Codeine, Acetaminophen, Magnesium Salicylate and Phenyltoloxamine

  • Generic Name or Active Ingridient: Codeine
Drug Class: Codeine, Acetaminophen, Magnesium Salicylate And Phenyltoloxamine > Codeine > Opiate > Opioids > Opioid Agonist > Analgesic.

Uses

Doctors prescribe codeine, acetaminophen, magnesium salicylate and phenyltoloxamine combination drugs to treat head pain, painful periods and generalized pain. Learn More About Codeine, Acetaminophen, Magnesium Salicylate and Phenyltoloxamine Uses

Other, off label uses for this medicine

Phenyltoloxamine is an antihistamine that reduces itchy and watery eyes, runny nose and sneezing. Codeine suppresses the cough reflex. Together, these drugs can reduce symptoms associated with allergies, the common cold and the flu. More Off-Label Uses for Codeine, Acetaminophen, Magnesium Salicylate and Phenyltoloxamine

Administration/Dosage

A combination drug containing codeine, acetaminophen, magnesium salicylate and phenyltoloxamine is sold under the brand name Combiflex ES.

Take this and all medicines exactly as prescribed. Do not take excessive doses and do not use this drug more frequently than recommended by your physician.

Ask your doctor if you are supposed to take this medication on a regular schedule or only when you need it to relieve your symptoms. If your physician recommends you adhere to a schedule and you miss a dose, take the missed dose as soon as you remember, provided it is not nearly time to take another dose. Never double up on medication in an effort to make up for lost doses.

Speak with your doctor if your prescription stops working or does not provide adequate coverage for your symptoms. This may be a sign that your tolerance to the medication is increasing. Your physician may adjust the dosages or switch medications.

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Action

Trauma or illness injures the cells of your body. Injured cells release a protein known as a COX enzyme. COX enzymes produce prostaglandins. Prostaglandins serve many functions in the human body, including causing pain, inflammation and fever. Prostaglandins bind with pain receptors in nerve endings, sending specific information about the severity and location of the injury to your brain. Your brain responds by perceiving pain and taking action. Phenyltoloxamine is an antihistamine that is also a mild sedative and pain reliever. An antihistamine blocks the production of natural histamines which cause itchy, watery eyes, runny nose and sneezing. Magnesium salicylate is a non-steroidal anti-inflammatory drug; it reduces swelling. Acetaminophen works by reducing COX enzymes so that there is less prostaglandins in the body to cause pain. Codeine reduces pain by binding to pain receptors to interrupt the messages of pain. Codeine also reduces cough by acting directly on the part of the brain responsible for the cough reflex. Codeine makes your brain unaware of pain or the need to cough. More About How Codeine, Acetaminophen, Magnesium Salicylate and Phenyltoloxamine Works

Precautions

Any person can suffer an allergic reaction to any medication. Do not take codeine, acetaminophen, magnesium salicylate and phenyltoloxamine preparations if you are allergic to any component of that medication. Do not take this medication if you are allergic to other opioids, such as morphine or oxycodone. Tell your doctor if you are allergic to any medication. Seek immediate medical assistance when you first notice any symptom of an allergic reaction, as this medical condition can deteriorate rapidly into a life-or-death emergency. Symptoms of an allergic reaction include hives, difficulty breathing or swelling of the face, lips, tongue or throat.

Supply your doctor with a complete medical history. Codeine, acetaminophen, magnesium salicylate and phenyltoloxamine preparations may worsen some medical conditions. Certain illnesses may interfere with the way this medication works.

This medication may make you dizzy or drowsy. Do not operate heavy machinery or drive a car until you know how this drug affects you. Cough and cold medications may worsen these effects.

Do not drink alcohol while taking this medication. Alcohol enhances some of the adverse side effects associated with codeine. Tell your doctor if you drink more than three alcoholic beverages each day or if you have a history of cirrhosis of the liver. You may not be able to take preparations containing codeine and acetaminophen. Your doctor may choose a different medication or adjust your dosage.

Codeine can be habit-forming. Developing a habit of taking drugs leads to physical dependence and even addiction. Symptoms that a drug is becoming a habit include taking medication when you don't need it, taking large doses or using the drug more frequently than prescribed. You may find yourself become irritable just before it is time to take another dose.

