Codeine, Brompheniramine and Phenylephrine

  • Generic Name or Active Ingridient: Codeine
Drug Class: Codeine, Brompheniramine And Phenylephrine > Codeine > Opiate > Opioids > Opioid Agonist > Analgesic.


Doctors prescribe codeine, brompheniramine, and phenylephrine combination therapy to treat the symptoms associated with the common cold, flu and hay fever. These symptoms include coughing, stuffy nose, watery eyes and itchy nose and throat. Codeine, brompheniramine, and phenylephrine preparations combine a decongestant, cough suppressant and antihistamine to reduce symptoms so that you can sleep, work or go to school without coughing or sneezing. Learn More About Codeine, Brompheniramine and Phenylephrine Uses


The codeine, brompheniramine and phenylephrine combination drug is sold under the brand name Poly-Tussin AC.

Codeine, brompheniramine and phenylephrine preparation is available in a liquid. One such preparation for adults includes 6.33 mg of codeine, 1.33 mg of brompheniramine and 3.33 mg of phenylephrine in each 5 ml. The typical dose is 15 ml orally every 4 to 6 hours as needed to control symptoms. Do not take more than 90 ml in a 24-hour period. Children 6 to 11 years may take 7.5 ml orally every 4 to 6 hours, not to exceed 45 ml daily. Older children should take the adult dose under the direction of a pediatrician.

More potent codeine, brompheniramine and phenylephrine adult preparations offers 10 mg of codeine, 4 mg of brompheniramine and 7.5 mg of phenylephrine in each 5 ml dose, to be taken orally every 4 to 6 hours. Do not take more than 30 ml in a 24-hour period. Children 6 to 11 years may take 2.5 ml orally every 4 to 6 hours not to exceed 15 ml daily. Older children should take the adult dose under the direction of a pediatrician.

Codeine, brompheniramine, and phenylephrine should not be given to a child under the age of six years. Death can occur from the misuse of cough and cold medicines in very young children. Talk with your pediatrician before giving your child any cough or cold medicines.

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When mucus or debris irritates your throat or lungs, your body responds by sending a message to the brain's cough reflex center, the medulla. The medulla then sends a message to the lungs that they should cough. Codeine works by interrupting the message before it reaches the medulla; your brain is unaware of the need to cough. Brompheniramine is an antihistamine. When your body is exposed to allergens, it releases histamines which attach to cells and cause them to leak fluids. The result is watery eyes, runny nose and an itchy feeling in the nose and throat. Antihistamines block the production of histamines, reducing unpleasant symptoms. Phenylephrine relieves a stuffy nose by shrinking blood vessels in your nasal passages. Dilated blood vessels in your nose lead to congestion and stuffiness. Phenylephrine opens up your nasal passages, making it easier for you to breathe. More About How Codeine, Brompheniramine and Phenylephrine Works


Do not take codeine, brompheniramine and phenylephrine preparations if you are allergic to any of the active or inactive ingredients. An allergic reaction is a serious, potentially fatal, medical emergency. Contact your physician or local emergency room immediately if you notice symptoms of an allergic reaction after taking codeine, brompheniramine and phenylephrine products. Symptoms of an allergic reaction include hives, difficulty breathing or swelling of your face, lips, tongue or throat.

Your doctor may recommend a different treatment for your symptoms if you have suffered certain medical conditions in the past, including heart disease or high blood pressure, asthma or other breathing disorder. Tell your doctor if you have diabetes, a thyroid disorder, glaucoma, kidney disease, gallbladder disease, a seizure disorder, an enlarged prostate or problems with urination. She may choose different medication or adjust your dosage of codeine, brompheniramine and phenylephrine.

Codeine, brompheniramine and phenylephrine preparations may make you drowsy or dizzy. Do not drive a car or operate heavy machinery until you know how your body reacts to this medication. Alcohol and other drugs may enhance this effect.

Do not drink alcohol while taking codeine, brompheniramine and phenylephrine.

Do not use this product in combination with other cough, cold or allergy medications unless directed to do so by your physician. Combining medications may cause serious side effects, including respiratory depression. If you are unsure, talk with your pharmacist before purchasing over-the-counter or prescription drugs.

Narcotics can be habit-forming. Stop taking this medication when you no longer need it to treat your symptoms or when your doctor instructs you to quit. Talk with your doctor or qualified rehabilitation specialist if you have trouble quitting codeine, brompheniramine and phenylephrine.

