Codeine, Aspirin, Caffeine and Butalbital

  • Generic Name or Active Ingridient: Codeine
Drug Class: Codeine, Aspirin, Caffeine And Butalbital > Codeine > Opiate > Opioids > Opioid Agonist > Analgesic.


Doctors prescribe codeine, aspirin, caffeine and butalbital to treat tension headache. Tension headaches are caused by muscles spasms. Because codeine and butalbital are habit-forming, long-term use as a treatment for chronic headaches is discouraged. Learn More About Codeine, Aspirin, Caffeine and Butalbital Uses


Brand names include Ascomp-Codeine and Fiorinal with Codeine. Fiorinal with Codeine is available in a capsule. Each capsule contains 50 mg of butalbital, 325 mg of aspirin, 40 mg of caffeine and 30 mg of codeine phosphate.

The typical codeine, aspirin, caffeine and butalbital calls for one to two capsules every four hours as needed. Do not exceed six capsules in a 24-hour period.

There is a strong associated between aspirin and Reye's syndrome in children and teenagers, especially if the patient is suffering from chicken pox or flu. Caution should be used in administering codeine, aspirin, caffeine and butalbital products to children and teenagers.

Talk with your doctor about how to take codeine, aspirin, caffeine and butalbital. She may want you to take it only when you have a severe tension headache and not on a regular schedule. If you are supposed to take this drug on a regular schedule and miss a dose, take another dose as soon as you remember. If it is nearly time to take another dose, skip the missed dose and resume your normal schedule.

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Scientists do not know exactly how codeine, aspirin, caffeine and butalbital work to reduce symptoms. When you become sick or injured, a variety of chemicals interact with your nervous system to send signals of pain, inflammation and fever to your brain. Your brain reacts by perceiving pain. Codeine binds with pain receptors to change the way your brain perceives pain. It also acts directly on the part of your brain responsible for the cough reflex. Codeine makes your brain unaware of the need to cough. Aspirin reduces pain and inflammation by preventing the production of the chemical responsible for inflammation and for sending pain messages to the brain. Aspirin also reduces fever by acting directly on the brain to override chemicals responsible for inducing a fever. Butalbital is a short- to immediate-acting barbiturate. Butalbital works by slowing down nerve and brain impulses, causing relaxation. Caffeine is thought to reduce tension headaches by constricting dilated blood vessels. More About How Codeine, Aspirin, Caffeine and Butalbital Works


Go the emergency room or contact your doctor immediately if you experience an allergic reaction to codeine, aspirin, caffeine and butalbital. Allergic reaction is a serious, potentially fatal, medical emergency. Symptoms of an allergic reaction include hives, itchiness, rashes and watery eyes. Symptoms of a severe reaction may include abdominal pain, difficulty breathing, anxiety, feeling lightheaded or nausea and vomiting.

Some patients may be sensitive to the effects of codeine, aspirin, caffeine and butalbital, including very young, elderly or debilitated patients. People with a history of impaired renal function, coagulation disorders, head injuries, increased intracranial pressure or acute abdominal conditions should use this product with caution. Physicians should use care when prescribing codeine, aspirin, caffeine and butalbital to patients with a history of hypothyroidism, urethral stricture, Addison's disease, prostate problems or peptic ulcer.

Patients undergoing anticoagulant therapy should use aspirin products with caution. Hypersensitivity to aspirin may appear in patients with nasal polyps. Hypersensitivity to aspirin is common in those with asthma.

Codeine, aspirin, caffeine and butalbital preparations may make you drowsy or dizzy. Do not operate heavy machinery or drive a car until you know how this drug affects you. Dizziness may be worse in the morning, when rising from bed. To avoid this, stand up slowly, especially when you get out of bed in the morning.

Do not drink alcohol while taking codeine, aspirin, caffeine and butalbital products; alcohol increases your risk for stomach bleeding and can increase drowsiness and dizziness associated with this product.

Narcotics can be habit-forming. Never take more than your doctor prescribed. Tell your physician if your current prescription does not relieve your symptoms.

Avoid taking other medicines containing aspirin. It is a common ingredient in prescription and over-the-counter medications. Read the labels of all medicines before consuming the product to avoid aspirin overdose. Aspirin may be listed as acetylsalicylic acid or ASA. Consult with your pharmacist if you are uncertain if a product contains aspirin.

Your doctor may order laboratory tests to monitor liver and kidney functions if you have a history of hepatic or renal disease.

