Codeine, Brompheniramine and Pseudoephedrine

  • Generic Name or Active Ingridient: Codeine
Drug Class: Codeine, Brompheniramine And Pseudoephedrine > Codeine > Opiate > Opioids > Opioid Agonist > Analgesic.


Doctors prescribe codeine, brompheniramine and pseudoephedrine preparations to treat symptoms associated with the common cold, allergies and the flu. These symptoms include cough, itchy and watery eyes, sneezing, congestion and runny nose. Your physician may have suggested you use this preparation at night so you can sleep and during the day so you attend work or school. Learn More About Codeine, Brompheniramine and Pseudoephedrine Uses


Codeine, brompheniramine and pseudoephedrine preparations are sold as a single combination drug under the brand names of M-End WC and Mar-cof BP.

This drug is available in two doses. The weaker preparation contains 1.33 mg of brompheniramine, 6.33 mg of codeine and 10 mg of pseudoephedrine in every 5 ml teaspoon. The typical prescription for adults calls for 15 ml, or three teaspoons, every four to six hours by mouth. Children twelve years and older may also take this prescribed dose. Do not exceed 90 ml in a 24-hour period. The usual pediatric dose prescribed for children between the ages of six and eleven years for this strength is 7.5 ml, or one and a half teaspoons, every four to six hours, not to exceed 90 ml daily.

A more potent codeine, brompheniramine and pseudoephedrine preparation is available. Every 5 ml dose of this preparation contains 2 mg of brompheniramine, 7.5 mg of codeine and 30 mg of pseudoephedrine. Adults and children over the age of 12 years may take 10 ml, or two teaspoons, every four to six hours, not to exceed six doses in a single day. Children between the ages of six and eleven years may take one teaspoon, or 5 ml, every four to six hours. Do not exceed six doses daily.

Do not give this medication to child younger than four years old. Only give this preparation to a child under the guidance of a pediatrician. Misuse of cough and cold preparations in very young children may result in the child's death.

Your doctor probably prescribed this medication to be taken only when you need to control symptoms, rather than on a schedule, therefore you don't need to be concerned about missed doses. If your physician has recommended you take this medicine on a strict schedule and you miss a dose, take the missing dose as soon as you remember. If it is almost time to take a schedule dose and you can tolerate the symptoms, skip the missed dose and resume your normal schedule. Never take more than one dose at a time in an effort to make up for missed doses. Tell your doctor if you have trouble taking this medication as prescribed.

Notify your healthcare provider if the prescribed dose stops working for you or does not provide complete coverage for your symptoms. Your physician may adjust the dosages or switch medications.

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Invading bodies associated with the common cold, allergies and the flu cause your body to take certain defensive actions that result in some unpleasant symptoms. Irritants in your respiratory tract cause your lungs to send a distress message to the cough center in your brain; your brain receives the message and issues a command to cough to forcibly clear the debris from your lungs and airway. Blood vessels in the lining of your nasal passages grow inflamed, causing you to have a stuffy nose. In response to allergens, your body produces histamines that cause itchy and watery eyes, a runny nose and sneezing. Codeine works directly on the part of the brain responsible for the cough reflex; codeine makes your brain unaware of the need to cough. Brompheniramine is an antihistamine that reduces the amount of histamine in your system, thusly relieving your watery and itchy eyes, runny nose and sneezing. Pseudoephedrine shrinks dilated blood vessels in your nasal passages to relieve congestion. Together, these medicines provide complete relief for your wide variety of symptoms.

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An allergic reaction is a serious medical complication that can have fatal consequences. Anyone can experience an allergic reaction to any medication. Seek help at the first indication of an allergic reaction. Go to the nearest hospital or call an ambulance.

Symptoms of an allergic reaction include:

  • Swelling of the face, lips, throat or tongue.
  • Hives.
  • Trouble Breathing.

Codeine, brompheniramine and pseudoephedrine may worsen some existing medical conditions or interfere with the treatment of those illnesses. Some conditions may change the way codeine, brompheniramine and pseudoephedrine works in your system. Give your doctor a complete list of all your significant medical illnesses and injuries, including:

  • Blockage in Your Stomach or Intestines.
  • Colostomy or Ileostomy.
  • Diabetes.
  • Liver or Kidney Disease.
  • Epilepsy or Other Seizure Disorder.
  • Gallbladder Disease.
  • Enlarged Prostate or Urination Problems.
  • Addison's Disease.
  • If You Take Potassium.

Do not use cough and cold medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, or overactive thyroid.

This medication may make you dizzy or drowsy. Do not operate a vehicle or heavy machinery until you know how this drug affects you.

Do not consume alcohol while taking codeine, brompheniramine and pseudoephedrine preparations. Dangerous side effects can occur when combining alcohol with narcotics such as codeine.

Codeine is habit-forming, especially if you take large doses of this opioid or use it for long periods of time. A drug habit may lead to physical and mental dependence or even addiction. Symptoms of a drug habit include taking the drug even when you don't need it, using large doses or feeling agitated when it is nearly time to take another dose.

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Do not take this drug if you have recently suffered from liver disease, severe constipation, severe colitis or toxic megacolon. Tell the prescribing physician if you are unable to urinate, have had diarrhea, if you recently drank large amounts of alcohol, or if you have a head injury or brain tumor.