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You should not use codeine, brompheniramine and phenylephrine if you have a peptic ulcer, severe or uncontrolled high blood pressure, severe coronary artery disease, ischemic heart disease, glaucoma, if you are breast-feeding a baby or if you have trouble urinating.

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Drug Interactions

Codeine, brompheniramine and phenylephrine may interact with other prescription, over-the-counter and herbal remedies. Give your doctor and pharmacist a complete and updated list of all your medications. Do not take codeine, brompheniramine and phenylephrine if you have taken MAO inhibitors, such as Marplan, Nardil or Azilect in the past 14 days. Taking codeine, brompheniramine and phenylephrine while MAO inhibitors are still in your system can have serious, potentially fatal, consequences. More Drug Interactions

Side effects

You may experience side effects while taking codeine, brompheniramine and phenylephrine. If the more common side effects become intolerable or don't go away on their own, talk with your doctor. Common side effects include:

  • Dizziness, Drowsiness, Feeling Tired.
  • Feeling Excited or Restless.
  • Sleep Problems, Insomnia.
  • Nausea, Vomiting, Diarrhea, Constipation.
  • Dry Mouth, Nose or Throat.
  • Warmth, Numbness or Tingly Feeling.
  • Increased Sweating or Urination.
  • Blurred Vision, Dry Eyes.
  • Ringing In Your Ears.
  • Mild Skin Rash or Itching.

Some side effects can be severe or life-threatening. Seek medical assistance immediately if you experience severe side effects such as:

  • Fast or Pounding Heartbeat.
  • Feeling Like You Might Pass Out.
  • Confusion, Loss of Coordination, Unusual Thoughts or Behavior.
  • Severe Dizziness, Anxiety, Restless Feeling or Nervousness.
  • Increased Cough, Chest Tightness.
  • Shallow Breathing, Slow Heartbeat.
  • Easy Bruising or Bleeding, Unusual Weakness, Fever, Chills, Body Aches, Flu Symptoms.
  • Seizures.
  • Painful or Difficult Urination.

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Call 1-800-222-1222 or contact your local emergency room if you suspect that you or someone you know has taken an overdose of codeine, brompheniramine and phenylephrine. Overdose is a serious, life-threatening medical situation that can deteriorate rapidly. Overdose symptoms include:

  • Blurred Vision.
  • Cold and Clammy Skin.
  • Coma.
  • Confusion.
  • Hallucinations.
  • Seizures.
  • Severe Dizziness, Lightheadedness or Headache.
  • Severe Drowsiness.
  • Shallow Breathing.
  • Unusually Fast, Slow or Irregular Heartbeat.
  • Vomiting.

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The DEA classifies codeine as a Schedule II drug; these drugs have a high potential for abuse which may lead to severe psychological or physical dependence. People abuse codeine because the drug makes them feel relaxed and euphoric. This pleasant side effect can make stopping prescription drug use difficult without the help of qualified professionals. Abusers get codeine by visiting multiple doctors, phoning in bogus prescriptions to pharmacies or by presenting forged prescriptions, or by stealing from family and friends. Some of these drugs are available on the street.

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Withdrawals is a predictable, normal result of opioid drug use, especially for those people using high doses or have been using pain relievers for a long period of time. Withdrawal syndrome is not necessarily a sign of recreational or criminal abuse of drugs. Withdrawal symptoms vary from person to person. Some withdrawal symptoms may be so severe that they prevent you from quitting codeine use. If you cannot quit codeine use because your symptoms are too strong, talk with your doctor or qualified rehabilitation specialist.

Withdrawal symptoms include anxiety, irregular heartbeat, irritability, restlessness, trouble sleeping, and unusual sweating.

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You may need the assistance of a qualified rehabilitation specialist to detoxify your body from codeine, brompheniramine, and phenylephrine products. Rapid detox programs effectively reduce dependence and addiction to narcotics, including codeine. During rapid detox, you are sedated and anesthetized while medical professionals cleanse narcotics from your body. You awaken in a detoxified state, unaware of any unpleasant withdrawal symptoms.

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Keep codeine, brompheniramine and phenylephrine preparations at room temperature, between 59 degrees and 86 degrees Fahrenheit. Store this medicine away from heat, light and humidity. Do not keep codeine, brompheniramine and phenylephrine in the bathroom. Store this and all medicines out of the reach of children and pets. Do not share codeine, brompheniramine and phenylephrine with others. Keep this medicine where adults cannot consume it, either accidentally or on purpose.

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