Codeine, Brompheniramine, and Phenylpropanolamine

  • Generic Name or Active Ingridient: Codeine
Drug Class: Codeine, Brompheniramine, And Phenylpropanolamine > Codeine > Opiate > Opioids > Opioid Agonist > Analgesic.


Physicians use to prescribe codeine, brompheniramine and phenylpropanolamine preparations to treat symptoms associated with allergies and the common cold. This preparation treats symptoms such as upper respiratory congestion, stuffy nose and cough. Doctors use codeine to suppress coughs, brompheniramine to treat itchy, watery eyes, sneezing and runny nose. Phenylpropanolamine is a decongestant, used to relieve sinus, nose and chest congestion. Learn More About Codeine, Brompheniramine, and Phenylpropanolamine Uses


Codeine, brompheniramine and phenylpropanolamine preparations are pink syrups for oral administration. Each 5 ml, raspberry flavored dose contained 10 mg of codeine, 2 mg of brompheniramine and 12.5 mg of phenylpropanolamine.

Dosage for adults and children over the age of 12 years is two 5 ml teaspoons by mouth every four hours as need to control symptoms. Children between two and six years of age should use one-half a teaspoon every four hours as needed; children over the age of six can use one 5 ml teaspoon every four hours as necessary. Do not exceed six doses in a 24-hour period. Your pediatrician will suggest the dosage for your child between the ages of 6 months and 2 years.

This medication is typically prescribed to be taken only as needed to relieve symptoms and not on a regular schedule, so missing a dose is generally not an issue. If your doctor has suggested you take codeine, brompheniramine, and phenylpropanolamine on a regular schedule and you miss a dose, take the dose as soon as you remember. Skip the missed dose if it is nearly time to take another, as long as you can tolerate the symptoms.

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When invading organisms like allergens or viruses irritate your nose, throat and lungs, your body tries to expel the foreign bodies through sneezing, watery eyes and coughing. The linings of your nose and throat become inflamed, leaving you feeling congested and miserable. Your eyes may water and you may sneeze and cough so much that you cannot eat, sleep, work or study comfortably. Pharmacologists developed codeine, brompheniramine and phenylpropanolamine preparations to act directly on these symptoms to provide relief. Codeine works directly on the part of your brain responsible for the cough reflex; your brain is simply unaware of the need to cough after you take codeine. Phenylpropanolamine is a decongestant that works to shrink the blood vessels in your nose, sinuses and chest to relieve congestion. Brompheniramine is an antihistamine; it works to reduce histamines which are responsible for making your eyes and nose feel itchy and runny.

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Any person can suffer an allergic reaction to any medication. Allergic reaction is a serious medical condition that can deteriorate rapidly into a life-threatening emergency. Go to the emergency room immediately if you notice symptoms of an allergic reaction after taking codeine, brompheniramine, and phenylpropanolamine. Symptoms of an allergic reaction include hives, rash or swelling of your face, lips or throat.

Give your doctor a complete rundown of your significant medical history. She may change your dosage of codeine, brompheniramine and phenylpropanolamine preparations or prescribe an alternate medication if you have had a history of certain medical conditions. This medication may worsen your disease, or your medical condition may interfere with the way this preparation works. Notify your physician if your existing medical conditions worsen while you are taking this drug.

This medication may make you dizzy or drowsy. It may interfere with the way you make decisions. Do not operate heavy machinery, drive a vehicle or engage in potentially risky behavior until you know how codeine, brompheniramine, and phenylpropanolamine affect you.

Do not drink alcohol while taking codeine, brompheniramine and phenylpropanolamine preparations. Alcohol increases your risk for side effects associated with codeine, brompheniramine and phenylpropanolamine preparations.

Codeine may cause constipation. Drink six to eight full glasses of water each day while taking this medication. Speak with your doctor or dietician about ways to increase dietary fiber, known to improve constipation.

The codeine in this preparation can be habit-forming, especially if you have been taking high doses or using it for a long time. Tell your doctor if your prescription stops working to relieve your symptoms; this may be a sign you are developing a tolerance to codeine. Your physician may adjust your dosage or switch you to a different medication. Do not take extra doses or use codeine, brompheniramine and phenylpropanolamine preparations more often than recommended in an effort to relieve your symptoms. Stop using codeine, brompheniramine and phenylpropanolamine preparations as directed by your doctor. Tell your physician if you have trouble quitting this medication.

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Tell your doctor if you are pregnant or plan on becoming pregnant while taking codeine, brompheniramine and phenylpropanolamine products. Researchers have not yet determined whether taking this product can harm your unborn child but scientists do know nursing mothers should not take this medication. Codeine passes into breast milk and that it can have profound, if not fatal, effects on your nursing baby. Small infants, newborns and premature infants in particular, have a higher risk for intolerance to antihistamines.

Wean yourself from this medication when your doctor tells you to stop using it. Take smaller doses at less frequent intervals to slowly decrease the amount of codeine in your body. Sudden cessation may cause unpleasant withdrawal symptoms.