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Prolonged use of aspirin products increases the risk for stomach bleeding. Using codeine and butalbital for a long time increases your risk for dependency or addiction. Discontinue using codeine, aspirin, caffeine and butalbital when you no longer need it or when your doctor tells you to stop.

Significant bleeding can occur in patients with peptic ulcer or other lesions in the gastrointestinal tract. Tell your doctor if you have any significant abdominal problems. Codeine and butalbital can obscure the signs your physician needs to diagnose or judge the course of serious abdominal problems.

Science has not yet determined if codeine, aspirin, caffeine and butalbital can harm an unborn child. Codeine and butalbital should not be taken while pregnant unless clearly necessary. Taking aspirin prior to delivery may prolong labor or cause bleeding in the mother or the baby. Consuming codeine during labor may cause the baby to suffer respiratory depression after delivery. Codeine is secreted into breast milk; do not use this product while breastfeeding.

Don't stop taking codeine, aspirin, caffeine and butalbital suddenly.

More Warnings About Using Codeine, Aspirin, Caffeine and Butalbital

Drug Interactions

Give your doctor and pharmacist a complete and updated list of all your medications, including prescriptions, over-the-counter drugs and herbal remedies. Codeine, aspirin, caffeine and butalbital preparations can enhance or interrupt the way some medicines work, including anticoagulants, oral anti-diabetic agents and insulin, NSAIDs, other narcotics, alcohol, general anesthetics and tranquilizers. More Drug Interactions

Side effects

You may experience side effects while taking this medication. Tell your doctor if the more common side effects become acute or don't go away on their own. Less serious side effects include:

  • Dry Mouth, Nausea, Vomiting or Decreased Appetite.
  • Dizziness, Tiredness or Lightheadedness.
  • Ringing in Your Ears.

Some side effects can be severe. Seek immediate medical assistance if you experience:

  • Shallow Breathing, Slow Heart Rate.
  • Fast or Pounding Heart Rate, Muscle Twitching.
  • Confusion, Unusual Thoughts or Behavior.
  • Black, Bloody or Tarry Stools.
  • Coughing Up Blood or Vomit that Looks Like Coffee.

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Codeine, aspirin, caffeine and butalbital overdose is a serious, life-threatening medical emergency. If you suspect that you or someone you know has taken an overdose of codeine, aspirin, caffeine and butalbital, seek emergency assistance immediately by going to the emergency room or calling an ambulance. If you need immediate help, contact your local poison control center at 1-800-222-1222. You may suffer toxicity if you consume too much of any of the four ingredients, codeine, aspirin, caffeine and butalbital. An overdose of butalbital is marked by drowsiness, confusion, and coma. You may also suffer respiratory depression, low blood pressure and hypovolemic shock, which is a condition where severe blood and fluid loss makes it impossible for the heart to pump sufficient blood to the body. Symptoms of an aspirin overdose include abnormally deep or rapid breathing, acid-base disturbances with development of metabolic acidosis, vomiting and abdominal pain, ringing in the ears, elevated body temperature, restlessness, delirium or seizures. It is possible to consume too much caffeine. symptoms include insomnia, restlessness, tremor, and delirium. You may also experience a rapid heartbeat with abnormal heart rhythms. Symptoms of codeine overdose include pinpoint pupils, respiratory depression and loss of consciousness. Convulsions are also possible.

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Butalbital and codeine can be habit-forming. Recreational users seek out drugs containing butalbital and codeine because these drugs get them high. Abusers obtain drugs by presenting forged prescriptions, calling bogus orders into pharmacies or by stealing from family and friends. Read More About Codeine, Aspirin, Caffeine and Butalbital Abuse


You may experience withdrawal symptoms when you stop using codeine, aspirin, caffeine and butalbital preparations suddenly, especially if you have been taking high doses or using this medication for a long period of time. Your withdrawal symptoms may prevent you from quitting without professional help.

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Detoxification from codeine and butalbital can cause extreme anxiety and withdrawal symptoms if not done correctly. Weaning your body from opiates can be a significantly uncomfortable process, regardless of whether dependency was gained through prescription or recreational use. A medically-supervised detoxification program is advised to ensure safety and increase comfort during the weaning process. Rapid detox involves deep sedation during the most acute phase of the withdrawal process. In this procedure, your body's opiate receptors are cleansed of opioids while you are anaesthetized and asleep. Learn More About Codeine, Aspirin, Caffeine and Butalbital Detoxification Programs


Keep codeine, aspirin, caffeine and butalbital preparations in a tightly-sealed container at temperatures below 77 degrees Fahrenheit. Protect from moisture. Read More About Storing Codeine, Aspirin, Caffeine and Butalbital