you choose an in-patient facility or an out-patient program. Consult with your physician to find out the most effective treatment plan.

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Put codeine in a secure location where children and pets cannot accidentally consume it. Be aware of any adults who might take it accidently or on purpose. Do not share this medication with anyone, especially those with a known history of drug or alcohol abuse. Keep track of this narcotic and all your medications. Store this product at room temperature, away from excessive heat, humidity and light.

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