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Drug Interactions

Codeine, brompheniramine, and phenylpropanolamine preparations may interact with other medications in unsafe or unfavorable ways. Submit a complete and updated list of all your prescriptions, over-the-counter drugs and herbal remedies to your doctor and pharmacist. Do not start or stop any medication without first consulting your healthcare providers.

Do not take codeine, brompheniramine, and phenylpropanolamine preparations if you have taken MAO inhibitors in the previous 14 days. Taking this product while MAO inhibitors are still in your system may have serious, even fatal, consequences. Examples of band name MAO inhibitors include Furoxone, Marplan, Nardil, Azilect, Eldepryl, Emsam, Zelapar and Parnate.

MAO inhibitors also enhance the drying effect of antihistamines such as phenylpropanolamine. Antihistamine may also add to the effects with alcohol and other central nervous system depressants, such as hypnotics, sedatives, tranquilizers and anti-anxiety agents.

Your doctor may change the strength of your codeine, brompheniramine and phenylpropanolamine preparations prescription or switch you to a different drug if you already take certain medications to treat other illnesses. Tell your doctor about all your medications, including over-the-counter and herbal remedies.

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Side effects

Some side effects are commonly associated with codeine, brompheniramine, and phenylpropanolamine preparations. Tell your doctor if you cannot tolerate the severity of these side effects or if they don't go away on their own. Common side effects include:

  • Sleepiness, Fatigue or Dizziness.
  • Headache.
  • Dry Mouth.
  • Difficulty Urinating or an Enlarged Prostate.

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Overdose of codeine, brompheniramine, and phenylpropanolamine is a very serious, even life-threatening condition. Do not take more codeine, brompheniramine, and phenylpropanolamine than recommended or take it more frequently than prescribed, as this may result in overdose. If you think you or someone you know has taken an overdose, contact poison control center at 1-800-222-1222 or go to the emergency room. Doctors and nurses there will perform life-saving measures such as pumping the stomach, administering medications to reverse the effects of overdose and other life support measures. Antihistamine overdose may cause hallucinations, seizures and death. Codeine overdose symptoms include slow, shallow breathing, extreme drowsiness, coma and cardiac arrest. Brompheniramine overdose may depress or stimulate the central nervous system. Overdose of phenylpropanolamine is associated with fast heartbeat, high blood pressure and heart arrhythmias.

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People abuse narcotics for several reasons; some may use them for recreational purposes while others abuse drugs because they have inadvertently become physically dependent on narcotics through the use of prescription pain killers. Researchers think about 9 percent of the American population have misused opioids over the course of their lifetimes, including illegal and prescription drugs. Codeine, like other opioids, is a favorite among recreational users because it gets them high. Illicit users can buy codeine on the street, present phony prescriptions to pharmacies, go to multiple doctors or steal it from pharmacies, friends or family.

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Taking high doses of codeine, or using this drug for extended periods of time, causes your body may to physically dependent on this opioid. Dependence means your body relies on a chemical to prevent symptoms of withdrawal. Physical dependence causes you to experience unpleasant, flu-like symptoms when you stop taking codeine as your body chemistry returns to normal. Withdrawal symptoms are a predictable, normal physiological reaction to your body's dependence on a chemical and not necessarily an indication of illicit or recreational drug abuse. Dependence on drugs is not a indication of your moral or ethical character - it is a physical reaction to extended use of prescription drugs. Withdrawal is different for every person. Some people who had been given opioids in the hospital don't even realize they are suffering from withdrawal and attribute the unpleasant physical symptoms to the flu. A person who has associated his symptoms with withdrawal might start craving codeine because he knows that codeine will ease his discomfort. Withdrawal symptoms may be so strong in some individuals that the physical distress keeps them coming back to codeine.


You may need the supportive care and medication that rehabilitation specialists can provide to detoxify your body from codeine use. These specialists know which medications will ease withdrawal symptoms and cleanse the opioid from your body and speed restoration of your chemical balance. Supportive care such as counseling and other social services increase your chances for success. Rapid detox is a new, humane way method of detoxifying your system. Physicians administer sedatives and anesthesia along with the regular detoxification medications so that you are sedated during withdrawal, unaware of the pleasant flu-like symptoms that prevented you from quitting on your own. You awaken refreshed and stabilized, already finished with the physically demanding part of rehabilitation. Learn More About Codeine, Brompheniramine, and Phenylpropanolamine Detoxification Programs


This drug should be stored at room temperature, between 59 and 86 degrees Fahrenheit. Keep codeine, brompheniramine and phenylpropanolamine preparations away from excessive heat, light and moisture. Put this and all medications out of the reach of children and pets. Do not share codeine, brompheniramine and phenylpropanolamine preparations with others. Keep this opioid away from adults who might mistakenly or purposefully take this drug. Monitor your medications and account for all doses.

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Miscellaneous information

The brand name of codeine, brompheniramine and phenylpropanolamine, Dimetane, is no longer on the market although generic versions of this preparation may still be available. Miscellaneous Information About Codeine, Brompheniramine, and Phenylpropanolamine