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Warnings

The Food and Drug Administration, or FDA, classifies drugs according to the potential harm they pose to you or your unborn child. The FDA classifies this medicine as a pregnancy Category C, which means scientists have not yet determined whether taking this drug during pregnancy will harm an unborn child. Some components of this drug may pass into breast milk and onto your nursing child; do not take this medication while breastfeeding your baby. Tell your doctor if you are pregnant or plan to become pregnant while taking this medication. Call your physician if you become pregnant while using this drug.

Do not stop taking this medication unless directed to do so by a physician. Sudden cessation may result in unpleasant withdrawal symptoms. Try weaning yourself from this drug by taking smaller doses further apart. Talk with your doctor or rehabilitation specialist if withdrawal symptoms prevent you from quitting this medication.

More Warnings About Using Codeine, Acetaminophen, Magnesium Salicylate and Phenyltoloxamine

Drug Interactions

This medication may interact with other drugs in unsafe or unfavorable ways. Give your doctor and pharmacist a complete list of all your medications, including prescriptions, over-the-counter preparations and herbal remedies. Do not start or stop any medication, including over-the-counter and herbal remedies, without consulting your physician.

More Drug Interactions

Side effects

You may experience side effects from using this medication. Contact your doctor if the common side effects become intolerable or if they don't go away on their own. Common side effects include a thickening of lung secretions, stomach irritation, drowsiness and trouble sleeping.

Contact your doctor or local emergency room if you experience serious side effects. These side effects may become life-threatening.

Serious side effects include:

  • Shallow Breathing, Slow Heartbeat.
  • Feeling Light-Headed, Fainting.
  • Confusion, Unusual Thoughts or Behavior.
  • Seizure.
  • Easy Bruising or Bleeding. or
  • Nausea, Stomach Pain, Loss of Appetite, Itching, Dark Urine, Clay-Colored Stools, Jaundice.

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Overdose

Overdose is a serious medical condition that may deteriorate rapidly into a life-or-death emergency. If you suspect that you or someone you know has taken an overdose of this or any other medication, contact the poison control center at 1-800-222-1222 or go to the emergency room immediately. You can overdose on codeine or acetaminophen. Adults should not take more than 4000 mg of acetaminophen in a 24-hour period; children should consume less than 90 mg daily. Codeine overdose symptoms include extreme drowsiness, pinpoint pupils, cold and clammy skin, fainting, weak pulse, seizures, coma, blue lips, shallow breathing or no breathing.

Acetaminophen overdose may present symptoms in two waves. The first symptoms of acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating and confusion or weakness. Later symptoms may include upper abdominal pain, dark urine and yellowing of your skin or eyes, a condition known as jaundice.

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Abuse

Drug abuse means to habitually take addictive or illegal drugs. You can abuse drugs by taking medication for recreational purposes or by continuing to take a drug after your physician has discontinued the prescription. You can also abuse drugs by taking large doses of a drug or taking it more often than prescribed. Codeine is often the target of recreational drug abusers because of the sense of euphoria you feel after taking this product. Abusers get this drug by filing phony prescriptions at pharmacies, visiting multiple doctors or by stealing it.

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Withdrawal

Drug dependence means you need to continue taking the drug to avoid unpleasant withdrawal symptoms. Withdrawal symptoms are a predictable, normal physiological response to taking large doses of opioids or taking them for a long period of time. Withdrawal symptoms are not necessarily a sign of illegal drug abuse - you may experience withdrawal symptoms after taking drugs given to you in the hospital or after a lengthy illness. Everyone experiences withdrawal slightly differently. Some people may be able to quit taking this drug on their own, while severe withdrawal symptoms may prevent other people from quitting without the help of rehabilitation specialists. Tell your doctor if your withdrawal symptoms prevent you from quitting this drug. Learn More About Codeine, Acetaminophen, Magnesium Salicylate and Phenyltoloxamine Withdrawal

Detox

Rehabilitation specialists will give your medication to detoxify and cleanse your body while easing your withdrawal symptoms. Some programs include counseling and other social services to increase your chances of successfully quitting this drug. Rapid detox is state-of-the-art rehabilitation care. During rapid detox, physicians administer anesthesia and sedatives along with detoxification medications so that you sleep through the withdrawal process, unaware of the unpleasant withdrawal symptoms. When you awaken, you will have no memory of any physical discomfort associated with withdrawal. Learn More About Codeine, Acetaminophen, Magnesium Salicylate and Phenyltoloxamine Detoxification Programs

Storage

Keep this medication at room temperature, away from excessive heat, light and moisture. Put this drug out of the reach of children and pets. Make sure adults do not take this medication by accident or on purpose.

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