The Food and Drug Administration, or FDA, classifies drugs according to the potential harm they pose to you or your unborn child. The FDA classifies this medicine as a pregnancy Category C, which means researchers have not yet determined if using this drug during pregnancy will harm an unborn baby. Some components, especially codeine, of this drug may pass into breast milk and onto your nursing child. Do not take medications containing codeine while breastfeeding. Tell your healthcare provider if you are pregnant or plan to become pregnant while taking this medication. Notify the prescribing physician immediately if you become pregnant while using this drug.

Do not quit using codeine, brompheniramine and pseudoephedrine unless instructed to do so by a physician. Stopping abruptly may result in unpleasant withdrawal symptoms. Try to wean yourself from this drug by taking smaller doses further apart. Confide in your doctor or rehabilitation specialist if withdrawal symptoms prevent you from quitting codeine, brompheniramine and pseudoephedrine.

More Warnings About Using Codeine, Brompheniramine and Pseudoephedrine

Drug Interactions

Codeine, brompheniramine and pseudoephedrine may interact with other drugs in unsafe or unfavorable ways. Give your healthcare provider and pharmacist a complete list of all your medications, including prescriptions, over-the-counter drugs and herbal remedies. Do not start or stop any medication while you are taking codeine, brompheniramine and pseudoephedrine without consulting the prescribing physician.

Do not take this medication or any other cough and cold preparation if you have taken MAO inhibitors within the past 14 days. Taking these types of drugs while MAO inhibitors are still in your system can cause dangerous, even fatal, drug interactions. Examples of brand name MAO inhibitors include Furoxone, Marplan, Nardil and Parnate. Ask your doctor to review all your medications if you are not certain if you have taken an MAO inhibitor.

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Side effects

You may experience side effects from using this medication. Contact your doctor if your common side effects become intolerable or if they don't go away on their own.

Common side effects include:

  • Dizziness, Drowsiness, Problems with Memory or Concentration.
  • Dry Mouth, Nose, or Throat.
  • Increased Sweating or Urination.
  • Mild Stomach Pain, Diarrhea or Constipation.
  • Sleep Problems, Such as Insomnia.
  • Blurred Vision.
  • Flushing.

Contact your doctor or local emergency room if you experience serious side effects. These side effects may become life-threatening.

Serious side effects include:

  • Fast or Pounding Heartbeats.
  • Confusion, Hallucinations, Unusual Thoughts or Behavior.
  • Severe Dizziness, Anxiety, Feeling Restless or Nervous.
  • Urinating Less Than Usual or Not At All.
  • Easy Bruising or Bleeding, Unusual Weakness.
  • Flu Symptoms, Such As Fever, Chills, Body Aches.
  • Dangerously High Blood Pressure

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Overdose is a serious medical condition that may deteriorate rapidly into a life-or-death emergency. If you suspect that you or someone you know has taken an overdose of this or any other medication, contact the poison control center at 1-800-222-1222 or go to the emergency room immediately. While you are at the hospital, you can expect live-saving procedures including stomach pumping to remove excess medication from your digestive tract, medicine to reduce toxic chemicals in your blood and intravenous fluids to restore your body's chemistry. Overdose symptoms include:

  • Confusion.
  • Extreme Weakness.
  • Pinpoint Pupils.
  • Cold and Clammy Skin.
  • Weak Pulse.
  • Slow Breathing.
  • Fainting.
  • Breathing That Stops

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Drug abuse means to habitually take addictive or illegal substances. You can abuse medications by taking prescription drugs for recreational purposes or by continuing to take a drug after your healthcare provider has discontinued the prescription. You can also abuse drugs by taking large doses of a drug or using it more often than prescribed. Codeine is often a favorite among recreational drug abusers because of the way codeine gets them high. Abusers obtain this drug on the street, by filing phony prescriptions at pharmacies, visiting multiple doctors or by stealing from friends and family members.

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Being physically dependent on a drug means you need to continue taking the drug to avoid unpleasant withdrawal symptoms. Withdrawal and its accompanying symptoms are predictable, normal physiological responses to taking large doses of narcotics or taking opioids for a long time. Withdrawal symptoms are not necessarily a sign of illegal drug abuse or an indication of moral character - you may experience withdrawal symptoms after taking drugs given to you in the hospital or after a lengthy illness. Everyone experiences withdrawal slightly differently. Some people may be able to quit taking this drug on their own, while severe withdrawal symptoms may prevent other people from quitting without the help of rehabilitation specialists. Being unable to overcome withdrawal symptoms on your own does not indicate a lack of willpower. Tell your doctor if your withdrawal symptoms are so overwhelming that they prevent you from quitting this drug.

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Rehabilitation specialists will give your medication to detoxify and cleanse your body while easing your withdrawal symptoms. Some advanced programs include counseling and other social services to increase your chances of successfully quitting this drug. Rapid detox is state-of-the-art, humane rehabilitation care. During rapid detox, physicians administer anesthesia and sedatives along with detoxification medications so that you sleep through the withdrawal process, unaware of the unpleasant withdrawal symptoms. When you awaken, you will have no memory of any physical discomfort associated with withdrawal. With the physical suffering behind you, you are free to address other issues that may prevent you from successfully breaking your dependence on opioids. Learn More About Codeine, Brompheniramine and Pseudoephedrine Detoxification Programs


Keep codeine, brompheniramine and pseudoephedrine preparations at room temperature, away from excessive heat, light and moisture. Put this drug out of the reach of children and pets. Prevent adults from taking this medication on purpose or by accident. Keep track of all your medications, especially those containing opioids. Do not make it widely known that you are taking opioids to reduce the chances someone will steal your medication.